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Mark Lange, Ph. D. Market America Director of Quality Control The Science of  Resveratrol
Important Statement ,[object Object],[object Object],[object Object]
Berry and Fruit Extracts to be Discussed ,[object Object],[object Object],[object Object]
Resveravine ® ,[object Object],[object Object],[object Object]
Resveratrol is naturally produced by plants as a defense system against infection and oxidative stress due to external attacks. UV Fungi Copper Ozone time Resveratrol level
Sources of  Resveratrol ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Benefits of  Resveratrol ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Apoptosis   ,[object Object]
Microscope View of Apoptosis ,[object Object],[object Object],[object Object],[object Object]
Apoptosis is a Normal Process ,[object Object],[object Object],[object Object],[object Object]
Apoptosis in Cancer Cells ,[object Object],[object Object]
Importance of Apoptosis ,[object Object],[object Object]
Resveratrol  Research ,[object Object],[object Object],[object Object]
NIH  Resveratrol  Study ,[object Object]
Increased frequency of apoptosis in two tumor cell lines induced by polyphenolic extracts   (Japanese knotweed) Cells death rate (%) Cells death rate (%)
Nuclear factor-kappa B ,[object Object],[object Object],[object Object]
Resveratrol  and NF-kB ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Resveratrol  Inflammation Research ,[object Object],[object Object],[object Object],[object Object],[object Object]
Non-Steroidal Anti-Inflammatory Drugs ,[object Object],[object Object]
Resveratrol  for Cardiovascular Support ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Resveratrol  Inhibits Platelet Aggregation ,[object Object],[object Object],[object Object]
Resveratrol  stimulates eNOS ,[object Object],[object Object]
A study of mechanisms involved in vasodilation by  Resveratrol Li  etal.  A Study of Mechanisms Involved in Vasodilation Induced by Resveratrol in Isolated Porcine Coronary Artery.  Physiol. Res .   55:365-72,  200 6. 1 5 50 100 0 20 40 60 80 100 Control E-NOS Inhibitor (L-NNA) Endothelium Removed Endothelium Intact Arterial   Relaxation (%) 1 55 10 10 50 100 Red Wine Extract Concentration (μM)
Cardiovascular Support ,[object Object],[object Object],[object Object],[object Object],Low-density Lipoprotein Particle (LDL)
  Resveravine protects LDL from oxidation better than synthetic resveratrol, catechin  and vitamin E
Caloric Restriction ,[object Object],[object Object]
Resveratrol  Research in Extending Life Span  ,[object Object],[object Object],[object Object],[object Object]
Sirtuins Help Cells Survive ,[object Object],[object Object]
Studies Backing  Resveratrol’s  Activation of Sirtuins ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Studies Backing  Resveratrol’s  Activation of Sirtuins ,[object Object],[object Object],[object Object],[object Object]
Resveratrol  is a Superior Antioxidant ,[object Object],[object Object]
Resveratrol  as an Antioxidant ,[object Object],[object Object],[object Object],[object Object]
Protection against oxidative stress Influence of three related polyphenols on the oxidative stress of lymphocytes infected by the Epstein-Barr virus (EBV) Peroxidation rate (%)
Resveratrol  Might Fight Obesity ,[object Object],[object Object],[object Object]
Resveratrol  Might Fight Obesity ,[object Object]
Safety of  Resveratrol ,[object Object],[object Object],[object Object],[object Object]
Possible Herb-Drug Interactions ,[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],As mentioned, Resveravine also provides    - Viniferin , which is a dimer of Resveratrol :
BioVin ®  Advanced ,[object Object],[object Object],[object Object]
BioVin ®  Advanced vs. Wine Amount of Resveratrol in 200mg BioVin ®  Advanced Amount required to be equivalent to 200 mg BioVin® Advanced Red Wine White Wine 10 mg 10 glasses  (1500 ml) 40 glasses  (6000 ml)
Benefits of BioVin ®  Advanced ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
VitaBlue™ Wild Blueberry Extract ,[object Object],[object Object],[object Object]
ORAC of Selected Foods     2007 U.S. Department of Agriculture   ,[object Object]
Benefits of Blueberries ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Blueberries and Cell Health ,[object Object],[object Object],[object Object],[object Object]
Hypoxia-Inducible Factor (HIF) – Why Antioxidants May Help to Prevent Cancer NORMAL CONDITIONS OXYGEN Hypoxia  OXYGEN Nat Rev Cancer. 2003 Oct;3(10):721-32
HIF Helps Cells Survive, But Free Radicals Must Be Present OXYGEN Hypoxia HIF FREE RADICALS "HIF-1 helps an oxygen- starved cell convert sugar to energy without using oxygen and also initiates the construction of new blood vessels to bring in a fresh oxygen supply."
Cancer Cells Consume All The Oxygen Around Them OXYGEN Hypoxia OXYGEN
But HIF Can’t Help the Cancer Cells Survive When Antioxidants Have Neutralized All The Free Radicals .  OXYGEN Hypoxia HIF FREE RADICALS Antioxidants
And the Cancer Cells Die….  OXYGEN Hypoxia Antioxidants
Resveratrol Blueberries Grape Extract Heart, Antioxidants Eyes Longevity, Obesity?, Diabetes? Apoptosis, Inflammation Skin Cells
Conclusions about Berry Extracts and Cell Health ,[object Object],[object Object],[object Object]

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Resveratrol - Improve Cellular & Heart Health

  • 1. Mark Lange, Ph. D. Market America Director of Quality Control The Science of Resveratrol
  • 2.
  • 3.
  • 4.
  • 5. Resveratrol is naturally produced by plants as a defense system against infection and oxidative stress due to external attacks. UV Fungi Copper Ozone time Resveratrol level
  • 6.
  • 7.
  • 8.
  • 9.
  • 10.
  • 11.
  • 12.
  • 13.
  • 14.
  • 15. Increased frequency of apoptosis in two tumor cell lines induced by polyphenolic extracts (Japanese knotweed) Cells death rate (%) Cells death rate (%)
  • 16.
  • 17.
  • 18.
  • 19.
  • 20.
  • 21.
  • 22.
  • 23. A study of mechanisms involved in vasodilation by Resveratrol Li etal. A Study of Mechanisms Involved in Vasodilation Induced by Resveratrol in Isolated Porcine Coronary Artery. Physiol. Res . 55:365-72, 200 6. 1 5 50 100 0 20 40 60 80 100 Control E-NOS Inhibitor (L-NNA) Endothelium Removed Endothelium Intact Arterial Relaxation (%) 1 55 10 10 50 100 Red Wine Extract Concentration (μM)
  • 24.
  • 25. Resveravine protects LDL from oxidation better than synthetic resveratrol, catechin and vitamin E
  • 26.
  • 27.
  • 28.
  • 29.
  • 30.
  • 31.
  • 32.
  • 33. Protection against oxidative stress Influence of three related polyphenols on the oxidative stress of lymphocytes infected by the Epstein-Barr virus (EBV) Peroxidation rate (%)
  • 34.
  • 35.
  • 36.
  • 37.
  • 38.
  • 39.
  • 40. BioVin ® Advanced vs. Wine Amount of Resveratrol in 200mg BioVin ® Advanced Amount required to be equivalent to 200 mg BioVin® Advanced Red Wine White Wine 10 mg 10 glasses (1500 ml) 40 glasses (6000 ml)
  • 41.
  • 42.
  • 43.
  • 44.
  • 45.
  • 46. Hypoxia-Inducible Factor (HIF) – Why Antioxidants May Help to Prevent Cancer NORMAL CONDITIONS OXYGEN Hypoxia OXYGEN Nat Rev Cancer. 2003 Oct;3(10):721-32
  • 47. HIF Helps Cells Survive, But Free Radicals Must Be Present OXYGEN Hypoxia HIF FREE RADICALS "HIF-1 helps an oxygen- starved cell convert sugar to energy without using oxygen and also initiates the construction of new blood vessels to bring in a fresh oxygen supply."
  • 48. Cancer Cells Consume All The Oxygen Around Them OXYGEN Hypoxia OXYGEN
  • 49. But HIF Can’t Help the Cancer Cells Survive When Antioxidants Have Neutralized All The Free Radicals . OXYGEN Hypoxia HIF FREE RADICALS Antioxidants
  • 50. And the Cancer Cells Die…. OXYGEN Hypoxia Antioxidants
  • 51. Resveratrol Blueberries Grape Extract Heart, Antioxidants Eyes Longevity, Obesity?, Diabetes? Apoptosis, Inflammation Skin Cells
  • 52.

Editor's Notes

  1. The growth of cancer cells is unchecked.
  2. Cancer is caused by genetic mutations. Sometimes the mutations are inherited and there is a predisposition to cancer. But most of the time, the mutations slowly accumulate over time. Cancer is caused by multiple genetic mutations. Resveratrol tells cells with genetic mutations to shut down and die, thus preventing cancer from developing.
  3. Resveratrol supresses tumor development and its progression. In other words, it stops cancer in its tracks.
  4. Rheumatoid arthritis and bronchial asthma.
  5. Platelets are particles circulating in the blood that are necessary for blood clots to form. Blood clotting is important because it stops us from bleeding when we get cut. However, if a blood clot forms inside an artery, it blocks the flow of blood to the tissue that the artery supplies, and that can damage the tissue. For example, a blood clot in a coronary artery causes a heart attack and a blood clot that forms in an artery supplying blood to the brain causes a stroke.
  6. The endothelium is a single layer of cells which line the internal wall of blood vessels. It enables blood to flow smoothly inside the blood vessels. The endothelium has many different biological actions, but the one we’re focusing on is controlling blood pressure. Nitroglycerine patches or taking pills?
  7. Resveratrol’s antioxidant capability has been demonstrated in numerous studies. READ SLIDE .
  8. Let’s move on to another berrry extract—this one called BioVin® Advanced. READ SLIDE . It’s still being isolated from French red grapes like Resveravine®, but in this extract contains oligomeric proanthocyanidins (OPCs), anthocyanins, other phenolic acids and 5% naturally occurring resveratrol. Here we are looking at the possibility of more beneficial interactions among these compounds.
  9. We move on to another potent berry extract, called Vita Blue™ Blueberry Extract , which concentrates anthocyanins, other polyphenolic acids, and another interesting compound pterostilbene —a close chemical cousin of resveratrol.
  10. READ SLIDE