Marine protected areas (MPAs) and freshwater protected areas (FPAs) share many commonalities in their design, establishment and management, suggesting great potential for sharing lessons learned. However, surprisingly little has been exchanged to date, and both realms of inquiry and practice have progressed mostly independent of each other. Both MPAs and FPAs, collectively Aquatic Protected Areas (APAs), are frequently used as community fisheries management tools to support the sustainability of small-scale fisheries. In a transdisciplinary effort to explore crossover lessons between marine and freshwater realms, a team of researchers synthesized case studies of four MPAs and five FPAs (or clusters of FPAs) from nine countries, including Bangladesh, Cambodia, Chile, Madagascar, Mexico, Myanmar, Lao PDR, Thailand, and the United States. This presentation explores similarities, differences, and transferable lessons between MPAs and FPAs under five themes: 1) ecological system; 2) establishment approaches; 3) effectiveness monitoring; 4) sustaining APAs; and 5) challenges and external threats. In particular, the findings indicate many similarities around the human dimension of both MPA and FPA establishment and management, which highlight clear opportunities for exchanging lessons related to stakeholder engagement and community support. Additionally, similar socioeconomic and governance assessment methods could be used to address gaps in effectiveness data in both realms. Continued exchange between MPAs and FPAs, as well as increased transdisciplinary collaboration would benefit both realms, and practitioners could work together to address shared challenges, such as developing mechanisms for diversified and sustained funding, and employing integrated coastal/watershed management to address system-level threats.