Ketoconazole cream is used to treat fungal and yeast infections of the skin, including conditions like athlete's foot and jock itch, by killing the fungus causing the infection. It contains 2% ketoconazole and should be applied to the affected area once or twice daily, with precautions for allergies and possible side effects like irritation. The cream must be stored at controlled room temperature, and its use during pregnancy is only recommended if the benefits outweigh the risks.