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The Secret of
Healthy Aging
The greatest medical break thru
                        on cellular aging that has taken
                             a lifetime to discover.
The greatest discover
 on aging and aging
  related disease.
Dr. David Sinclair is one of the top 4
  anti-aging scientists in the world
                            •
                                Director of the Paul F. Glenn Laboratories for
                                Molecular Biology of Aging

                            •
                                Associate Professor of Pathology at Harvard
                                Medical School

                            •
                                He has spent his lifetime working on discovering
                                the secrets to anti-aging and his research has
                                taken him all over the world
                                “We now know that the rate of aging is not
                                predetermined—it is naturally regulated by
                                a few critical genes.” Dr. David Sinclair




Dr. David Sinclair, Ph.D.
Who discovered resveratrol’s
                                                                                    Professor John Pezzuto
 ability to extend life-spans?
MIT researchers discovered a gene, Sirtuin 1, which controls
the rate of aging. This gene is switched on by caloric restriction.
In 2003, Harvard scientist David Sinclair and team discovered
trans-resveratrol also switches on the Sirtuin 1 gene, thus
mimicking calorie restriction. Sinclair was first to show a living
organism, yeast cells, lives far longer when given
resveratrol. He later showed resveratrol’s ability to promote
quality of life. Resveratrol may soon become the most prized
molecule on our planet.




                                                                      Who found resveratrol?
                                                                      Leroy Creasy, professor of pomology at Cornell
                                                                      discovered resveratrol in 1992. Excitement for this
                                                                      molecule boomed in 1997 when a team led by
                                                                      Professor John Pezzuto, pictured above,
                                                                      (University of Illinois), reported resveratrol inhibited
                                                                      the onset and progression of cancer in mice like no
                                                                      other molecule. Comparing resveratrol to 19,000
                                                                      other substances, he said – “Resveratrol is by far
          Dr. David Sinclair, Ph.D.                                   the most promising against cancer.”
VIVIX Clinical Study
                     NRF2 ACTIVATION
 Key Ingredients

                      Anti-
                                     Antioxidants
                      Inflammatory
Detoxifying
Enzymes

                                                Anti-
Immune
                                                stress
Balance


      VIVIX ACTIVATES A KEY GENETIC REGULATOR
       AND HELPS TURN DOWN CELLULAR AGING
Vivix – A Science based product to start
    repairs of all four kinds of cellular
                  damage

Vivix – Sends a message to the body to
 start repairs of cellular damage due to
             biological aging
1. Cell Defense
                                     2. Cell Energy




                  POWERFUL RESULTS

3. Cell Repair                 4. Cell Performance
12 types of Muscadine
Shaklee Patent Pending On
   Most Active Varieties
SUPER GRAPE POLYPHENOLS
         Ellagic acid     Quercetin
         Ellagitannins    Myricetin
         Gallic acids     Caffeic acid
         Anthocyanins     Kaempherol
         Proanthocyanidins Resveratrol
         Chlorogenic acid    Catechins

                        Super Grape


               Muscadine (Vitis rotundifolia)
DNA Damaging Assaults
  Every cell in the body is bombarded daily by up to a million DNA damaging assaults that can harm your
 genetic data base – creating a typo that may compromise cell functions and longevity

 Cellular              UV Light                Ionizing             Chemical             Replication
Metabolism             Exposure               Radiation             Exposure               Errors



                                          DNA


                                      DAMAGE
    Cell Cycle          Transcriptional                  DNA Repair                      Apoptosis
   Checkpoint              Program                     Direct reversal
   Activation             Activation                 Base excision repair
                                                      Mismatch repair
                                                  Double strand break repair
Genetic Regulators
Genetic regulators contribute to the age related cellular deterioration by controlling the
dynamic balance between damage and repair




                   Scientists have found that a gene linked to diabetes and cholesterol
Advanced
              Glycation
Excess accumulation of advanced glycation end products can cause
cellular damage that can compromise cell longevity and integrity
Sources of Cell Damage
An INFLAMATORY Meal
    Inflammation can cause aging, heart attack, stroke,
          cancer and many other health threats

                        NY
                      SU-
                     rk
                  Yo
               ew
             fN
         yo
          it
       rs
        ve
      ni
    eU
  at
St




                            CLINICAL STUDY: 910 Cal junk food breakfast
                                  Measured anti-aging outcomes for 5 h
INFLAMMATIO
N
LEADS TO...
 •Heart Disease
 •Diabetes
 •Obesity
 •Cancer
Mitochondri
     a    Mitochondria in our cells
                    create energy which we
                    cannot live without. As
                    mitochondria decreases
                    cell functions declines.
Vivix Increases Cellular Energy*




  Control    Resveratrol   Vivix
Biological aging –
occurs – very early
after birth and on into
later in life

After we stop growing
this leads to
accumulation of
loss of body
function through
the changes at
cellular level
Emerging research reveals
that natural substances can
 influence these biological
aging processes in a positive
            way
Biological Aging

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Dr. David Sinclair's Discovery on Aging and Disease

  • 2. The greatest medical break thru on cellular aging that has taken a lifetime to discover. The greatest discover on aging and aging related disease.
  • 3. Dr. David Sinclair is one of the top 4 anti-aging scientists in the world • Director of the Paul F. Glenn Laboratories for Molecular Biology of Aging • Associate Professor of Pathology at Harvard Medical School • He has spent his lifetime working on discovering the secrets to anti-aging and his research has taken him all over the world “We now know that the rate of aging is not predetermined—it is naturally regulated by a few critical genes.” Dr. David Sinclair Dr. David Sinclair, Ph.D.
  • 4. Who discovered resveratrol’s Professor John Pezzuto ability to extend life-spans? MIT researchers discovered a gene, Sirtuin 1, which controls the rate of aging. This gene is switched on by caloric restriction. In 2003, Harvard scientist David Sinclair and team discovered trans-resveratrol also switches on the Sirtuin 1 gene, thus mimicking calorie restriction. Sinclair was first to show a living organism, yeast cells, lives far longer when given resveratrol. He later showed resveratrol’s ability to promote quality of life. Resveratrol may soon become the most prized molecule on our planet. Who found resveratrol? Leroy Creasy, professor of pomology at Cornell discovered resveratrol in 1992. Excitement for this molecule boomed in 1997 when a team led by Professor John Pezzuto, pictured above, (University of Illinois), reported resveratrol inhibited the onset and progression of cancer in mice like no other molecule. Comparing resveratrol to 19,000 other substances, he said – “Resveratrol is by far Dr. David Sinclair, Ph.D. the most promising against cancer.”
  • 5. VIVIX Clinical Study NRF2 ACTIVATION Key Ingredients Anti- Antioxidants Inflammatory Detoxifying Enzymes Anti- Immune stress Balance VIVIX ACTIVATES A KEY GENETIC REGULATOR AND HELPS TURN DOWN CELLULAR AGING
  • 6. Vivix – A Science based product to start repairs of all four kinds of cellular damage Vivix – Sends a message to the body to start repairs of cellular damage due to biological aging
  • 7. 1. Cell Defense 2. Cell Energy POWERFUL RESULTS 3. Cell Repair 4. Cell Performance
  • 8. 12 types of Muscadine Shaklee Patent Pending On Most Active Varieties
  • 9. SUPER GRAPE POLYPHENOLS Ellagic acid Quercetin Ellagitannins Myricetin Gallic acids Caffeic acid Anthocyanins Kaempherol Proanthocyanidins Resveratrol Chlorogenic acid Catechins Super Grape Muscadine (Vitis rotundifolia)
  • 10. DNA Damaging Assaults Every cell in the body is bombarded daily by up to a million DNA damaging assaults that can harm your genetic data base – creating a typo that may compromise cell functions and longevity Cellular UV Light Ionizing Chemical Replication Metabolism Exposure Radiation Exposure Errors DNA DAMAGE Cell Cycle Transcriptional DNA Repair Apoptosis Checkpoint Program Direct reversal Activation Activation Base excision repair Mismatch repair Double strand break repair
  • 11. Genetic Regulators Genetic regulators contribute to the age related cellular deterioration by controlling the dynamic balance between damage and repair Scientists have found that a gene linked to diabetes and cholesterol
  • 12. Advanced Glycation Excess accumulation of advanced glycation end products can cause cellular damage that can compromise cell longevity and integrity
  • 13. Sources of Cell Damage
  • 14. An INFLAMATORY Meal Inflammation can cause aging, heart attack, stroke, cancer and many other health threats NY SU- rk Yo ew fN yo it rs ve ni eU at St CLINICAL STUDY: 910 Cal junk food breakfast Measured anti-aging outcomes for 5 h
  • 15. INFLAMMATIO N LEADS TO... •Heart Disease •Diabetes •Obesity •Cancer
  • 16. Mitochondri a Mitochondria in our cells create energy which we cannot live without. As mitochondria decreases cell functions declines.
  • 17. Vivix Increases Cellular Energy* Control Resveratrol Vivix
  • 18. Biological aging – occurs – very early after birth and on into later in life After we stop growing this leads to accumulation of loss of body function through the changes at cellular level
  • 19. Emerging research reveals that natural substances can influence these biological aging processes in a positive way

Editor's Notes

  1. Mito Mass/biogenesis increase = promotes longevity/cellular function. * Green area represents mitochondrial mass in human muscle cells Mitochondrial mass increase promotes cellular function & longevity