The document describes a standardized classification system for grading the severity of liver injuries. The classification system ranges from Grade I to Grade VI injuries, with higher grades indicating more severe injuries involving deeper lacerations, larger hematomas, and greater parenchymal disruption or vascular injuries. CT imaging is useful for evaluating the extent of injuries and assigning a grade.
Isolated traumatic rupture of the duodenum: Case report - Perforations, prefe...iosrjce
IOSR Journal of Dental and Medical Sciences is one of the speciality Journal in Dental Science and Medical Science published by International Organization of Scientific Research (IOSR). The Journal publishes papers of the highest scientific merit and widest possible scope work in all areas related to medical and dental science. The Journal welcome review articles, leading medical and clinical research articles, technical notes, case reports and others.
EMGuideWire's Radiology Reading Room: Blunt Aortic InjurySean M. Fox
The Department of Emergency Medicine at Carolinas Medical Center is passionate about education! Dr. Michael Gibbs is a world-renowned clinician and educator and has helped guide numerous young clinicians on the long path of Mastery of Emergency Medical Care. With his oversight, the EMGuideWire team aim to help augment our understanding of emergent imaging. You can follow along with the EMGuideWire.com team as they post these educational, self-guided radiology slides or you can also use this section to learn more in-depth about specific conditions and diseases. This Radiology Reading Room pertains to Blunt Aortic Injury and is brought to you by Rachel Plate, MD and Oriane Longerstaey, MD. It is has special guest editors: Bryant Allen, MD
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4° meeting internazionale "Quality in Healthcare and Patient Safety", hotel Baia Verde, il 14 aprile 2018.
Il tema sarà "Errore, Fattori Umani e Cultura della Sicurezza".
Scopo dell’evento è conoscere quali metodologie e strumenti sono utilizzati dalle organizzazioni complesse ad alta affidabilità per fronteggiare gli errori umani e da essi prendere spunto per migliorare la sicurezza dei pazienti negli ospedali.
Al meeting parteciperanno:
M. Egerth, esperto in fattori umani della Lufthansa – Francoforte - Germania
P. Lachman, CEO International Society for Quality in Healthcare (ISQua), Dublino - Irlanda
D. van Stralen, High Reliability Organizing, San Bernardino Group, California - USA
J. Teixeira, Laboratorio Léon Brillouin and Research nuclear reactor Orphée at Saclay Commissariat à l'Energie atomique – Francia
All'evento saranno presenti operatori di tutte le professioni sanitarie della nostra Regione ed anche oltre. Nell'edizione del 2017 erano presenti colleghi di altre Regioni.
A conclusione si svolgerà una tavola rotonda, moderata dal prof. M. Mirabella, regista e divulgatore scientifico, noto conduttore del programma televisivo di medicina Elisir, alla quale parteciperanno i presidenti di alcune società scientifiche nazionali, autorità accademiche e professionisti.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
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Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
2. Classification
Organ Injury Scaling
Grade Injury Description
Haematoma Subcapsular <10% surface area
I Laceration Capsular tear, < 1cm parenchymal depth
Haematoma Subcapsular, 10-50% surface area
II Haematoma Intraparenchymal, <10cm diameter
Laceration 1-3cm parenchymal depth, <10cm length
Haematoma Subcapsular, >50% surface area or expanding.
Ruptured subcapsular or parenchymal haematoma
III Intraparenchymal haematoma >10cm or expanding
Laceration >3cm parenchymal depth
Laceration Parenchymal disruption involving 25-75% of hepatic lobe or 1-3 Coinaud's segments in a single
IV lobe
Laceration Parenchymal disruption involving >75% of hepatic lobe or >3 Coinaud's segments within a single
V lobe
Vascular Juxtahepatic venous injuries ie. retrohepatic vena cava/central major hepatic veins
Vascular Hepatic Avulsion
VI
3. Classification
Organ Injury Scaling
Grade 1 hepatic injury in a 21-year-old man with a stabbing injury to the right upper
quadrant of the abdomen. Axial, contrast-enhanced computed tomography (CT) scan
demonstrates a small, crescent-shaped subcapsular and parenchymal hematoma less than 1
cm thick.
http://emedicine.medscape.com/article/370508-overview
http://emedicine.medscape.com/article/370508-overview
Ali Nawaz Khan, Hemant Vadeyar, Sumaira MacDonald, Muthusamy Chandramohan.
Ali Nawaz Khan, Hemant Vadeyar, Sumaira MacDonald, Muthusamy Chandramohan.
4. Classification
Organ Injury Scaling
A 20-year-old man with systemic lupus erythematosus presented with grade 2 liver injury
after minor blunt abdominal trauma. Nonenhanced axial CT scan at the level of the hepatic
veins shows a subcapsular hematoma 3 cm thick.
http://emedicine.medscape.com/article/370508-overview
http://emedicine.medscape.com/article/370508-overview
Ali Nawaz Khan, Hemant Vadeyar, Sumaira MacDonald, Muthusamy Chandramohan.
Ali Nawaz Khan, Hemant Vadeyar, Sumaira MacDonald, Muthusamy Chandramohan.
5. Classification
Organ Injury Scaling
A 20-year-old man with systemic lupus erythematosus presented with grade 2 liver injury
after minor blunt abdominal trauma (same patient as in Images above). Axial CT image
through the inferior aspect of the right lobe of the liver demonstrates multiple low-
attenuation lesions in the liver consistent with parenchymal contusion
http://emedicine.medscape.com/article/370508-overview
http://emedicine.medscape.com/article/370508-overview
Ali Nawaz Khan, Hemant Vadeyar, Sumaira MacDonald, Muthusamy Chandramohan.
Ali Nawaz Khan, Hemant Vadeyar, Sumaira MacDonald, Muthusamy Chandramohan.
6. Classification
Organ Injury Scaling
Gunshot to right lobe of liver. Grade 2 injury.
Entrance wound Gunshot wound - exit
www.trauma.org
www.trauma.org
Ronald Stewart
Ronald Stewart
7. Classification
Organ Injury Scaling
Grade 3 liver injury in a 22-year-old woman after blunt abdominal trauma. Contrast-
enhanced axial CT scan through the upper abdomen shows a 4-cm-thick subcapsular
hematoma associated with parenchymal hematoma and laceration in segments 6 and 7 of
the right lobe of the liver. Free fluid is seen around the spleen and left lobe of the liver
consistent with hemoperitoneum.
http://emedicine.medscape.com/article/370508-overview
http://emedicine.medscape.com/article/370508-overview
Ali Nawaz Khan, Hemant Vadeyar, Sumaira MacDonald, Muthusamy Chandramohan.
Ali Nawaz Khan, Hemant Vadeyar, Sumaira MacDonald, Muthusamy Chandramohan.
8. Classification
Organ Injury Scaling
Gunshot to right lobe of liver. Grade 3 injury.
Entrance Gunshot wound to right flank - liver injury gunshot wound
www.trauma.org
www.trauma.org
Arieh Eitan, Western Galilee Hospital, Nahariyya, Israel
Arieh Eitan, Western Galilee Hospital, Nahariyya, Israel
9. Classification
Organ Injury Scaling
Grade 3 injury.
Entrance Gunshot wound to right flank - liver injury gunshot wound
www.trauma.org
www.trauma.org
Arieh Eitan, Western Galilee Hospital, Nahariyya, Israel
Arieh Eitan, Western Galilee Hospital, Nahariyya, Israel
10. Classification
Organ Injury Scaling
Image obtained in a 35-year-old male bouncer after blunt abdominal injury. Nonenhanced
axial CT scan of the abdomen demonstrates a large subcapsular hematoma measuring more
than 10 cm. The high-attenuating areas within the lesion represent clotted blood. The
injury was classified as a grade 4 liver injury.
http://emedicine.medscape.com/article/370508-overview
http://emedicine.medscape.com/article/370508-overview
Ali Nawaz Khan, Hemant Vadeyar, Sumaira MacDonald, Muthusamy Chandramohan.
Ali Nawaz Khan, Hemant Vadeyar, Sumaira MacDonald, Muthusamy Chandramohan.
11. Classification
Organ Injury Scaling
Contrast-enhanced axial CT scan in a 39-year-old man with a grade 4 liver injury shows a
large parenchymal hematoma in segments 6 and 7 of the liver with evidence of an active
bleed. Note the capsular laceration and large hemoperitoneum.
http://emedicine.medscape.com/article/370508-overview
http://emedicine.medscape.com/article/370508-overview
Ali Nawaz Khan, Hemant Vadeyar, Sumaira MacDonald, Muthusamy Chandramohan.
Ali Nawaz Khan, Hemant Vadeyar, Sumaira MacDonald, Muthusamy Chandramohan.
12. Classification
Organ Injury Scaling
Multisegment infarct (segments 2, 3, 4a, and 4b) in a 40-year-old man who was in a motor
vehicle accident and underwent emergency segmental resection of the right lobe. Note the
sharply demarcated wedge-shaped area of infarction; hence, the classification as grade 4
http://emedicine.medscape.com/article/370508-overview
http://emedicine.medscape.com/article/370508-overview
Ali Nawaz Khan, Hemant Vadeyar, Sumaira MacDonald, Muthusamy Chandramohan.
Ali Nawaz Khan, Hemant Vadeyar, Sumaira MacDonald, Muthusamy Chandramohan.
13. Classification
Organ Injury Scaling
Grade 4 injury.
liver laceration (blunt trauma)
www.trauma.org
www.trauma.org
Ronald Stewart
Ronald Stewart
14. Classification
Organ Injury Scaling
Grade 5 injury in a 36-year-old man who was involved in a motor vehicle accident
demonstrates global injury to the liver.
http://emedicine.medscape.com/article/370508-overview
http://emedicine.medscape.com/article/370508-overview
Ali Nawaz Khan, Hemant Vadeyar, Sumaira MacDonald, Muthusamy Chandramohan.
Ali Nawaz Khan, Hemant Vadeyar, Sumaira MacDonald, Muthusamy Chandramohan.
15. Classification
Organ Injury Scaling
Grade 5 injury in a 36-year-old man who was involved in a motor vehicle accident
demonstrates global injury to the liver.
http://emedicine.medscape.com/article/370508-overview
http://emedicine.medscape.com/article/370508-overview
Ali Nawaz Khan, Hemant Vadeyar, Sumaira MacDonald, Muthusamy Chandramohan.
Ali Nawaz Khan, Hemant Vadeyar, Sumaira MacDonald, Muthusamy Chandramohan.
16. Classification
Organ Injury Scaling
Grade 5 injury.
liver laceration with laceration of retrohepatic vena cava and right hepatic vein
www.trauma.org
www.trauma.org
Horacio A. Massotto, Costa Rica
Horacio A. Massotto, Costa Rica
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