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10/24/08
Lecture 20 – Sexual Reproduction and Meiosis 1

   There are two main forms of reproduction.
    1. Asexual reproduction
        Mitosis
        Cloning.
    2. Sexual reproduction
        Meiosis




   When you have a diploid number, chromosomes are in homologous pairs.

   In humans, there are 22 pairs of autosomes and on pair of sex chromosomes.
     Females have XX.
     Males have XY.

   Meiosis
     Meiosis I
        Interphase
             S phase: DNA replications itself → single-stranded to double-stranded.
             Prophase I
               Nuclear membrane and nucleolus breaks down.
               Spindle starts to form.
               Homologous pairs line up adjacent to each other.
               Chiasmata: the points where chromosomes interact with another.
                  Tetrad: The structure that results when two replicated homologous chromosomes pair
                  during prophase I of meiosis.
               Crossing over may occur.
             Metaphase I
               Tetrads line up at the equator of the cell.
             Anaphase
               One member of each homologous pair moves to opposite poles.
               No serparation at the centromere.
             Telophase I
               Cytokinesis.
               Resulting in two haploid cells (only one member of each homologous pair).
     Meiosis II (No S phrase – no replication between Meiosis I and II)
     Prophase II
        New spindle forms
        Haploid member of double-stranded chromosomes begin to organize themselves for secondary
division.
   Metaphase II
     Hapliods line up at the equator.
   Anaphase II
     Separation at the centromere and the single-stranded chromosomes move to the poles.
   Telophase II
     A new nuclei forms.
     Cytokinesis.
     At the end, 4 haploid cells (each being genetically distinct) are created.

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Lecture 20

  • 1. 10/24/08 Lecture 20 – Sexual Reproduction and Meiosis 1  There are two main forms of reproduction. 1. Asexual reproduction  Mitosis  Cloning. 2. Sexual reproduction  Meiosis  When you have a diploid number, chromosomes are in homologous pairs.  In humans, there are 22 pairs of autosomes and on pair of sex chromosomes.  Females have XX.  Males have XY.  Meiosis  Meiosis I  Interphase  S phase: DNA replications itself → single-stranded to double-stranded.  Prophase I  Nuclear membrane and nucleolus breaks down.  Spindle starts to form.  Homologous pairs line up adjacent to each other.  Chiasmata: the points where chromosomes interact with another. Tetrad: The structure that results when two replicated homologous chromosomes pair during prophase I of meiosis.  Crossing over may occur.  Metaphase I  Tetrads line up at the equator of the cell.  Anaphase  One member of each homologous pair moves to opposite poles.  No serparation at the centromere.  Telophase I  Cytokinesis.  Resulting in two haploid cells (only one member of each homologous pair).  Meiosis II (No S phrase – no replication between Meiosis I and II)  Prophase II  New spindle forms  Haploid member of double-stranded chromosomes begin to organize themselves for secondary
  • 2. division.  Metaphase II  Hapliods line up at the equator.  Anaphase II  Separation at the centromere and the single-stranded chromosomes move to the poles.  Telophase II  A new nuclei forms.  Cytokinesis.  At the end, 4 haploid cells (each being genetically distinct) are created.