1. BIOENGINEERS DISCOVER SINGLE
CANCER CELL CAN PRODUCE UP TO FIVE
DAUGHTER CELLS AND SCIENTISTS
PLACE 500-MILLION-YEAR-OLD
GENE IN MODERN ORGANISM
Valentina Cartagena Sierra.
Medicine Student -III Semester.
Universidad Pontificia Bolivariana
Molecular Biology- july 16 20120

2. MEDICAL UTILITY BIBLIOGRAPHY MOLECULAR BIOLOGY
know the importance of cell BIOENGINEERS DISCOVER SINGLE
division by which an
CANCER CELL CAN PRODUCE UP
organism grows and the need
to mutations that gives a
TO FIVE DAUGHTER CELLS
form of adaptation in the AND
environment, is of great SCIENTISTS PLACE 500-MILLION-
importance to medical YEAR-OLD GENE IN MODERN
knowledge. because through ORGANISM
this can be study the
evolution of countless
diseases which would lead to
MARTINEZ S, Lina Maria.
a more successful treatment
Biología Molecular. 5 ed
manufacturing, also with
Medellin: UPB Fac.
these investigations maybe
Medicina
will be seen how will be
diseases that are coming and
Scientists place 500-
so act and be prepared for
million-year-old gene in
these.
modern organism, Georgia
Institute of Technology ,
(11 jul 2012)
bioengineers discover Valentina Cartagena Sierra
single cancer cell can Student- III semester
produce up to five Universidad Pontificia Bolivariana
daughter cells, .plos one Molecular Biology
journal , (05 jul 20120) 16/07/12

3. July 5th 2012 / plos one journal july 11th 2012./ Georgia Institute
INTRODUCTION Bioengineers discover of Technology
single cancer cell can Scientists place 500-
produce up to five million-year-old gene in
until now it was known that
daughter cells modern organism
the cells reproduce by About cell division, people known
duplicating their contents To observe the evolution and the
that a cell gives rise to two
and then they divided into need of mutations, a group of
completely identical cells leading to
two completely equal cells, researchers managed to obtain a
the development, but research has
but some researches genetic sequence of a gene they
shown that cancer cells can
called ancient EF-Tu15, then it was
allowed us to know that produce to five daughters cell
inserted into a bacterium (E. coli)
cancer cells reproduce in division and it is much faster, which
and the ancient gene suffered
another way, and this can can lead to chromosomal
enough mutations for your
explain the fast growth of differences known as aneuploidy
evolution even though it was a little
tumors in the body which can disrupt biological
slow this process
processes.
Observation: In my opinion I think Observation: I think that was
that changes of the division of demonstrated once again the
Other research demonstrated need for us to mutate, to
how the mutations are very cancer cells show us how a
mutation can change the entire change, how Charles Darwim
important for the adaptation. said only survives who else fits.
component of the body in so little
when a group of investigation what helps us adapt to our
time and is more a warning about
achieved that some genes how fast the body can change, conditions of life beginning with
can continue with evolution and for that reason we have to our genes, and we need to
by bacteria work on how we will face these apply to our daily living as we
changes. are complex organisms

4. INTRODUCTION
Mutation of Division of
until now it was known that proteins cancer cells
the cells reproduce by
duplicating their contents
and then they divided into
two completely equal, but
some research allowed to
know as cancer cells
reproduce in another way,
Help to another Help to look the
and this can explain the fast
growth of tumors in the body to their evolution of
evolution disease
Other research demonstrated treatments more effective and
how the mutations are very timely
important for the adaptation.
when a group of investigation
achieved that some genes
can continue with evolution
by bacteria

5. July 5, 2012.
Bioengineers discover single Bioengineers discover single cancer cell
cancer cell can produce up can produce up to five daughter cells
to five daughter cells
About cell division, people known that a
cell gives rise to two completely identical
leading to the development, but research
has shown that cancer cells can produce
to five daughters cell division and it is
much faster, which can lead to
chromosomal differences known as
aneuploidy which can disrupt biological
processes, this was done in an in vivo
simulation in 3D space-constrained
growth of a tumor.
Observation: In my opinion I think that
changes of the division of cancer cells
a somatic cell of the body undergoes a division
show us how a mutation can change the called mitosis and it results in two haploid
entire component of the body in so little daughter cells, this process has four steps are:
time and is more a warning about how prophase, metaphase, anaphase and telophase
fast the body can change, and for that
reason we have to work on how we will and result is the development of the organism
face these changes.

6. Bioengineers discover single cancer cell
can produce up to five daughter cells
the cancer cells are not divide as normal cells of the body,
these cells can produce up to 5 daughters, the different
process of this division causes the daughters have more or
fewer chromosomes than a normal one leading to
aneuploidy

7. Bioengineers discover single cancer cell
Genetic can produce up to five daughter cells
information
Diferent cell
division
Habits of life
Diferent mutations
Can produce
By investigating the contributing factors that
lead to mismanagement during the process of
chromosome segregation, scientists may
CANCER CELLS better understand the progression of cancer
even though cancer can arise from a set of
precise mutations

8. Bioengineers discover single cancer cell
Bioengineers at UCLA from can produce up to five daughter cells
a 3D platform, they can
observe how the cell
division is, through certain Dino Di Carlo, an associate professor of
constraints under which bioengineering at UCLA and principal
the research was done in investigator on the research, said: "We hope
vivo. that this platform will allow us to better
understand how the 3-D mechanical
environment may play a role in the progression
of a benign tumor into a malignant tumor that
kills”
benign tumor malignant tumor

9. OBSERVATION
I think that they can have
3D platform, that would
be a very important
avance because it allows
you to see the growth and
reproduction of diferent
type of cancer cells, and
thus see not only
malignant tumors also as
benign tumors occur and
how they can evolve

10. july 11 th 2012.
Scientists place 500-million- Scientists place 500-million-year-old
year-old gene in modern
gene in modern organism
organism
To observe the evolution and the need
of mutations, a group of researchers A mutation is an alteration in the DNA
managed to obtain a genetic sequence sequence. It can involve from a small event as
of a gene they called ancient EF-Tu, the alteration of a single nucleotide base pair
then it was inserted into a bacterium
(E. coli) and the ancient gene up the gain or loss of whole chromosomes, but
suffered enough mutations for your of we depend of these for our adaptation
evolution even though it was a little
slow this process
Observation: I think that was
demonstrated once again the need
for us to mutate, to change, how
Charles Darwim said only survives
who else fits. what helps us adapt to
our conditions of life beginning with
our genes, and we need to apply to
our daily living as we are complex
organisms

11. Scientists place 500-million-year-old
gene in modern organism
EF-Tu is found in all life, is one of the most
abundant protein and is essential for the
bacterium E. coli
Genetic sequence Current genome of
of 500 million year Were inserted into E. coli
ago
Evolution was They produce 8
observed lineages

12. Scientists place 500-million-year-old
gene in modern organism
after the first 500 generations, it was
observed that some lineages of
EF-Tu had reached a higher being to
modern.
the protein of the EF-Tu is not
mutual, but if they did the
proteins of bacteria

13. Scientists place 500-million-year-old
gene in modern organism
"We think that this process will allow us
to address several longstanding
questions in evolutionary and molecular
biology," said Kaçar. "Among them, we
want to know if an organism's history
limits its future and if evolution always
leads to a single, defined point or
whether evolution has multiple
solutions to a given problem.“Georgia
Institute of Technology (july 11. 2012)

14. OBSERVATION
OBSERVATION
• In the middle of Adaptive
microorganisms that last
more time and reproduce
more easily are those that
are better adapted to the
environment, or as in this
case that make the
environment adapts to
them

15. MEDICAL UTILITY MEDICAL UTILITY
know the importance of cell
division by which an
organism grows and the need
to mutations that gives a the importance of knowing how a cell is
form of adaptation in the
environment, is of great
divided of any kind and how it is mutating as it
importance to medical goes along its evolution, is that it guide how
knowledge. because through will be a big number of diseases and how to
this can be study the prepare for them
evolution of countless
diseases which would lead to
a more successful treatment
manufacturing, also with
these investigations maybe
will be seen how will be
diseases that are coming and
so act and be prepared for
these.

16. MEDICAL UTILITY
how advanced the how is the chromosome
disease division
few cells are born
daughters
according to this
what is the right in what time should be
treatment applied
better information and
future for patients

17. MEDICAL UTILITY
Is a breakthrough for medicine
see how proteins were mutated
for improvement of a protein
so old, because this can show
which mutations are necessary
to survive to some diseases
when they see the genetic
sequences

18. MEDICAL UTILITY
This researches allow to be known more
about diseases which there is not much
knowledge about, and be treated in
different ways, to reach a hundred percent
of reliability in the process by doing the
mutations that may be

19. BIBLIOGRAPHY
• MARTINEZ S, Lina Maria. Biología Molecular.
5 ed Medellin: UPB Fac. Medicina
• Scientists place 500-million-year-old gene in
modern organism, … , (11 jul 2012)
• bioengineers discover single cancer cell can
produce up to five daughter cells, .. , (05 jul
20120)