Melanoma therapy requires three drugs administered in the correct sequence to activate the immune system against cancer, similar to a combination lock. The drugs include chemo/radiation to shed dead tumor cells and promote antigen presentation, anti-CTLA-4/antiPD-1 blockade to activate T cells while suppressing regulatory T cells, and interluekin-2 to activate and maintain cytotoxic T cells, with the goal of unleashing the immune system against cancer throughout the body.

1. Melanoma Therapy is like a combination Lock.
Melanoma Therapy is like a combination Lock. You need three drugs, they must be in the
right sequence to open the door to your immune system
1). Chemo/Radiation to shed dead tumor cells to be taken up by Dentritic Cells (DCs) as
antigen presenting Cells (APCs)
2).Anti-CTLA-4/AntiPD-1 Blockade to keep the activation on and suppress the Tregs
cells function.
3). Interluekin-2 for the activation, maintain their cytotoxic function, and their survival
The end result, the unleashing of the host’s Immune system on the cancer at large.