This document provides an overview and framework for understanding how global drivers influence river basins and water, food, and development systems. It discusses 10 basin focal projects that examined these interlinked systems. While individual ecosystem services are understood to some degree, the complex interactions between societies and ecosystem services as development occurs represents both opportunities and risks. The framework aims to organize information on global drivers, identify how basins may respond to drivers through scenarios and learning, and relate responses to system resilience. The workshop aims to expand on concepts and scenarios to understand how global drivers can inform the Challenge Program on Water and Food.