This document discusses various asthma phenotypes or endotypes that have been identified based on differences in clinical characteristics, biomarkers and treatment responses. The two main endotypes discussed are TH2-high asthma and non-TH2 asthma. TH2-high asthma includes early-onset allergic asthma, late-onset eosinophilic asthma and exercise-induced asthma. It is characterized by eosinophilia, TH2 biomarkers and good response to corticosteroids and anti-TH2 targeted therapies. Non-TH2 asthma includes obesity-related asthma, neutrophilic asthma and smoking asthma. It has fewer clinical allergies and TH2 biomarkers, and poorer responses to corticosteroids. Distinct clinical features, genetics,
Pneumonia is an infection of the lungs caused by bacteria, viruses or other pathogens. It is commonly transmitted when germs are inhaled into the lungs. Risk factors include impaired immunity, smoking, neurological conditions that impact swallowing, and chronic lung diseases. Diagnosis involves chest x-ray, sputum culture, blood tests and assessment of severity using CURB65 score. Treatment focuses on antibiotics, oxygen supplementation, hydration and symptom relief. Complications can include respiratory failure and sepsis.
This document discusses asthma-COPD overlap (ACO), where patients exhibit features of both asthma and chronic obstructive pulmonary disease (COPD). It defines the conditions and notes that distinguishing them can be difficult, especially in smokers and older adults. Patients with ACO features experience more exacerbations and poorer outcomes than those with asthma or COPD alone. The document provides guidance on diagnosing and initially treating ACO based on GINA and GOLD guidelines, emphasizing inhaled corticosteroids to reduce exacerbation risk in all patients with chronic airflow limitation. Further research is still needed to better classify and treat ACO phenotypes.
The document discusses the physiological causes of hypoxemia, including hypoventilation, ventilation-perfusion (V/Q) mismatching, and diffusion impairment. Hypoxemia can result from decreased alveolar ventilation leading to higher PaCO2 and lower PAO2, or from V/Q mismatching like shunts or dead space. Disease states like COPD, pulmonary edema, and fibrotic lung disease cause hypoxemia through various combinations of V/Q mismatching and diffusion impairment. Understanding the alveolar gas and ventilation equations is key to determining the root cause and response to hypoxemia in clinical practice.
Copd systemic inflammation or systemic manifestationsWaheed Shouman
COPD is associated with systemic inflammation that can lead to several extra-pulmonary effects and comorbidities. Low-grade systemic inflammation in COPD patients is characterized by elevated levels of pro-inflammatory cytokines and acute phase proteins. This systemic inflammation may originate from pulmonary inflammation spilling over into the systemic circulation, or from other sources like smoking, hypoxia, or bacterial products during exacerbations. Systemic inflammation in COPD has been implicated in several systemic effects and comorbidities including weight loss, muscle dysfunction, cardiovascular diseases, osteoporosis, and depression. Treatments like pulmonary rehabilitation, smoking cessation, and some medications can help reduce systemic inflammation and its associated manifestations in COPD.
TUBERCULOSIS HAS BEEN EXCLUDED BECAUSE IN INDIA TUBERCULOSIS IS THE MOST COMMON CAUSE OF CHRONIC COUGH AND REST OTHER CAUSES OF CHRONIC COUGHS ARE IGNORED
This document discusses various asthma phenotypes or endotypes that have been identified based on differences in clinical characteristics, biomarkers and treatment responses. The two main endotypes discussed are TH2-high asthma and non-TH2 asthma. TH2-high asthma includes early-onset allergic asthma, late-onset eosinophilic asthma and exercise-induced asthma. It is characterized by eosinophilia, TH2 biomarkers and good response to corticosteroids and anti-TH2 targeted therapies. Non-TH2 asthma includes obesity-related asthma, neutrophilic asthma and smoking asthma. It has fewer clinical allergies and TH2 biomarkers, and poorer responses to corticosteroids. Distinct clinical features, genetics,
Pneumonia is an infection of the lungs caused by bacteria, viruses or other pathogens. It is commonly transmitted when germs are inhaled into the lungs. Risk factors include impaired immunity, smoking, neurological conditions that impact swallowing, and chronic lung diseases. Diagnosis involves chest x-ray, sputum culture, blood tests and assessment of severity using CURB65 score. Treatment focuses on antibiotics, oxygen supplementation, hydration and symptom relief. Complications can include respiratory failure and sepsis.
This document discusses asthma-COPD overlap (ACO), where patients exhibit features of both asthma and chronic obstructive pulmonary disease (COPD). It defines the conditions and notes that distinguishing them can be difficult, especially in smokers and older adults. Patients with ACO features experience more exacerbations and poorer outcomes than those with asthma or COPD alone. The document provides guidance on diagnosing and initially treating ACO based on GINA and GOLD guidelines, emphasizing inhaled corticosteroids to reduce exacerbation risk in all patients with chronic airflow limitation. Further research is still needed to better classify and treat ACO phenotypes.
The document discusses the physiological causes of hypoxemia, including hypoventilation, ventilation-perfusion (V/Q) mismatching, and diffusion impairment. Hypoxemia can result from decreased alveolar ventilation leading to higher PaCO2 and lower PAO2, or from V/Q mismatching like shunts or dead space. Disease states like COPD, pulmonary edema, and fibrotic lung disease cause hypoxemia through various combinations of V/Q mismatching and diffusion impairment. Understanding the alveolar gas and ventilation equations is key to determining the root cause and response to hypoxemia in clinical practice.
Copd systemic inflammation or systemic manifestationsWaheed Shouman
COPD is associated with systemic inflammation that can lead to several extra-pulmonary effects and comorbidities. Low-grade systemic inflammation in COPD patients is characterized by elevated levels of pro-inflammatory cytokines and acute phase proteins. This systemic inflammation may originate from pulmonary inflammation spilling over into the systemic circulation, or from other sources like smoking, hypoxia, or bacterial products during exacerbations. Systemic inflammation in COPD has been implicated in several systemic effects and comorbidities including weight loss, muscle dysfunction, cardiovascular diseases, osteoporosis, and depression. Treatments like pulmonary rehabilitation, smoking cessation, and some medications can help reduce systemic inflammation and its associated manifestations in COPD.
TUBERCULOSIS HAS BEEN EXCLUDED BECAUSE IN INDIA TUBERCULOSIS IS THE MOST COMMON CAUSE OF CHRONIC COUGH AND REST OTHER CAUSES OF CHRONIC COUGHS ARE IGNORED
This document discusses pneumonia, including its definition, causes, classification, prevalence, and treatment. Key points include:
- Pneumonia is an inflammatory lung disease that can be caused by bacteria, viruses, fungi or other particles. The most common type is bacterial pneumonia.
- Risk factors for pneumonia include aging, smoking, underlying diseases, and immunosuppression. It is classified based on location (lobar, foliar, interstitial), cause (bacterial, viral, fungal), and place of infection (community-acquired, hospital-acquired).
- Common bacterial causes are Streptococcus pneumoniae, Haemophilus influenzae, and Staphylococcus aureus. Diagn
COPD - Chronic obstructive pulmonary disease - Aby Aby Thankachan
Obstructive lung diseases are characterized by airway obstruction. Chronic obstructive pulmonary disease (COPD) refers specifically to chronic bronchitis and emphysema, where the airways become narrowed over time due to inflammation and mucus, limiting airflow. The main symptoms of COPD are cough, sputum production, and shortness of breath. A diagnosis of COPD requires respiratory testing showing airflow limitation. While there is no cure, symptoms can be treated through smoking cessation, bronchodilators, pulmonary rehabilitation, oxygen supplementation, and managing exacerbations.
The document discusses various COPD phenotypes including:
1) Asthma-COPD overlap phenotype characterized by incompletely reversible airway obstruction and asthma-like features.
2) Frequent exacerbator phenotype defined as 2 or more exacerbations per year which increases health risks.
3) Upper lobe-predominant emphysema phenotype where surgical lung volume reduction may help.
4) Infrequent exacerbator phenotype experiencing less than two exacerbations per year requiring only bronchodilators.
5) Alpha-1 antitrypsin deficiency phenotype which is a genetic cause of panlobular emphysema.
This document discusses occupational asthma, beginning with a definition of asthma as a chronic inflammatory airway disorder causing wheezing, breathlessness and coughing. It describes the different types of occupational asthma including extrinsic, intrinsic, work-related and work-aggravated. Extrinsic asthma is mediated by an IgE response while intrinsic is not antigen specific. Common occupational agents that can cause asthma are discussed including metal working fluids, isocyanates, cleaning agents, carpets and flour. Signs and symptoms, diagnosis and management of occupational asthma are also summarized.
This document discusses systemic inflammation and comorbidities in COPD. It notes that COPD is associated with various important comorbidities beyond the lungs, and inflammation is seen systemically, not just in the lungs. Common comorbidities discussed include cardiovascular diseases like heart disease, hypertension, and stroke. It also mentions increased risk of osteoporosis, diabetes, lung cancer, and other conditions. The systemic inflammation in COPD can be caused by factors like smoking and hypoxia and may contribute to the development and severity of these comorbid conditions.
1) Kaposi's sarcoma, lymphoma, and lymphocytic interstitial pneumonitis are common AIDS-associated malignancies and conditions that can be seen radiographically.
2) Chest x-rays and CT scans of patients with these conditions often show bilateral pulmonary infiltrates, nodules, ground glass opacities, and lymphadenopathy.
3) Specific findings include peribronchovascular thickening, interlobular septal thickening, and poorly defined small nodules in Kaposi's sarcoma and reticulonodular infiltrates without pleural effusions in lymphocytic interstitial pneumonitis.
The document discusses the mechanisms of action, structures, pharmacokinetics, and comparisons of different inhaled corticosteroids as well as the mechanisms of different inhaler devices and their advantages and disadvantages. It also reviews the side effects of inhaled corticosteroids and factors that influence clinical responses to treatment.
Non-communicable diseases like heart disease, cancer, respiratory diseases and diabetes are now the leading causes of death worldwide according to the WHO. Chronic respiratory diseases such as COPD are a major contributor to this global burden. COPD is characterized by persistent airflow limitation that is usually progressive and associated with an enhanced inflammatory response in the lungs to noxious particles or gases like cigarette smoke. Spirometry is required to diagnose COPD, with a post-bronchodilator FEV1/FVC ratio of less than 0.7 used to indicate airflow limitation. The severity of COPD is classified based on symptoms and the degree of airflow obstruction measured by spirometry. Treatment involves smoking cessation, bronchodil
COPD systemic effects and comorbiditiesAshique Ali
This document discusses systemic inflammation and comorbidities in COPD. It states that COPD is associated with various important comorbidities that contribute to its overall severity. Markers of systemic inflammation are consistently increased in COPD patients, including CRP, fibrinogen, and cytokines. This systemic inflammation is thought to be caused by spillover from the lungs and an independent pro-inflammatory phenotype. The systemic inflammation is linked to several comorbidities like cardiovascular disease, diabetes, osteoporosis, and cancer. Cardiovascular disease is a major cause of death in COPD patients. Endothelial dysfunction and a pro-coagulant state brought on by systemic inflammation may also contribute to comorbidities.
A 32-year-old male presented with fever, cough and sputum for 3 days. Chest X-ray showed pneumonia in the left lower lobe. Over the next few days, the patient developed acute shortness of breath and cyanosis. Blood gas analysis showed hypoxemia and acidosis, indicating acute respiratory distress syndrome (ARDS). The patient was intubated and received mechanical ventilation.
This document discusses diffuse parenchymal lung diseases (DPLD), also known as interstitial lung diseases. It describes the different categories and subtypes of DPLD, including idiopathic interstitial pneumonias (IIP) such as idiopathic pulmonary fibrosis (IPF). IPF is the most important subtype of IIP, with a poor prognosis. The document outlines approaches to diagnosing and treating IPF.
Chronic obstructive pulmonary disease (copd) power pointwandatardy
COPD is a chronic lung condition characterized by permanently narrowed airways and difficulty breathing. It encompasses chronic bronchitis and emphysema. COPD develops over many years as a result of lung damage, most commonly from cigarette smoking. It causes inflammation and narrowing of the airways and destruction of lung tissue over time. Symptoms include cough, wheezing, shortness of breath, and frequent respiratory infections. Treatment focuses on reducing symptoms, slowing lung function decline, and improving quality of life through medications, oxygen therapy, and smoking cessation.
1. The document discusses DLCO (diffusing capacity of the lungs for carbon monoxide), which measures the efficiency of the lungs in transporting oxygen across the alveolar capillary membrane.
2. It describes the single breath hold method for measuring DLCO, which involves inhaling a gas mixture containing carbon monoxide and exhaling into a collection device to measure gas concentrations.
3. DLCO can be lowered in conditions that decrease the surface area for diffusion like emphysema, or increase the thickness of the alveolar capillary membrane like interstitial lung diseases.
This presentation provides an overview of Chronic Obstructive Pulmonary Disease (COPD). It begins with an introduction and defines COPD as a group of lung diseases including emphysema, chronic bronchitis, and refractory asthma. It describes the pathophysiology of each condition and explains how chronic inflammation in the lungs leads to structural changes over time. Risk factors and clinical manifestations of COPD are outlined. The presentation reviews methods for diagnosing COPD including spirometry and pulse oximetry. It discusses treatment options and medications to manage COPD as well as potential complications. The presentation concludes with references used.
This document discusses pneumothorax, beginning with the causes and types. Primary spontaneous pneumothorax is usually caused by a ruptured bleb and occurs more often in young, thin males who smoke. Secondary spontaneous pneumothorax has an underlying lung disease like emphysema. Traumatic pneumothorax results from blunt or penetrating chest trauma or medical procedures. Imaging findings and complications are also described, including recurrent pneumothorax, tension pneumothorax, and re-expansion pulmonary edema. Ultrasound is a sensitive test for pneumothorax diagnosis.
Pneumonia is an inflammatory process of the lung parenchyma commonly caused by infectious agents. It is classified according to cause and area involved, and can be community-acquired, hospital-acquired, affect the immunocompromised, or result from aspiration. Symptoms include fever, cough, and shortness of breath. Diagnosis involves chest x-ray, sputum culture, and blood tests. Treatment consists of antibiotics, oxygen therapy, chest physiotherapy, and maintaining fluid and electrolyte balance. Nursing care focuses on airway clearance, respiratory support, infection control, and patient education. Complications can include respiratory failure or sepsis.
Chronic obstructive pulmonary disease (COPD) is characterized by airflow limitation that is usually progressive and associated with an abnormal inflammatory response in the lungs. The most common causes of COPD are cigarette smoking and exposure to occupational dusts and fumes. Spirometry is required for diagnosis and shows airflow limitation defined as a reduced FEV1/FVC ratio. The severity of COPD is classified based on post-bronchodilator FEV1 levels. Management involves smoking cessation, vaccinations, rehabilitation, pharmacotherapy including bronchodilators and inhaled corticosteroids, and long-term oxygen therapy in severe cases.
This document discusses pneumonia, including its causes, symptoms, diagnosis, classification, treatment, and prevention. Pneumonia is an inflammation of the lungs caused by infection from bacteria, viruses, fungi or other causes. It damages the alveoli in the lungs, causing fluid buildup that consolidates the lungs and reduces oxygen intake. Diagnosis involves examining symptoms, medical history, x-rays, blood tests, and sputum cultures. Pneumonia is classified based on location, microorganism, duration, and other factors. Treatment depends on the cause but generally involves antibiotics, rest, and fluids. Vaccines can help prevent pneumonia from some common bacteria.
Imaging plays a key role in the diagnosis of diseases of the trachea, bronchi and small airways. The technical advances relating to CT, and in particular the ability to rapidly acquire a volume of data with multidetector CT, has revolutionised the investigation of patients with suspected airway disease.
Tracheal abnormalities can be due to intrinsic or extrinsic causes and may be focal, multifocal or diffuse. CT is now the investigation of choice for suspected bronchiectasis. Asthma remains a clinical diagnosis, but advances in CT technology now allow quantitative assessment of the bronchial wall and this is providing insights into the nature of airway remodelling that occurs in asthma.
Small airways (for practical purposes the bronchioles) are numerous and thus clinical tests are insensitive in detecting disease. This has increased the role and importance of CT in identifying either of the two main categories of small airway disease—constrictive bronchiolitis and exudative bronchiolitis.
This document provides information on the anatomy and structural abnormalities of the trachea and bronchi. It begins with a description of the normal anatomy of the trachea including its length, diameter, cartilage structure, and changes during inspiration and expiration. It then discusses various congenital anomalies such as bronchus suis, bronchial atresia, and tracheoesophageal fistula. Acquired conditions of the trachea and bronchi are also summarized such as tracheobronchomegaly, saber sheath trachea, relapsing polychondritis, stenosis, malacia, and neoplasms. Common lung diseases like bronchiectasis, emphysema, asthma, and chronic bronchitis are briefly explained as well.
This document discusses pneumonia, including its definition, causes, classification, prevalence, and treatment. Key points include:
- Pneumonia is an inflammatory lung disease that can be caused by bacteria, viruses, fungi or other particles. The most common type is bacterial pneumonia.
- Risk factors for pneumonia include aging, smoking, underlying diseases, and immunosuppression. It is classified based on location (lobar, foliar, interstitial), cause (bacterial, viral, fungal), and place of infection (community-acquired, hospital-acquired).
- Common bacterial causes are Streptococcus pneumoniae, Haemophilus influenzae, and Staphylococcus aureus. Diagn
COPD - Chronic obstructive pulmonary disease - Aby Aby Thankachan
Obstructive lung diseases are characterized by airway obstruction. Chronic obstructive pulmonary disease (COPD) refers specifically to chronic bronchitis and emphysema, where the airways become narrowed over time due to inflammation and mucus, limiting airflow. The main symptoms of COPD are cough, sputum production, and shortness of breath. A diagnosis of COPD requires respiratory testing showing airflow limitation. While there is no cure, symptoms can be treated through smoking cessation, bronchodilators, pulmonary rehabilitation, oxygen supplementation, and managing exacerbations.
The document discusses various COPD phenotypes including:
1) Asthma-COPD overlap phenotype characterized by incompletely reversible airway obstruction and asthma-like features.
2) Frequent exacerbator phenotype defined as 2 or more exacerbations per year which increases health risks.
3) Upper lobe-predominant emphysema phenotype where surgical lung volume reduction may help.
4) Infrequent exacerbator phenotype experiencing less than two exacerbations per year requiring only bronchodilators.
5) Alpha-1 antitrypsin deficiency phenotype which is a genetic cause of panlobular emphysema.
This document discusses occupational asthma, beginning with a definition of asthma as a chronic inflammatory airway disorder causing wheezing, breathlessness and coughing. It describes the different types of occupational asthma including extrinsic, intrinsic, work-related and work-aggravated. Extrinsic asthma is mediated by an IgE response while intrinsic is not antigen specific. Common occupational agents that can cause asthma are discussed including metal working fluids, isocyanates, cleaning agents, carpets and flour. Signs and symptoms, diagnosis and management of occupational asthma are also summarized.
This document discusses systemic inflammation and comorbidities in COPD. It notes that COPD is associated with various important comorbidities beyond the lungs, and inflammation is seen systemically, not just in the lungs. Common comorbidities discussed include cardiovascular diseases like heart disease, hypertension, and stroke. It also mentions increased risk of osteoporosis, diabetes, lung cancer, and other conditions. The systemic inflammation in COPD can be caused by factors like smoking and hypoxia and may contribute to the development and severity of these comorbid conditions.
1) Kaposi's sarcoma, lymphoma, and lymphocytic interstitial pneumonitis are common AIDS-associated malignancies and conditions that can be seen radiographically.
2) Chest x-rays and CT scans of patients with these conditions often show bilateral pulmonary infiltrates, nodules, ground glass opacities, and lymphadenopathy.
3) Specific findings include peribronchovascular thickening, interlobular septal thickening, and poorly defined small nodules in Kaposi's sarcoma and reticulonodular infiltrates without pleural effusions in lymphocytic interstitial pneumonitis.
The document discusses the mechanisms of action, structures, pharmacokinetics, and comparisons of different inhaled corticosteroids as well as the mechanisms of different inhaler devices and their advantages and disadvantages. It also reviews the side effects of inhaled corticosteroids and factors that influence clinical responses to treatment.
Non-communicable diseases like heart disease, cancer, respiratory diseases and diabetes are now the leading causes of death worldwide according to the WHO. Chronic respiratory diseases such as COPD are a major contributor to this global burden. COPD is characterized by persistent airflow limitation that is usually progressive and associated with an enhanced inflammatory response in the lungs to noxious particles or gases like cigarette smoke. Spirometry is required to diagnose COPD, with a post-bronchodilator FEV1/FVC ratio of less than 0.7 used to indicate airflow limitation. The severity of COPD is classified based on symptoms and the degree of airflow obstruction measured by spirometry. Treatment involves smoking cessation, bronchodil
COPD systemic effects and comorbiditiesAshique Ali
This document discusses systemic inflammation and comorbidities in COPD. It states that COPD is associated with various important comorbidities that contribute to its overall severity. Markers of systemic inflammation are consistently increased in COPD patients, including CRP, fibrinogen, and cytokines. This systemic inflammation is thought to be caused by spillover from the lungs and an independent pro-inflammatory phenotype. The systemic inflammation is linked to several comorbidities like cardiovascular disease, diabetes, osteoporosis, and cancer. Cardiovascular disease is a major cause of death in COPD patients. Endothelial dysfunction and a pro-coagulant state brought on by systemic inflammation may also contribute to comorbidities.
A 32-year-old male presented with fever, cough and sputum for 3 days. Chest X-ray showed pneumonia in the left lower lobe. Over the next few days, the patient developed acute shortness of breath and cyanosis. Blood gas analysis showed hypoxemia and acidosis, indicating acute respiratory distress syndrome (ARDS). The patient was intubated and received mechanical ventilation.
This document discusses diffuse parenchymal lung diseases (DPLD), also known as interstitial lung diseases. It describes the different categories and subtypes of DPLD, including idiopathic interstitial pneumonias (IIP) such as idiopathic pulmonary fibrosis (IPF). IPF is the most important subtype of IIP, with a poor prognosis. The document outlines approaches to diagnosing and treating IPF.
Chronic obstructive pulmonary disease (copd) power pointwandatardy
COPD is a chronic lung condition characterized by permanently narrowed airways and difficulty breathing. It encompasses chronic bronchitis and emphysema. COPD develops over many years as a result of lung damage, most commonly from cigarette smoking. It causes inflammation and narrowing of the airways and destruction of lung tissue over time. Symptoms include cough, wheezing, shortness of breath, and frequent respiratory infections. Treatment focuses on reducing symptoms, slowing lung function decline, and improving quality of life through medications, oxygen therapy, and smoking cessation.
1. The document discusses DLCO (diffusing capacity of the lungs for carbon monoxide), which measures the efficiency of the lungs in transporting oxygen across the alveolar capillary membrane.
2. It describes the single breath hold method for measuring DLCO, which involves inhaling a gas mixture containing carbon monoxide and exhaling into a collection device to measure gas concentrations.
3. DLCO can be lowered in conditions that decrease the surface area for diffusion like emphysema, or increase the thickness of the alveolar capillary membrane like interstitial lung diseases.
This presentation provides an overview of Chronic Obstructive Pulmonary Disease (COPD). It begins with an introduction and defines COPD as a group of lung diseases including emphysema, chronic bronchitis, and refractory asthma. It describes the pathophysiology of each condition and explains how chronic inflammation in the lungs leads to structural changes over time. Risk factors and clinical manifestations of COPD are outlined. The presentation reviews methods for diagnosing COPD including spirometry and pulse oximetry. It discusses treatment options and medications to manage COPD as well as potential complications. The presentation concludes with references used.
This document discusses pneumothorax, beginning with the causes and types. Primary spontaneous pneumothorax is usually caused by a ruptured bleb and occurs more often in young, thin males who smoke. Secondary spontaneous pneumothorax has an underlying lung disease like emphysema. Traumatic pneumothorax results from blunt or penetrating chest trauma or medical procedures. Imaging findings and complications are also described, including recurrent pneumothorax, tension pneumothorax, and re-expansion pulmonary edema. Ultrasound is a sensitive test for pneumothorax diagnosis.
Pneumonia is an inflammatory process of the lung parenchyma commonly caused by infectious agents. It is classified according to cause and area involved, and can be community-acquired, hospital-acquired, affect the immunocompromised, or result from aspiration. Symptoms include fever, cough, and shortness of breath. Diagnosis involves chest x-ray, sputum culture, and blood tests. Treatment consists of antibiotics, oxygen therapy, chest physiotherapy, and maintaining fluid and electrolyte balance. Nursing care focuses on airway clearance, respiratory support, infection control, and patient education. Complications can include respiratory failure or sepsis.
Chronic obstructive pulmonary disease (COPD) is characterized by airflow limitation that is usually progressive and associated with an abnormal inflammatory response in the lungs. The most common causes of COPD are cigarette smoking and exposure to occupational dusts and fumes. Spirometry is required for diagnosis and shows airflow limitation defined as a reduced FEV1/FVC ratio. The severity of COPD is classified based on post-bronchodilator FEV1 levels. Management involves smoking cessation, vaccinations, rehabilitation, pharmacotherapy including bronchodilators and inhaled corticosteroids, and long-term oxygen therapy in severe cases.
This document discusses pneumonia, including its causes, symptoms, diagnosis, classification, treatment, and prevention. Pneumonia is an inflammation of the lungs caused by infection from bacteria, viruses, fungi or other causes. It damages the alveoli in the lungs, causing fluid buildup that consolidates the lungs and reduces oxygen intake. Diagnosis involves examining symptoms, medical history, x-rays, blood tests, and sputum cultures. Pneumonia is classified based on location, microorganism, duration, and other factors. Treatment depends on the cause but generally involves antibiotics, rest, and fluids. Vaccines can help prevent pneumonia from some common bacteria.
Imaging plays a key role in the diagnosis of diseases of the trachea, bronchi and small airways. The technical advances relating to CT, and in particular the ability to rapidly acquire a volume of data with multidetector CT, has revolutionised the investigation of patients with suspected airway disease.
Tracheal abnormalities can be due to intrinsic or extrinsic causes and may be focal, multifocal or diffuse. CT is now the investigation of choice for suspected bronchiectasis. Asthma remains a clinical diagnosis, but advances in CT technology now allow quantitative assessment of the bronchial wall and this is providing insights into the nature of airway remodelling that occurs in asthma.
Small airways (for practical purposes the bronchioles) are numerous and thus clinical tests are insensitive in detecting disease. This has increased the role and importance of CT in identifying either of the two main categories of small airway disease—constrictive bronchiolitis and exudative bronchiolitis.
This document provides information on the anatomy and structural abnormalities of the trachea and bronchi. It begins with a description of the normal anatomy of the trachea including its length, diameter, cartilage structure, and changes during inspiration and expiration. It then discusses various congenital anomalies such as bronchus suis, bronchial atresia, and tracheoesophageal fistula. Acquired conditions of the trachea and bronchi are also summarized such as tracheobronchomegaly, saber sheath trachea, relapsing polychondritis, stenosis, malacia, and neoplasms. Common lung diseases like bronchiectasis, emphysema, asthma, and chronic bronchitis are briefly explained as well.
(1) This document discusses several types of congenital lung anomalies including bronchial anomalies like tracheal bronchi and accessory cardiac bronchi, bronchial isomerism, bronchial atresia, and congenital lobar overinflation.
(2) It also discusses bronchogenic cysts which are congenital malformations of the bronchial tree that present as mediastinal masses. Congenital pulmonary airway malformations (CPAM), previously known as congenital cystic adenomatoid malformation, are characterized by abnormal bronchial proliferation resulting in multicystic lung tissue.
(3) Pulmonary arteriovenous malformations are also discussed which are abnormal direct connections between arteries and veins in the
This document discusses radiological imaging findings for chronic obstructive airway diseases such as chronic bronchitis and emphysema. Chest x-rays and CT scans can reveal features of chronic bronchitis like hyper-expanded lungs, thickened bronchial walls, and irregular bronchovascular structures. Emphysema appears on CT as destruction of alveolar walls and enlargement of airspaces in various lung regions. Bullae and flattened diaphragms indicate severe COPD. Congenital lobar emphysema involves one lung lobe and appears as unilateral translucency on x-ray or hyperinflation on CT. Pulmonary interstitial emphysema shows air in the interstitium appearing as streak
Malinosculation-bronchopulmonary sequestration and beyondPgt Radiology
This document discusses congenital bronchopulmonary vascular malformations (BPVMs), which involve abnormalities in communication between the lung's airways, arteries, and veins. It presents a classification system that categorizes BPVMs based on the components involved: isolated airway abnormalities (Type A), isolated arterial abnormalities (Type B), isolated venous abnormalities (Type C), combinations of the above, and complex malformations involving all three components. Contrast-enhanced CT is useful for evaluating each disease entity within this framework.
Presentation1.pptx, radiological imaging of copd.Abdellah Nazeer
This document discusses radiological imaging findings for various chronic obstructive airway diseases. Chest x-rays and CT scans can show features of chronic bronchitis like bronchovascular thickening and markings. Emphysema appears on imaging as alveolar destruction and airspace enlargement. Bullous lung disease involves air collections like bullae. Congenital lobar emphysema involves overinflation of one or more lobes. Pulmonary interstitial emphysema shows air within the pulmonary interstitium. Pulmonary hypertension can be seen as enlargement of the pulmonary arteries.
Radiological Presentation of Pulmonary PathologyGamal Agmy
This document discusses various radiographic signs seen on chest x-rays and CT scans related to different types of lung collapse and cystic lung lesions. It describes signs such as the flat waist sign seen in left lower lobe collapse, the juxtaphrenic peak sign seen in upper lobe collapse, and the fallen lung sign seen with bronchial fractures. It also discusses cystic lung patterns seen in conditions like lymphangioleiomyomatosis (LAM), Langerhans cell histiocytosis, and lymphocytic interstitial pneumonia. Different characteristics of cysts such as their size, distribution and appearance on imaging are described for these various conditions.
The document summarizes several common chest x-ray abnormalities seen with pleural disease:
1. Pleural effusions appear as a collection of fluid in the pleural space that obscures structures like the costophrenic angle. A large left pleural effusion is seen with an underlying bronchogenic carcinoma in one example.
2. Pneumothoraces form when air is trapped in the pleural space, usually from trauma or underlying lung disease. A left pneumothorax is seen due to a rib fracture in one example.
3. Asbestos exposure can lead to benign calcified pleural plaques appearing on chest x-rays as irregular, well-defined shadows similar to holly
This document discusses tracheal anatomy and disorders. It provides details on the structure and dimensions of the trachea, as well as its relations to surrounding structures. Various congenital abnormalities, injuries, and diseases that can cause tracheal narrowing or stenosis are described. Post-intubation stenosis is highlighted as a common cause of acquired tracheal narrowing, often appearing as eccentric or concentric soft tissue narrowing on imaging while the cartilage remains intact.
This document provides an overview of interpreting chest x-rays and musculoskeletal x-rays. It discusses the basics of x-ray production and penetration. It then describes the ABCDEFG systematic approach for reading chest x-rays, covering airways, bones, cardiac structures, diaphragm, equipment, lung fields, and great vessels. Common shadow patterns like pneumothorax, consolidation, and atelectasis are also covered. Unique imaging findings for conditions like pneumonia, bronchiolitis, and asthma are discussed. Musculoskeletal x-ray patterns are briefly mentioned as well.
Thoracic Ultrasound For The Respiratory System In Critically Ill PatientsBassel Ericsoussi, MD
Thoracic ultrasound can be used to diagnose pneumothorax in critically ill patients. It is more sensitive than chest x-ray and can detect even very small pneumothoraces. Normal lung ultrasound shows the sliding of the visceral and parietal pleura and A-lines, while a pneumothorax is identified by the absence of sliding, A-lines only, and the lung point sign. Ultrasound can also assess endotracheal tube position and risk of post-extubation stridor.
Radiological signs in chest medicine Part 1Gamal Agmy
This document discusses various radiological signs seen on chest imaging. It provides examples of different signs seen on chest x-ray and CT scan related to masses, atelectasis, vascular structures, esophageal disorders, pneumomediastinum, extrapulmonary masses, interstitial lung disease, and pulmonary nodule patterns. It also discusses CT features of different lung diseases and conditions including sarcoidosis, Langerhans cell histiocytosis, lymphangioleiomyomatosis, and others. Finally, it examines histopathological definitions and CT appearance of various types of emphysema.
Interpretation of the paediatric chest x ray 1Archita Goel
This document provides guidance on interpreting pediatric chest x-rays by discussing how technique, age, and anatomical factors can influence the appearance of chest x-rays in children. It outlines a systematic approach to evaluating chest x-rays, including assessing the lungs, heart, mediastinum, diaphragm and skeleton. Common normal variations and abnormal findings are described. The importance of considering clinical history and prior imaging is also emphasized when interpreting pediatric chest x-rays.
This document provides information about interpreting HRCT scans of the chest. It describes bronchial and lobar anatomy, Hounsfield units, and patterns seen on HRCT such as ground glass opacity, consolidation, reticulation, nodules, honeycombing, and vascular anatomy. Common diseases that can cause each pattern are listed, such as sarcoidosis presenting with perilymphatic nodules or pulmonary edema seen as smooth septal thickening. The document emphasizes using patterns and distributions to narrow the differential diagnosis on HRCT scans.
The document provides information on the mediastinum including its definition, boundaries, and divisions. It discusses the normal lines and stripes seen on a chest radiograph. Key points include outlining the right and left paratracheal stripes, azygoesophageal recess, and aorticopulmonary window. Common conditions affecting the anterior, middle, and posterior mediastinum are listed.
This document provides information on various laryngeal pathologies that can be diagnosed using imaging techniques like CT and MRI. It discusses laryngeal cysts, laryngoceles, thyroglossal cysts, laryngotracheitis, epiglottitis, Wegener's granulomatosis, laryngeal stenosis, vascular malformations, vocal cord paralysis, laryngeal trauma, squamous cell carcinoma, supraglottic carcinoma, glottic carcinoma, transglottic carcinoma, subglottic carcinoma, atypical squamous cell carcinomas, hemangiomas and more. Imaging findings that help diagnose and characterize these conditions are also described.
This document provides information on interpreting chest x-rays in pediatrics. It discusses examining the entire x-ray using the "ABC" approach to systematically evaluate the abdomen, bones, and chest. Common respiratory conditions seen in children are described, including their etiology, pathology, clinical presentation, and key imaging findings. Conditions covered include asthma, atelectasis, bronchiolitis, bronchogenic cyst, croup, cystic fibrosis, and epiglottitis among others. The importance of careful evaluation for foreign body aspiration is also emphasized.
Thoracic Imaging in critically ill patientsGamal Agmy
Chest radiography remains the primary imaging modality for critically ill patients, however images are often limited quality due to patient movement and positioning challenges. Mistakes can occur in assessing conditions like pleural effusions or infiltrates. Routine daily chest x-rays are not recommended for ICU patients unless clinically indicated. Ultrasound is a useful bedside tool for evaluating the lungs, IVC, heart, and detecting pneumothorax. Computed tomography can also be used but requires transporting unstable patients.
Radiological imaging of pleural diseases Pankaj Kaira
The document discusses the anatomy, imaging, and common diseases of the pleura. It begins by describing the normal anatomy of the pleural layers and thickness. Common pleural diseases are then reviewed, including pleural effusions, pneumothorax, hemothorax, and empyema. Imaging findings on chest x-ray, ultrasound, CT, and MRI are provided for diagnosing and characterizing various pleural conditions. Key signs that help differentiate pleural, pulmonary, and extra-pleural masses are also outlined.
The document discusses the triad of COPD which includes chronic bronchitis, emphysema, and chronic obstructive asthma. It describes the signs, symptoms, diagnosis, and imaging findings of COPD. On chest x-ray, COPD may show rapidly tapering vascular shadows and increased lung radiolucency. CT scanning can detect emphysema and determine if it is centriacinar, panacinar, or paraseptal. Management involves bronchodilators, rehabilitation, and glucocorticoids depending on the severity from mild to very severe COPD.
Similar to Looking at the windpipe in CT chest (dr eid elagamy).pptx (20)
These lecture slides, by Dr Sidra Arshad, offer a quick overview of the physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar lead (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
6. Describe the flow of current around the heart during the cardiac cycle
7. Discuss the placement and polarity of the leads of electrocardiograph
8. Describe the normal electrocardiograms recorded from the limb leads and explain the physiological basis of the different records that are obtained
9. Define mean electrical vector (axis) of the heart and give the normal range
10. Define the mean QRS vector
11. Describe the axes of leads (hexagonal reference system)
12. Comprehend the vectorial analysis of the normal ECG
13. Determine the mean electrical axis of the ventricular QRS and appreciate the mean axis deviation
14. Explain the concepts of current of injury, J point, and their significance
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. Chapter 3, Cardiology Explained, https://www.ncbi.nlm.nih.gov/books/NBK2214/
7. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
- Video recording of this lecture in English language: https://youtu.be/kqbnxVAZs-0
- Video recording of this lecture in Arabic language: https://youtu.be/SINlygW1Mpc
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Basavarajeeyam is a Sreshta Sangraha grantha (Compiled book ), written by Neelkanta kotturu Basavaraja Virachita. It contains 25 Prakaranas, First 24 Chapters related to Rogas& 25th to Rasadravyas.
Integrating Ayurveda into Parkinson’s Management: A Holistic ApproachAyurveda ForAll
Explore the benefits of combining Ayurveda with conventional Parkinson's treatments. Learn how a holistic approach can manage symptoms, enhance well-being, and balance body energies. Discover the steps to safely integrate Ayurvedic practices into your Parkinson’s care plan, including expert guidance on diet, herbal remedies, and lifestyle modifications.
Muktapishti is a traditional Ayurvedic preparation made from Shoditha Mukta (Purified Pearl), is believed to help regulate thyroid function and reduce symptoms of hyperthyroidism due to its cooling and balancing properties. Clinical evidence on its efficacy remains limited, necessitating further research to validate its therapeutic benefits.
Osteoporosis - Definition , Evaluation and Management .pdfJim Jacob Roy
Osteoporosis is an increasing cause of morbidity among the elderly.
In this document , a brief outline of osteoporosis is given , including the risk factors of osteoporosis fractures , the indications for testing bone mineral density and the management of osteoporosis
Cell Therapy Expansion and Challenges in Autoimmune DiseaseHealth Advances
There is increasing confidence that cell therapies will soon play a role in the treatment of autoimmune disorders, but the extent of this impact remains to be seen. Early readouts on autologous CAR-Ts in lupus are encouraging, but manufacturing and cost limitations are likely to restrict access to highly refractory patients. Allogeneic CAR-Ts have the potential to broaden access to earlier lines of treatment due to their inherent cost benefits, however they will need to demonstrate comparable or improved efficacy to established modalities.
In addition to infrastructure and capacity constraints, CAR-Ts face a very different risk-benefit dynamic in autoimmune compared to oncology, highlighting the need for tolerable therapies with low adverse event risk. CAR-NK and Treg-based therapies are also being developed in certain autoimmune disorders and may demonstrate favorable safety profiles. Several novel non-cell therapies such as bispecific antibodies, nanobodies, and RNAi drugs, may also offer future alternative competitive solutions with variable value propositions.
Widespread adoption of cell therapies will not only require strong efficacy and safety data, but also adapted pricing and access strategies. At oncology-based price points, CAR-Ts are unlikely to achieve broad market access in autoimmune disorders, with eligible patient populations that are potentially orders of magnitude greater than the number of currently addressable cancer patients. Developers have made strides towards reducing cell therapy COGS while improving manufacturing efficiency, but payors will inevitably restrict access until more sustainable pricing is achieved.
Despite these headwinds, industry leaders and investors remain confident that cell therapies are poised to address significant unmet need in patients suffering from autoimmune disorders. However, the extent of this impact on the treatment landscape remains to be seen, as the industry rapidly approaches an inflection point.
5. The trachea
from cricoid cartilage, just
below the true VC,
to the carina
10 –12
Midline in position
slightly to the right at the level of the aortic arch (This
displacement may be accentuated in older patients)
6. Tracheal wall
Visible (1- to 3-mm) soft-tissue density stripe,
demarcated internally by the air- filled tracheal
lumen and externally by the adjacent fat-density
of the mediastinum
The posterior wall is typically thinner
‘‘paper thin’’ (black arrow) than the
anterior and lateral walls (white arrow).
- Connected posteriorly by the membranous wall
of the trachea (No cartilage) and is supported by
trachealis ms
- These cartilage rings can calcify with old age &
those on long standing warfarin therapy
18-22 C-shaped tracheal cartilage
7. End Inspiration End Expiration
the tracheal lumen has narrowed slightly, with
anterior bowing of the posterior membranous
wall
Rounded lumen
Tracheal length is dynamic, changing with respiration and neck flexion and extension==>
carina can change in position up to 3 cm between inspiration and expiration
Also the lumen
11. Tracheal bronchus
(Pig bronchus or Bronhus suis)
a bronchus originate directly from the lateral wall of the trachea
This bronchus may be
Rudimentary (it forms a blind-ending pouch) OR Accessory (Supernumerary) OR Displaced,
replacing the anatomical bronchus Right upper lobe bronchus or apical segment (pig
bronchus or bronchus suis)
12. if this patient is intubated, right upper
lobe atelectasis if the endotracheal tube
projects below the opening.
Incidental findings NO symptoms. However
* Recurent infection and hemoptysis.
* In children, it is a recognized cause of recurrent right
upper lobe pneumonia or atelectasis and localized
bronchiectasis
13. Cardiac bronchus
Accessory bronchus which comes
off the medial aspect of the
bronchus intermedius.
(a true supernumerary bronchus)
This bronchus usually is blind ending but occasionally
supplies a rudimentary lobe of lung tissue
No signs or symptoms but can be associated with
recurrent infection and hemoptysis.
14. CARDIAC BRONCHUS
Contrast-enhanced chest CT (lung window) of a 21-year-old man with
hemoptysis an accessory cardiac bronchus demonstrates an air-filled tubular
structure (arrow) that arises from the medial wall of the bronchus intermedius
and courses toward the mediastinum.
16. Tracheobronchomegaly = Tracheobronchiectasis
= Mounier-Kuhn disease
Tracheal
diverticulosis =
Irregular
corrugated
appearance of
trachea
Tracheal lumen
> 3 cm in size.
absence of
significant
pulmonary fibrosis
Bronchiectasis
(segmental and
subsegmental)
main bronchus
{Rt or Lt}lumen
> 2.4cm &2.3cm
17. Tracheobronchomegaly
- Dilated trachea and main bronchi (asterisk) with corrugated
appearance of the wall due to redundant mucosa
(arrowheads).
- Bilateral bronchiectasis
Presentation
Recurrent
pulmonary
infections
19. Tracheal Narrowing (stenosis)
Long segment
Tracheal Stricture
Saber- Sheath Trachea
Tracheomalacia
Relapsing polychondritis
Trachebronchopathia
osteochondroplastica (TPO)
Amyloidosis
Rhinoscleroma
Wegener Granulomatosis
TB
Compression from outside
Short segment
Less common amyloidosis,
Wegener's granulomatosis, tumors,
inflammatory bowel disease & airway
burns
Sarcoidosis
inflammatory bowel disease
Tumors
20. Saber sheath trachea
NORMAL Tracheal index
= coronal / sagittal diameter = 1
Tracheal index <0.6
Sagittal : Coronal ratio >1.5 (??2)
Saber-sheath trachea
Acquired intrathoracic tracheal deformity Marked ↓ coronal
diameter and ↑ sagittal diameter ; measured 1 cm above the
superior aspect of the aortic arch.
strongly associated with COPD. ??correlates with severity of airway
obstruction??
fixed deformity While tracheomalacia not fixed
21. Weakness of the airway walls (posterior
tracheal membranous wall or supporting
cartilage) excessive expiratory
collapse of the airway lumen (≥ 50
reduction in AP diameter ) The
posterior tracheal wall bulges into the
tracheal lumen with forced expiration or
coughing.
Trachebronchomalacia
End-inspiratory
Normal
Dynamic expiratory
Tracheobronchomalacia
The tracheal collapse of 50% can
be seen in healthy persons, and
hence the cutoff of 70% has been
suggested to avoid false positives
22. Tracheomalacia
Tracheomalacia refers to the trachea being softer than norma
breathes out or coughs the calibre of the trachea gets smalle
chest showing an abnormal “D” or kidney shape to t he trache
the trachea is round.
End-inspiratory: trachea is normal. Dynamic expiratory : circumferential
narrowing of tracheal lumen.
excessive expiratory collapse
(abnormal “D” or kidney
excessive expiratory collapse
(semilunate or crescentic )
25. accentuation of coronal (transverse)
diameter with a relative narrowing of
sagittal (AP) diameter
Coronal : Sagittal ratio >1
= Lunate trachea
Dynamic expiratory : near complete
expiratory tracheal collapse (arrow)
end-inspiratory: elongated coronal
diameter of trachea with relative
decrease in sagittal dimension
Computed tomography (CT) may reveal a semilunate,
discoid, or crescentic trachea when viewed in cross
section
26. Relapsing Polychondritis
autoimmune disorder inflammation and destruction of cartilaginous structures
(ears, nose, joints, and laryngotracheobronchial and Aorta ) the last 2 are fatal
Airway involvement in relapsing
polychondritis is a poor prognostic sign
and is the leading cause of death
- Fixed narrowing of lumen
- smooth diffuse thickening of the anterior and lateral walls
of the trachea (arrows)
- sparing of the posterior membranous portion (arrowhead).
27. Smooth Calcified thickening of the anterior and lateral walls of the trachea and
mainstem bronchi that spares the posterior wall with lumen narrowing
= relapsing polychondritis.
28. Tracheobronchopathia
osteochondroplastica (TPO) Benign disease
asymptomatic (often cough, shortness
of breath, and hemoptysis )
discovered incidentally at imaging.
characterized by the presence of
osseous and cartilaginous submucosal
nodules connected to tracheal cartilage
Recognition of TPO allow exclusion of
the other causes of nodular tracheal
wall thickening
CT:
Calcified nodular opacities that protrude into the airway lumen resulting in
Diffuse irregular tracheal narrowing which spares the posterior membranous portion
of the airway wall is spared.
((Calcification is typically present BUT not all lesions are calcified))
29.
30. Post-
intubation/tracheostomy
Tracheal Stenosis or
Stricture
Typical stenosis on the coronal image gives an
“hour-glass” shape to trachea due to focal
involvement.
Focal (0.2 - 3.5 cm) stricture (Stenosis or web) at the site of the tube cuff (2.5–5 cm from the vocal cord)
Very thin cut of CT to avoid under or overestimation
CT with coronal and sagittal reconstructions has high
accuracy in assessment of location and severity
31. Goiter extrinsic mass effect on
the trachea with resultant luminal
narrowing.
Tracheal Stenosis due to
compression from
outside
35. Malignant tumors
Primary as
Squamous cell carcinoma
And adenoid cystic carcinoma
CT mass or circumferential thickening of tracheal
wall with irregular narrowing of the lumen
Secondary as
direct invasion from thyroid, esophagus, larynx, lung
Hematogenous mets mostly from melanoma , breast ,
genitourinary
CT single or multiple polypoid intraluminal mass