The document discusses modified release drug products, which alter the timing or rate of drug release, highlighting their advantages such as reduced blood level fluctuations and improved patient compliance. It categorizes these products into types such as delayed release, extended release, and orally disintegrating tablets, providing examples for each. The text concludes with a reference to a relevant pharmacokinetics textbook.

1. MODIFIED RELEASE DRUG
PRODUCT
NAME – MUKESH V KAPSE
CLASS – M PHARM 1th
YEAR 2th
SEM
ROLL NO – 06
SUBJECT – Advanced Biopharmaceutics
and Pharmacokinetics

2. CONTENTS
• Introduction
• Advantages
• Types of Modified release drug products
• Examples of modified release dosage forms
• Types of Extended Release Products
• References

3. INTRODUCTION
 Modified release drug product are those that
alter the timing and/or the rate of release of drug
substance.

4. ADVANTAGES
 Reduction in drug blood level fluctuation
 Frequency reduction in dosing
 Patient compliance
 Reduced adverse side effect
 Reduction in health care cost

5. TYPES OF MODIFIED RELEASE DRUG
PRODUCTS
 1. Delayed release
 2. Extended release
 3. Orally disintegrating tablet

6. DELAYED RELEASE DRUG
PRODUCTS
 Releases a discrete portion of drug at a time
other than promptly after administration.e.g -
enterric coated dosage forms like enterric coated
aspirin,other NSAIDS, etc.

7. EXTENDED RELEASE DRUG
PRODUCTS
 Two fold release indosage frequency,examples
include controlled release, sustained release and
long acting drug products.

8. ORALLY DISINTEGRATING TABLETS
 Disintegrate rapidly in saliva after oral
administration.
 Can be used without addition of water.
 Drug dispersed in saliva and swallowed.

9. EXAMPLES OF MODIFIED RELEASE
DOSAGE FORMS

10. TYPES OF EXTENDED RELEASE
PRODUCTS
 Coated beads, granules, or microspheres
 Multitablet system
 Microencapsulated drug
 Embedding drug in slowly eroding or hydrophilic
matrix system
 Embedding drug in inert plastic matrix
 Complex formation
 lon-exchange resins

11. REFERENCE
 Shargel leon, WU Pong Susanna, B.C. YU
Andrew, Applied Biopharmaceutics and
Pharmacokinetics, 5° edition,rights by McGraw-
hill, page no.-516-551

12. Thank You