The knee joint is a modified hinge joint that allows flexion and extension. It is supported by ligaments including the ACL, PCL, MCL and LCL. The joint is lined by a synovial membrane and contains two menisci that absorb shock and deepen the tibial surfaces. Flexion is powered by the hamstrings while extension is powered by the quadriceps femoris muscle. The knee provides stability during weight bearing and locomotion.
The knee joint is the largest and most complicated joint in the body. It allows for weight bearing, walking, climbing stairs, running, jumping and kicking. The knee joint is formed where the femur meets the tibia and patella. It contains ligaments like the anterior and posterior cruciate ligaments, menisci, synovial membrane and bursae that provide stability and cushioning. Injuries to the cruciate ligaments or menisci are common in sports and require immobilization followed by physiotherapy.
The knee joint is the largest and most complicated joint in the body. It consists of three joints: the medial and lateral condylar joints between the femur and tibia, and the patellofemoral joint between the patella and femur. The knee joint is stabilized by numerous ligaments including the anterior and posterior cruciate ligaments, medial and lateral collateral ligaments, and menisci. It is supplied by the femoral, popliteal, and genicular arteries and innervated by branches of the femoral and tibial nerves. The knee allows for flexion, extension, and some rotational movements.
The knee joint is the largest and most complicated joint in the body. It consists of three joints: the medial and lateral tibiofemoral joints and the patellofemoral joint. The knee joint is stabilized by numerous ligaments including the anterior and posterior cruciate ligaments, the medial and lateral collateral ligaments, and the transverse ligament. It also contains two menisci that help distribute weight forces and provide shock absorption. The knee is supplied by branches from the femoral, tibial and common peroneal nerves and receives its blood supply from the femoral, popliteal and genicular arteries.
The knee joint is composed of three joints: the medial and lateral tibiofemoral joints and the patellofemoral joint. It is supported by numerous ligaments including the anterior and posterior cruciate ligaments, medial and lateral collateral ligaments, menisci, and synovial membrane. The patella glides within the femoral groove during knee flexion and extension to enhance the leverage of the quadriceps muscle. The medial and lateral menisci act as shock absorbers between the femur and tibia.
The knee joint is the largest and most complex joint in the body. It is formed by the fusion of the femorotibial joints and femoropatellar joint. The knee joint is supported by numerous ligaments including the cruciate ligaments, menisci, and fibrous capsule. It allows for flexion and extension movements through the actions of various muscles and tendons. Injuries commonly occur to the ligaments and menisci, and inflammation can develop in the bursae around the knee.
The document discusses knee instability and describes the structure of the knee including the osseous, extra-articular, and intra-articular structures. It provides details on the menisci, ligaments including the ACL and PCL, and muscles. The document also covers causes of meniscal injuries, diagnostic tests, treatment options including non-operative treatment and surgical procedures like meniscectomy and repair.
Ligamnet around knee and injury and managementBirajkc5
The document discusses knee instability and describes the structure of the knee including the osseous, extra-articular, and intra-articular structures. It provides details on the menisci, ligaments including the ACL and PCL, muscles, and classification of knee stabilizers. The document also covers mechanisms and classification of meniscal injuries, diagnostic tests, imaging studies, and surgical and non-surgical treatment options.
The knee joint is a modified hinge joint that allows for flexion and extension as well as some rotation. It is formed by the articulation of the femur, tibia, and patella. The knee joint contains two joint cavities - the patellofemoral joint and tibiofemoral joint. Various ligaments such as the cruciate ligaments and menisci provide stability and cushioning to the joint. Injuries commonly involve the collateral ligaments, menisci, or anterior cruciate ligament due to their location and function. The knee is an important and complex joint that enables mobility but is also susceptible to trauma.
The knee joint is the largest and most complicated joint in the body. It allows for weight bearing, walking, climbing stairs, running, jumping and kicking. The knee joint is formed where the femur meets the tibia and patella. It contains ligaments like the anterior and posterior cruciate ligaments, menisci, synovial membrane and bursae that provide stability and cushioning. Injuries to the cruciate ligaments or menisci are common in sports and require immobilization followed by physiotherapy.
The knee joint is the largest and most complicated joint in the body. It consists of three joints: the medial and lateral condylar joints between the femur and tibia, and the patellofemoral joint between the patella and femur. The knee joint is stabilized by numerous ligaments including the anterior and posterior cruciate ligaments, medial and lateral collateral ligaments, and menisci. It is supplied by the femoral, popliteal, and genicular arteries and innervated by branches of the femoral and tibial nerves. The knee allows for flexion, extension, and some rotational movements.
The knee joint is the largest and most complicated joint in the body. It consists of three joints: the medial and lateral tibiofemoral joints and the patellofemoral joint. The knee joint is stabilized by numerous ligaments including the anterior and posterior cruciate ligaments, the medial and lateral collateral ligaments, and the transverse ligament. It also contains two menisci that help distribute weight forces and provide shock absorption. The knee is supplied by branches from the femoral, tibial and common peroneal nerves and receives its blood supply from the femoral, popliteal and genicular arteries.
The knee joint is composed of three joints: the medial and lateral tibiofemoral joints and the patellofemoral joint. It is supported by numerous ligaments including the anterior and posterior cruciate ligaments, medial and lateral collateral ligaments, menisci, and synovial membrane. The patella glides within the femoral groove during knee flexion and extension to enhance the leverage of the quadriceps muscle. The medial and lateral menisci act as shock absorbers between the femur and tibia.
The knee joint is the largest and most complex joint in the body. It is formed by the fusion of the femorotibial joints and femoropatellar joint. The knee joint is supported by numerous ligaments including the cruciate ligaments, menisci, and fibrous capsule. It allows for flexion and extension movements through the actions of various muscles and tendons. Injuries commonly occur to the ligaments and menisci, and inflammation can develop in the bursae around the knee.
The document discusses knee instability and describes the structure of the knee including the osseous, extra-articular, and intra-articular structures. It provides details on the menisci, ligaments including the ACL and PCL, and muscles. The document also covers causes of meniscal injuries, diagnostic tests, treatment options including non-operative treatment and surgical procedures like meniscectomy and repair.
Ligamnet around knee and injury and managementBirajkc5
The document discusses knee instability and describes the structure of the knee including the osseous, extra-articular, and intra-articular structures. It provides details on the menisci, ligaments including the ACL and PCL, muscles, and classification of knee stabilizers. The document also covers mechanisms and classification of meniscal injuries, diagnostic tests, imaging studies, and surgical and non-surgical treatment options.
The knee joint is a modified hinge joint that allows for flexion and extension as well as some rotation. It is formed by the articulation of the femur, tibia, and patella. The knee joint contains two joint cavities - the patellofemoral joint and tibiofemoral joint. Various ligaments such as the cruciate ligaments and menisci provide stability and cushioning to the joint. Injuries commonly involve the collateral ligaments, menisci, or anterior cruciate ligament due to their location and function. The knee is an important and complex joint that enables mobility but is also susceptible to trauma.
The knee joint is the largest and most complex joint in the body. It consists of three joints: the medial and lateral condylar joints between the femur and tibia, and the patellofemoral joint between the femur and patella. The knee joint contains numerous ligaments that connect the femur, tibia, and patella, including the anterior and posterior cruciate ligaments, medial and lateral collateral ligaments, and medial and lateral menisci. The knee joint also contains bursae that reduce friction between bones, muscles, tendons, and ligaments during movement.
The knee joint is a hinge synovial joint consisting of the femur, tibia, and patella. It has two collateral ligaments - the lateral collateral ligament and medial collateral ligament - as well as two cruciate ligaments - the anterior cruciate ligament and posterior cruciate ligament. The stability of the knee joint depends on surrounding muscles like the quadriceps femoris and ligaments connecting the femur and tibia. It is surrounded by a fibrous capsule and synovial membrane, and contains two menisci that absorb shock between the femur and tibia.
The knee joint is the largest and most complex joint in the body. It consists of three joints: the medial and lateral condylar joints between the femur and tibia, and the patellofemoral joint between the femur and patella. The articular surfaces include the femoral and tibial condyles and the patella. The knee joint is supported by ligaments including the cruciate ligaments, collateral ligaments, and menisci which absorb shock and distribute forces across the joint. The knee has a complex blood supply and is surrounded by bursae and synovial membrane.
The knee joint is the largest and most complex joint in the body. It consists of three joints: the medial and lateral condylar joints between the femur and tibia, and the patellofemoral joint between the femur and patella. Key structures include the cruciate ligaments which provide stability, menisci which absorb shock and distribute force, and synovial membrane which lines the joint space. The document provides detailed descriptions of the articular surfaces, ligaments, bursae, and other anatomical structures that make up the knee joint.
The knee joint is the largest and most complex joint in the body. It is a modified hinge joint that allows flexion, extension, and some rotation. The knee joint is composed of three articulations: the medial and lateral tibiofemoral joints between the femur and tibia, and the patellofemoral joint between the femur and patella. The knee joint is supported by ligaments such as the anterior and posterior cruciate ligaments, as well as menisci that cushion the joint surfaces.
To discuss the knee joint: At the end of the presentation we should be able to note the following
The type of joint.
Bones and part of the bone that forms the joints
Type of cartilage covering the articular surface.
Attachment of fibrous capsule.
The attachment or lining of the synovial membrane.
Structures found outside the fibrous capsules (Extracapsular structures).
Structures found within the capsules (Intracapsular structures).
Movement and muscle causing the movement.
Blood and Nerve supply.
Applied Anatomy.
The knee joint is the largest and most complex joint in the body, formed by the fusion of three joints. It contains articular surfaces on the femur, patella, and tibia. Stability is provided by muscles, collateral ligaments, and cruciate ligaments. The knee allows for flexion, extension, and medial/lateral rotation. Locking and unlocking during walking is enabled by the quadriceps and popliteus muscles respectively. Injuries like meniscal tears and dislocations are clinically relevant.
The document provides an anatomical overview of the knee structures. It discusses the osseous structures including the patella, femoral condyles, and tibial plateaus. It then describes the extra-articular structures such as muscles, ligaments, and tendons that provide stability to the knee joint. These include the quadriceps mechanism, hamstrings, iliotibial band, gastrocnemius, and collateral and cruciate ligaments. The document outlines the layers of soft tissues and ligaments on the medial and lateral sides of the knee.
The knee is the largest and most complicated joint in the human body. It consists of two condylar joints between the femur and tibia, as well as the patellofemoral joint. The stability of the knee relies primarily on soft tissues like ligaments rather than bony structure. The knee joint is divided into the medial and lateral compartments by the menisci. It contains several important ligaments like the ACL, PCL, MCL and LCL that provide stability. The muscles that act on the knee include the quadriceps, hamstrings, pes anserine group and iliotibial band.
The document provides an overview of the anatomy and structures of the knee joint. It describes the osseous structures including the femur, tibia, and patella. It also discusses the extra-articular tendinous structures, ligamentous structures including the capsule, collateral ligaments, and cruciate ligaments. The intra-articular structures of the menisci and synovial membrane are also outlined. Blood supply and innervation of the various structures is summarized.
The ankle joint, or talocrural joint, is a hinged synovial joint that connects the distal ends of the tibia and fibula to the proximal end of the talus bone. It is stabilized by strong collateral ligaments on the sides, interlocking articular surfaces, and tendons crossing the joint. The ankle joint functions as a hinge to allow dorsiflexion and plantarflexion motions of the foot.
The knee joint is composed of two articulations, the tibiofemoral joint and patellofemoral joint. The tibiofemoral joint allows 3 degrees of freedom of motion and contains the femoral condyles which articulate with the menisci and tibial plateaus. The menisci improve joint congruence and distribute weight forces. Ligaments such as the ACL, PCL, MCL and LCL provide stability to the joint. The patellofemoral joint contains the patella which articulates with the femur and is stabilized by surrounding structures like the quadriceps tendon.
The knee joint is made up of two joints - the patellofemoral joint and the tibiofemoral joint. It is a complex hinge joint that lacks inherent stability and relies on surrounding soft tissues like ligaments, muscles, and menisci. The menisci absorb shock, increase congruency, and decrease pressure in the joint. Major ligaments include the ACL, PCL, MCL, and LCL. Common injuries involve tears to these ligaments from forces of valgus, varus, twisting, or anterior/posterior displacement. Other common knee conditions include meniscal tears, patellofemoral pain syndrome, tendinitis, bursitis, and osteochondromatosis. The
The document provides details about the ankle joint and joints of the foot. It discusses the tibiofibular articulation including the superior, interosseous, and inferior tibiofibular joints. It then describes the ankle (talocrural) joint, including its range of motion, articulating surfaces, joint capsule, ligaments, synovial membrane, vascular supply, innervation, and factors maintaining stability. Finally, it summarizes the small joints of the foot including the talocalcaneal, talocalcaneonavicular, calcaneocuboid, naviculocuneiform, and intercuneiform joints.
The document describes the anatomy of the leg, including:
- The leg is divided into anterior, posterior, and lateral compartments by connective tissue like the interosseous membrane.
- The posterior compartment contains superficial muscles like gastrocnemius and soleus that plantarflex the foot, and deep muscles that also plantarflex and invert the foot.
- Gastrocnemius originates on the femur and inserts on the calcaneus via the Achilles tendon. Soleus originates on the tibia and fibula and also inserts on the calcaneus.
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
ANATOMY OF KNEE JOINT
In this presentation of " Anatomy of Knee Joint" you will know about structures present in Knee Joint.
Bones, Joints, Ligaments, Muscles, Mechanism of movements of Knee Joint, Nerve and Blodd supply of Knee Joint.
The knee joint is the largest synovial joint in the body. It consists of the articulation between the femur and tibia, which bears weight, and the articulation between the patella and femur. Two menisci act as shock absorbers between the femoral condyles and tibial plateau. The knee joint allows for flexion and extension like a hinge and is stabilized by ligaments and locking mechanisms when standing.
introduction about joints, types of joints . joints are present with in upper limb, movements of all joints and finally with clinical correlation of all joints.
The document discusses the benefits of exercise for mental health. Regular physical activity can help reduce anxiety and depression and improve mood and cognitive function. Exercise causes chemical changes in the brain that may help protect against mental illness and improve symptoms.
MOCK ORTHOPAEDICS CASE PRESENTATION(LOWER BACK PAIN).pptxApoorvGarg28
The document provides a summary of a mock orthopaedics case presentation. It includes demographic details of a 45 year old male patient complaining of lower back pain radiating to his right ankle. On examination, the patient has reduced range of motion, muscle weakness on the right side, and a left lateral shift in his spine. Differential diagnoses include prolapsed disc, piriformis syndrome, and sciatic nerve impingement. Treatment will focus on reducing pain, increasing mobility, and correcting posture through techniques like heat, ultrasound, stretching, and interferential therapy.
The knee joint is the largest and most complex joint in the body. It consists of three joints: the medial and lateral condylar joints between the femur and tibia, and the patellofemoral joint between the femur and patella. The knee joint contains numerous ligaments that connect the femur, tibia, and patella, including the anterior and posterior cruciate ligaments, medial and lateral collateral ligaments, and medial and lateral menisci. The knee joint also contains bursae that reduce friction between bones, muscles, tendons, and ligaments during movement.
The knee joint is a hinge synovial joint consisting of the femur, tibia, and patella. It has two collateral ligaments - the lateral collateral ligament and medial collateral ligament - as well as two cruciate ligaments - the anterior cruciate ligament and posterior cruciate ligament. The stability of the knee joint depends on surrounding muscles like the quadriceps femoris and ligaments connecting the femur and tibia. It is surrounded by a fibrous capsule and synovial membrane, and contains two menisci that absorb shock between the femur and tibia.
The knee joint is the largest and most complex joint in the body. It consists of three joints: the medial and lateral condylar joints between the femur and tibia, and the patellofemoral joint between the femur and patella. The articular surfaces include the femoral and tibial condyles and the patella. The knee joint is supported by ligaments including the cruciate ligaments, collateral ligaments, and menisci which absorb shock and distribute forces across the joint. The knee has a complex blood supply and is surrounded by bursae and synovial membrane.
The knee joint is the largest and most complex joint in the body. It consists of three joints: the medial and lateral condylar joints between the femur and tibia, and the patellofemoral joint between the femur and patella. Key structures include the cruciate ligaments which provide stability, menisci which absorb shock and distribute force, and synovial membrane which lines the joint space. The document provides detailed descriptions of the articular surfaces, ligaments, bursae, and other anatomical structures that make up the knee joint.
The knee joint is the largest and most complex joint in the body. It is a modified hinge joint that allows flexion, extension, and some rotation. The knee joint is composed of three articulations: the medial and lateral tibiofemoral joints between the femur and tibia, and the patellofemoral joint between the femur and patella. The knee joint is supported by ligaments such as the anterior and posterior cruciate ligaments, as well as menisci that cushion the joint surfaces.
To discuss the knee joint: At the end of the presentation we should be able to note the following
The type of joint.
Bones and part of the bone that forms the joints
Type of cartilage covering the articular surface.
Attachment of fibrous capsule.
The attachment or lining of the synovial membrane.
Structures found outside the fibrous capsules (Extracapsular structures).
Structures found within the capsules (Intracapsular structures).
Movement and muscle causing the movement.
Blood and Nerve supply.
Applied Anatomy.
The knee joint is the largest and most complex joint in the body, formed by the fusion of three joints. It contains articular surfaces on the femur, patella, and tibia. Stability is provided by muscles, collateral ligaments, and cruciate ligaments. The knee allows for flexion, extension, and medial/lateral rotation. Locking and unlocking during walking is enabled by the quadriceps and popliteus muscles respectively. Injuries like meniscal tears and dislocations are clinically relevant.
The document provides an anatomical overview of the knee structures. It discusses the osseous structures including the patella, femoral condyles, and tibial plateaus. It then describes the extra-articular structures such as muscles, ligaments, and tendons that provide stability to the knee joint. These include the quadriceps mechanism, hamstrings, iliotibial band, gastrocnemius, and collateral and cruciate ligaments. The document outlines the layers of soft tissues and ligaments on the medial and lateral sides of the knee.
The knee is the largest and most complicated joint in the human body. It consists of two condylar joints between the femur and tibia, as well as the patellofemoral joint. The stability of the knee relies primarily on soft tissues like ligaments rather than bony structure. The knee joint is divided into the medial and lateral compartments by the menisci. It contains several important ligaments like the ACL, PCL, MCL and LCL that provide stability. The muscles that act on the knee include the quadriceps, hamstrings, pes anserine group and iliotibial band.
The document provides an overview of the anatomy and structures of the knee joint. It describes the osseous structures including the femur, tibia, and patella. It also discusses the extra-articular tendinous structures, ligamentous structures including the capsule, collateral ligaments, and cruciate ligaments. The intra-articular structures of the menisci and synovial membrane are also outlined. Blood supply and innervation of the various structures is summarized.
The ankle joint, or talocrural joint, is a hinged synovial joint that connects the distal ends of the tibia and fibula to the proximal end of the talus bone. It is stabilized by strong collateral ligaments on the sides, interlocking articular surfaces, and tendons crossing the joint. The ankle joint functions as a hinge to allow dorsiflexion and plantarflexion motions of the foot.
The knee joint is composed of two articulations, the tibiofemoral joint and patellofemoral joint. The tibiofemoral joint allows 3 degrees of freedom of motion and contains the femoral condyles which articulate with the menisci and tibial plateaus. The menisci improve joint congruence and distribute weight forces. Ligaments such as the ACL, PCL, MCL and LCL provide stability to the joint. The patellofemoral joint contains the patella which articulates with the femur and is stabilized by surrounding structures like the quadriceps tendon.
The knee joint is made up of two joints - the patellofemoral joint and the tibiofemoral joint. It is a complex hinge joint that lacks inherent stability and relies on surrounding soft tissues like ligaments, muscles, and menisci. The menisci absorb shock, increase congruency, and decrease pressure in the joint. Major ligaments include the ACL, PCL, MCL, and LCL. Common injuries involve tears to these ligaments from forces of valgus, varus, twisting, or anterior/posterior displacement. Other common knee conditions include meniscal tears, patellofemoral pain syndrome, tendinitis, bursitis, and osteochondromatosis. The
The document provides details about the ankle joint and joints of the foot. It discusses the tibiofibular articulation including the superior, interosseous, and inferior tibiofibular joints. It then describes the ankle (talocrural) joint, including its range of motion, articulating surfaces, joint capsule, ligaments, synovial membrane, vascular supply, innervation, and factors maintaining stability. Finally, it summarizes the small joints of the foot including the talocalcaneal, talocalcaneonavicular, calcaneocuboid, naviculocuneiform, and intercuneiform joints.
The document describes the anatomy of the leg, including:
- The leg is divided into anterior, posterior, and lateral compartments by connective tissue like the interosseous membrane.
- The posterior compartment contains superficial muscles like gastrocnemius and soleus that plantarflex the foot, and deep muscles that also plantarflex and invert the foot.
- Gastrocnemius originates on the femur and inserts on the calcaneus via the Achilles tendon. Soleus originates on the tibia and fibula and also inserts on the calcaneus.
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
ANATOMY OF KNEE JOINT
In this presentation of " Anatomy of Knee Joint" you will know about structures present in Knee Joint.
Bones, Joints, Ligaments, Muscles, Mechanism of movements of Knee Joint, Nerve and Blodd supply of Knee Joint.
The knee joint is the largest synovial joint in the body. It consists of the articulation between the femur and tibia, which bears weight, and the articulation between the patella and femur. Two menisci act as shock absorbers between the femoral condyles and tibial plateau. The knee joint allows for flexion and extension like a hinge and is stabilized by ligaments and locking mechanisms when standing.
introduction about joints, types of joints . joints are present with in upper limb, movements of all joints and finally with clinical correlation of all joints.
The document discusses the benefits of exercise for mental health. Regular physical activity can help reduce anxiety and depression and improve mood and cognitive function. Exercise causes chemical changes in the brain that may help protect against mental illness and improve symptoms.
MOCK ORTHOPAEDICS CASE PRESENTATION(LOWER BACK PAIN).pptxApoorvGarg28
The document provides a summary of a mock orthopaedics case presentation. It includes demographic details of a 45 year old male patient complaining of lower back pain radiating to his right ankle. On examination, the patient has reduced range of motion, muscle weakness on the right side, and a left lateral shift in his spine. Differential diagnoses include prolapsed disc, piriformis syndrome, and sciatic nerve impingement. Treatment will focus on reducing pain, increasing mobility, and correcting posture through techniques like heat, ultrasound, stretching, and interferential therapy.
Inflammation is the body's response to harmful stimuli and involves increased blood flow, swelling, heat, redness, and pain. The goals of inflammation are to eliminate the initial cause, remove damaged cells, and initiate tissue repair. The cardinal signs of inflammation come from Latin and include pain, heat, redness, swelling, and loss of function. Acute inflammation lasts less than 48 hours and involves neutrophils, while chronic inflammation lasts longer and involves mononuclear cells. Acute inflammation may resolve, progress to chronic, lead to abscess formation, or result in tissue repair through scarring.
Unit 3 Topic 1 Indian Partnership Act.pptxApoorvGarg28
The document discusses the key aspects of partnership law in India as governed by the Indian Partnership Act of 1932. It defines a partnership as an agreement between two or more persons to share profits of a business. The essential elements of a partnership include mutual agency between partners. A partnership is formed through an agreement and can be registered, with types including partnerships at will and particular partnerships defined by duration. The document outlines rights and duties of partners, and circumstances for dissolution of a partnership through court order, agreement, operation of law or notice.
Thyrotoxicosis is a clinical syndrome caused by excess circulating thyroid hormones. It is most commonly caused by Graves' disease. Symptoms include goiter, exophthalmos, weight loss, nervousness, tremors, and increased sweating. Diagnosis is made through blood tests showing elevated FT3 and FT4 with low TSH. Treatment involves antithyroid drugs, radioactive iodine ablation, or surgery. Hypothyroidism is caused by low thyroid hormone levels and can be primary or secondary. Symptoms include fatigue, weight gain, dry skin, and mental sluggishness. It is diagnosed through blood tests showing low FT3 and FT4 with high TSH. Treatment is lifelong thyroid hormone
This document defines hematuria and describes its classification and various etiologies. It can be caused by diseases of the urinary system, glomerular issues, interstitial diseases, uroepithelium malignancy, systemic disorders, adjacent organ diseases, drugs, and unknown sources. Clinical features depend on red blood cell amount and urine pH. Differential diagnosis considers contaminated urine, drugs, porphyria, and hemoglobinuria. Evaluation includes a three-glass urine test, accompanying symptoms, laboratory tests, renal biopsy if indicated, and cystoscopy or imaging tests. Glomerular bleeding shows red cell casts, dysmorphic cells, and proteinuria while extraglomerular bleeding lacks casts and shows uniform cells.
PGx Analysis in VarSeq: A User’s PerspectiveGolden Helix
Since our release of the PGx capabilities in VarSeq, we’ve had a few months to gather some insights from various use cases. Some users approach PGx workflows by means of array genotyping or what seems to be a growing trend of adding the star allele calling to the existing NGS pipeline for whole genome data. Luckily, both approaches are supported with the VarSeq software platform. The genotyping method being used will also dictate what the scope of the tertiary analysis will be. For example, are your PGx reports a standalone pipeline or would your lab’s goal be to handle a dual-purpose workflow and report on PGx + Diagnostic findings.
The purpose of this webcast is to:
Discuss and demonstrate the approaches with array and NGS genotyping methods for star allele calling to prep for downstream analysis.
Following genotyping, explore alternative tertiary workflow concepts in VarSeq to handle PGx reporting.
Moreover, we will include insights users will need to consider when validating their PGx workflow for all possible star alleles and options you have for automating your PGx analysis for large number of samples. Please join us for a session dedicated to the application of star allele genotyping and subsequent PGx workflows in our VarSeq software.
“Psychiatry and the Humanities”: An Innovative Course at the University of Mo...Université de Montréal
“Psychiatry and the Humanities”: An Innovative Course at the University of Montreal Expanding the medical model to embrace the humanities. Link: https://www.psychiatrictimes.com/view/-psychiatry-and-the-humanities-an-innovative-course-at-the-university-of-montreal
STUDIES IN SUPPORT OF SPECIAL POPULATIONS: GERIATRICS E7shruti jagirdar
Unit 4: MRA 103T Regulatory affairs
This guideline is directed principally toward new Molecular Entities that are
likely to have significant use in the elderly, either because the disease intended
to be treated is characteristically a disease of aging ( e.g., Alzheimer's disease) or
because the population to be treated is known to include substantial numbers of
geriatric patients (e.g., hypertension).
Osvaldo Bernardo Muchanga-GASTROINTESTINAL INFECTIONS AND GASTRITIS-2024.pdfOsvaldo Bernardo Muchanga
GASTROINTESTINAL INFECTIONS AND GASTRITIS
Osvaldo Bernardo Muchanga
Gastrointestinal Infections
GASTROINTESTINAL INFECTIONS result from the ingestion of pathogens that cause infections at the level of this tract, generally being transmitted by food, water and hands contaminated by microorganisms such as E. coli, Salmonella, Shigella, Vibrio cholerae, Campylobacter, Staphylococcus, Rotavirus among others that are generally contained in feces, thus configuring a FECAL-ORAL type of transmission.
Among the factors that lead to the occurrence of gastrointestinal infections are the hygienic and sanitary deficiencies that characterize our markets and other places where raw or cooked food is sold, poor environmental sanitation in communities, deficiencies in water treatment (or in the process of its plumbing), risky hygienic-sanitary habits (not washing hands after major and/or minor needs), among others.
These are generally consequences (signs and symptoms) resulting from gastrointestinal infections: diarrhea, vomiting, fever and malaise, among others.
The treatment consists of replacing lost liquids and electrolytes (drinking drinking water and other recommended liquids, including consumption of juicy fruits such as papayas, apples, pears, among others that contain water in their composition).
To prevent this, it is necessary to promote health education, improve the hygienic-sanitary conditions of markets and communities in general as a way of promoting, preserving and prolonging PUBLIC HEALTH.
Gastritis and Gastric Health
Gastric Health is one of the most relevant concerns in human health, with gastrointestinal infections being among the main illnesses that affect humans.
Among gastric problems, we have GASTRITIS AND GASTRIC ULCERS as the main public health problems. Gastritis and gastric ulcers normally result from inflammation and corrosion of the walls of the stomach (gastric mucosa) and are generally associated (caused) by the bacterium Helicobacter pylor, which, according to the literature, this bacterium settles on these walls (of the stomach) and starts to release urease that ends up altering the normal pH of the stomach (acid), which leads to inflammation and corrosion of the mucous membranes and consequent gastritis or ulcers, respectively.
In addition to bacterial infections, gastritis and gastric ulcers are associated with several factors, with emphasis on prolonged fasting, chemical substances including drugs, alcohol, foods with strong seasonings including chilli, which ends up causing inflammation of the stomach walls and/or corrosion. of the same, resulting in the appearance of wounds and consequent gastritis or ulcers, respectively.
Among patients with gastritis and/or ulcers, one of the dilemmas is associated with the foods to consume in order to minimize the sensation of pain and discomfort.
Computer in pharmaceutical research and development-Mpharm(Pharmaceutics)MuskanShingari
Statistics- Statistics is the science of collecting, organizing, presenting, analyzing and interpreting numerical data to assist in making more effective decisions.
A statistics is a measure which is used to estimate the population parameter
Parameters-It is used to describe the properties of an entire population.
Examples-Measures of central tendency Dispersion, Variance, Standard Deviation (SD), Absolute Error, Mean Absolute Error (MAE), Eigen Value
Summer is a time for fun in the sun, but the heat and humidity can also wreak havoc on your skin. From itchy rashes to unwanted pigmentation, several skin conditions become more prevalent during these warmer months.
The biomechanics of running involves the study of the mechanical principles underlying running movements. It includes the analysis of the running gait cycle, which consists of the stance phase (foot contact to push-off) and the swing phase (foot lift-off to next contact). Key aspects include kinematics (joint angles and movements, stride length and frequency) and kinetics (forces involved in running, including ground reaction and muscle forces). Understanding these factors helps in improving running performance, optimizing technique, and preventing injuries.
How to Control Your Asthma Tips by gokuldas hospital.Gokuldas Hospital
Respiratory issues like asthma are the most sensitive issue that is affecting millions worldwide. It hampers the daily activities leaving the body tired and breathless.
The key to a good grip on asthma is proper knowledge and management strategies. Understanding the patient-specific symptoms and carving out an effective treatment likewise is the best way to keep asthma under control.
These lecture slides, by Dr Sidra Arshad, offer a simplified look into the mechanisms involved in the regulation of respiration:
Learning objectives:
1. Describe the organisation of respiratory center
2. Describe the nervous control of inspiration and respiratory rhythm
3. Describe the functions of the dorsal and respiratory groups of neurons
4. Describe the influences of the Pneumotaxic and Apneustic centers
5. Explain the role of Hering-Breur inflation reflex in regulation of inspiration
6. Explain the role of central chemoreceptors in regulation of respiration
7. Explain the role of peripheral chemoreceptors in regulation of respiration
8. Explain the regulation of respiration during exercise
9. Integrate the respiratory regulatory mechanisms
10. Describe the Cheyne-Stokes breathing
Study Resources:
1. Chapter 42, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 36, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 13, Human Physiology by Lauralee Sherwood, 9th edition
2. Osteology
• Distal Femur with Proximal Tibia
• Largest Joint Cavity in the Body
• A modified hinge joint with significant passive
rotation
• Technically, one degree of freedom
(Flexion/Extension) but passive rotary
component is essential
• Unites the two longest levers in the body
3. Support
• Knee supports the weight of the body and
transmits forces from the ground
• Functional stability of the joint is derived from
the passive restraint of the ligaments, the
active support of muscles, the joint geometry,
and the compressive forces pushing the bones
together
4. Joint Capsule
• Largest in body
• Surrounds entire joint, except anteriorly
• Originally (in utero) is three capsule that merge into
one
• MCL – flat band, attached above medial condyle of the
femur and below to the medial surface of the shaft of
the tibia – resists lateral displacement
• LCL – cordlike, attached above the lateral condyle of
femur and below the head of the fibula – resists medial
displacement
5. Capsule
• Oblique Popliteal – derived from
semimembranosus on posterior aspect of the
capsule, runs from that tendon to medial
aspect of the lateral femoral condyle
(posteriorly)
• Arcuate popliteal from head of fibula, runs
over the popliteus muscle to attach into
posterior joint capsule
6. CAPSULE
• It is absent Anteriorly.
• It is
• Replaced by :
• Quadriceps femoris
tendon.
• Patella.
• Ligamentum patellae.
7. CAPSULE
• Posteriorly :
• (a) Superior :
• Attached proximal to the
articular margins of the
femoral condyles and to
the intercondylar fossa
• It is deficient above the
lateral condyle for the
passage of tendon of
popliteus
9. CAPSULE
• (b) Inferior :
• Attached to the tibia
EXCEPT when the
tendon of Popliteus
crosses the bone.
10. EXTRACAPSULAR LIGAMENTS
• 1. Ligamentum Patellae
• It is the inter mediate part
of the tendon of quadriceps
femoris .It is supported by
the patellar retinaculi
(expansions from the vasti)
• They strengthen the
capsule on each side.
11. 2. TIBIAL (MEDIAL) COLLATERAL
• A flat band.
• Attachment:
• Above to the medial
condyle of the femur.
• Below to the medial
surface of the shaft of the
tibia.
• Firmly attached to the
medial meniscus.
13. 3. LATERAL (FIBULAR) COLLATERAL
• Cord like.
• Attachment :
• Above : lateral condyle of
the femur.
• Below : head of the
fibula.
• Separated from the
lateral meniscus by the
tendon of popliteus.
15. 4. OBLIQUE POPLITEAL LIG.
• An expansion of the
Semimembranosus.
• It strengthens the
capsule posteriorly.
16. CRUCIATE LIGAMENTS
• They are the main
bond between the
femur and tibia
throughout the joint’s
movements.
• They Cross each other
within the joint cavity.
• They are named
Anterior and Posterior
according to their
tibial attachments.
17. ANTERIOR CRUCIATE
• Tibial attachment :
• Anterior intercondylar
area.
• Course :
• Upward, backward and
laterally.
• Femoral attachment:
• Posterior part of medial
surface of the lateral
condyle.
18. ANTERIOR CRUCIATE
• FUNCTION
• Prevent posterior
displacement of the
femur on the tibia
and the tibia from
being pulled
anteriorly when the
knee joint is flexed.
• It is taught in hyper
extension.
19. POSTERIOR CRUCIATE
• Tibial attachment :
• posterior inter condylar
area.
• Direction:
• upward, forward and
medially.
• Femoral attachment:
• Anterior part of the lateral
surface of the medial
condyle.
20. POSTERIOR CRUCIATE
• Function:
• prevents anterior
displacement of
the femur on the
tibia and the tibia
from being pulled
posteriorly when
the knee joint is
flexed.
• It is taught in hyper
flexion.
21.
22. Menisci
• The surface of the tibia is covered by fibrocartilaginous
menisci - They:
– Enhance the joint stability by deepening the contact
surface
– They help with shock absorption by transmitting ½ of
weight bearing load in full extension and some in
flexion as well
– They protect the articular cartilage
– They transmit the load across the surface of the joint,
thus reducing the load per unit area on the tibio-
femoral contact sites. The contact area in the joint is
reduced 50% when the menisci are absent
24. Menisci
• In hi load situations, 70% of the load is absorbed
by the menisci, especially the lateral meniscus
• The menisci assist in lubrication of the joint by
acting as a space filling mechanism, more fluid is
dispersed to the surface of tibia and femur
• 20% increase in friction following meniscal
removal
• Medial Meniscus – larger, reflects the shape of
medial tibial condyle A + P horns – attached to
medial collateral ligament and basically immobile
• Lateral Meniscus – smaller, tighter, almost a
complete circle A+ P horns – NOT attached to
lateral collateral ligament
25. MENISCI
• C shaped sheets of fibro
cartilage.
• The peripheral border is
thick and attached to the
capsule.
• The inner border is thin
and concave and forms a
free edge.
26. MENISC
• The upper concave
surfaces are in contact
with the femoral
condyles.
• The lower flat surfaces
are in contact with the
tibial condyles.
27. MENISCI
• Functions :
• 1. Deepen the
tibial articular
surfaces.
• 2. Act as cushions
between the two
bones.
28. MEDIAL MENISCUS
• Crescentic in shape.
• More liable to injury
due to its
attachment to the
medial collateral
ligament and to the
capsule.
• It is relatively
immobile.
30. LATERAL MENISCUS
• More rounded in shape.
• Its anterior and posterior
ends lie within the ends of
the medial meniscus.
• Posteriorly it is separated
from the fibular collateral
ligament by the tendon of
popliteus.
• Less liable to injury.
31. Menisci - Attachments
• Transverse ligament anteriorly
• Meniscopatellar fibers or ligaments: Fibrous bands
connecting the anterior horns of both menisci to the
medial and lateral retinaculum
• The medial collateral ligament attaches to the medial
meniscus
• The tendon of semimenbranosis sends fibers to the
posterior edge of medial meniscus
• The popliteus muscle sends fibers to the lateral meniscus
• The meniscofemoral ligament extends from the lateral
meniscus (post) to the inside of the medial condyle near
the PCL
• The coronary liagaments – meniscotibial
34. INJURY OF THE MENISCI
• The menisci are frequently
injured especially in
footballers and cricketers.
• The medial is torn three
times more often than the
lateral.
• The injury is produced by the
rotation of the femur on the
tibia or the reverse with the
knee joint partially flexed and
carries the weight of the
body.
35. INJURY OF THE MENISCI
• The torn part of the
meniscus is wedged
between the tibial and
femoral condyles.
• No further movement
is allowed and the
joint is kept locked.
36. SYNOVIAL MEMBRANE
• It lines the lateral and
medial parts of the capsule.
• Anteriorly :
• It forms the supra patellar
bursa.
• It is attached to the inter
condylar area of the tibia
and to the lateral and
medial borders of the
patella.
37. SYNOVIAL MEMBRANE
• It is reflected backward
from the posterior surface
of the ligamentum
patellae to form the
Infrapatellar fold.
• The free borders of the
fold are the Alar folds.
• The space between these
folds contains fat
(Infrapatellar pad of fat).
38. SYNOVIAL MEMBRANE
• Posteriorly :
• It Passes out to
surround the cruciate
ligaments.
• It is continuous with the
surface layer of the
menisci.
• It covers the tendon of
popliteus and forms a
bursa around it
(popliteal bursa).
• It forms the
semimembranosus
bursa.
39. Bursa
• 20 + associated with
the knee
• Most important
• Subcutaneous
prepatellar
• Subcutaneous
infrapatellar
• Deep infrapatellar
• Anserine bursa
• Bursa deep to iliotibial
band
• Inferior subtendinous
bursa of biceps
40. ANTERIOR BURSAE
• They are four :
• 1. Suprapatellar :
• It is 3 fingerbreadths above the
patella.
• Always continuous with the
joint cavity.
• Held in position by the
articularis genus muscle.
• Accumulation of fluid in the
joint causes excees fluid in the
bursa leading to floating
patella.
44. POSTERIOR BURSAE (6)
• 1. POPLITEAL
• Always continuous with
the joint cavity.
• 2.SEMIMEMBRANOSU
• Usually communicates
with the joint cavity.
• 3 & 4. GASTROCNEMIUS
• Around sartorius,gracilis
and semitendinosus.
45. MOVEMENTS
• 1. FLEXION
• Hamstrings( supplied
by the sciatic nerve).
• Assisted by sartorius,
popliteus and gracilis.
– Checked by back of calf
in contact with the back
of the thigh.
46. MOVEMENTS
– 2. EXTENSION
– Quadriceps Femoris
(supplied by the femoral
nerve.)
– Limited by tension of the
cruciate and collateral
ligaments.
47. Knee Motion
• The long articulating surface of the femoral condyles
is about twice the length of the tibial condyles
• Therefore the activity of flexion and extension can
not be a pure hinge motion or simple rolling of one
bone over the other
• Instead the condyles execute both rolling and sliding
motions
• Rolling is predominant at the initiation of flexion and
sliding occurs more at the end of flexion
48. UNLOCKING
• At the commencement of Flexion
of the extended knee.
• Aim :
• To slack the ligaments especially
the cruciate.
• FEMUR: Lateral rotation (the foot
is on the ground)
• TIBIA: Medial rotation.
• Muscle: POPLITEUS
49. LOCKING • The joint assumes the position
of full extension.
• It becomes a rigid structure.
• The menisci are compressed
between the tibial and femoral
condyles.
• Tightening of all the major
ligaments.
• The femur is medially rotated
on the tibia.
51. RELATIONS
• Posterior :
• Boundaries and
contents of Popliteal
Fossa.
• Medial :
• SGS muscles.
• Lateral :
• Biceps femoris and
common peroneal
nerve.
52. STABILITY
• 1. Muscles :
• QUADRICEPS particularly
the inferior fibers of the
vasti lateralis and medialis.
• Many sport injuries can be
preventable through
appropriate training and
conditioning of the muscle.
53. STABILITY
• 2. Ligaments :
• The knee joint can function
well following a ligamentous
strain if the quadriceps is
intact.
54. INJURY OF THE JOINT
• TRIAD OF INJURY
• 1. Medial collateral
ligament.
• 2. Medial meniscus.
• 3. Anterior cruciate
ligament.
• The joint becomes swollen
because it is filled with
blood (hemarthrosis).
55. ANTERIOR CRUCIATE INJURY
• Tear of the anterior
cruciate ligament is
more common than
the posterior.
• The tibia can be
pulled excessively
forward on the femur
57. INJURY OF THE CRUCIATE LIGAMENTS
• Management :
• Knee is kept immobilized in
slight flexion.
• Active physiotherapy of the
quadriceps femoris at
once.
• Operative repair (incase of
torn of the capsule and
collateral ligaments).
58. Q Angle
• An angle found by drawing a line from ASIS to middle
of patella and a second line from mid patella to tibial
tuberosity
– Represents efficiency of Quads
– Most efficient = 10 degrees
– Males range from 10-14
– Females from 15-17
– Represents the valgus stress acting on knee and, if
excessive, can cause patello femoral problems
• Great than 17 degrees considered excessive, called
genu valgum or knock knees
• Very small angle causes genu varum
59. “Q” Angle
• Line from ASIS to midpoint
of the patella
• Line from Tibial tubercle
to midpoint of the patella
65. Cruciate Ligaments
• Major stabilizing
ligaments in the knee
• Anterior Cruciate
Ligament (ACL)-prevents
the tibia from sliding out
in front of the femur
• Injuries caused by
hyperflexion, internal
rotation, hyperextension