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John	
  R.	
  Martinelli,	
  MSIII	
   SGUSOM	
  
Case	
  #3:	
  History	
   01/13/14	
  
	
  
	
  
Identifying	
  Information	
  
	
  
Ms.	
  O.L.	
  is	
  a	
  pleasant	
  62-­‐year-­‐old	
  lady	
  of	
  Portuguese	
  descent	
  who	
  was	
  admitted	
  to	
  
SBMC	
  on	
  January	
  08,	
  2014	
  after	
  presenting	
  on	
  the	
  same	
  day	
  to	
  the	
  SBMC	
  ED.	
  
	
  
Chief	
  Complaint	
  
	
  
Pain	
  in	
  both	
  feet	
  and	
  lower	
  legs	
  with	
  increased	
  difficulty	
  walking.	
  
	
  
History	
  of	
  Present	
  Illness	
  
	
  
Approximately	
  one	
  week	
  prior	
  to	
  her	
  admission,	
  Ms.	
  O.L.	
  described	
  a	
  gradual	
  onset	
  
of	
  bilateral	
  lower	
  extremity	
  weakness	
  initially	
  involving	
  both	
  feet	
  and	
  subsequently	
  
progressing	
  upward	
  to	
  affect	
  both	
  legs	
  and	
  thighs.	
  During	
  this	
  time,	
  in	
  the	
  same	
  
lower	
  extremities,	
  she	
  also	
  began	
  to	
  experience	
  parathesia-­‐like	
  symptoms	
  
alternating	
  with	
  radiating	
  burning	
  pain	
  that	
  she	
  approximated	
  at	
  5/10	
  in	
  severity.	
  
She	
  has	
  found	
  it	
  increasingly	
  difficult	
  to	
  ambulate	
  for	
  which	
  she	
  became	
  dependent	
  
on	
  her	
  husband	
  and	
  children	
  for	
  assistance.	
  In	
  addition,	
  she	
  began	
  to	
  experience	
  
significant	
  constipation	
  just	
  prior	
  to	
  admission.	
  She	
  has	
  been	
  afebrile,	
  no	
  nuchal	
  
rigidity,	
  and	
  has	
  no	
  respiratory,	
  cardiopulmonary,	
  or	
  ophthalmoplegic	
  
symptomatology.	
  
	
  
Two	
  weeks	
  prior	
  to	
  the	
  beginning	
  of	
  her	
  symptoms,	
  she	
  recalled	
  a	
  self-­‐limiting	
  
gastrointestinal	
  type	
  illness	
  with	
  several	
  episodes	
  of	
  loose	
  non-­‐bloody	
  diarrhea.	
  She	
  
also	
  reports	
  having	
  a	
  recurrent	
  diarrheal	
  illness	
  at	
  nearly	
  the	
  same	
  time	
  each	
  year,	
  
with	
  the	
  last	
  occurrence	
  producing	
  similar	
  but	
  very	
  minimal	
  lower	
  extremity	
  
symptoms.	
  In	
  this	
  respect,	
  she	
  has	
  not	
  previously	
  pursued	
  medical	
  care	
  nor	
  has	
  she	
  
been	
  evaluated	
  by	
  neurology	
  or	
  gastroenterology.	
  
	
  
Past	
  Medical	
  History	
  
	
  
Chronic/Active	
  
	
  
1. Presumed	
  Guillain-­‐Barre’	
  Syndrome	
  (GBS)	
  
Plasmapheresis/Exchange	
  x	
  every	
  2	
  days	
  
Monitor	
  Pulmonary	
  Function/Tidal	
  Volume	
  x	
  4hrs	
  
Monitor	
  Neuromuscular	
  Function	
  
Consider	
  Immunosuppressive	
  or	
  IVIg	
  Therapy	
  
Physical	
  Therapy	
  
	
  
2. Hyperlipidemia	
  
Lipitor	
  (Atorvastatin)	
  
	
  
Acute/Resolved	
  
	
  
1. By	
  History:	
  Recurrent	
  Gastroenteritis	
  (Self	
  Limiting)	
  
	
  
Past	
  Surgical	
  History	
  
	
  
None	
  
	
  
Medication	
  (In-­‐Patient)	
  
	
  
Lipitor	
  (Atorvastatin)	
  10mg:	
  1	
  Tab,	
  PO,	
  QD	
  
NS	
  Flush	
  3ml:	
  IV	
  Push,	
  As	
  Directed,	
  PRN	
  
Percocet	
  (Oxycodone/Acetaminophen)	
  5mg/325mg:	
  2	
  Tabs,	
  PO,	
  Q4H,	
  PRN	
  
Tylenol	
  (Acetaminophen)	
  650mg:	
  1	
  Tab,	
  PO,	
  Q6H,	
  Fever,	
  PRN	
  
Azithromycin	
  250mg:	
  1	
  Cap,	
  PO,	
  QD	
  
Calcium/Vitamin	
  D	
  500mg/200IU:	
  1	
  Tab,	
  PO,	
  QD	
  
Heparin	
  5000U:	
  SQ,	
  Q8H	
  
Morphine	
  2mg:	
  IV	
  Push,	
  Q4H,	
  PRN	
  
Multivitamin:	
  1	
  Tab,	
  PO,	
  QD	
  
Senna	
  17.2mg:	
  PO,	
  HS,	
  PRN	
  
Triamterene:	
  1	
  Cap,	
  PO,	
  Q2H	
  
Pneumococcal	
  13-­‐valent	
  conjugate	
  vaccine:	
  IM	
  
	
  
Allergies	
  
	
  
Levaquin	
  
IV	
  Contrast	
  
	
  
Social	
  History	
  
	
  
Ms.	
  O.L.	
  is	
  of	
  Portuguese	
  descent,	
  a	
  housewife,	
  and	
  mother	
  of	
  two	
  adult	
  children.	
  She	
  
lives	
  with	
  her	
  husband	
  in	
  nearby	
  West	
  Orange,	
  NJ.	
  They	
  have	
  no	
  pets	
  and	
  have	
  a	
  
smoke-­‐free	
  home.	
  She	
  has	
  never	
  smoked,	
  never	
  drank	
  alcohol,	
  and	
  denies	
  illicit	
  drug	
  
use.	
  
	
  
Family	
  History	
  
	
  
Father:	
  	
  
Hypertension,	
  Hyperlipidemia	
  
Mother:	
  
Hypertension,	
  Hyperlipidemia	
  
	
  
Review	
  of	
  Systems	
  
	
  
Constitutional:	
  	
  
	
  
Weakness,	
  difficulty	
  ambulating.	
  
Eye:	
  	
   	
  
	
  
	
  
No	
  symptoms	
  of	
  ophthalmoplegia/diplopia.	
  
Ear/Nose/Mouth/Throat:	
  	
   No	
  nasal	
  congestion,	
  No	
  sore	
  throat.	
  
Respiratory:	
  	
   	
  
	
  
No	
  shortness	
  of	
  breath,	
  No	
  cough,	
  No	
  wheezing.	
  
Cardiovascular:	
  	
  
	
  
Gastrointestinal:	
  
	
  
Genitourinary:	
  	
  
	
  
Hematologic/Lymphatic:	
  	
  
Endocrine:	
  	
   	
  
	
  
Immunologic:	
  	
  
	
  
Musculoskeletal:	
  	
  
	
  
Integumentary:	
  	
  
	
  
Neurologic:	
  	
   	
  
	
  
Psychiatric:	
  	
   	
  
	
  
	
  

No	
  chest	
  pain,	
  No	
  palpitations.	
  
Recent	
  constipation.	
  
No	
  dysuria.	
  
No	
  complaints	
  of	
  lymphadenopathy.	
  
No	
  excessive	
  thirst,	
  weight	
  changes,	
  hair	
  loss,	
  tremors.	
  
Unremarkable	
  (except	
  for	
  HPI).	
  
B/L	
  lower	
  extremity	
  parathesia,	
  pain,	
  weakness.	
  
No	
  rash.	
  
Alert	
  and	
  oriented	
  x	
  4.	
  
Appropriate	
  affect.	
  

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Case History: Guillain-Barré Syndrome

  • 1. John  R.  Martinelli,  MSIII   SGUSOM   Case  #3:  History   01/13/14       Identifying  Information     Ms.  O.L.  is  a  pleasant  62-­‐year-­‐old  lady  of  Portuguese  descent  who  was  admitted  to   SBMC  on  January  08,  2014  after  presenting  on  the  same  day  to  the  SBMC  ED.     Chief  Complaint     Pain  in  both  feet  and  lower  legs  with  increased  difficulty  walking.     History  of  Present  Illness     Approximately  one  week  prior  to  her  admission,  Ms.  O.L.  described  a  gradual  onset   of  bilateral  lower  extremity  weakness  initially  involving  both  feet  and  subsequently   progressing  upward  to  affect  both  legs  and  thighs.  During  this  time,  in  the  same   lower  extremities,  she  also  began  to  experience  parathesia-­‐like  symptoms   alternating  with  radiating  burning  pain  that  she  approximated  at  5/10  in  severity.   She  has  found  it  increasingly  difficult  to  ambulate  for  which  she  became  dependent   on  her  husband  and  children  for  assistance.  In  addition,  she  began  to  experience   significant  constipation  just  prior  to  admission.  She  has  been  afebrile,  no  nuchal   rigidity,  and  has  no  respiratory,  cardiopulmonary,  or  ophthalmoplegic   symptomatology.     Two  weeks  prior  to  the  beginning  of  her  symptoms,  she  recalled  a  self-­‐limiting   gastrointestinal  type  illness  with  several  episodes  of  loose  non-­‐bloody  diarrhea.  She   also  reports  having  a  recurrent  diarrheal  illness  at  nearly  the  same  time  each  year,   with  the  last  occurrence  producing  similar  but  very  minimal  lower  extremity   symptoms.  In  this  respect,  she  has  not  previously  pursued  medical  care  nor  has  she   been  evaluated  by  neurology  or  gastroenterology.     Past  Medical  History     Chronic/Active     1. Presumed  Guillain-­‐Barre’  Syndrome  (GBS)   Plasmapheresis/Exchange  x  every  2  days   Monitor  Pulmonary  Function/Tidal  Volume  x  4hrs   Monitor  Neuromuscular  Function   Consider  Immunosuppressive  or  IVIg  Therapy   Physical  Therapy     2. Hyperlipidemia   Lipitor  (Atorvastatin)    
  • 2. Acute/Resolved     1. By  History:  Recurrent  Gastroenteritis  (Self  Limiting)     Past  Surgical  History     None     Medication  (In-­‐Patient)     Lipitor  (Atorvastatin)  10mg:  1  Tab,  PO,  QD   NS  Flush  3ml:  IV  Push,  As  Directed,  PRN   Percocet  (Oxycodone/Acetaminophen)  5mg/325mg:  2  Tabs,  PO,  Q4H,  PRN   Tylenol  (Acetaminophen)  650mg:  1  Tab,  PO,  Q6H,  Fever,  PRN   Azithromycin  250mg:  1  Cap,  PO,  QD   Calcium/Vitamin  D  500mg/200IU:  1  Tab,  PO,  QD   Heparin  5000U:  SQ,  Q8H   Morphine  2mg:  IV  Push,  Q4H,  PRN   Multivitamin:  1  Tab,  PO,  QD   Senna  17.2mg:  PO,  HS,  PRN   Triamterene:  1  Cap,  PO,  Q2H   Pneumococcal  13-­‐valent  conjugate  vaccine:  IM     Allergies     Levaquin   IV  Contrast     Social  History     Ms.  O.L.  is  of  Portuguese  descent,  a  housewife,  and  mother  of  two  adult  children.  She   lives  with  her  husband  in  nearby  West  Orange,  NJ.  They  have  no  pets  and  have  a   smoke-­‐free  home.  She  has  never  smoked,  never  drank  alcohol,  and  denies  illicit  drug   use.     Family  History     Father:     Hypertension,  Hyperlipidemia   Mother:   Hypertension,  Hyperlipidemia     Review  of  Systems     Constitutional:       Weakness,  difficulty  ambulating.   Eye:           No  symptoms  of  ophthalmoplegia/diplopia.   Ear/Nose/Mouth/Throat:     No  nasal  congestion,  No  sore  throat.   Respiratory:         No  shortness  of  breath,  No  cough,  No  wheezing.  
  • 3. Cardiovascular:       Gastrointestinal:     Genitourinary:       Hematologic/Lymphatic:     Endocrine:         Immunologic:       Musculoskeletal:       Integumentary:       Neurologic:         Psychiatric:           No  chest  pain,  No  palpitations.   Recent  constipation.   No  dysuria.   No  complaints  of  lymphadenopathy.   No  excessive  thirst,  weight  changes,  hair  loss,  tremors.   Unremarkable  (except  for  HPI).   B/L  lower  extremity  parathesia,  pain,  weakness.   No  rash.   Alert  and  oriented  x  4.   Appropriate  affect.