This document provides an overview of computer instructions and addressing modes. It defines an instruction as a specific operation or command given to a CPU to perform a task. Instructions are encoded in binary and form computer programs. The document discusses different types of instructions like arithmetic, logical, and data transfer instructions. It also explains various addressing modes like immediate, direct, indirect, register, and indirect register addressing that define how operands are accessed for instructions. Understanding instructions and addressing modes is important for writing efficient programs that optimize performance and hardware interaction.