This document provides information on Mumps, Measles, and Rubella. It discusses the causative agents, hosts, environments, pathogenesis, clinical manifestations, diagnosis, treatment, prevention, and vaccination for each disease. Mumps is caused by a paramyxovirus and presents with parotid gland swelling. Measles is caused by a morbillivirus and presents with a rash and Koplik's spots. Rubella is caused by a togavirus and often presents asymptomatically or with mild symptoms and rash. Complications can include encephalitis, deafness, and congenital rubella syndrome. Diagnosis involves virus detection and serology. Treatment is supportive. Prevention relies on vaccination with the
Chickenpox -symptoms |tests |management ( medical information ) martinshaji
Chickenpox is a highly contagious viral infection that causes an acute fever and blistered rash, mainly in children.
The name may be derived from the French term for chick pea, chiche pois. Another theory is that the word 'chicken' was derived from a slang term for 'child'. Chickenpox is also known as varicella.
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Chickenpox -symptoms |tests |management ( medical information ) martinshaji
Chickenpox is a highly contagious viral infection that causes an acute fever and blistered rash, mainly in children.
The name may be derived from the French term for chick pea, chiche pois. Another theory is that the word 'chicken' was derived from a slang term for 'child'. Chickenpox is also known as varicella.
please comment
thank you ...
meningococcal meningitis is a very serious and fatal disease if not treated in time. the case fatality rate can go upto 50% in untreated cases .there are many strains which are responsible for its occurrence .it tend to occur both in endemic as well as in epidemic form. a qudrivalent vaccine is available for protection. recipient of this vaccine are to be given chemo prophylaxis .recently a vaccine against type b strain has been made avialable in canada for use in routine immunization
Pertussis : Highly contagious respiratory infection caused by Bordetella pertussis
Outbreaks first described in 16th century
Bordetella pertussis isolated in 1906
Estimated >300,000 deaths annually worldwide
Before the availability of pertussis vaccine in the 1940s, public health experts reported more than 200,000 cases of pertussis annually.
Since widespread use of the vaccine began, incidence has decreased more than 75% compared with the pre-vaccine era.
In 2012, the last peak year, CDC reported 48,277 cases of pertussis.
Extremely contagious-attack rate 100%
Immunity is never complete
Protection begins to wane in 3-5 yrs after vaccination
Measles is a highly contagious viral infection.
It is exanthematous disease with fewer, cough, coryza (rhinitis) and conjunctivitis.
Before the widespread use of measles vaccines, it was estimated that measles caused between 5 million and 8 million deaths worldwide each year.
Measles is a highly infectious disease of childhood caused by Measles virus. It is characterized by fever, catarrhal symptoms of the upper respiratory tract infections followed by typical rash.
Measles is defined as an acute and highly contagious viral disease characterized by fever, runny nose, cough, red eyes and a spreading skin rash.
Causative agent: Rubeola virus, a RNA virus of paramyxoviridae family
Reservoir: Human
Source: Infected Human
Period of Communicability: Approximately 4 days prior and 4 days after the appearance of the rash
Mode of Transmission:
Airborne transmission(virus remains active and contagious in the air or on infected surfaces for up to 2 hours)
Droplet transmission i.e. it is spread by coughing and sneezing, close personal contact or direct contact with infected nasal or throat secretions
Portal of entry: Respiratory tract and Conjunctiva
Incubation Period: 10-15 days
Host:
Children between age of 1 and 5 years
Older children
Malnourished children
Environment: Winter and spring month ,Low socio-economic status .
Clinical manifestations of measles are in three stages:
STAGE 1: Prodromal/ Catarrhal Stage:
starts after 10 days of infection and lasts up to 3-5 days-
- Fever
- Malaise
- Coryza
- Sneezing
- Nasal Discharge
- Brassy Cough
- Redness of eye
- Lacrimation
- Photophobia
- Lymphadenopathy
- Vomiting
- Diarrhea
- Koplik spot – grayish or bluish white spots, fine tiny grain like papules on a faint red base, smaller than the head of pin.
- Spots appear before the appearance of rash
- Found on buccal mucosa opposite to first and second molar
- Usually disappear after the rash, appears a day
Stage 2: Eruptive Stage:
- Typical irregular dusky red macular or maculopapular rash found behind the ears and face first, usually 3-5 days after the onset of disease
- Then it spread to neck, trunk, limbs, palms and soles in the next 3-4 days.
- Anorexia
-Malaise
-Cervical lymphadenopathy
-Fever and rash usually disappear in 4-5 days in the same order of appearance
- Fine shedding of superficial skin of face, trunk and limbs leaving brownish discoloration that persists 2 months or more
Stage 3: Convalescent or Post- Measles Stage:
-Fever and rash disappear
-Child remains sick for number of days and lose weight
- Gradual deterioration into chronic illnesses due to bacterial or viral infections, nutritional and metabolic disturbances or other complications.
prevention- Active Immunization with live attenuated vaccines 0.5 ml subcutaneously in single dose at 9-12 months of age.
management,nursing management, nursing diagnosis
meningococcal meningitis is a very serious and fatal disease if not treated in time. the case fatality rate can go upto 50% in untreated cases .there are many strains which are responsible for its occurrence .it tend to occur both in endemic as well as in epidemic form. a qudrivalent vaccine is available for protection. recipient of this vaccine are to be given chemo prophylaxis .recently a vaccine against type b strain has been made avialable in canada for use in routine immunization
Pertussis : Highly contagious respiratory infection caused by Bordetella pertussis
Outbreaks first described in 16th century
Bordetella pertussis isolated in 1906
Estimated >300,000 deaths annually worldwide
Before the availability of pertussis vaccine in the 1940s, public health experts reported more than 200,000 cases of pertussis annually.
Since widespread use of the vaccine began, incidence has decreased more than 75% compared with the pre-vaccine era.
In 2012, the last peak year, CDC reported 48,277 cases of pertussis.
Extremely contagious-attack rate 100%
Immunity is never complete
Protection begins to wane in 3-5 yrs after vaccination
Measles is a highly contagious viral infection.
It is exanthematous disease with fewer, cough, coryza (rhinitis) and conjunctivitis.
Before the widespread use of measles vaccines, it was estimated that measles caused between 5 million and 8 million deaths worldwide each year.
Measles is a highly infectious disease of childhood caused by Measles virus. It is characterized by fever, catarrhal symptoms of the upper respiratory tract infections followed by typical rash.
Measles is defined as an acute and highly contagious viral disease characterized by fever, runny nose, cough, red eyes and a spreading skin rash.
Causative agent: Rubeola virus, a RNA virus of paramyxoviridae family
Reservoir: Human
Source: Infected Human
Period of Communicability: Approximately 4 days prior and 4 days after the appearance of the rash
Mode of Transmission:
Airborne transmission(virus remains active and contagious in the air or on infected surfaces for up to 2 hours)
Droplet transmission i.e. it is spread by coughing and sneezing, close personal contact or direct contact with infected nasal or throat secretions
Portal of entry: Respiratory tract and Conjunctiva
Incubation Period: 10-15 days
Host:
Children between age of 1 and 5 years
Older children
Malnourished children
Environment: Winter and spring month ,Low socio-economic status .
Clinical manifestations of measles are in three stages:
STAGE 1: Prodromal/ Catarrhal Stage:
starts after 10 days of infection and lasts up to 3-5 days-
- Fever
- Malaise
- Coryza
- Sneezing
- Nasal Discharge
- Brassy Cough
- Redness of eye
- Lacrimation
- Photophobia
- Lymphadenopathy
- Vomiting
- Diarrhea
- Koplik spot – grayish or bluish white spots, fine tiny grain like papules on a faint red base, smaller than the head of pin.
- Spots appear before the appearance of rash
- Found on buccal mucosa opposite to first and second molar
- Usually disappear after the rash, appears a day
Stage 2: Eruptive Stage:
- Typical irregular dusky red macular or maculopapular rash found behind the ears and face first, usually 3-5 days after the onset of disease
- Then it spread to neck, trunk, limbs, palms and soles in the next 3-4 days.
- Anorexia
-Malaise
-Cervical lymphadenopathy
-Fever and rash usually disappear in 4-5 days in the same order of appearance
- Fine shedding of superficial skin of face, trunk and limbs leaving brownish discoloration that persists 2 months or more
Stage 3: Convalescent or Post- Measles Stage:
-Fever and rash disappear
-Child remains sick for number of days and lose weight
- Gradual deterioration into chronic illnesses due to bacterial or viral infections, nutritional and metabolic disturbances or other complications.
prevention- Active Immunization with live attenuated vaccines 0.5 ml subcutaneously in single dose at 9-12 months of age.
management,nursing management, nursing diagnosis
Measles is an acute respiratory viral infection, contagious in nature. It may lead to epidemic if susceptible population is more than 40%. But with very effective vaccine, it can be eliminated
(May 29th, 2024) Advancements in Intravital Microscopy- Insights for Preclini...Scintica Instrumentation
Intravital microscopy (IVM) is a powerful tool utilized to study cellular behavior over time and space in vivo. Much of our understanding of cell biology has been accomplished using various in vitro and ex vivo methods; however, these studies do not necessarily reflect the natural dynamics of biological processes. Unlike traditional cell culture or fixed tissue imaging, IVM allows for the ultra-fast high-resolution imaging of cellular processes over time and space and were studied in its natural environment. Real-time visualization of biological processes in the context of an intact organism helps maintain physiological relevance and provide insights into the progression of disease, response to treatments or developmental processes.
In this webinar we give an overview of advanced applications of the IVM system in preclinical research. IVIM technology is a provider of all-in-one intravital microscopy systems and solutions optimized for in vivo imaging of live animal models at sub-micron resolution. The system’s unique features and user-friendly software enables researchers to probe fast dynamic biological processes such as immune cell tracking, cell-cell interaction as well as vascularization and tumor metastasis with exceptional detail. This webinar will also give an overview of IVM being utilized in drug development, offering a view into the intricate interaction between drugs/nanoparticles and tissues in vivo and allows for the evaluation of therapeutic intervention in a variety of tissues and organs. This interdisciplinary collaboration continues to drive the advancements of novel therapeutic strategies.
DERIVATION OF MODIFIED BERNOULLI EQUATION WITH VISCOUS EFFECTS AND TERMINAL V...Wasswaderrick3
In this book, we use conservation of energy techniques on a fluid element to derive the Modified Bernoulli equation of flow with viscous or friction effects. We derive the general equation of flow/ velocity and then from this we derive the Pouiselle flow equation, the transition flow equation and the turbulent flow equation. In the situations where there are no viscous effects , the equation reduces to the Bernoulli equation. From experimental results, we are able to include other terms in the Bernoulli equation. We also look at cases where pressure gradients exist. We use the Modified Bernoulli equation to derive equations of flow rate for pipes of different cross sectional areas connected together. We also extend our techniques of energy conservation to a sphere falling in a viscous medium under the effect of gravity. We demonstrate Stokes equation of terminal velocity and turbulent flow equation. We look at a way of calculating the time taken for a body to fall in a viscous medium. We also look at the general equation of terminal velocity.
Observation of Io’s Resurfacing via Plume Deposition Using Ground-based Adapt...Sérgio Sacani
Since volcanic activity was first discovered on Io from Voyager images in 1979, changes
on Io’s surface have been monitored from both spacecraft and ground-based telescopes.
Here, we present the highest spatial resolution images of Io ever obtained from a groundbased telescope. These images, acquired by the SHARK-VIS instrument on the Large
Binocular Telescope, show evidence of a major resurfacing event on Io’s trailing hemisphere. When compared to the most recent spacecraft images, the SHARK-VIS images
show that a plume deposit from a powerful eruption at Pillan Patera has covered part
of the long-lived Pele plume deposit. Although this type of resurfacing event may be common on Io, few have been detected due to the rarity of spacecraft visits and the previously low spatial resolution available from Earth-based telescopes. The SHARK-VIS instrument ushers in a new era of high resolution imaging of Io’s surface using adaptive
optics at visible wavelengths.
Nutraceutical market, scope and growth: Herbal drug technologyLokesh Patil
As consumer awareness of health and wellness rises, the nutraceutical market—which includes goods like functional meals, drinks, and dietary supplements that provide health advantages beyond basic nutrition—is growing significantly. As healthcare expenses rise, the population ages, and people want natural and preventative health solutions more and more, this industry is increasing quickly. Further driving market expansion are product formulation innovations and the use of cutting-edge technology for customized nutrition. With its worldwide reach, the nutraceutical industry is expected to keep growing and provide significant chances for research and investment in a number of categories, including vitamins, minerals, probiotics, and herbal supplements.
The ability to recreate computational results with minimal effort and actionable metrics provides a solid foundation for scientific research and software development. When people can replicate an analysis at the touch of a button using open-source software, open data, and methods to assess and compare proposals, it significantly eases verification of results, engagement with a diverse range of contributors, and progress. However, we have yet to fully achieve this; there are still many sociotechnical frictions.
Inspired by David Donoho's vision, this talk aims to revisit the three crucial pillars of frictionless reproducibility (data sharing, code sharing, and competitive challenges) with the perspective of deep software variability.
Our observation is that multiple layers — hardware, operating systems, third-party libraries, software versions, input data, compile-time options, and parameters — are subject to variability that exacerbates frictions but is also essential for achieving robust, generalizable results and fostering innovation. I will first review the literature, providing evidence of how the complex variability interactions across these layers affect qualitative and quantitative software properties, thereby complicating the reproduction and replication of scientific studies in various fields.
I will then present some software engineering and AI techniques that can support the strategic exploration of variability spaces. These include the use of abstractions and models (e.g., feature models), sampling strategies (e.g., uniform, random), cost-effective measurements (e.g., incremental build of software configurations), and dimensionality reduction methods (e.g., transfer learning, feature selection, software debloating).
I will finally argue that deep variability is both the problem and solution of frictionless reproducibility, calling the software science community to develop new methods and tools to manage variability and foster reproducibility in software systems.
Exposé invité Journées Nationales du GDR GPL 2024
Professional air quality monitoring systems provide immediate, on-site data for analysis, compliance, and decision-making.
Monitor common gases, weather parameters, particulates.
Earliest Galaxies in the JADES Origins Field: Luminosity Function and Cosmic ...Sérgio Sacani
We characterize the earliest galaxy population in the JADES Origins Field (JOF), the deepest
imaging field observed with JWST. We make use of the ancillary Hubble optical images (5 filters
spanning 0.4−0.9µm) and novel JWST images with 14 filters spanning 0.8−5µm, including 7 mediumband filters, and reaching total exposure times of up to 46 hours per filter. We combine all our data
at > 2.3µm to construct an ultradeep image, reaching as deep as ≈ 31.4 AB mag in the stack and
30.3-31.0 AB mag (5σ, r = 0.1” circular aperture) in individual filters. We measure photometric
redshifts and use robust selection criteria to identify a sample of eight galaxy candidates at redshifts
z = 11.5 − 15. These objects show compact half-light radii of R1/2 ∼ 50 − 200pc, stellar masses of
M⋆ ∼ 107−108M⊙, and star-formation rates of SFR ∼ 0.1−1 M⊙ yr−1
. Our search finds no candidates
at 15 < z < 20, placing upper limits at these redshifts. We develop a forward modeling approach to
infer the properties of the evolving luminosity function without binning in redshift or luminosity that
marginalizes over the photometric redshift uncertainty of our candidate galaxies and incorporates the
impact of non-detections. We find a z = 12 luminosity function in good agreement with prior results,
and that the luminosity function normalization and UV luminosity density decline by a factor of ∼ 2.5
from z = 12 to z = 14. We discuss the possible implications of our results in the context of theoretical
models for evolution of the dark matter halo mass function.
Comparing Evolved Extractive Text Summary Scores of Bidirectional Encoder Rep...University of Maribor
Slides from:
11th International Conference on Electrical, Electronics and Computer Engineering (IcETRAN), Niš, 3-6 June 2024
Track: Artificial Intelligence
https://www.etran.rs/2024/en/home-english/
3. AGENT
• RNA virus
• Genus: Rubula
• Family: Paramyxoviridae
• Only one serotype; No carriers
• Incubation period: 16-18 days
• Communicable period: from 6 days before to 9 days after facial swelling is
apparent.
HOST
• Man
• Maternal antibody is protective for the infant in the first 6 months
ENVIRONMENT
• Late winter and spring
• Crowded places
4. Direct contact
Air borne droplets
Fomites contaminated
by saliva Initial multiplication in
respiratory tract
Blood borne to many
tissues
More to salivary glands&
lymphoid tissues
Viremia
Spread throughout the
body
PATHOGENESIS
5. CLINICAL MANIFESTATIONS
Approximately 1/3rd - asymptomatic (subclinical)
Nonspecific prodromal symptoms :
• Myalgia
• Malaise
• Head ache
• Low-grade fever
precede the parotid swelling by 12 to 24 hours
Parotitis - 30%-40%
• Unilateral or bilateral
• Self limiting
• Swollen parotid gland lifts the earlobe upward outward, &the angle of the
mandible is obscured
Other salivary glands maybe involved
9. • Routine laboratory tests are nonspecific
• Leukopenia- relative lymphocytosis.
• Rise in serum amylase level
parallels the parotid swelling
return to normal within 2 week
• Samples collected from:
buccal swabs (stensons duct exudates)
throat washings
saliva
spinal fluid
• Virus isolation from Saliva – 7 days before through 8 days after the onset of swelling
• Detection of mumps antigen by PCR
• Serologic testing:
Mumps specific IgM antibody
Significant increase in IgG antibody between acute &convalescent specimens
DIAGNOSIS
10. TREATMENT
• No specific antiviral therapy;
• Entirely supportive (Antipyretics, bed rest)
• MMR vaccination
PREVENTION
12. AGENT
• RNA virus
• Genus: Morbillivirus
• Family: Paramyxoviridae
• Only one serotype; Can’t survive outside the human body; No carriers
• Incubation period: 10-14 days
• Period of communicability: 4 days before to 4 days after appearance of rash
• Secondary Attack Rate(SAR): > 80% (Probability that infection occurs in susceptible,
within an incubation period, following a known contact with an infectious source)
HOST
• Age group: commonly 6 months - 3 years
• One attack-life long immunity
• Malnourished children highly susceptible
• Maternal antibody is protective for the infant in the first 6 month of life
ENVIRONMENT
• Over crowding
• January to April
15. PRODROMAL PHASE
From 10th day of infection to 14th day
3 Cs (Cough, Coryza & Conjunctivitis)
Lacrimation and photophobia
Fever
May be- vomiting or diarrhea
Koplik’s spots
Pathognomic sign
1-2 days before appearance of rash
Small, bluish-white spots over a red base
On buccal mucosa opposite the first& second lower molars
16. ERUPTIVE PHASE
Dusky red, generalized, maculopapular, erythematous rash
Begins behind the ear and rapidly spreads to face, neck and
extends down the body within 2-3 days
In the absence of complications, rash and fever disappears in
3-4 days
Rash fades in the order of appearance
Leaving behind branny desquamation
and brownish discoloration
18. COMPLICATIONS
• Otitis media
• Interstitial pneumonitis Hecht giant cell pneumonia
• Bronchopneumonia secondary bacterial infection
• Encephalomyelitis perivascular demyelination in brain and
spinal cord
• Subacute sclerosing pan encephalitis (SSPE)- degeneration of
the cortex and white matter with intranuclear and
intracytoplasmic inclusion bodies
19. DIAGNOSIS
Usually clinical diagnosis; laboratory confirmation is rarely needed
Isolation of measles virus by tissue culture in human embryonic or
rhesus monkey kidney cells
Demonstration of cytopathic changes with multinucleated giant cells
(Warthin Finkeldey), during prodromal stage, in smears of nasal mucosa
Serology
Measles IgM antibodies when the rash appears
Testing of acute and convalescent sera demonstrates the
diagnostic seroconversion or fourfold increase in titer
20. TREATMENT
No specific antiviral therapy
Entirely supportive (Antipyretics, bed rest, good nutrition, adequate fluid
intake, humidification, protection from exposure to sunlight)
Bacterial complications of otitis media and bronchopneumonia require
appropriate antimicrobial therapy
Vitamin A supplementation for
6 months- 2 years of age who are hospitalized for measles &its complications
>6 months of age with measles and immunodeficiency
Recommended regimen : single dose of
100,000 IU orally - 6 month to 1 year
200,000 IU orally - >1 year of age
Children with ophthalmologic evidence of vitamin A deficiency
additional doses the next day and 4 weeks later
21. PREVENTION
• Isolation from 7th day of exposure to 5 days after appearance of rash
• Maternal antibody protection till 6 months of life
• Measles vaccine at 9 months or 270 completed days, 0.5ml, s.c.
• Seroconversion rate : 95-98%
• Catch up vaccination
• Beyond 12 months MMR
• Measles vaccine administered during outbreaks aged 6 through 11 months
• Revaccinated with 2 doses of measles vaccine
• First, at ages 12 through 15 months, at least 4 weeks after the previous dose
• Second, at ages 4 through 6 years
22.
23. POST EXPOSURE PROPHYLAXIS
• Passive immunization with immune globulin is effective for
prevention and attenuation of measles.
• Immuno compromised persons should receive immune globulin (0.5
mL/kg; maximum: 15 mL) intramuscularly regardless of immunization
status.
• Infants 6 months of age or younger born to non-immune mothers
Immune globulin
• Infants 6 months of age or younger born to immune mothers by
maternal antibody
• 6-12 months Measles vaccine within 72 hours of exposure
• >12 months Measles or MMR vaccine within 72 hours of exposure.
25. AGENT
• RNA virus
• Family: Togo virus
• Source of infection: majority subclinical cases, minorclinical cases
• Transmission- droplets, vertical transmission
• Portal of entry: respiratory
• Incubation period: 2 to 3 weeks (average 18 days)
• Period of communicability: A week before to a week after the rash
HOST
• 3-10 years of age
• Life long immunity after first attack
• Maternal immunity up to 6 months of age
ENVIRONMENT
• Winter and spring season, with epidemics every 4-9 years
26. PATHOGENESIS
Rubella virus
Via respiratory
droplets
Infects cells in upper
respiratory tract
Virus multiplies
Extends to regional
lymph nodes
Virus replicates via
nasopharynx
Infection established
in skin &other tissues
Rash develops, cough
etc
27. CLINICAL FEATURES
• 50-60% asymptomatic
• Prodromal phase(mild): coryza, sore throat, low grade fever
• Lymphadenopathy- post auricular &posterior cervical lymph nodes
• Rash
Minute, discrete, pinkish, macular
Starts on face within 24 hours of onset of the prodromal symptoms
Spreads to trunk and extremities
Clears more rapidly in 3 days
Absent in 25% of subclinical cases
28.
29. DIAGNOSIS
Virus isolation by throat or nasal swab cell culture
Detection of rubella virus RNA by RT PCR
Serology
Four fold increase in antibody titer
Seroconversion between acute and convalescent Ig G titers
32. RATE OF ORGAN ANOMALIES
1- 8 WEEKS
• Cardiac defect & hearing impairment
• 80%
9-12 WEEKS
• Hearing impairment & features of CRS
• 50%
13- 16 WEEKS
• Hearing loss is prominent than others
• 30%
>20 WEEKS
• Chances of fetal damage is minimal to none
35. DIAGNOSIS
• ELISA for IgM antibody at birth till 3 months of life
• Followed by stable increase in rubella specific IgG over several
months
36. TREATMENT
• Treatment is supportive.
• Provide vision screening and hearing screening asymptomatic
newborns.
• Treatment of symptomatic newborns is as follows:
• Provide careful evaluation of the eyes ophthalmology referral corneal
clouding, cataract, and retinopathy. Corneal clouding may indicate infantile
glaucoma.
• Hepatosplenomegaly is monitored clinically. No intervention is required.
• Hyperbilirubinemia phototherapy or exchange transfusions if jaundice is
severe to prevent kernicterus.
• Severe thrombocytopenia IVIG. Corticosteroids are not indicated.
• Heart abnormality carefully observed for signs of congestive heart failure
Echocardiography
38. • Live attenuated strains of:
• Edmonston-Zagreb Measles virus
• L-Zagreb Mumps virus
• Wistar RA 27/3 Rubella virus
• The reconstituted vaccine contains, in single dose of 0.5 ml.
not less than
• 1000 CCID50 of Measles virus
• 5000 CCID50 of Mumps virus
• 1000 CCID50 of Rubella virus
• Diluent: Sterile water for injection.
• Minimum age: 12 months of age.
• Dose: 0.5 ml, deep SC in the upper arm
• First dose: 12 through 18 months, 4 weeks apart,
• Second dose: 4 through 6 years
39. • After reconstitution the vaccine should be used immediately
• If the vaccine is not used immediately then it should be stored
in the dark at 2°- 8°C, for no longer than 8 hour
• Catch up
• All school aged children & adolescents
• 2 doses, 4 weeks apart
• One dose if previously vaccinated