MOSIX Cluster allows connecting computers together to function as a single system for compute and data intensive applications. It can be used in a virtual environment by downloading a VMDK file, extracting it, copying it for each node, changing the UUID, creating VMs using the VMDK files, and running the "cluster" command on one node to automatically configure all nodes in the network to function as a cluster. Common MOSIX commands include mosrun to run programs on the cluster, mosps to view processes, and mosmon to monitor cluster status.