Communication plays an important role in building understanding and support for science and conservation. One of the goals of the interdisciplinary Wonders of the Mekong project is to communicate the region’s diverse wonders, including its richness of wildlife and fishes, its unique hydrology, and its deep cultural connection to the people of the region. Through the use of images, video, and original stories, the project has used Facebook and other social media channels to reach an audience of Cambodians and other Southeast Asians. This effort has included the creation of the Mekong Conservation Heroes program, which uses online profiles of stories, photos, and video to shine a spotlight on inspiring individuals working to study, protect, and communicate the Mekong’s many wonders. Printed materials such as coloring books, playing cards, calendars and posters have been used to communicate environmental topics in rural, technology-limited schools and villages. Through the use of diverse communication approaches, we hope to foster a deep sense of appreciation and value of the Mekong River and the many services it provides, especially among those living in the Mekong Basin.