contains the basic information you need to know about meningitis - definition, etiology, pathophysiology, clinical signs and symptoms, investigation, complications, management
Meningitis is an inflammation of the protective membranes covering the brain and spinal cord. It can be caused by bacteria, viruses, fungi, or certain drugs. Common symptoms include fever, headache, and neck stiffness. Diagnosis involves examining cerebrospinal fluid obtained via lumbar puncture. Treatment involves immediate antibiotics, steroids, and other drugs depending on the cause. Complications can include brain damage, hearing loss, and death if not treated promptly.
Bacterial meningitis is a common central nervous system infection caused by various bacteria. Neisseria meningitidis is a major cause and produces an endotoxin responsible for circulatory collapse. It occurs sporadically or in epidemics, is transmitted via droplets, and prevalence is higher in young children and spleenectomized patients. Clinical presentation includes headache, fever, vomiting, and neck stiffness. Investigations include CSF analysis and blood cultures. Treatment involves antibiotics and supportive care while complications can include neurological deficits if left untreated. Vaccination and chemoprophylaxis can help prevent further spread.
Complications from meningitis can arise from the spread of infection or the healing process. Infection can spread to areas like the brain ventricles, subdural spaces, veins and sinuses, and bloodstream, potentially causing issues like ependymitis, thrombophlebitis, and metastatic infections. During healing, complications include arachnoid fibrosis which can lead to hydrocephalus, cranial nerve compression causing palsies, and obliterative endarteritis resulting in brain ischemia or infarcts. While viral meningitis complications are rare, bacterial meningitis poses greater risks like subdural effusion and neurological sequelae such as deafness, blindness, seizures, and mental retardation
Meningitis is an inflammation of the membranes (meninges) surrounding the brain and spinal cord. It can be caused by bacteria, viruses, fungi or parasites. Bacterial meningitis is the most dangerous form and can cause death within hours if not treated promptly with antibiotics. Symptoms include sudden onset of fever, headache and stiff neck. Those at highest risk include adolescents, young adults living in dorms, infants, and people with certain medical conditions. While the disease is contagious through respiratory and mouth secretions, vaccination provides protection against some common types. Proper hygiene and promptly treating infections can also help prevent meningitis.
Meningitis is an inflammation of the membranes surrounding the brain and spinal cord. It can be caused by various bacteria, viruses, and fungi. Bacterial meningitis requires immediate medical treatment with antibiotics to prevent permanent damage or death. Symptoms include headache, fever, and neck stiffness. While meningitis is most common in sub-Saharan Africa, outbreaks can occur anywhere. Vaccines exist for some causes of bacterial meningitis.
This document discusses acute CNS infections such as acute pyogenic meningitis, meningoencephalitis, and tuberculous meningitis (TBM). It covers the etiology, pathogenesis, clinical features, diagnosis, and treatment of these conditions. Common causes of acute pyogenic meningitis in children include Group B streptococcus, pneumococcus, meningococcus, and HIB. Meningoencephalitis can be caused by enteroviruses, arboviruses, or herpes viruses. TBM most often affects children ages 6 months to 4 years and has distinct prodromal, abrupt, and coma stages. Lumbar puncture and CSF analysis are important for diagnosing these infections
This document provides information on acute central nervous system infections, including bacterial meningitis and cerebral malaria. It defines meningitis as inflammation of the two inner layers of tissue covering the brain and spinal cord. It describes the relevant anatomy of the brain and meninges. Common causes of bacterial meningitis are discussed for different age groups. Risk factors, pathogenesis, clinical features, differential diagnosis, and initial investigations for meningitis and cerebral malaria are summarized. Lumbar puncture indications, contraindications, and analysis of cerebrospinal fluid are also outlined.
Meningitis is an inflammation of the meninges that can be caused by bacteria, viruses, fungi or other pathogens. Bacterial meningitis requires urgent treatment and has the highest risk of complications. Common bacterial causes include streptococcus pneumoniae, neisseria meningitidis, and haemophilus influenzae. Viral meningitis is generally milder and self-limiting. Tubercular meningitis has a subacute onset and causes thick basal exudates. Fungal meningitis occurs more often in immunocompromised individuals. Diagnosis involves CSF analysis showing pleocytosis and characteristic findings depending on the cause. Treatment involves antibiotics, antivirals or antitubercular drugs depending on the
Meningitis is an inflammation of the protective membranes covering the brain and spinal cord. It can be caused by bacteria, viruses, fungi, or certain drugs. Common symptoms include fever, headache, and neck stiffness. Diagnosis involves examining cerebrospinal fluid obtained via lumbar puncture. Treatment involves immediate antibiotics, steroids, and other drugs depending on the cause. Complications can include brain damage, hearing loss, and death if not treated promptly.
Bacterial meningitis is a common central nervous system infection caused by various bacteria. Neisseria meningitidis is a major cause and produces an endotoxin responsible for circulatory collapse. It occurs sporadically or in epidemics, is transmitted via droplets, and prevalence is higher in young children and spleenectomized patients. Clinical presentation includes headache, fever, vomiting, and neck stiffness. Investigations include CSF analysis and blood cultures. Treatment involves antibiotics and supportive care while complications can include neurological deficits if left untreated. Vaccination and chemoprophylaxis can help prevent further spread.
Complications from meningitis can arise from the spread of infection or the healing process. Infection can spread to areas like the brain ventricles, subdural spaces, veins and sinuses, and bloodstream, potentially causing issues like ependymitis, thrombophlebitis, and metastatic infections. During healing, complications include arachnoid fibrosis which can lead to hydrocephalus, cranial nerve compression causing palsies, and obliterative endarteritis resulting in brain ischemia or infarcts. While viral meningitis complications are rare, bacterial meningitis poses greater risks like subdural effusion and neurological sequelae such as deafness, blindness, seizures, and mental retardation
Meningitis is an inflammation of the membranes (meninges) surrounding the brain and spinal cord. It can be caused by bacteria, viruses, fungi or parasites. Bacterial meningitis is the most dangerous form and can cause death within hours if not treated promptly with antibiotics. Symptoms include sudden onset of fever, headache and stiff neck. Those at highest risk include adolescents, young adults living in dorms, infants, and people with certain medical conditions. While the disease is contagious through respiratory and mouth secretions, vaccination provides protection against some common types. Proper hygiene and promptly treating infections can also help prevent meningitis.
Meningitis is an inflammation of the membranes surrounding the brain and spinal cord. It can be caused by various bacteria, viruses, and fungi. Bacterial meningitis requires immediate medical treatment with antibiotics to prevent permanent damage or death. Symptoms include headache, fever, and neck stiffness. While meningitis is most common in sub-Saharan Africa, outbreaks can occur anywhere. Vaccines exist for some causes of bacterial meningitis.
This document discusses acute CNS infections such as acute pyogenic meningitis, meningoencephalitis, and tuberculous meningitis (TBM). It covers the etiology, pathogenesis, clinical features, diagnosis, and treatment of these conditions. Common causes of acute pyogenic meningitis in children include Group B streptococcus, pneumococcus, meningococcus, and HIB. Meningoencephalitis can be caused by enteroviruses, arboviruses, or herpes viruses. TBM most often affects children ages 6 months to 4 years and has distinct prodromal, abrupt, and coma stages. Lumbar puncture and CSF analysis are important for diagnosing these infections
This document provides information on acute central nervous system infections, including bacterial meningitis and cerebral malaria. It defines meningitis as inflammation of the two inner layers of tissue covering the brain and spinal cord. It describes the relevant anatomy of the brain and meninges. Common causes of bacterial meningitis are discussed for different age groups. Risk factors, pathogenesis, clinical features, differential diagnosis, and initial investigations for meningitis and cerebral malaria are summarized. Lumbar puncture indications, contraindications, and analysis of cerebrospinal fluid are also outlined.
Meningitis is an inflammation of the meninges that can be caused by bacteria, viruses, fungi or other pathogens. Bacterial meningitis requires urgent treatment and has the highest risk of complications. Common bacterial causes include streptococcus pneumoniae, neisseria meningitidis, and haemophilus influenzae. Viral meningitis is generally milder and self-limiting. Tubercular meningitis has a subacute onset and causes thick basal exudates. Fungal meningitis occurs more often in immunocompromised individuals. Diagnosis involves CSF analysis showing pleocytosis and characteristic findings depending on the cause. Treatment involves antibiotics, antivirals or antitubercular drugs depending on the
This document discusses different types of meningitis, including acute pyogenic meningitis, acute lymphocytic meningitis, and chronic meningitis. Acute pyogenic meningitis is caused by bacteria and results in inflammation of the meninges around the brain. Common causative organisms vary with age. Acute lymphocytic meningitis is usually viral and has milder symptoms that resolve more quickly. Chronic meningitis includes tuberculous and cryptococcal types, which cause long-term granulomatous inflammation that may lead to hydrocephalus. Diagnosis is based on examination of cerebrospinal fluid characteristics.
This document provides information about Neisseria meningitidis, the bacteria that causes meningococcal meningitis. It describes the morphological features and virulence factors of N. meningitidis, including its gram-negative diplococcal shape, polysaccharide capsule that allows it to evade the immune system, and pili that enable it to attach to cells in the nasopharynx. The document also outlines the pathogenesis of meningococcal meningitis, noting that the bacteria spread from the nasopharynx via the bloodstream to the meninges, where it can cause inflammation and potentially fatal infection.
This document provides information on acute bacterial meningitis, including:
- The most common causative organisms are Streptococcus pneumoniae, Neisseria meningitidis, and Group B streptococci.
- Clinical presentation typically includes the classic triad of fever, headache, and nuchal rigidity, along with decreased consciousness.
- Diagnosis involves examination of CSF which shows pleocytosis, low glucose, and high protein. Blood cultures and neuroimaging may also be used.
- Treatment involves prompt empiric administration of antibiotics like ceftriaxone, vancomycin, and dexamethasone, with specific therapy guided by diagnostic testing.
summary of Bacterial meningitis
Describe the properties, transmission and pathogenesis of
Neisseria meningitidis, Streptococcus pneumoniae and Haemophilus influenzae
as causative agents of meningitis.
Pathophysiology and Treatment of Meningoencephalitis - A journal readingAlda Simbolon
This document discusses the pathophysiology and treatment of bacterial meningitis. It begins by defining bacterial meningitis as an inflammation of the meninges caused by bacterial invasion. It then discusses the pathogenesis, which involves bacterial invasion across the blood-brain barrier, an inflammatory response, and neuronal damage caused by bacterial toxins and immune responses. Clinical diagnosis is based on nonspecific symptoms but is confirmed by cerebrospinal fluid analysis showing inflammation. Treatment involves immediate empirical antibiotics along with corticosteroids to reduce inflammation and intracranial pressure.
The document describes Waterhouse-Friderichsen syndrome (WFS), which is defined as adrenal gland failure caused by hemorrhaging into the adrenal glands due to severe bacterial infection, most commonly by Neisseria meningitidis bacteria. WFS is characterized by petechial rashes, fever, septic shock, and disseminated intravascular coagulation. It typically affects infants and children under 10 years old. Treatment involves antibiotics, adrenal hormone replacement, and managing shock. Two case studies are presented of patients who died from WFS caused by group A streptococcus and Streptococcus pneumoniae respectively.
This document discusses acute bacterial meningitis (BM), including its definition, incidence, risk factors, etiology, clinical presentation, diagnosis, treatment goals and principles, specific treatment recommendations for common causative organisms, prevention through vaccination, and outpatient management considerations. The prognosis of untreated BM is poor, with high treatment failure rates and risk of neurological complications; however, prompt administration of appropriate antibiotic therapy can significantly improve outcomes.
Meningococcal meningitis is caused by the bacteria Neisseria meningitidis and causes inflammation of the membranes surrounding the brain and spinal cord. Symptoms include severe headache, neck stiffness, nausea, confusion, and a rash. Diagnosis involves lumbar puncture of cerebrospinal fluid to check for bacteria and inflammation. Treatment involves intravenous antibiotics such as penicillin or ceftriaxone. Vaccines can help prevent disease. A case study describes a 21-year-old man who developed meningitis after traveling to China and was successfully treated with antibiotics.
Waterhouse–Friderichsen syndrome (WFS) is defined as adrenal gland failure due to bleeding into the adrenal glands, most commonly caused by the bacterial infection meningococcus. It typically occurs in infants and children under 10 years old. Clinically, it presents with a sudden high fever, rash, shock, and disseminated intravascular coagulation. The adrenal glands hemorrhage and lead to adrenal insufficiency. Treatment involves antibiotics, adrenal support with hydrocortisone, and managing shock. Prevention includes routine meningococcal vaccination in certain groups.
Meningitis is an inflammation of the membranes covering the brain and spinal cord caused by bacterial or viral infections. The two most common types of bacterial meningitis are caused by Neisseria meningitidis (meningococcal meningitis) and Streptococcus pneumoniae (pneumococcal meningitis). Viruses from the enterovirus group are the most common cause of viral meningitis. Symptoms of meningitis include fever, headache, stiff neck, and sensitivity to light. While bacterial meningitis requires intravenous antibiotics, viral meningitis is usually treated with supportive care. Handwashing is the best way to prevent transmission between people through contact with nose and throat secretions.
Meningitis is an inflammation of the protective membranes (meninges) surrounding the brain and spinal cord. It is usually caused by a viral or bacterial infection of the fluid surrounding the brain and spinal cord. Common causes include bacteria like pneumococcus, meningococcus, and viruses like enterovirus. Symptoms include severe headache, fever, neck stiffness, nausea, and altered mental status. Diagnosis involves examination, history, and evaluation of cerebrospinal fluid. Treatment depends on the cause but may include antibiotics for bacterial infections and medications to reduce swelling and control seizures. Prevention involves vaccines for common causes.
This document summarizes bacterial meningitis. It is an inflammation of the meninges caused by bacteria entering the bloodstream from infections like pneumonia or ear infections. The most common types are pneumococcal, meningococcal, Hib, and listeria. Symptoms include high fever, severe headache, stiff neck, and confusion. Treatment involves intravenous antibiotics and managing complications. Prevention focuses on immunizations, hand washing, and food safety.
Acute CNS infection can cause meningoencephalitis, which is inflammation of the meninges and brain tissue. Common causes include viruses like enterovirus and herpes virus. In the CSF there is lymphocytic predominance but culture and gram stain are negative. Clinically patients may experience fever, headache, irritability and seizures. Diagnosis involves CSF analysis and detecting viruses through PCR, culture or antigen tests. Treatment focuses on antivirals for specific viruses and symptom relief.
Acute bacterial meningitis is a medical emergency characterized by infection of the membranes surrounding the brain and spinal cord. The classic triad of symptoms includes fever, headache, and neck stiffness. Common causative organisms vary by age but include Streptococcus pneumoniae in about 50% of cases. Diagnosis involves lumbar puncture and CSF analysis showing elevated white blood cells, low glucose, and high protein levels. Treatment involves prompt administration of antibiotics like third generation cephalosporins and vancomycin before diagnostic tests. Outcomes depend on causative organism and presence of complications like seizures, altered mental status, and increased intracranial pressure.
This document discusses inflammatory conditions of the brain, specifically meningitis. It defines meningitis as an acute inflammation of the meningeal tissues surrounding the brain and spinal cord. The causes can be bacterial, viral, fungal, or due to other inflammatory diseases or cancers. Symptoms include fever, severe headache, nausea, photophobia, and decreased level of consciousness. Diagnosis involves lumbar puncture, CSF analysis, and tests for meningeal irritation. Treatment involves antibiotics, dexamethasone, osmotic diuretics, anticonvulsants, and IV fluids. Complications can include cranial nerve dysfunction, seizures, memory loss, and even death.
The document provides an overview of acute bacterial meningitis, including:
- Common causes are Streptococcus pneumoniae, Neisseria meningitidis, and group B Streptococcus.
- Clinical presentation often includes the classic triad of fever, neck stiffness, and altered mental status. Investigations include lumbar puncture and analysis of CSF.
- Differentiating between bacterial and viral meningitis can be done using factors like CSF white blood cell count, glucose and protein levels, and peripheral blood markers.
- Treatment involves early administration of empirical antibiotics like ceftriaxone or penicillin, with duration typically 5 days if the patient responds well. Prognosis depends on factors like
Acute meningoencephalitis Powerpoint presentation.
It comprises of acute meningitis and acute encephalitis, their clinical features, physical assesment, diagnosis and treatment.
A lumbar puncture is a medical procedure where cerebrospinal fluid is extracted from the lower back for testing. Analyzing the CSF can help determine if meningitis is present by examining values like glucose, protein, white blood cells and cell differentials. However, lumbar punctures have limitations as a diagnostic tool and should not be performed if there is suspected increased intracranial pressure. Other diagnostic methods include blood tests, physical exams like Kernig's and Brudzinski's signs, and polymerase chain reaction testing of blood and CSF. The most important factor is administering antibiotics as quickly as possible for suspected bacterial meningitis.
Bacterial meningitis is a serious infection of the membranes surrounding the brain and spinal cord. It is usually caused by bacteria such as Streptococcus pneumoniae or Neisseria meningitidis. Symptoms include sudden onset of fever, headache, and neck stiffness. Without prompt treatment, bacterial meningitis can cause death or permanent disability. Diagnosis involves examination of cerebrospinal fluid obtained through lumbar puncture. Empirical antibiotic therapy with drugs such as ceftriaxone and vancomycin is started immediately while diagnostic tests are pending. Vaccination is the most effective way to prevent certain types of bacterial meningitis.
Coxsackieviruses and echoviruses are enteroviruses that can cause aseptic meningitis and other diseases. They are spherical, non-enveloped viruses that infect the intestines and respiratory tract. Common illnesses include hand-foot-and-mouth disease, herpangina, myocarditis, and pleurodynia. While symptoms are generally mild and self-limiting, last several days, in rare cases they can cause long-term complications like diabetes. Diagnosis involves identifying viruses from stool or throat swabs using PCR or serum antibody tests. Treatment is supportive with fluids and acetaminophen for fever.
This document provides an overview of meningitis and encephalitis. It discusses the different types of bacterial, viral and fungal meningitis including their causes, symptoms, diagnosis and treatment. Key points include that bacterial meningitis can be caused by organisms like pneumococcus, meningococcus and haemophilus influenza. Viral meningitis causes aseptic meningitis while encephalitis involves brain inflammation. Diagnosis involves lumbar puncture and CSF analysis. Treatment depends on the identified organism and may involve antibiotics, antivirals or antifungals.
This document discusses different types of meningitis, including acute pyogenic meningitis, acute lymphocytic meningitis, and chronic meningitis. Acute pyogenic meningitis is caused by bacteria and results in inflammation of the meninges around the brain. Common causative organisms vary with age. Acute lymphocytic meningitis is usually viral and has milder symptoms that resolve more quickly. Chronic meningitis includes tuberculous and cryptococcal types, which cause long-term granulomatous inflammation that may lead to hydrocephalus. Diagnosis is based on examination of cerebrospinal fluid characteristics.
This document provides information about Neisseria meningitidis, the bacteria that causes meningococcal meningitis. It describes the morphological features and virulence factors of N. meningitidis, including its gram-negative diplococcal shape, polysaccharide capsule that allows it to evade the immune system, and pili that enable it to attach to cells in the nasopharynx. The document also outlines the pathogenesis of meningococcal meningitis, noting that the bacteria spread from the nasopharynx via the bloodstream to the meninges, where it can cause inflammation and potentially fatal infection.
This document provides information on acute bacterial meningitis, including:
- The most common causative organisms are Streptococcus pneumoniae, Neisseria meningitidis, and Group B streptococci.
- Clinical presentation typically includes the classic triad of fever, headache, and nuchal rigidity, along with decreased consciousness.
- Diagnosis involves examination of CSF which shows pleocytosis, low glucose, and high protein. Blood cultures and neuroimaging may also be used.
- Treatment involves prompt empiric administration of antibiotics like ceftriaxone, vancomycin, and dexamethasone, with specific therapy guided by diagnostic testing.
summary of Bacterial meningitis
Describe the properties, transmission and pathogenesis of
Neisseria meningitidis, Streptococcus pneumoniae and Haemophilus influenzae
as causative agents of meningitis.
Pathophysiology and Treatment of Meningoencephalitis - A journal readingAlda Simbolon
This document discusses the pathophysiology and treatment of bacterial meningitis. It begins by defining bacterial meningitis as an inflammation of the meninges caused by bacterial invasion. It then discusses the pathogenesis, which involves bacterial invasion across the blood-brain barrier, an inflammatory response, and neuronal damage caused by bacterial toxins and immune responses. Clinical diagnosis is based on nonspecific symptoms but is confirmed by cerebrospinal fluid analysis showing inflammation. Treatment involves immediate empirical antibiotics along with corticosteroids to reduce inflammation and intracranial pressure.
The document describes Waterhouse-Friderichsen syndrome (WFS), which is defined as adrenal gland failure caused by hemorrhaging into the adrenal glands due to severe bacterial infection, most commonly by Neisseria meningitidis bacteria. WFS is characterized by petechial rashes, fever, septic shock, and disseminated intravascular coagulation. It typically affects infants and children under 10 years old. Treatment involves antibiotics, adrenal hormone replacement, and managing shock. Two case studies are presented of patients who died from WFS caused by group A streptococcus and Streptococcus pneumoniae respectively.
This document discusses acute bacterial meningitis (BM), including its definition, incidence, risk factors, etiology, clinical presentation, diagnosis, treatment goals and principles, specific treatment recommendations for common causative organisms, prevention through vaccination, and outpatient management considerations. The prognosis of untreated BM is poor, with high treatment failure rates and risk of neurological complications; however, prompt administration of appropriate antibiotic therapy can significantly improve outcomes.
Meningococcal meningitis is caused by the bacteria Neisseria meningitidis and causes inflammation of the membranes surrounding the brain and spinal cord. Symptoms include severe headache, neck stiffness, nausea, confusion, and a rash. Diagnosis involves lumbar puncture of cerebrospinal fluid to check for bacteria and inflammation. Treatment involves intravenous antibiotics such as penicillin or ceftriaxone. Vaccines can help prevent disease. A case study describes a 21-year-old man who developed meningitis after traveling to China and was successfully treated with antibiotics.
Waterhouse–Friderichsen syndrome (WFS) is defined as adrenal gland failure due to bleeding into the adrenal glands, most commonly caused by the bacterial infection meningococcus. It typically occurs in infants and children under 10 years old. Clinically, it presents with a sudden high fever, rash, shock, and disseminated intravascular coagulation. The adrenal glands hemorrhage and lead to adrenal insufficiency. Treatment involves antibiotics, adrenal support with hydrocortisone, and managing shock. Prevention includes routine meningococcal vaccination in certain groups.
Meningitis is an inflammation of the membranes covering the brain and spinal cord caused by bacterial or viral infections. The two most common types of bacterial meningitis are caused by Neisseria meningitidis (meningococcal meningitis) and Streptococcus pneumoniae (pneumococcal meningitis). Viruses from the enterovirus group are the most common cause of viral meningitis. Symptoms of meningitis include fever, headache, stiff neck, and sensitivity to light. While bacterial meningitis requires intravenous antibiotics, viral meningitis is usually treated with supportive care. Handwashing is the best way to prevent transmission between people through contact with nose and throat secretions.
Meningitis is an inflammation of the protective membranes (meninges) surrounding the brain and spinal cord. It is usually caused by a viral or bacterial infection of the fluid surrounding the brain and spinal cord. Common causes include bacteria like pneumococcus, meningococcus, and viruses like enterovirus. Symptoms include severe headache, fever, neck stiffness, nausea, and altered mental status. Diagnosis involves examination, history, and evaluation of cerebrospinal fluid. Treatment depends on the cause but may include antibiotics for bacterial infections and medications to reduce swelling and control seizures. Prevention involves vaccines for common causes.
This document summarizes bacterial meningitis. It is an inflammation of the meninges caused by bacteria entering the bloodstream from infections like pneumonia or ear infections. The most common types are pneumococcal, meningococcal, Hib, and listeria. Symptoms include high fever, severe headache, stiff neck, and confusion. Treatment involves intravenous antibiotics and managing complications. Prevention focuses on immunizations, hand washing, and food safety.
Acute CNS infection can cause meningoencephalitis, which is inflammation of the meninges and brain tissue. Common causes include viruses like enterovirus and herpes virus. In the CSF there is lymphocytic predominance but culture and gram stain are negative. Clinically patients may experience fever, headache, irritability and seizures. Diagnosis involves CSF analysis and detecting viruses through PCR, culture or antigen tests. Treatment focuses on antivirals for specific viruses and symptom relief.
Acute bacterial meningitis is a medical emergency characterized by infection of the membranes surrounding the brain and spinal cord. The classic triad of symptoms includes fever, headache, and neck stiffness. Common causative organisms vary by age but include Streptococcus pneumoniae in about 50% of cases. Diagnosis involves lumbar puncture and CSF analysis showing elevated white blood cells, low glucose, and high protein levels. Treatment involves prompt administration of antibiotics like third generation cephalosporins and vancomycin before diagnostic tests. Outcomes depend on causative organism and presence of complications like seizures, altered mental status, and increased intracranial pressure.
This document discusses inflammatory conditions of the brain, specifically meningitis. It defines meningitis as an acute inflammation of the meningeal tissues surrounding the brain and spinal cord. The causes can be bacterial, viral, fungal, or due to other inflammatory diseases or cancers. Symptoms include fever, severe headache, nausea, photophobia, and decreased level of consciousness. Diagnosis involves lumbar puncture, CSF analysis, and tests for meningeal irritation. Treatment involves antibiotics, dexamethasone, osmotic diuretics, anticonvulsants, and IV fluids. Complications can include cranial nerve dysfunction, seizures, memory loss, and even death.
The document provides an overview of acute bacterial meningitis, including:
- Common causes are Streptococcus pneumoniae, Neisseria meningitidis, and group B Streptococcus.
- Clinical presentation often includes the classic triad of fever, neck stiffness, and altered mental status. Investigations include lumbar puncture and analysis of CSF.
- Differentiating between bacterial and viral meningitis can be done using factors like CSF white blood cell count, glucose and protein levels, and peripheral blood markers.
- Treatment involves early administration of empirical antibiotics like ceftriaxone or penicillin, with duration typically 5 days if the patient responds well. Prognosis depends on factors like
Acute meningoencephalitis Powerpoint presentation.
It comprises of acute meningitis and acute encephalitis, their clinical features, physical assesment, diagnosis and treatment.
A lumbar puncture is a medical procedure where cerebrospinal fluid is extracted from the lower back for testing. Analyzing the CSF can help determine if meningitis is present by examining values like glucose, protein, white blood cells and cell differentials. However, lumbar punctures have limitations as a diagnostic tool and should not be performed if there is suspected increased intracranial pressure. Other diagnostic methods include blood tests, physical exams like Kernig's and Brudzinski's signs, and polymerase chain reaction testing of blood and CSF. The most important factor is administering antibiotics as quickly as possible for suspected bacterial meningitis.
Bacterial meningitis is a serious infection of the membranes surrounding the brain and spinal cord. It is usually caused by bacteria such as Streptococcus pneumoniae or Neisseria meningitidis. Symptoms include sudden onset of fever, headache, and neck stiffness. Without prompt treatment, bacterial meningitis can cause death or permanent disability. Diagnosis involves examination of cerebrospinal fluid obtained through lumbar puncture. Empirical antibiotic therapy with drugs such as ceftriaxone and vancomycin is started immediately while diagnostic tests are pending. Vaccination is the most effective way to prevent certain types of bacterial meningitis.
Coxsackieviruses and echoviruses are enteroviruses that can cause aseptic meningitis and other diseases. They are spherical, non-enveloped viruses that infect the intestines and respiratory tract. Common illnesses include hand-foot-and-mouth disease, herpangina, myocarditis, and pleurodynia. While symptoms are generally mild and self-limiting, last several days, in rare cases they can cause long-term complications like diabetes. Diagnosis involves identifying viruses from stool or throat swabs using PCR or serum antibody tests. Treatment is supportive with fluids and acetaminophen for fever.
This document provides an overview of meningitis and encephalitis. It discusses the different types of bacterial, viral and fungal meningitis including their causes, symptoms, diagnosis and treatment. Key points include that bacterial meningitis can be caused by organisms like pneumococcus, meningococcus and haemophilus influenza. Viral meningitis causes aseptic meningitis while encephalitis involves brain inflammation. Diagnosis involves lumbar puncture and CSF analysis. Treatment depends on the identified organism and may involve antibiotics, antivirals or antifungals.
Meningitis is an infection of the meninges that covers the brain and spinal cord. It can be caused by bacteria like Neisseria meningitidis or viruses. Symptoms include headache, fever, and nuchal rigidity. Diagnosis involves lumbar puncture and imaging. Treatment involves antibiotics, steroids, and IV fluids. People remain contagious until 24-48 hours after antibiotics. Vaccines prevent certain bacterial causes.
The document discusses the management of meningitis in children. It defines meningitis and describes the common causes as bacteria, viruses, fungi and parasites. It then covers the clinical presentation of symptoms in young infants and older children. Laboratory investigations and treatment approaches are outlined for bacterial meningitis, including specific antibiotic regimens. The document concludes with details on supportive care and nursing management of children with meningitis.
Bacterial meningitis typically begins as a localized infection that spreads to the meninges, causing inflammation. Common symptoms include headache, fever, and neck stiffness. Examination of cerebrospinal fluid shows increased white blood cells and protein levels, along with low glucose. Treatment involves antibiotics and measures to prevent complications. The diagnosis and treatment depends on the specific causative organism and patient age.
This document discusses meningitis and encephalitis. It defines meningitis as an infection of the meninges and encephalitis as an inflammation of the brain parenchyma. It outlines the different types of meningitis and common causative organisms. It describes the clinical features, investigations, complications, prognosis and treatment for both conditions. The goals of physical therapy for patients with these inflammatory central nervous system disorders are also mentioned.
Meningitis is an inflammation of the meninges that surrounds the brain and spinal cord. It can be caused by bacterial, viral, or fungal infections. Bacterial meningitis is the most severe form and can be life threatening if not treated quickly with antibiotics. Common symptoms include fever, headache, stiff neck, nausea, confusion, and seizures. A lumbar puncture of cerebrospinal fluid can determine if the meningitis is bacterial or viral by examining the fluid for signs of infection. Early diagnosis and treatment are critical for recovery from bacterial meningitis.
Meningitis is an inflammation (swelling) of the protective membranes covering the brain and spinal cord. A bacterial or viral infection of the fluid surrounding the brain and spinal cord usually causes the swelling. However, injuries, cancer, certain drugs, and other types of infections also can cause meningitis.
This document provides an overview of central nervous system infections, focusing on acute bacterial meningitis. It describes the typical causes, pathogenesis, clinical manifestations, diagnosis, complications and treatment of bacterial meningitis. Key points include that the most common causes are Neisseria meningitidis, Streptococcus pneumoniae and Haemophilus influenzae. Bacteria reach the subarachnoid space via the bloodstream or direct invasion. Typical symptoms are fever, headache, vomiting and signs of meningeal irritation. Diagnosis involves CSF analysis showing cloudy appearance, high pressure, neutrophil pleocytosis, elevated proteins and low glucose. Complications can include subdural effusions, hydrocephalus and brain damage.
This document provides an overview of central nervous system infections, focusing on acute bacterial meningitis. It describes the typical causes, pathogenesis, clinical manifestations, diagnosis, complications and treatment of bacterial meningitis. Key points include that the most common causes are Neisseria meningitidis, Streptococcus pneumoniae and Haemophilus influenzae. Bacteria reach the subarachnoid space via the bloodstream or direct invasion. Typical symptoms are fever, headache, vomiting and signs of meningeal irritation. Diagnosis involves CSF analysis showing cloudy appearance, high pressure, neutrophil pleocytosis, elevated proteins and low glucose. Complications can include subdural effusions, hydrocephalus and brain damage.
This document provides information about meningitis, including definitions, causes, types, symptoms, diagnosis, treatment and nursing management. It defines meningitis as inflammation of the meninges, or protective membranes covering the brain and spinal cord. It can be caused by viruses, bacteria, fungi, parasites, toxins or malignancies. The main types discussed are pyogenic (bacterial), viral, fungal/aseptic and tuberculous meningitis. Bacterial meningitis requires urgent treatment with antibiotics to prevent complications like brain damage or hydrocephalus. Nursing goals include pain management, temperature control and seizure prevention through interventions like medication administration and environmental modifications.
The document discusses infections of the central nervous system (CNS), including meningitis. It lists the main causes of CNS infections as bacterial, viral, fungal, and protozoal. It then provides examples of specific infections for each category. The document focuses on meningitis, describing the introduction, clinical features, complications, types (pyogenic bacterial, tubercular, and viral), investigations, management, and physiotherapy assessment and management goals.
This document provides information on various types of meningitis and encephalitis. It begins by describing the typical presentation of bacterial meningitis, including fever, headache, and meningismus. It then discusses the most common causative organisms of bacterial meningitis according to age. The diagnostic evaluation and treatment of bacterial meningitis is also outlined. Tuberculous meningitis is then reviewed, including its pathogenesis, clinical features, diagnosis and treatment approach. Finally, the document briefly discusses various viral causes of meningitis and encephalitis.
This document discusses central nervous system infections including different types of meningitis (bacterial, viral, fungal, chemical), encephalitis, meningoencephalitis, and abscesses. It provides details on common causative agents for different types of infections, characteristics of cerebrospinal fluid, symptoms, signs, diagnosis, and treatment approaches. Bacterial meningitis is discussed in most depth with specifics on common bacteria that cause meningitis in different age groups.
Complications of csom Dr.sithanandha Kumar,29.02.2016ophthalmgmcri
Complications of chronic suppurative otitis media (CSOM) can include both intracranial and extracranial complications. Intracranial complications include meningitis, lateral sinus thrombosis, brain abscess, otitic hydrocephalus, and extradural/subdural abscesses. Extracranial complications involve spread of infection to nearby structures like the mastoid bone, petrous bone, facial nerve, and labyrinth. Prompt diagnosis and treatment of complications is important to prevent morbidity.
Complications of csom dr.sithanandha kumar,29.02.2016ophthalmgmcri
Complications of chronic suppurative otitis media (CSOM) can include both intracranial and extracranial complications. Intracranial complications include meningitis, lateral sinus thrombosis, brain abscess, otitic hydrocephalus, and extradural/subdural abscesses. Extracranial complications involve spread of infection to nearby structures like the mastoid bone, petrous bone, facial nerve, and labyrinth. Prompt diagnosis and treatment of complications is important to prevent morbidity.
2. Meningitis diseses of the brain membrane.pptxabdinuh1997
The meninges, which cover the brain and spinal cord, become inflamed in meningitis. Bacterial meningitis is more severe and can cause death or brain damage if untreated. Viral meningitis is usually mild and self-limiting. A lumbar puncture collects cerebrospinal fluid which can be analyzed to distinguish between bacterial and viral meningitis and identify the specific cause. Common symptoms include headache, fever, and neck stiffness, while signs include Kernig's sign and Brudzinski's sign.
Albendazole or praziquantel
b) Inflammatory phase
Corticosteroids to reduce inflammation
c) Seizures
Antiepileptic drugs
Surgical
For cysts causing mass effect or hydrocephalus
Prevention
Improved sanitation, pork inspection, health education
The document discusses central nervous system infections, listing the main causes as bacterial, viral, fungal, and protozoal. It then provides more detailed information on specific types of infections, including listings of examples for each category. It also includes sections on meningitis that describe the introduction, clinical features, types (pyogenic bacterial, tubercular, and viral), investigations, treatment, and physical therapy management goals for meningitis patients.
This document provides an overview of bacterial meningitis beyond the neonatal period. It defines meningitis as inflammation of the leptomeninges surrounding the brain and spinal cord. The most common causes of meningitis in this age group are Neisseria meningitidis, Streptococcus pneumoniae, and Haemophilus influenzae type b. Risk factors include young age, recent contact with an infected individual, crowding, and conditions causing impaired immunity. Clinical manifestations may include fever, headache, vomiting, altered mental status, and neck stiffness. Diagnosis involves lumbar puncture and analysis of CSF for pleocytosis, elevated proteins, and low glucose. Management includes supportive care, antibiotics, and corticosteroids
This document provides an overview of meningitis beyond the neonatal period. It discusses the epidemiology, etiology, pathogenesis, clinical manifestations, diagnosis, treatment, complications and prognosis of meningitis. The most common causative organisms include Streptococcus pneumoniae, Neisseria meningitidis, and Haemophilus influenzae. Clinical features may include fever, headache, vomiting, and signs of meningeal irritation. Diagnosis involves lumbar puncture and culture of CSF. Empiric antibiotic treatment is initiated while awaiting culture results. Complications can be early like seizures or late like hearing loss. Prognosis depends on causative organism, age of presentation, and presence of co-morbidities.
This document discusses meningitis, including its classification, causative organisms, incidence, risk factors, pathophysiology, clinical features, diagnosis, treatment, prevention, and nursing management. It defines meningitis as an inflammation of the membranes surrounding the brain and spinal cord, most commonly caused by bacteria or viruses. The main types are acute bacterial meningitis, which requires emergency treatment, and chronic meningitis, present for over a month. Common causative organisms are pneumococcal, meningococcal, and H. influenza bacteria. Clinical features include headache, fever, neck stiffness, and altered mental status. Diagnosis involves examination of cerebrospinal fluid. Treatment involves antibiotics and supportive care. Nursing focuses on
The three membranes covering the brain and spinal cord are the dura mater, arachnoid mater, and pia mater. Meningitis is inflammation of these meninges and is most commonly caused by acute bacterial meningitis from Streptococcus pneumoniae, Neisseria meningitidis, or Haemophilus influenzae type B. These bacteria enter the cerebrospinal fluid and cause an inflammatory response, potentially leading to complications like cerebral infarction, increased intracranial pressure, and hydrocephalus. Clinical manifestations of meningitis include nonspecific symptoms like fever and headache as well as signs of meningeal irritation like nuchal rigidity.
Meningitis is an inflammation of the meninges that covers the brain and spinal cord. It is usually caused by viral or bacterial infections, though fungi, drugs, and cancer can also cause meningitis. Symptoms include fever, headache, nausea, and neck stiffness. Diagnosis involves spinal fluid analysis, imaging, and culture tests. Treatment focuses on antibiotics, antivirals, or antifungals depending on cause, with supportive care like IV fluids and fever control. Complications can be serious if untreated and include long term neurological deficits.
Osteoporosis - Definition , Evaluation and Management .pdfJim Jacob Roy
Osteoporosis is an increasing cause of morbidity among the elderly.
In this document , a brief outline of osteoporosis is given , including the risk factors of osteoporosis fractures , the indications for testing bone mineral density and the management of osteoporosis
Cell Therapy Expansion and Challenges in Autoimmune DiseaseHealth Advances
There is increasing confidence that cell therapies will soon play a role in the treatment of autoimmune disorders, but the extent of this impact remains to be seen. Early readouts on autologous CAR-Ts in lupus are encouraging, but manufacturing and cost limitations are likely to restrict access to highly refractory patients. Allogeneic CAR-Ts have the potential to broaden access to earlier lines of treatment due to their inherent cost benefits, however they will need to demonstrate comparable or improved efficacy to established modalities.
In addition to infrastructure and capacity constraints, CAR-Ts face a very different risk-benefit dynamic in autoimmune compared to oncology, highlighting the need for tolerable therapies with low adverse event risk. CAR-NK and Treg-based therapies are also being developed in certain autoimmune disorders and may demonstrate favorable safety profiles. Several novel non-cell therapies such as bispecific antibodies, nanobodies, and RNAi drugs, may also offer future alternative competitive solutions with variable value propositions.
Widespread adoption of cell therapies will not only require strong efficacy and safety data, but also adapted pricing and access strategies. At oncology-based price points, CAR-Ts are unlikely to achieve broad market access in autoimmune disorders, with eligible patient populations that are potentially orders of magnitude greater than the number of currently addressable cancer patients. Developers have made strides towards reducing cell therapy COGS while improving manufacturing efficiency, but payors will inevitably restrict access until more sustainable pricing is achieved.
Despite these headwinds, industry leaders and investors remain confident that cell therapies are poised to address significant unmet need in patients suffering from autoimmune disorders. However, the extent of this impact on the treatment landscape remains to be seen, as the industry rapidly approaches an inflection point.
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These lecture slides, by Dr Sidra Arshad, offer a quick overview of the physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar lead (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
6. Describe the flow of current around the heart during the cardiac cycle
7. Discuss the placement and polarity of the leads of electrocardiograph
8. Describe the normal electrocardiograms recorded from the limb leads and explain the physiological basis of the different records that are obtained
9. Define mean electrical vector (axis) of the heart and give the normal range
10. Define the mean QRS vector
11. Describe the axes of leads (hexagonal reference system)
12. Comprehend the vectorial analysis of the normal ECG
13. Determine the mean electrical axis of the ventricular QRS and appreciate the mean axis deviation
14. Explain the concepts of current of injury, J point, and their significance
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. Chapter 3, Cardiology Explained, https://www.ncbi.nlm.nih.gov/books/NBK2214/
7. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
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Adhd Medication Shortage Uk - trinexpharmacy.comreignlana06
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Does Over-Masturbation Contribute to Chronic Prostatitis.pptxwalterHu5
In some case, your chronic prostatitis may be related to over-masturbation. Generally, natural medicine Diuretic and Anti-inflammatory Pill can help mee get a cure.
3. Meningitis is an inflammatory disease of the
leptomeninges and is defined by abnormal
number of cells in the CSF
Epidemiology
Over one million cases annually worldwide
Causes more than 130,000 deaths worldwide
In Ghana more prevalent in the north
In neonates : group B streptococcus
4. In children : Strep. pneumoniae, H. influenza,
N. meningitidis
In adults : strep. pneumoniae and N.
meningitidis
TB and Listeria monocytogenes can also
cause meningitis
Viral meningitis : HIV, Enterovirus,
Fungal meningitis : candida, Cryptococcus
5. Hematogenous spread : Strep pneumoniae
from pneumonia
Entry via the URT: N. meningitidis
Ear infection : H influenza
Post surgery or trauma: Staph, gram -ve
This enable microorganisms to colonize ,
invade and cross the blood brain barrier , and
multiply within the CSF.