students

1. Pathology
“Study of disease & it’s characteristics ”
Pathogenesis
“Origination & Development of disease”

2.  Measles is caused by enveloped RNA virus of the
genus Morbillivirus
Morbili means small kind of smallpox
 Family Paramyxoviridae
Para means beyond, myxo
means mucous
 Spherical in shape
 Single Stranded

4. Portal Entery
> Respiratory tract and lymph nodes
 Enters into blood stream
 Affects the bronchi,intestine tissues,brain
and conjunctiva etc
 Suppresses the immune system

5. Target Organs
 Skin
 Conjunctiva
 NASOPHYARNX
 LUNGS
 INTESTINE TRACT

7.  Virus
(Morbillivirus)
(Attack)
 Mucous membrane
(Damage)
 Lung Tissue
 Local lymph nodes

8. Blood Stream (Virus present in it)
(Damages)
 Intestinal tract ( Diarrhea)
 Lungs Tissues (Pneumonia)
 Brain OR Spinal cord (Encephalitis)
 Enanthem (Koplik Spots)

10. Hyperplasia of lymphoid tissue usually
occurs.

11.  Koplik Spots are grayish white dots at pre-
pathogenic stage, usually as small as grains
of sand.
 After that became slight reddish at
pathogenic stage with whity centre.

12. It’s video time
about Koplik
Spots!

13. MYOCADITIS
CNS (ENCEPHALITS)
CONJUNCTIVITS
Otitis media
Croup(Kind of cough)

15.  Measles has three clinical stages:
1. Incubation stage
2. Prodromal stage with an enanthem
(Koplik spots)
3.Rash Stage or Recovery Stage

16. Incubation period:
 08-12days (average 10 days)
Prodromal period:
 3-5 days
 Specific symptoms > fever,
anorexia,headache ,cough & conjunctivitis
Recovery period: (10-12 days)
(In this stage, red spots disappeared known
as rash stage)

18. Rubeola is actually an
ordinary Measles.
Rubella is a German Measles.
Roseola in eruption of red
spots

21. 1. Health Department
2. Education
3. Population
4. PHED

22. 5. Food
6. Agriculture
7. Fisheries and
Livestock
8. Social protection

24.  In 1954, John F. Enders and Dr. Thomas C. Peebles
collected blood samples from several ill students
during a measles outbreak in Boston. They wanted to
isolate the measles virus in the student’s blood and
create a measles vaccine. They succeeded in isolating
measles in 13-year-old David Edmonston’s blood.
 In 1968, an improved and even weaker measles
vaccine, developed by Maurice Hilleman and
colleagues, began to be distributed. This vaccine,
called the Edmonston-Enders (formerly “Moraten”)
strain has been the only measles vaccine used in the
United States since 1968. Measles vaccine is usually
combination of weaken infectious factors of rubella ,
mumps and measles.