The document summarizes the Water, Land and Ecosystems (WLE) research program. WLE aims to improve livelihoods and food security through sustainable agriculture within healthy ecosystems. It does this through targeted research in four priority regions and globally on issues like land degradation, resource management, and variability. The research portfolio focuses on information systems, rainfed and irrigated farming, resource recovery and reuse, and basin management. It also integrates cross-cutting themes of gender, poverty, institutions, and ecosystem services into all projects. The document provides details on research areas and opportunities to engage or partner with the WLE program.