The knee joint is a hinge synovial joint consisting of the femur, tibia, and patella. It has two collateral ligaments - the lateral collateral ligament and medial collateral ligament - as well as two cruciate ligaments - the anterior cruciate ligament and posterior cruciate ligament. The stability of the knee joint depends on surrounding muscles like the quadriceps femoris and ligaments connecting the femur and tibia. It is surrounded by a fibrous capsule and synovial membrane, and contains two menisci that absorb shock between the femur and tibia.
To discuss the knee joint: At the end of the presentation we should be able to note the following
The type of joint.
Bones and part of the bone that forms the joints
Type of cartilage covering the articular surface.
Attachment of fibrous capsule.
The attachment or lining of the synovial membrane.
Structures found outside the fibrous capsules (Extracapsular structures).
Structures found within the capsules (Intracapsular structures).
Movement and muscle causing the movement.
Blood and Nerve supply.
Applied Anatomy.
introduction about joints, types of joints . joints are present with in upper limb, movements of all joints and finally with clinical correlation of all joints.
ANATOMY OF KNEE JOINT
In this presentation of " Anatomy of Knee Joint" you will know about structures present in Knee Joint.
Bones, Joints, Ligaments, Muscles, Mechanism of movements of Knee Joint, Nerve and Blodd supply of Knee Joint.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
To discuss the knee joint: At the end of the presentation we should be able to note the following
The type of joint.
Bones and part of the bone that forms the joints
Type of cartilage covering the articular surface.
Attachment of fibrous capsule.
The attachment or lining of the synovial membrane.
Structures found outside the fibrous capsules (Extracapsular structures).
Structures found within the capsules (Intracapsular structures).
Movement and muscle causing the movement.
Blood and Nerve supply.
Applied Anatomy.
introduction about joints, types of joints . joints are present with in upper limb, movements of all joints and finally with clinical correlation of all joints.
ANATOMY OF KNEE JOINT
In this presentation of " Anatomy of Knee Joint" you will know about structures present in Knee Joint.
Bones, Joints, Ligaments, Muscles, Mechanism of movements of Knee Joint, Nerve and Blodd supply of Knee Joint.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Integrating Ayurveda into Parkinson’s Management: A Holistic ApproachAyurveda ForAll
Explore the benefits of combining Ayurveda with conventional Parkinson's treatments. Learn how a holistic approach can manage symptoms, enhance well-being, and balance body energies. Discover the steps to safely integrate Ayurvedic practices into your Parkinson’s care plan, including expert guidance on diet, herbal remedies, and lifestyle modifications.
Adv. biopharm. APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMSAkankshaAshtankar
MIP 201T & MPH 202T
ADVANCED BIOPHARMACEUTICS & PHARMACOKINETICS : UNIT 5
APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMS By - AKANKSHA ASHTANKAR
These lecture slides, by Dr Sidra Arshad, offer a quick overview of the physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar lead (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
6. Describe the flow of current around the heart during the cardiac cycle
7. Discuss the placement and polarity of the leads of electrocardiograph
8. Describe the normal electrocardiograms recorded from the limb leads and explain the physiological basis of the different records that are obtained
9. Define mean electrical vector (axis) of the heart and give the normal range
10. Define the mean QRS vector
11. Describe the axes of leads (hexagonal reference system)
12. Comprehend the vectorial analysis of the normal ECG
13. Determine the mean electrical axis of the ventricular QRS and appreciate the mean axis deviation
14. Explain the concepts of current of injury, J point, and their significance
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. Chapter 3, Cardiology Explained, https://www.ncbi.nlm.nih.gov/books/NBK2214/
7. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Basavarajeeyam is a Sreshta Sangraha grantha (Compiled book ), written by Neelkanta kotturu Basavaraja Virachita. It contains 25 Prakaranas, First 24 Chapters related to Rogas& 25th to Rasadravyas.
Local Advanced Lung Cancer: Artificial Intelligence, Synergetics, Complex Sys...Oleg Kshivets
Overall life span (LS) was 1671.7±1721.6 days and cumulative 5YS reached 62.4%, 10 years – 50.4%, 20 years – 44.6%. 94 LCP lived more than 5 years without cancer (LS=2958.6±1723.6 days), 22 – more than 10 years (LS=5571±1841.8 days). 67 LCP died because of LC (LS=471.9±344 days). AT significantly improved 5YS (68% vs. 53.7%) (P=0.028 by log-rank test). Cox modeling displayed that 5YS of LCP significantly depended on: N0-N12, T3-4, blood cell circuit, cell ratio factors (ratio between cancer cells-CC and blood cells subpopulations), LC cell dynamics, recalcification time, heparin tolerance, prothrombin index, protein, AT, procedure type (P=0.000-0.031). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and N0-12 (rank=1), thrombocytes/CC (rank=2), segmented neutrophils/CC (3), eosinophils/CC (4), erythrocytes/CC (5), healthy cells/CC (6), lymphocytes/CC (7), stick neutrophils/CC (8), leucocytes/CC (9), monocytes/CC (10). Correct prediction of 5YS was 100% by neural networks computing (error=0.000; area under ROC curve=1.0).
Muktapishti is a traditional Ayurvedic preparation made from Shoditha Mukta (Purified Pearl), is believed to help regulate thyroid function and reduce symptoms of hyperthyroidism due to its cooling and balancing properties. Clinical evidence on its efficacy remains limited, necessitating further research to validate its therapeutic benefits.
2. Outline
• Introduction
• Stability of knee joint
• Stabilizing muscle
• capsule of knee joint
• ligament of knee joint
• Bursae around knee joint
3. Introduction
• Type of joint
1. Fibrous or immobile joint
2. Cartilaginous Or slightly moveable joint
3. Synovial Joint
4. Type of synovial joint
1. ball and socket joint
2. Hing Joint
3. Pivot joint
4. Gliding joint
5. Saddle joint
6. Condyloid Joint
5. Knee joint
• The knee joint is the largest and most
superficial joint
• It is hinge type of synovial joint
Consists of 3 articulation
1. Medial femorotibial articulation
2. Lateral femorotibial articulation
3. Femoropatellar articulation
11. Patella
• Is sesamoid bone
• Several ossifi cation centres appear at 3 years
and fuse at puberty .
• A bipartite (or multipartite) patella is a
common variant when the superolateral
corner fails to fuse.
13. Stability Of knee joint
The stability of knee joint depends on
1. the strength and action of the surrounding
muscle and their tendon
2. The ligament that connect the femur and
tibia
the erect, extended position is the most
stable position of the knee joint
18. Capsule Of Knee Joint
• It is consisting of fibrous capsule and synovial
membrane
19. Fibrous capsule
Superiorly , fibrous layer attaches to the femur,
just proximal to the articular margin of the
condyles
Inferiorly ,margin of the superior articular surface
of tibia except where the tendon of popliteus
crosses the bone
Posteriorly, encloses the condyles and the
intercondylar fossa. It has an opening to allow the
tendon of popliteus to pass
Anteriorly, the quadriceps tendon and patellar
ligament replace the fibrous layer
20.
21. Synovial membrane
• Superiorly, it continuous with synovial lining of
suprapatelar bursa
• Posteriorly, an anterior synovium reflection
from the capsule covers the front and sides of
the cruciate ligament , rendering them
intracapsular but extrasynovial
22. Extracapsular Ligament Of Knee Joint
1 patellar ligament
Receives the medial and lateral patelar
retinacula play important role in maintaining
alignment of patella
23.
24. 2 lateral collateral ligament(FCL
• Tendon of popliteus separating FCL from the
lateral meniscus
• Tendon of biceps femoris is split into two part
by the FCL
28. 4 oblique popliteal ligament
• Is atendinous expansion derived from the
semimembranosus muscle
• It strengthens the posterior aspect of the
capsule
29.
30. Arcuate Popliteal Ligament
It arises from the posterior aspect of the fibula
head ,passes superomedially over the tendon of
the popliteus surface of the knee joint
31. Intra articular ligament
1 anterior cruciate ligament(ACL)
• Arise from the anterior
intercondylar area of tibia
to attach to the posterior
part of the medial side of
lateral condyle of femur
• Weaker than PCL
• Has relatively poor blood
supply
32. 2 posterior cruciate ligament
• Arise from posterior
intercondylar area of
the tibia to attached to
anterior part of the
lateral surface of the
medial femoral condyle
33. Menisci of the knee joint
• Are crescentric plates of fibrocartilage on the
articular surface of the tibia that deepen the
surface and play a role in shock absorption
• The coronary ligaments are portion of the
joint capsule extending between the margins
of the menisci and most of the periphery of
the tibial condyle
• Transverse ligament of knee joins the anterior
edge of menisci
34.
35. Medial meniscus
• Mesial meniscus firmly adheres to the deep
surface of TCL
• Is less mobile on the tibial plateau than is the
lateral meniscus
36. Lateral meniscus
• Is smaller and
more freely
movable than the
median meniscus
• Posterior
meniscofemoral
ligament joins
the lateral
meniscus to PCL
and the medial
femoral condyle
37. Bursae around knee joint
• They are found wherever skin ,muscle ,or
tendon rubs against bone
• Four bursae communicate with the synovial
cavity of knee joint
1. Suprapatellar bursa
2. Popliteus bursa
3. Anserine bursa
4. Gastrocnemius bursa
Type of joint 1, fibrous or fixed joint, 2cartilaginous or slightly moveable joint ,3 synovial joint
Type of synovial joint ,1ball and socket ,2 hing joint,3pivot joint ,4 gliding joint, 5 saddle joint,6 condyloid joint
The most important muscle in stabilizing the knee joint is
the large quadriceps femoris, particularly the inferior fi bers
of the vastus medialis and lateralis
Superior part of medial surface of tibia
Lateral condyle of tibia
Lateral epicondyle of femur to lateral surface of fibula head
Medial epicondyle to medial condyle and superior part of medial surface
Tendon of semimembranous to lateral femoral condyle
aspect of the fi bular head, passes superomedially over the tendon of the popliteus, and spreads over the posterior surface of the knee joint. Its development appears to be inversely related to the presence and size of a fabella in the proximal attachment of the lateral head of gastrocnemius (see blue box “Fabella in Gastrocnemius;” Fig. B5.21 on p. 606). Both structures are thought to contribute to posterolateral stabilityaspect of the fi bular head, passes superomedially over the tendon of the popliteus, and spreads over the posterior surface of the knee joint. Its development appears to be inversely related to the presence and size of a fabella in the proximal attachment of the lateral head of gastrocnemius (see blue box “Fabella in Gastrocnemius;” Fig. B5.21 on p. 606). Both structures are thought to contribute to posterolateral stability