The ever-increasing number of parameters in deep neural networks poses challengesfor memory-limited applications. Regularize-and-prune methods aim at meetingthese challenges by sparsifying the network weights. In this context we quantifythe outputsensitivityto the parameters (i.e. their relevance to the network output)and introduce a regularization term that gradually lowers the absolute value ofparameters with low sensitivity. Thus, a very large fraction of the parametersapproach zero and are eventually set to zero by simple thresholding. Our methodsurpasses most of the recent techniques both in terms of sparsity and error rates. Insome cases, the method reaches twice the sparsity obtained by other techniques atequal error rates.