This study presents the reconstructive options used in 12 patients who underwent maxillectomy for cancer treatment. The patients underwent maxillectomy types I-IV and reconstruction included obturator prosthesis, local temporalis muscle flap, or free radial forearm or latissimus dorsi flaps. Outcomes were satisfactory functionally, though two patients developed pneumonia and one had partial flap necrosis. The study concludes that reconstructive choice should consider maxillectomy type, age, cancer stage and comorbidities, with obturator prosthesis reserved for limited defects and microsurgery preferred for types II-IV to achieve best function and aesthetics.