Scientists grew human embryos in a lab for nearly two weeks, the longest period of time embryos have developed outside the womb. This breakthrough may help improve assisted reproduction and stem cell therapies. It also showed that embryos can mature beyond a few days in vitro, challenging a 14-day rule on developing embryos in labs. While hailed as an advancement, it also raises ethical issues as it pushes scientific boundaries.

1. Lab-grown human embryo
lives for 14 days
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2. Contd…
Scientists reported on Wednesday that they had grown human embryos in
the lab for nearly two weeks, an unprecedented feat that promises advances
in assisted reproduction, stem-cell therapies and the basic understanding of
how human beings form. Besides opening a window onto the first steps in
the creation of an individual, the findings in parallel studies may help explain
early miscarriages and why in vitro fertilisation has such a high failure rate.
The research also showed for the first time that newly-forming human
embryos can mature beyond a few days outside a mother's womb,
something that was previously thought to be impossible.
But the widely hailed results also set science on a collision course with
national laws and ethical guidelines, experts cautioned. Up to now, a so-
called “14-day rule“ -which says that human embryos cannot be cultured in
the lab for more than two weeks -has never been seriously challenged simply
because no one had succeeded in keeping them alive that long.
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3. Contd…
In this case, the scientists destroyed the embryos to avoid breaching that
limit. The findings were published in Nature and Nature Cell Biology.
Next to nothing is known about how the small, hollow bundle of cells called
a blastocyst -emerging from a fertilised egg -attach to the uterus, allowing an
embryo to begin to take shape. “This portion of human development“ -called
implantation -“was a complete black box,“ said Ali Brivanlou, a professor at
The Rockefeller University in New York. Building on previous work with mice,
Brivanlou and colleagues concocted a chemical soup and scaffolding to
duplicate this process “in vitro“, or in a petri dish. “We were able to create a
system that properly recapitulates what happens during human
implantation,“ said scientist and lead author Alessia Deglincerti.
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