Transforming Clinical Practice InitiativeCitiusTech
The Transforming Clinical Practice Initiative (TCPI) is designed to help small practices and clinicians achieve large-scale health transformation. The initiative is designed to support more than 140,000 clinician practices over four years duration in sharing, adapting and further developing their comprehensive quality improvement strategies. The TCPI is one part of a unique strategy advanced by the Affordable Care Act to strengthen the quality of patient care and manage health care expenditures, ultimately saving the taxpayer from substantial costs. This document describes the initiative in detail with the type of participants, eligibility and reporting requirements of the participants. Understanding the implementation of this initiative not only helps clinicians, but opens up a huge market for Healthcare IT companies offering the products and services like EHR implementation, Integration, EHR/ Data Migration, Implementation of HIE etc.
Current Trends in Data Protection for Integrated Health, Centralized Peer Rev...PYA, P.C.
A webinar hosted by PYA and the Alliance for Quality Improvement (AQIPS) explored “Current Trends in Data Protection for Integrated Health, Centralized Peer Review Systems, and Other Innovative Programs.” PYA Principal Martie Ross participated in the webinar, which focused on how patient safety organization (PSO) protections can bring value to accountable care organizations and other integrated health systems.
In addition, the webinar provided instruction for using:
Patient Safety and Quality Improvement Act (PSQIA) protections in Medicare Shared Savings Programs, centralized peer review programs, and other collaboratives.
PSQIA protections for new types of clinical analysis, clinical quality reports, and performance tools that contain information that may not be protected under existing state peer review privilege or are shared among an integrated network.
Transforming Post-Acute Care with IMPACTCitiusTech
On October 6, 2014, a bipartisan bill on Improving Medicare Post-Acute Care Transformation (IMPACT) was signed. The IMPACT Act seeks to standardize assessments for vital care issues across the gamut of post-acute care (PAC) providers and builds a framework to ensure that the delivered care is mindful of the patient needs; thereby eliminating the current silo-focused approach to quality measurement and resource utilization.
Transforming Clinical Practice InitiativeCitiusTech
The Transforming Clinical Practice Initiative (TCPI) is designed to help small practices and clinicians achieve large-scale health transformation. The initiative is designed to support more than 140,000 clinician practices over four years duration in sharing, adapting and further developing their comprehensive quality improvement strategies. The TCPI is one part of a unique strategy advanced by the Affordable Care Act to strengthen the quality of patient care and manage health care expenditures, ultimately saving the taxpayer from substantial costs. This document describes the initiative in detail with the type of participants, eligibility and reporting requirements of the participants. Understanding the implementation of this initiative not only helps clinicians, but opens up a huge market for Healthcare IT companies offering the products and services like EHR implementation, Integration, EHR/ Data Migration, Implementation of HIE etc.
Current Trends in Data Protection for Integrated Health, Centralized Peer Rev...PYA, P.C.
A webinar hosted by PYA and the Alliance for Quality Improvement (AQIPS) explored “Current Trends in Data Protection for Integrated Health, Centralized Peer Review Systems, and Other Innovative Programs.” PYA Principal Martie Ross participated in the webinar, which focused on how patient safety organization (PSO) protections can bring value to accountable care organizations and other integrated health systems.
In addition, the webinar provided instruction for using:
Patient Safety and Quality Improvement Act (PSQIA) protections in Medicare Shared Savings Programs, centralized peer review programs, and other collaboratives.
PSQIA protections for new types of clinical analysis, clinical quality reports, and performance tools that contain information that may not be protected under existing state peer review privilege or are shared among an integrated network.
Transforming Post-Acute Care with IMPACTCitiusTech
On October 6, 2014, a bipartisan bill on Improving Medicare Post-Acute Care Transformation (IMPACT) was signed. The IMPACT Act seeks to standardize assessments for vital care issues across the gamut of post-acute care (PAC) providers and builds a framework to ensure that the delivered care is mindful of the patient needs; thereby eliminating the current silo-focused approach to quality measurement and resource utilization.
Enhancing Competitive Advantage through Improved HEDIS Reporting and NCQA Rat...CitiusTech
The objective of this document is to provide a high level understanding of the Healthcare Effectiveness Data and Information Set (HEDIS), which is a tool used by more than 90 percent of America's health plans to measure performance on important dimensions of care and service. This document helps in understanding different components of the HEDIS in terms of the measure sets (what it is meant for health plans, changes to the previous year), different methods of collecting data for HEDIS and key requirements for reporting HEDIS
Quality and safety: using information to assure quality and achieve governanceMental Health Partnerships
This presentation by Alison Moores, Director of Nursing and Practice, Devon Partnership NHS Trust, shows how accurate, high quality and timely data is driving improvements in local mental health services.
Alison suggests ingredients for effective quality governance include:
Team to Board lines of accountability
Clarity of standards and metrics to measure them.
Active and ‘real time’ use of information at the right level (ie governance is not about writing reports)
Use the information to measure emerging risk and be clear about the actions that will follow.
Useful questions to consider include:
How do commissioners move from ‘assurance from data’ to ‘assurance that data is being used to improve services’?
How far should quality measures be standardised?
How will providers, commissioners and people who use services work together to decide the measures of quality?
How do we balance data value with data cost?
Key Compliance Issues In Clinical Research: What Sites, CROs, and Start-Ups N...Polsinelli PC
Clinical research presents a host of potential compliance and legal risks. This webinar will provide an overview of key legal issues in clinical research applicable to all involved parties, including sponsors, sites and CROs. We will also review recent enforcement activities related to research studies, and provide strategies for addressing issues that arise, both preemptively (through compliance plans) and in response to identified concerns.
Our agenda:
• Understand key rules and regulations and how they apply in the context of clinical research
• Review key areas of compliance risk, ranging from Medicare reimbursement and billing concerns to informed consent and use of equipment and materials in clinical research
• Outline key components of compliance plans and specifics relevant to clinical research
Accelerating Patient Care with Real World EvidenceCitiusTech
Life sciences and pharma companies are evolving their strategies to utilize Real World Data (RWD) to demonstrate value of pharmaceutical and medical device innovations. Technology advancements at the point of care and improvements in data collection strategies have led to a significant increase in the availability of RWD in healthcare
Real World Evidence (RWE) can provide actionable patient insights and accelerates time to market of new medical products in order to gain competitive advantage
With the emergence of wearable technologies, Internet of Things (IOT), Cognitive Computing, Genomics, Blockchain, etc., future RWE data sources will become more diverse and extensive. This document introduces the concept of Real World Evidence studies in healthcare, describes the various data sources for performing real world analytics and illustrates the role of RWE in better patient care. It then summarizes challenges faced while performing RWE analytics with respect to regulatory compliance, data accessibility and sharing, analysis reporting, costs etc.
Extract Insights from non-traditional Data sources that can lead to better business decisions resulting in an unfair competitive advantage for stakeholders across the drug development & commercialization value chain.
Real world data is set to revolutionize the business of pharmaceuticals, from R&D to commercialization and beyond. With exploding real-world data streams – from EHR and claims data to social analytics – that promises to disrupt research & innovation, provide product risk-benefit to payers, and bring a more customer-centric approach to Pharmaceutical marketing.
21st Century Act and its Impact on Healthcare ITCitiusTech
This document gives an overview, core objectives of the act and enumerates purpose of each part / division of the 21st Century Act. It lists down the sections of the act which have a direct impact on Healthcare IT and gives a brief overview of each section.This document also explains the impact of 21st Century Cures Act on regulatory bodies: FDA / NIH / HSS.
The Top Ten Issues in Physician Practice Acquisition and ValuationPYA, P.C.
A webinar hosted by The National Association of Certified Valuators and Analysts (NACVA) and presented by PYA Consulting Principal Darcy Devine outlines ten common, but often complex, issues that arise during the physician practice acquisition process. The webinar took place Friday, February 13, 2015. “Don’t Stumble Coming Out of the Gate—The Top Ten Issues in Physician Practice Acquisition and Valuation” is geared toward health system and physician practice financial executives as well as business valuators working with those entities.
Enhancing Competitive Advantage through Improved HEDIS Reporting and NCQA Rat...CitiusTech
The objective of this document is to provide a high level understanding of the Healthcare Effectiveness Data and Information Set (HEDIS), which is a tool used by more than 90 percent of America's health plans to measure performance on important dimensions of care and service. This document helps in understanding different components of the HEDIS in terms of the measure sets (what it is meant for health plans, changes to the previous year), different methods of collecting data for HEDIS and key requirements for reporting HEDIS
Quality and safety: using information to assure quality and achieve governanceMental Health Partnerships
This presentation by Alison Moores, Director of Nursing and Practice, Devon Partnership NHS Trust, shows how accurate, high quality and timely data is driving improvements in local mental health services.
Alison suggests ingredients for effective quality governance include:
Team to Board lines of accountability
Clarity of standards and metrics to measure them.
Active and ‘real time’ use of information at the right level (ie governance is not about writing reports)
Use the information to measure emerging risk and be clear about the actions that will follow.
Useful questions to consider include:
How do commissioners move from ‘assurance from data’ to ‘assurance that data is being used to improve services’?
How far should quality measures be standardised?
How will providers, commissioners and people who use services work together to decide the measures of quality?
How do we balance data value with data cost?
Key Compliance Issues In Clinical Research: What Sites, CROs, and Start-Ups N...Polsinelli PC
Clinical research presents a host of potential compliance and legal risks. This webinar will provide an overview of key legal issues in clinical research applicable to all involved parties, including sponsors, sites and CROs. We will also review recent enforcement activities related to research studies, and provide strategies for addressing issues that arise, both preemptively (through compliance plans) and in response to identified concerns.
Our agenda:
• Understand key rules and regulations and how they apply in the context of clinical research
• Review key areas of compliance risk, ranging from Medicare reimbursement and billing concerns to informed consent and use of equipment and materials in clinical research
• Outline key components of compliance plans and specifics relevant to clinical research
Accelerating Patient Care with Real World EvidenceCitiusTech
Life sciences and pharma companies are evolving their strategies to utilize Real World Data (RWD) to demonstrate value of pharmaceutical and medical device innovations. Technology advancements at the point of care and improvements in data collection strategies have led to a significant increase in the availability of RWD in healthcare
Real World Evidence (RWE) can provide actionable patient insights and accelerates time to market of new medical products in order to gain competitive advantage
With the emergence of wearable technologies, Internet of Things (IOT), Cognitive Computing, Genomics, Blockchain, etc., future RWE data sources will become more diverse and extensive. This document introduces the concept of Real World Evidence studies in healthcare, describes the various data sources for performing real world analytics and illustrates the role of RWE in better patient care. It then summarizes challenges faced while performing RWE analytics with respect to regulatory compliance, data accessibility and sharing, analysis reporting, costs etc.
Extract Insights from non-traditional Data sources that can lead to better business decisions resulting in an unfair competitive advantage for stakeholders across the drug development & commercialization value chain.
Real world data is set to revolutionize the business of pharmaceuticals, from R&D to commercialization and beyond. With exploding real-world data streams – from EHR and claims data to social analytics – that promises to disrupt research & innovation, provide product risk-benefit to payers, and bring a more customer-centric approach to Pharmaceutical marketing.
21st Century Act and its Impact on Healthcare ITCitiusTech
This document gives an overview, core objectives of the act and enumerates purpose of each part / division of the 21st Century Act. It lists down the sections of the act which have a direct impact on Healthcare IT and gives a brief overview of each section.This document also explains the impact of 21st Century Cures Act on regulatory bodies: FDA / NIH / HSS.
The Top Ten Issues in Physician Practice Acquisition and ValuationPYA, P.C.
A webinar hosted by The National Association of Certified Valuators and Analysts (NACVA) and presented by PYA Consulting Principal Darcy Devine outlines ten common, but often complex, issues that arise during the physician practice acquisition process. The webinar took place Friday, February 13, 2015. “Don’t Stumble Coming Out of the Gate—The Top Ten Issues in Physician Practice Acquisition and Valuation” is geared toward health system and physician practice financial executives as well as business valuators working with those entities.
Brightcove presentation on Automated TestingMassTLC
Keith Williams, Senior Software Engineer in Test at Brightcove presented at MassTLC's automated testing event on June 12, 2013 at Brightcove, Boston, MA
While Healthcare 1.0 was broadly defined by a focus on defensive medicine, billing, and fee-for-service, culminating in the mass adoption of EMRs, Healthcare 2.0 is a new wave focused on improving clinical efficiency, quality of care, affordability, and fee-for-value; culminating in a new age of healthcare analytics. This new age of analytics will require a new set of organizational skills and a foundational set of analytic information systems that many executives have not anticipated.
Join Dale Sanders, a 20-year healthcare CIO veteran and the industry's leading analytics expert, as he discusses his lessons learned, best practices in analytics, and what the C-level suite needs to know about this topic, now. Listen to Dale discuss 1) A step-by-step curriculum for analytic adoption and maturity in healthcare organizations, 2) the basic approach to a late-binding data warehouse, 3) pros and cons of early versus late binding, 4) the volatility in vocabulary and business rules in healthcare, 5) how to engineer your data to accommodate volatility in the future
Healthcare Analytics Adoption Model -- UpdatedHealth Catalyst
The Healthcare Analytics Adoption Model is the result of a collaboration of healthcare industry veterans over the last 15 years. The model borrows lessons learned from the HIMSS EMR Adoption Model, and describes an analogous approach for assessing the adoption of analytics in healthcare.
The Healthcare Analytics Adoption Model provides:
1) A framework for evaluating the industry’s adoption of analytics
2) A roadmap for organizations to measure their own progress toward analytic adoption
3) A framework for evaluating vendor products
This Analytics Adoption Model will enable healthcare organizations to fully understand and leverage the capabilities of analytics and so achieve the ultimate goal that has eluded most provider organizations – that of improving the quality of care while lowering costs and enhancing clinician and patient satisfaction.
The Imperative of Linking Clinical and Financial Data to Improve Outcomes - H...Health Catalyst
Quality and cost improvements require the intelligent use of financial and clinical data coupled with education for multi-disciplinary teams who are driving process improvements. Once a data warehouse is established, healthcare organizations need to set up multi-disciplinary clinical, financial, and IT specialist teams to make the best use of the data. Sometimes, financial involvement is minimized or even excluded for a number of reasons that can turn out to be counterproductive. However, including financial measurements and participation up front can help enhance the recognized value and sustainability of quality improvement or waste reduction efforts. the In this session you will learn keys to success and real-life examples of linking clinical, financial and patient satisfaction data via multi-disciplinary teams that produce impressive results.
Harness Your Clinical and Financial Data with an Enterprise Health Informat...Perficient, Inc.
The importance of Enterprise Health Information Exchange (EHIE) as a key way to empower your physicians and patients and demonstrate meaningful use of electronic health records:
- Present the business case for EHIE as an important architecture that matters to progressive health systems
- Take a look at some of the market-leading EHIE architectures and products
- Provide real exam...ples of organizations that are using EHIE to improve their operations
Assessment 2
Quality Improvement Proposal
Overview:
Write a quality improvement proposal, 5–7 pages in length, that provides your recommendations for expanding a hospital's HIT to include quality metrics that will help the organization qualify as an accountable care organization.
Health care has undergone a transformation since the release of the Institute of Medicine's 2000 report
To Err Is Human: Building a Safer Health System.
The report highlighted medical errors as a contributing factor leading to poor patient outcomes. The Institute of Medicine challenged organizations to implement evidence-based performance improvement strategies in order to improve patient quality and safety. Multiple governmental and regulatory agencies, such as the Centers for Medicare and Medicaid Services (CMS) and the Agency for Healthcare Quality and Research (AHRQ), vowed to strengthen and improve incentives for participation, safety, quality, and efficiency in accountable care organizations (ACOs).
Health information technology (HIT) performs an essential role in improving health outcomes of individuals, the community, and populations. Health organizations, consumer advocacy groups, and regulatory committees have made a commitment to explore current and future opportunities that HIT offers to continue momentum to meet the Institute of Medicine's goal of improving safety and quality.
Understanding HIT is important to improving individual, community, and population access to health care and health information. HIT enables quick and easy access to information for both patients and providers. Accessible information has been shown to improve the patient care experience and reduce redundancies, thereby reducing health care costs.
This assessment provides an opportunity for you to make recommendations for expanding a hospital's HIT in ways that will help the hospital qualify as an ACO.
By successfully completing this assessment, you will demonstrate your proficiency in the following course competencies and assessment criteria:
Competency 2: Explain the relationship between care coordination and evidence-based data.
Recommend ways to expand an organization's HIT to include quality metrics.
Identify potential problems that can arise with data gathering systems and outputs.
Competency 3: Use health information technology to guide care coordination and organizational practice.
Describe the main focus of information gathering in health care and how it contributes to guiding the development of organizational practice.
Competency 4: Communicate effectively with diverse audiences, in an appropriate form and style, consistent with applicable organizational, professional, and scholarly standards.
Write clearly and concisely, using correct grammar and mechanics.
Support main points, claims, and conclusions with relevant and credible evidence, correctly formatting citations and references using APA style.
Reference
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Going Beyond the EMR for Data-driven Insights in HealthcarePerficient, Inc.
Join Dr. Marcie Stoshak-Chavez, MD, FACEP, Director of Healthcare Strategic Advisory Services at Perficient and Mr. J.D. Whitlock, Director of Clinical & Business Intelligence at Catholic Health Partners to learn how analytics is being used to measure and monitor performance and provide service-line directors and financial administrators with reporting and analysis that enhances clinical care processes and business operations.
Learn how clinicians and administrators armed with the data-driven insights from the EMR and beyond can:
Derive meaningful insights for care delivery by analyzing clinical, financial and operational data
Collaborate more effectively and improve quality of care by securely sharing insights among providers
Meaningfully measure and understand performance across key Federally mandated measures and take prescribed action
Stay on top of shifts in regulatory policy that impact reimbursements and quality requirements
Presentation I used as a Strategic Account Manager to sell affiliate programs (purchase subsidies) to strategic accounts. RAMP stands for Regional Affiliate Marketing Program.
The Operational Excellence Healthcare Alliance (OEHA) is an innovative membership organization dedicated to improving clinical, operational, and financial outcomes by shaping the future of healthcare operations.
The adoption of Electronic Health Records (EHRs) has become ubiquitous. These digital platforms have revolutionized the way medical information is collected, stored, and utilized, offering unprecedented opportunities to improve patient care, streamline administrative processes, and enhance overall efficiency within healthcare organizations. As EHR systems continue to proliferate, an emerging trend is taking centre stage: the rise of EHR data management services.
How to Address Scotland’s Five Strategic eHealth Goals an Orion Health Perspe...NHSScotlandEvent
Orion Health's eHealth Maturity Model provides some signposts as to the challenges and opportunities ahead as the new national eHealth strategy is implemented - particularly as Scotland faces the growing 'care burden' of patients with long term conditions.
A connected city brings benefits to the residents and the municipal agencies and departments that serve them. For instance, smart lighting is more efficient, saving substantial costs to the city which can be passed down to the residents, and it also provides added safety and security. Connected cars and street lights can enable traffic managers to control traffic lights to optimize the flow of traffic in the most congested areas. From services to safety a smart, connected city, will be a successful and economically sound city.
MassIntelligence 2018: How to Rapidly Prototype an AI SolutionMassTLC
Dr. Ames discusses how new tools and technologies in AI are disrupting the traditional AI workflow. She shares pragmatic and tangible recommendations for building an AI solution (faster, better and smarter) and shares new tools on the market today to help you rapidly prototype your AI Solution.
MassIntelligence 2018: Connecting the Nation's Top Fishing PortMassTLC
Ed Anthes-Washburn, Executive Director of the New Bedford (MA) Port Authority, details how the port's data bank can be used to protect fishing resources while providing fishermen with a financial asset
MassIntelligence 2018: Transportation & Mobility, Alex WyglinskiMassTLC
Transportation is one of the most fundamental aspects facing humanity around the world. Advances in the automotive industry will allow all individuals to travel in a variety of conditions. Our panel of experts will discuss the role AI currently plays, what is being deployed in vehicles today, and what is on the horizon, both in and outside of the vehicles.
Andres Corrada-Emmanuel - Ground Truth Problems in BusinessMassTLC
Ground truth for data is frequently missing in business. It is either
unavailable, expensive to get, or private. This talk focuses on the
ubiquity of this problem in today’s world in which more and more of the data
production flows require Machine Learning/Artificial Intelligence
algorithms. How can we measure the accuracy of our algorithms/robots
when curated data is scarce or missing? We offer a universal
suggestion to solving these problems – bypass the need for detailed
knowledge of the ground truth for your data by estimating directly the
statistics of interest for research and business development. We
suggest that a future with smart robots will require that they measure
their own errors so they can function autonomously from humans.
We illustrate this approach with four real-world examples
Focusing multiple aerial maps into a precise final map – ground truthunknown.
Studying the dynamics of data flows in a large ad-tech database withHyperLogLog – ground truth expensive.
Measuring the accuracy of a unique web ID service (super cookie)without user identity – ground truth private.
Measuring the accuracy of binary classifiers – ground truth unknown.
MassTLC product launch campaign strategies, Jason Baudreau, NetBrainMassTLC
In June of 2018, MassTLC's product marketing peer group met to discuss product launch campaign strategies. Jason Baudreau from NetBrain facilitated one of the conversations, here is his presentation.
MassTLC product launch campaign strategies, ben austin, Carbon BlackMassTLC
In June of 2018, MassTLC's product marketing peer group met to discuss product launch campaign strategies. Ben Austin from Carbon Black facilitated one of the conversations, here is his presentation.
Allison MacLeod, Sr. Director of Demand Gen at Rapid7 presented "Making Predictive Analytics Work" at the MassTLC sales and marketing conference, March 2016
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
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