Ovarian Hyperstimulation Syndrome(OHSS), is a Rare iatrogenic complication of ovarian stimulation occurring during the luteal phase or during early pregnancy where a patient's ovaries become swollen and fluid builds up around her abdomen
Ovarian Hyperstimulation Syndrome(OHSS), is a Rare iatrogenic complication of ovarian stimulation occurring during the luteal phase or during early pregnancy where a patient's ovaries become swollen and fluid builds up around her abdomen
Ovulation Stimulation Protocols for IUI - Dr Dhorepatil BharatiBharati Dhorepatil
What are important factors to be considered important
Ovarian reserve
Previous ovarian response
Basic hormone profile
Role of LH
Trigger
Luteal phase support
Pregnancy rate/cycle
AUB in ADOLESCENTS Dr. Jyoti Bhaskar Dr. Sharda Jain Dr. Jyoti AgarwalLifecare Centre
PREVALENCE
A population based study of 1000 adolescents:
Incidence of AUB is 40%
Out of those who have AUB
20% have bleeding disorders
Von Willebrand disease, 5%-36%;
Platelet function defects, 2%-44%;
Thrombocytopenia, 13%- 20%
Clotting factor deficiencies, 8%-9%.
Ovulation Stimulation Protocols for IUI - Dr Dhorepatil BharatiBharati Dhorepatil
What are important factors to be considered important
Ovarian reserve
Previous ovarian response
Basic hormone profile
Role of LH
Trigger
Luteal phase support
Pregnancy rate/cycle
AUB in ADOLESCENTS Dr. Jyoti Bhaskar Dr. Sharda Jain Dr. Jyoti AgarwalLifecare Centre
PREVALENCE
A population based study of 1000 adolescents:
Incidence of AUB is 40%
Out of those who have AUB
20% have bleeding disorders
Von Willebrand disease, 5%-36%;
Platelet function defects, 2%-44%;
Thrombocytopenia, 13%- 20%
Clotting factor deficiencies, 8%-9%.
nausea and vomiting in pregnancy is very common. it may be a manifestation of some medical - surgical - gynecological complications. hyperemesis gravidarum is a severe type of vomiting in pregnancy which has got deleterious effects on the health of the mother. it is a very important topic and it is also a topic in obstetrics. we should encourage and help young mothers to identify the symptoms. please read it and get knowledge about nausea and vomiting in pregnancy. stay tuned.
Urinary tract infection in pregnancy by dr alka mukherjee dr apurva mukherj...alka mukherjee
Urinary tract infections (UTIs) are frequently encountered in pregnant women. Pyelonephritis is the most common serious medical condition seen in pregnancy. Thus, it is crucial for providers of obstetric care to be knowledgeable about normal findings of the urinary tract, evaluation of abnormalities, and treatment of disease. Fortunately, UTIs in pregnancy are most often easily treated with excellent outcomes. Rarely, pregnancies complicated by pyelonephritis will lead to significant maternal and fetal morbidity.
Changes of the urinary tract and immunologic changes of pregnancy predispose women to urinary tract infection. Physiologic changes of the urinary tract include dilation of the ureter and renal calyces; this occurs due to progesterone-related smooth muscle relaxation and ureteral compression from the gravid uterus. Ureteral dilation may be marked. Decreased bladder capacity commonly results in urinary frequency. Vesicoureteral reflux may be seen. These changes increase the risk of urinary tract infections.
During pregnancy, urinary tract changes predispose women to infection. Ureteral dilation is seen due to compression of the ureters from the gravid uterus. Hormonal effects of progesterone also may cause smooth muscle relaxation leading to dilation and urinary stasis, and vesicoureteral reflux increases. The organisms which cause UTI in pregnancy are the same uropathogens seen in non-pregnant individuals. As in non-pregnant patients, these uropathogens have proteins found on the cell-surface which enhance bacterial adhesion leading to increased virulence. Urinary catheterization, frequently performed during labor, may introduce bacteria leading to UTI. In the postpartum period, changes in bladder sensitivity and bladder overdistention may predispose to UTI.
In ectopic pregnancy, implantation occupies at a site other than the endometrium. Ectopic pregnancies are responsible for approximately 10 percent of all maternal mortality. The prognosis for future reproduction is poor. Only one half of women having an ectopic pregnancy are eventually delivered of a liveborn infant. Various factors contribute to ectopic pregnancies, the most common being infection. Unlike intrauterine spontaneous abortions, genetic factors are not paramount in the etiology of ectopic pregnancy.
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
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- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
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TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
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Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
3. Introduction
• Ovarian hyperstimulation syndrome (OHSS)
was first described in 1943 by Rydberg et al.
as a loss of control over the intended
therapeutic stimulation of the ovaries
• In 1951, the first fatal case of OHSS was
reported
4. Introduction
• Ovarian hyperstimulation syndrome (OHSS)
is an important and potentially fatal
complication of ovulation induction
• Generally self-limiting and varies from mild
to severe life-threatening symptoms that
may require hospital admission in up to
1.9% of all OHSS cases
5. Introduction
• Mainly associated with multifollicular
response seen with gonadotrophin
stimulation but may also occur following
use of clomiphene citrate, gonadotrophin-
releasing hormone and rarely, spontaneous
conception cycles
11. Clinical presentation
• OHSS is generally a self-limiting disorder and
symptoms typically resolve spontaneously
within 7 to 10 days
• Can be described as early or late depending
on time of onset of symptoms
12. Clinical presentation
• Early OHSS occurs within 10 days of hCG
trigger and reflects ovarian response to
exogenous hormone
• Late OHSS occurs more than 10 days after
hCG trigger (≈7 days after ET), response to
endogenous hCG from pregnancy –
prolonged course, risk of severity
19. Treatment
• Management is generally supportive until
spontaneous resolution occurs
• May require hospitalization for severe to
critical OHSS and moderate OHSS with
poor symptom control
20. Treatment
• Patient education – vital component
• Discontinue hCG for luteal support,
progesterone may be used
• Avoid strenuous exercise and sexual
intercourse – risk of torsion
21. Treatment – outpatient care
• Adequate hydration – drink to thirst
• Antiemetics – metoclopramide, cyclizine
• Analgesics – paracetamol, codeine. Avoid
NSAIDs – risk of renal compromise
• Monitoring of care – review every 2-3 days
usually adequate
22. Treatment – outpatient care
• Symptom monitoring – appearance of new
symptoms or worsening of existing ones
• Daily weight measurement –
>2pounds/day (≈1kg/day)
• Monitoring of urinary output
• Urgent clinical review may be required
23. Treatment - hospitalisation
• Usually required for severe cases, poor
symptom control, social considerations
• Multidisciplinary care, intensive care
• Mainly analgesics and antiemetics, fluid
management, thromboprophylaxis and
treatment of complications
24. Treatment - hospitalisation
•Fluid management:
• Oral fluid intake preferable to intravenous
• 2-3L/day of fluid with strict fluid balance
• Urine output >20-30ml/hr
• Avoid worsening third-space fluid shift
• Correction of hypovolaemia, hypotension
and haemoconcentration
25. Treatment - hospitalisation
• Fluid management:
• Crystalloids – use of physiological saline or
dextrose in normal saline preferred over
ringer’s lactate – hyponatraemia
• Colloids like albumin, mannitol, dextran,
hydroxyethyl starch (HES) may be required
for plasma expansion
26. Treatment - hospitalisation
•Fluid management:
• Diuretics avoided due to depletion of
intravascular volume. May have a role in
cases of persistent oliguria despite
adequate intravascular volume expansion
and normal intraabdominal pressure
(after paracentesis)
33. OHSS and pregnancy
• Severe OHSS commonly associated with
pregnancy
• Pregnancy may continue normally despite
OHSS
• No evidence of increased risk of congenital
abnormalities
34. Prevention
• Begins with identification of patients at-
risk
• Prior history of OHSS
• Young age
• Low BMI
• Polycystic ovarian syndrome (PCOS)
• Use of GnRH-agonists
35. Prevention
• Increased antral follicle count; ≥ 24
• High anti-Mullerian hormone; ≥ 3.36ng/ml
• Multiple follicles (>14 follicles with diameter of
11mm)
• Rapidly rising serum oestradiol level
• Prevention can be primary or secondary
36. Prevention – primary
• Reduced dose of gonadotrophins - chronic
low-dose step-up protocol, limited ovarian
stimulation, avoiding FSH on day of hCG
trigger; response monitored with serial
ultrasound scans and serum oestradiol
levels (2,500pg/ml threshold for risk)
37. Prevention – primary
• Reduced duration of exposure to
gonadotrophins – mild stimulation
protocol (clomiphene, GnRH-antagonists)
• Use of GnRH-antagonist protocols (cf
agonist) for controlled ovarian stimulation
38. Prevention – primary
• No use of hCG for luteal support
• In-vitro maturation of oocytes
• Use of insulin-sensitizing agents like
metformin in patients with PCOS
39. Prevention – secondary
• Coasting – withhold further gonadotropin
stimulation and delay hCG administration
until oestradiol levels plateau or decrease
significantly. No reduction in incidence of
moderate and severe OHSS in RCTs. Delay
usually less than 3 days.
40. Prevention – secondary
• Cycle cancellation – waste of resources,
risk of spontaneous ovulation
• Reduced hCG doses as ovulation trigger –
5,000 IU cf 10,000IU used successfully in
some centres
41. Prevention – secondary
•Alternative ovulation triggers –
• GnRH-agonists in antagonist-stimulated
cycles – likelihood of clinical pregnancy
lower
• recombinant LH – lower pregnancy rate,
poor cost/benefit ratio
42. Prevention – secondary
• Cryopreservation of oocytes – prevents
late OHSS and exacerbation of early OHSS
by pregnancy
• Dopamine agonists like cabergoline
reverse VEGF-mediated vascular
permeability. Started on day of hCG trigger
as 0.5mg for 8 days.
47. Conclusion
• Ovarian hyperstimulation syndrome is a
mostly iatrogenic and self-limiting disorder
• Good clinical acumen required to diagnose
• Multiple options of prevention available to
reduce incidence and limit severity
48. References
• Khalid S, Gray T, Hashim SS. Ovarian hyperstimulation
syndrome. InnovAiT: Education and inspiration for general
practice. 2015 Sep 1;8(9):531-8.
• Mahajan N. Ovarian hyperstimulation syndrome. Int J Infertil
Fetal Med. 2013 Sep;4:71-8.
• Onofriescu AL, Luca A, Bors A, HOLICOV M, ONOFRIESCU M,
VULPOI C. Principles of diagnosis and management in the
ovarian hyperstimulation syndrome. Curr Health Sci J. 2013 Jul
1;39:187-92.
• Kaur H. Prevention of Ovarian Hyperstimulation Syndrome.
Journal of Infertility and Reproductive Biology. 2013;1(4):63-8.
• Smith V, Osianlis T, Vollenhoven B. Prevention of Ovarian
Hyperstimulation Syndrome: A Review. Obstetrics and
gynaecology international. 2015 May 14;2015.