This chapter discusses the history and impact of the Persian Empire from 2000 BCE to 637 CE. It covers the rise of the Persian Empire under Cyrus the Great and its expansion under Darius. The chapter also examines Persian governance, society, and the influence of Zoroastrianism. It describes Persia's confrontations with Greece, including Xerxes' invasion, and the eventual conquest of the Persian Empire by Alexander the Great and the Macedonians. The chapter concludes with the Parthian and Sasanian Empires that succeeded Persian rule up until the 7th century CE.