This document discusses key concepts in cancer epidemiology including definitions, incidence, mortality, survival rates, and prevalence. It provides statistics on cancer occurrences and outcomes in the UK. Some key points made are that cancer incidence is increasing, about 320,000 new cases are diagnosed in the UK annually, and survival rates have been improving over time for most cancers though the UK still lags behind some of Europe. Cancer epidemiology helps inform how cancer services, research, and education are organized across large populations.
The presentation briefly describe details regarding different types of cancers prevalance in Pakistan and the opportunity this country offer in Cancer Research Projects by the availability of mostly chemo naive cancer patients
Cancer Epidemiology, Risk factors for most common types, mortality, prevention and yeild of cancer prevention. gender, geography, infections, tobacco, environmental riskk factors.
The presentation briefly describe details regarding different types of cancers prevalance in Pakistan and the opportunity this country offer in Cancer Research Projects by the availability of mostly chemo naive cancer patients
Cancer Epidemiology, Risk factors for most common types, mortality, prevention and yeild of cancer prevention. gender, geography, infections, tobacco, environmental riskk factors.
Different types of diseases and infections have always threatened man.However, one disease that is considered almost deadly and has a very high rate of recurrence is cancer.
Understanding how intermittent fasting may not only help weight loss but have multiple other health benefits including life prolongation, preventing cancer and dementia
Different types of diseases and infections have always threatened man.However, one disease that is considered almost deadly and has a very high rate of recurrence is cancer.Know more by visiting https://www.plus100years.com
Cancer is a disease caused when cells divide uncontrollably and spread into surrounding tissues. Cancer is caused by changes to DNA. Most cancer-causing DNA changes occur in sections of DNA called genes. These changes are also called genetic changes.
The presentation begins with a brief history of how cancer epidemiology evolved, and what is the status at present. After describing the burden of the disease of cancer globally and in India, the presentation includes a brief description of Cancer causes and prevention including screening activities. It also talks about the national Cancer Registry Program, NPCDCS and NCCP.
Cancer sites associated with tobacco form 35 to 50% of all
cancers in men and about 17% of cancers in women. These cancers
are amenable to primary prevention and can be controlled to a large
extent.
Different types of diseases and infections have always threatened man.However, one disease that is considered almost deadly and has a very high rate of recurrence is cancer.
Understanding how intermittent fasting may not only help weight loss but have multiple other health benefits including life prolongation, preventing cancer and dementia
Different types of diseases and infections have always threatened man.However, one disease that is considered almost deadly and has a very high rate of recurrence is cancer.Know more by visiting https://www.plus100years.com
Cancer is a disease caused when cells divide uncontrollably and spread into surrounding tissues. Cancer is caused by changes to DNA. Most cancer-causing DNA changes occur in sections of DNA called genes. These changes are also called genetic changes.
The presentation begins with a brief history of how cancer epidemiology evolved, and what is the status at present. After describing the burden of the disease of cancer globally and in India, the presentation includes a brief description of Cancer causes and prevention including screening activities. It also talks about the national Cancer Registry Program, NPCDCS and NCCP.
Cancer sites associated with tobacco form 35 to 50% of all
cancers in men and about 17% of cancers in women. These cancers
are amenable to primary prevention and can be controlled to a large
extent.
All change: responses to the public libraries crisis in England 2010 to 2013Public Libraries News
Includes reductions in usage, closure of libraries, protests, campaigns, co-location, outsourcing and the Government response. Produced for the Assocation de Bibliothecaires Francais conference in Lyons, June 2013.
This beginner's guide is packed with tools and techniques to show you who is on your website and what their needs are. Fully armed, you'll be able to design and write a website that addresses them head on.
But every organisation needs to make sure that it follows good health, safety and environmental practices.
Auditing is a structured comprehensive process used for verifying the efficiency, effectiveness and reliability of an organisation's occupational health, safety and environmental management system.
Green World Group in association BSCIC trains OHSAS 18001 Auditor courses. For further details Please visit http://greenwgroup.ae/
A series of Be Clear on Cancer awareness events were held prior to the campaign launch in Autumn 2013. These slides are from the London event on 10 September 2012
The events included:
An update on the 'Blood in Pee' campaign Oct-Nov 2013
Sharing experiences from BCOC pilots
A review of the impact of the BCOC campaigns
Latest plans for BCOC February 20145 campaigns
An opportunity for delegates to feedback on experience of campaigns and make suggestions for improvement
Events were aimed at SCNs - Programme leads, Clinicians, Public Health, National NAEDI Partners - DH, Public Health England, NHS England and Charities
A strategy for cancer in england over the next five years, pop up uni, 11am, ...NHS England
Expo is the most significant annual health and social care event in the calendar, uniting more NHS and care leaders, commissioners, clinicians, voluntary sector partners, innovators and media than any other health and care event.
Expo 15 returned to Manchester and was hosted once again by NHS England. Around 5000 people a day from health and care, the voluntary sector, local government, and industry joined together at Manchester Central Convention Centre for two packed days of speakers, workshops, exhibitions and professional development.
This year, Expo was more relevant and engaging than ever before, happening within the first 100 days of the new Government, and almost 12 months after the publication of the NHS Five Year Forward View. It was also a great opportunity to check on and learn from the progress of Greater Manchester as the area prepares to take over a £6 billion devolved health and social care budget, pledging to integrate hospital, community, primary and social care and vastly improve health and well-being.
More information is available online: www.expo.nhs.uk
a presentation that helps to educate us about the rising incidence of cancer in our environment. it also tells us about the silent nature of some cancers, which at the point of diagnosis is in the late stages
Honoring Cancer Survivors in Northwest Ohio- Know How To Keep Yourself Safe f...AvaWilson88
Each year in the US, about 71,000 men and 64,000 women are diagnosed with colorectal cancer. Explore here some hidden facts about cancer and it's survivor. Know here about the success stories of cancer survivors and their caregivers: https://bit.ly/2VTC4QP
A series of Be Clear on Cancer awareness events were held prior to the campaign launch in Autumn 2013. These slides are from the Leeds event on 4 September 2012
The events included
An update on the 'Blood in Pee' campaign Oct-Nov 2013
Sharing experiences from BCOC pilots
A review of the impact of the BCOC campaigns
Latest plans for BCOC February 20145 campaigns
An opportunity for delegates to feedback on experience of campaigns and make suggestions for improvement
Events were aimed at SCNs - Programme leads, Clinicians, Public Health, National NAEDI Partners - DH, Public Health England, NHS England and Charities
Improving the Physical health care of people with mental ill health: Cardiovascular health of people with serious mental illness National Learning Network Event 29th April 2015.
Main Slide: NHS IQ CVD SMI LNE 29 April 2015 slides - 1-152
BREAKOUT 1_PATIENT VOICE slides 153-161
BREAKOUT 2a_IMPROVING CARDIOVASCULAR CARE FOR PEOPLE WITH SMI - slides 162-188
BREAKOUT 2b_UCLP PROGRAMME ON CVDSMI - slides 188-195
BREAKOUT 3_PHYSICAL ACTIVITY IN MENTAL HEALTH - slides 196-212
BREAKOUT 4_REASONS FOR TEWVS SUCCESS - slides 213-225
BREAKOUT 5_ PHYSICAL HEALTH AND WELLBEING - slides 226-243
BREAKOUT 6_SHAPE - slides 244-271
BREAKOUT 7_SCREENING FOR CARDIOMETABOLIC RISK FACTORS - slides 272 -296
Death and dying - understanding the dataMarie Curie
Phil McCarvill, Marie Curie's Head of Policy and Public Affairs, presented at 'Improving outcomes at the end of life' on 9 July, 2013 in London.
He presented on the data from Marie Curie's report 'Death and Dying' which looks at variations on the provision, spending and identification of end of life services across the country.
It draws together and analyses data from the Marie Curie End of Life Care Atlas and other sources including the Nuffield Trust study and the VOICES survey of bereaved relatives.
For more information on commissioning, have a look at our website mariecurie.org.uk/commissioning or get in touch at servicedevelopment@mariecurie.org.uk
Cancer Awareness - Kaplan University Dept. of Public Healthsmtibor
Cancer awareness, including general definitions, detection, prevention, treatment, and risk factors. Emphasis on skin and prostate cancers and at-risk populations.
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June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
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Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
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Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
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New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...
Introduction to cancer epidemiology basics mr es021012
1. The Christie NHS Foundation Trust
Introduction to Cancer
Epidemiology Basics
Dr Chris Harrison
Medical Director, The Christie
Clinical Director (Cancer), NHS London
3. The Christie NHS Foundation Trust
Definition of Epidemiology
• “The study of the occurrence and distributions of
health related states or events in specified
populations, including the study of the
determinants influencing such states, and the
application of this knowledge to control health
problems”
• A Dictionary of Epidemiology
4. The Christie NHS Foundation Trust
Alternatively
• “Epidemiology is the study of the health of
human communities”
Prof Alwyn Smith
Descriptive v Analytic Epidemiology
Uses of Epidemiology
5. The Christie NHS Foundation Trust
Key Terms
• Incidence
• Mortality
• Survival
• Prevalence
6. The Christie NHS Foundation Trust
Key Terms
• Incidence – rate of new cases in a defined
period
• Mortality – rate of death in the total population in
a defined period
• Prevalence – proportion of total population who
have had a cancer diagnosis and are still alive
• Survival – proportion of cases surviving a
defined period of time
11. The Christie NHS Foundation Trust
Incidence Key Messages
• Cancer Incidence is increasing
• About 320,000 cases per year in the UK
• In both men and women 4 cancers make up
about 70% of cases
• Cancer gets more common with increasing age
13. The Christie NHS Foundation Trust
Mortality
England Scotland Wales Northern Ireland UK
Male
Deaths 68,207 7,807 4,388 2,079 82,481
Crude Rate 264.8 308.5 298.3 235.1 269.2
AS Rate 198.4 232 200.8 209.3 201.6
AS Rate - 95% LCL* 196.9 226.9 194.9 200.3 200.3
AS Rate - 95% UCL* 199.9 237.2 206.8 218.2 203
Female
Deaths 61,316 7,516 4,088 1,874 74,794
Crude Rate 231.6 279.2 266.2 204.8 236.5
AS Rate 143.9 170.7 152.2 146.7 146.8
AS Rate - 95% LCL* 142.8 166.9 147.6 140 145.8
AS Rate - 95% UCL* 145.1 174.6 156.9 153.3 147.9
Persons
Deaths 129,523 15,323 8,476 3,953 157,275
Crude Rate 248 293.4 281.9 219.7 252.6
AS Rate 167.1 195.9 172.7 172.5 170
AS Rate - 95% LCL* 166.2 192.8 169 167.1 169.2
AS Rate - 95% UCL* 168 199 176.4 177.8 170.9
14. The Christie NHS Foundation Trust
Key Messages - Mortality
• Population Mortality has been falling
• Cancer is 28% of all deaths in UK
15. The Christie NHS Foundation Trust
Survival – Cancer Types
2%
6%
8%
13%
15%
22%
34%
36%
43%
45%
48%
52%
61%
68%
76%
79%
83%
90%
3%
6%
7%
12%
13%
24%
38%
45%
45%
46%
51%
61%
67%
71%
78%
84%
95%
Pancreas
Lung
Oesophagus
Stomach
Brain
Multiple myeloma
Ovary
Leukaemia
Kidney
Colon
Rectum
NHL
Bladder
Cervix
Uterus
Breast
Hodgkin's lymphoma
Melanoma
Pancreas
Lung
Oesophagus
Stomach
Brain
Multiple myeloma
Leukaemia
Kidney
Rectum
Colon
NHL
Prostate
Larynx
Bladder
Melanoma
Hodgkin's lymphoma
Testis
WomenMen
Five-year relative survival
10-50% survival:
29% of cases diagnosed
More than 50% survival:
38% of cases diagnosed
less than 10% survival:
24% of cases diagnosed
More than 50% survival:
50% of cases diagnosed
10-50% survival:
27% of cases diagnosed
less than 10% survival:
15% of cases diagnosed
16. The Christie NHS Foundation Trust
5 Year Survival – All Cancers
• People – 50%
• Men – 43%
• Women – 56%
• National (CRUK) and Manchester Target is 66%
17. The Christie NHS Foundation Trust
Survival - Trends
-4 -2 0 2 4 6 8 10 12
Pancreas
Larynx
Brain
Bladder
Cervix
Lung
Oesophagus
Stomach
Multiple myeloma
Uterus
Testis
NHL
Leukeamia
Ovary
Colon
Melanoma
Kidney
Breast
Rectum
Prostate
Average % change every five years
Men
Women
18. The Christie NHS Foundation Trust
Survival – Key Messages
• Survival for most cancers has been increasing
• Beware artefacts of change in diagnosis
• Survival does vary across the UK but not as
much as mortality
• UK survival compares poorly with Europe
19. The Christie NHS Foundation Trust
Prevalence - UK
1 year prevalence 5 year prevalence 10 year prevalence
Males 98,726 339,971 507,840
Females 101,796 382,030 622,875
Persons 200,522 722,001 1,130,715
20. The Christie NHS Foundation Trust
Prevalence – Key Messages
• Prevalence increasing due to higher incidence
and better survival
• Much higher prevalence then previous estimates
and expected to grow
21. The Christie NHS Foundation Trust
North and East
CMO: Kathy Pritchard-Jones
Director: Charlotte Williams
South and West
Interim CMO:
Arnie Purushotham
Project manager: Claire Dowling
21
Two integrated cancer systems
22. The Christie NHS Foundation Trust
Largest and most complex network
• 3.2 million population
• 11 primary care trusts
• 11 acute trusts
• 15 hospitals
• Secondary care referrals
• 1 tertiary cancer centre
24. The Christie NHS Foundation Trust
The Organisation of European Cancer
Centres
Mission
• To bring together cancer
research, care and educational
institutes within Europe to
create a critical mass of
expertise and competence
• Founded in 1977 now has 81
cancer centre members from
across Europe
25. The Christie NHS Foundation Trust
WP 12
EurocanPlatform
MEMBERS
Données cartographique
MEMBERS
Données cartographique
26. The Christie NHS Foundation Trust
Key Points
• Cancer Services need to be organised across
large populations
• No single organisation has the critical mass
required
• The epidemiology of cancer is a key factor in
driving how services, research and education
are organised
