C-Reactive Protein (CRP) is a protein produced by the liver during inflammation or infection. CRP levels are used to detect and monitor various conditions, including infection, tissue damage, cardiovascular disease risk, and postoperative monitoring of transplant patients. CRP assays including standard CRP, high sensitivity CRP, and full range CRP are offered by Randox Laboratories to measure CRP levels across its normal and elevated ranges on many automated chemistry analyzers.

1. C-Reactive Protein (CRP)
A highly accurate and sensitive test for
inflammation and infection

2. C-Reactive Protein (CRP)
C-Reactive Protein (CRP) is an acute phase protein produced by the liver in response
to inflammation and infection. The measurement of CRP is therefore useful in the
detection of viral infections, infectious diseases, tissue injury, stress, trauma and
inflammatory conditions.
One of the most common uses of CRP is the post operative Features of the Randox CRP assay
monitoring of renal transplant patients. Elevated levels of CRP
seven to twelve days after surgery correlate with the risk of • Assay range 2.88 - 220mg/l
rejection. If the surgery was successful levels should fall to within • iquid ready-to-use reagents stable to expiry date at +2-8oC
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the normal range after five to seven days. • o significant interference from free bilirubin up to 25mg/dl,
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conjugated bilirubin up to 25mg/dl, haemoglobin up to 1000mg/
CRP is used to: dl, intralipid up to 200mg/dl and triglycerides up to 250mg/dl
• ntra-assay precision 5.9% CV at 5.91mg/l, 1.68% CV at 154mg/l
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• Predict the risk of CVD • nter-assay precision 9.95% CV at 5.94mg/l, 2.98% CV at
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• Detect neonatal bacterial infection 156mg/l
• Predict renal allograft rejection • ully automated applications available for wide range of
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• etect inflammatory disorders and bacterial/viral infections
D instruments
The normal range for CRP is <6mg/l however levels within this Will Randox CRP run on my analyser?
range are associated with cardiac risk. Levels between 10-20mg/l
are associated with viral infections while levels from 10-40mg/l Randox provides freedom of choice by offering a range of CRP
are seen in myocardial infarction and upper respiratory tract reagents that will run on a wide variety of analysers.
infections. Levels between 30-200mg/l are often found post The Randox CRP range is compatible for use on over 40 clinical
surgery as well as in bacterial infections and rheumatoid arthritis. chemistry analysers, including the RX series.
CRP levels showing cardiac risk and diseases
rheumatoid arthritis
high risk after surgery
intermediate risk myocardial infarction
low risk viral infection
normal range
0 1 3 6 10 20 30 40 100 180
CRP assay range
hsCRP assay range
Full Range CRP assay range

3. Randox has a complete range of CRP
tests available:
• Full range CRP
• High sensitivity CRP
• CRP
Randox Full Range CRP – High Sensitivity CRP
2 in 1 convenience
The American Heart Association and Centre for Disease Control
The extended reporting capability of the
and Prevention, recommend high sensitivity CRP (hsCRP) as a
Randox Full Range CRP assay enables labs to
improve efficiency, save time and costs by using more sensitive marker of Cardiovascular Disease (CVD) risk
a single method for both low and elevated CRP compared to traditional CRP assays. hsCRP is particularly useful in
concentrations. predicting future cardiac events in individuals with no previous
history of CVD. Healthy individuals with CRP levels higher than
Full range CRP assays are particularly important 3mg/l are two to four times more likely to have a heart attack or stroke.
for the early detection of bacterial infections in
newborn babies, where initial values are very low
Approximately half of all heart attacks occur in patients who have
and can rise rapidly with the onset of infection.
a normal lipid profile and are classified as low risk based on traditional
methods of risk estimation. The measurement of hsCRP can therefore
help clinicians to identify these individuals earlier; it can also be used
to evaluate the risk of a recurrent cardiac event. In high risk groups
there have even been indications that CRP could be used as a
prognostic tool.
Features of the Randox hsCRP assay
• Assay range 0.477 – 10.0mg/l
• Liquid ready-to-use reagents stable to expiry date at +2-8oC
Features of the Randox • No significant interference from free bilirubin up to 25mg/dl,
Full Range CRP assay conjugated bilirubin up to 25mg/dl, haemoglobin up to
1000mg/dl, intralipid up to 800mg/dl and triglycerides up to
• Assay range 0.3 – 161mg/l 1000mg/dl
• Liquid ready-to-use reagents stable to expiry date at +2-8oC • Antigen excess effects are not noted with
• No significant interference from free bilirubin up to concentrations <500mg/l
25mg/dl, conjugated bilirubin up to 25mg/dl, haemoglobin up to
• Intra-assay precision 2.57% CV at 1.10mg/l,
1000mg/dl, intralipid up to 800mg/dl and triglycerides up to 1000mg/dl
1.21% CV at 4.91mg/l
• Antigen excess effects are not noted with concentrations <740mg/l
• Inter-assay precision 4.44% CV at 1mg/l,
• Intra-assay precision 2.78% CV at 1.07mg/l, 1.03% CV at 150mg/l
• Inter-assay precision 5.47% CV at 1.08mg/l, 1.72% CV at 151mg/l
1.22% CV at 4.98mg/l
• A correlation coefficient of r = 1.00 was obtained with another • Fully automated applications
commercially available method available for wide range of
• Fully automated applications available for wide range of instruments instruments

4. Description Assay Range Size Cat. No.
CRP 5 - 200mg/l R1 7 x 50ml, R2 1 x 50ml CP2572
CRP (Dimension) 3.57 - 219mg/l 200 Tests CP2852
CRP 2.88 - 220mg/l R1 6 x 20ml, R2 3 x 9ml CP3826
CRP 5 - 200mg/l R1 8 x 100ml, R2 2 x 70ml CP7949
CRP 5 - 200mg/l R1 7 x 20ml, R2 2 x 12ml CP7950
CRP 5 - 200mg/l R1 6 x 66ml, R2 6 x 13ml CP9742
Full Range CRP 0.3 - 161mg/l R1 2 x 11ml, R2 2 x 11ml CP3847
Full Range CRP 0.3 - 161mg/l R1 4 x 50ml, R2 4 x 50ml CP3849
Full Range CRP 0.3 - 161mg/l R1 5 x 100ml, R2 5 x 100ml CP3850
Full Range CRP 0.26 - 184mg/l R1 2 x 13ml, R2 2 x 13ml CP8028
High Sensitivity CRP 0.477 - 10mg/l R1 2 x 11ml, R2 2 x 11ml CP3885
High Sensitivity CRP 0.27 - 9.07mg/l R1 2 x 13ml, R2 2 x 13ml CP8029
Dedicated liquid ready-to-use CRP controls and calibrators are RIQAS is the largest international EQA scheme in the world.
also available to complement our complete range of CRP assays. The RIQAS specific proteins programme is suitable for
• Liquid ready-to-use monitoring 26 different protein assays including CRP.
• 100% human material • Bi-weekly reporting
• Standardised to BCR/CAP/IFCC CRM470 • 100% human
• Stable to expiry date when stored at +2-8oC • Liquid ready-to-use samples
Description Size Cat. No.
High Sensitivity CRP Control Level 1 10 x 1ml CP2476
High Sensitivity CRP Control Level 2 10 x 1ml CP2477
CRP Control Level 2 10 x1ml CP2480
CRP Control Level 3 10 x 1ml CP2481
Liquid Specific Protein Control Level 1 3 x 1ml PS2682
Liquid Specific Protein Control Level 2 3 x 1ml PS2683
Liquid Specific Protein Control Level 3 3 x 1ml PS2684
CRP Multi-Point Calibrator Set 3 x 1ml CP2179
CRP Calibrator Series 6 x 2ml CP2479
High Sensitivity CRP Calibrator Series 6 x 2ml CP2478
Full Range CRP Calibrator Series 6 x 1ml CP2499
Liquid Specific Protein Calibrator 5 x 1ml IT2691
RIQAS Specific Proteins Programme Bi-weekly RQ9114
LT118 JAN12
Randox Laboratories Limited, 55 Diamond Road, Crumlin, County Antrim, BT29 4QY, United Kingdom
T +44 (0) 28 9442 2413 F +44 (0) 28 9445 2912 E marketing@randox.com I www.randox.com
Information correct at time of print. All Randox products made in the UK.
Randox Laboratories Limited is a company registered within Northern Ireland with company number N.I. 15738. VAT Registered Number: GB 353 030 400. Product availability may vary from country to country. Please contact your local Randox representative for information.