This document provides an introduction and overview of tablets, including their definition, general properties, advantages, disadvantages, and classification. It discusses the main types of tablets based on use, structure, and action. The document also covers tablet design and formulation, describing the various excipients used (diluents, binders, disintegrants, lubricants) and their functions. It provides examples of different tablet types and dosage forms, such as chewable, dispersible, effervescent, and sublingual tablets.
Capsules are tasteless, odorless and can easily be
administered.
Combination of powders we can use
There are attractive in appearance.
The drugs having un-pleasant odor and taste are
enclosed in a tasteless shell.
They can be filled quickly and conveniently.
Physician can change the dose and combination of drug
according to patient requirement.
They are economical.
They are easy to handle and carry.
A detailed study on tablets, its classification, excipients, tablet granulation, methods of granulation, compression machines, equipment tooling and the problems that occur during the tablet manufacturing process. This presentation is based on the PCI syllabus for bpharm students of fifth semester.
Direct compression is the most advanced technology. It involves only blending and compression. Thus offering advantage particularly in terms of speedy production. Because it requires fewer unit operations, less machinery, reduced number of personnel and considerably less processing time along with increased product stability.
Capsules are tasteless, odorless and can easily be
administered.
Combination of powders we can use
There are attractive in appearance.
The drugs having un-pleasant odor and taste are
enclosed in a tasteless shell.
They can be filled quickly and conveniently.
Physician can change the dose and combination of drug
according to patient requirement.
They are economical.
They are easy to handle and carry.
A detailed study on tablets, its classification, excipients, tablet granulation, methods of granulation, compression machines, equipment tooling and the problems that occur during the tablet manufacturing process. This presentation is based on the PCI syllabus for bpharm students of fifth semester.
Direct compression is the most advanced technology. It involves only blending and compression. Thus offering advantage particularly in terms of speedy production. Because it requires fewer unit operations, less machinery, reduced number of personnel and considerably less processing time along with increased product stability.
A detailed study on Tablets which describes about tablets, coating of tablets and then a study on the quality control of tablets. The chapter deals with the minute aspects of tablets and gives us an enlightenment of the solid dosage form which is commonly used all around the world
Tablets: a.Introduction, ideal characteristics of tablets, Classification of tablets. Excipients, Formulation of tablets, granulation methods, compression and processing problems.
Introduction about tablet, classification or type of tablets, process of granulation in that moist granulation, dry granulation, slugging method, detail information about additives used for preparation of tablets, single punch tablet punching machine, multiple tablet punching machine, rotary tablet punching machine, dry cota tablet punching machine, evaluation tests for tablets, coating techniques for tablets
Dosage forms come in many types, depending on the method or route of administration. Solid dosage forms, semi-solid dosage forms, liquid dosage forms, and gaseous dosage forms are used for the diagnosis or treatment of the disease by various routes. Solid dosage forms are the most significant dosage forms in pharmaceuticals; it has one or more unit dose of medicament. The solid dosage form is the most commonly used and prescribed by doctors as compared to other dosage forms. It can be administered orally in the form of tablets, capsules, powders, etc. Of these, the tablet is one of the most commonly used oral solid dosage forms.
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What are greenhouse gasses how they affect the earth and its environment what is the future of the environment and earth how the weather and the climate effects.
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
Richard's entangled aventures in wonderlandRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
Earliest Galaxies in the JADES Origins Field: Luminosity Function and Cosmic ...Sérgio Sacani
We characterize the earliest galaxy population in the JADES Origins Field (JOF), the deepest
imaging field observed with JWST. We make use of the ancillary Hubble optical images (5 filters
spanning 0.4−0.9µm) and novel JWST images with 14 filters spanning 0.8−5µm, including 7 mediumband filters, and reaching total exposure times of up to 46 hours per filter. We combine all our data
at > 2.3µm to construct an ultradeep image, reaching as deep as ≈ 31.4 AB mag in the stack and
30.3-31.0 AB mag (5σ, r = 0.1” circular aperture) in individual filters. We measure photometric
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z = 11.5 − 15. These objects show compact half-light radii of R1/2 ∼ 50 − 200pc, stellar masses of
M⋆ ∼ 107−108M⊙, and star-formation rates of SFR ∼ 0.1−1 M⊙ yr−1
. Our search finds no candidates
at 15 < z < 20, placing upper limits at these redshifts. We develop a forward modeling approach to
infer the properties of the evolving luminosity function without binning in redshift or luminosity that
marginalizes over the photometric redshift uncertainty of our candidate galaxies and incorporates the
impact of non-detections. We find a z = 12 luminosity function in good agreement with prior results,
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models for evolution of the dark matter halo mass function.
This pdf is about the Schizophrenia.
For more details visit on YouTube; @SELF-EXPLANATORY;
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Slide 1: Title Slide
Extrachromosomal Inheritance
Slide 2: Introduction to Extrachromosomal Inheritance
Definition: Extrachromosomal inheritance refers to the transmission of genetic material that is not found within the nucleus.
Key Components: Involves genes located in mitochondria, chloroplasts, and plasmids.
Slide 3: Mitochondrial Inheritance
Mitochondria: Organelles responsible for energy production.
Mitochondrial DNA (mtDNA): Circular DNA molecule found in mitochondria.
Inheritance Pattern: Maternally inherited, meaning it is passed from mothers to all their offspring.
Diseases: Examples include Leber’s hereditary optic neuropathy (LHON) and mitochondrial myopathy.
Slide 4: Chloroplast Inheritance
Chloroplasts: Organelles responsible for photosynthesis in plants.
Chloroplast DNA (cpDNA): Circular DNA molecule found in chloroplasts.
Inheritance Pattern: Often maternally inherited in most plants, but can vary in some species.
Examples: Variegation in plants, where leaf color patterns are determined by chloroplast DNA.
Slide 5: Plasmid Inheritance
Plasmids: Small, circular DNA molecules found in bacteria and some eukaryotes.
Features: Can carry antibiotic resistance genes and can be transferred between cells through processes like conjugation.
Significance: Important in biotechnology for gene cloning and genetic engineering.
Slide 6: Mechanisms of Extrachromosomal Inheritance
Non-Mendelian Patterns: Do not follow Mendel’s laws of inheritance.
Cytoplasmic Segregation: During cell division, organelles like mitochondria and chloroplasts are randomly distributed to daughter cells.
Heteroplasmy: Presence of more than one type of organellar genome within a cell, leading to variation in expression.
Slide 7: Examples of Extrachromosomal Inheritance
Four O’clock Plant (Mirabilis jalapa): Shows variegated leaves due to different cpDNA in leaf cells.
Petite Mutants in Yeast: Result from mutations in mitochondrial DNA affecting respiration.
Slide 8: Importance of Extrachromosomal Inheritance
Evolution: Provides insight into the evolution of eukaryotic cells.
Medicine: Understanding mitochondrial inheritance helps in diagnosing and treating mitochondrial diseases.
Agriculture: Chloroplast inheritance can be used in plant breeding and genetic modification.
Slide 9: Recent Research and Advances
Gene Editing: Techniques like CRISPR-Cas9 are being used to edit mitochondrial and chloroplast DNA.
Therapies: Development of mitochondrial replacement therapy (MRT) for preventing mitochondrial diseases.
Slide 10: Conclusion
Summary: Extrachromosomal inheritance involves the transmission of genetic material outside the nucleus and plays a crucial role in genetics, medicine, and biotechnology.
Future Directions: Continued research and technological advancements hold promise for new treatments and applications.
Slide 11: Questions and Discussion
Invite Audience: Open the floor for any questions or further discussion on the topic.
A brief information about the SCOP protein database used in bioinformatics.
The Structural Classification of Proteins (SCOP) database is a comprehensive and authoritative resource for the structural and evolutionary relationships of proteins. It provides a detailed and curated classification of protein structures, grouping them into families, superfamilies, and folds based on their structural and sequence similarities.
Professional air quality monitoring systems provide immediate, on-site data for analysis, compliance, and decision-making.
Monitor common gases, weather parameters, particulates.
2. CONTENTS
Definition
General properties.
Advantages
Disadvantages
Classification of tablets
Tablet Design and formulation
Evaluation tests for compressed and coated tablets
3. Defination
Tablet is defined as a compressed solid dosage form
containing medicaments with or without excipients.
According to Indian Pharmacopoeia pharmaceutical
tablets are solid, flat, or biconvex dishes, unit dosage
form , prepared by compressing a drugs or a mixture of
drugs, with or without excipients.
They vary in shape and differ greatly in size and
weight, depending on amount of medicinal substances
and the intended mode of administration.
It is the most popular dosage form and 70% of the total
medicines are dispensed in the form of tablet.
4. General Properties
Accurate dosage of medicament , uniform in weight,
appearance and diameter.
Have the strength to withstand the rigors of
mechanical shocks encountered in its production,
packaging, shipping and dispensing.
Release the medicinal agents in the body in a
predictable and a reproducible manner.
Elegant product, acceptable size and shape.
Chemical and physical stabilities.
5. Advantages
Production aspects
Large scale production at lowest cost.
Easiest and cheapest to package and ship.
Greatest chemical and microbial stability over all
dosage form.
User aspects (doctor, pharmacist,
patient)
Easy to handling.
Lightest and more compact.
Greatest dose precision & least content variability.
Coating can mask unpleasant tastes & improve
patient acceptability.
6. Disadvantages
Some drugs resist compression into compacts.
Drugs with poor wetting, slow dissolution,
intermediate to large dosages may be difficult or
impossible to formulate and manufacture as a
tablet that provide adequate or full drug
bioavailability.
Bitter taste drugs, drugs with an objectionable
odor, or sensitive to oxygen or moisture may
require encapsulation or entrapment prior to
compression or the tablets may require coating.
7. Classification of tablet
Use
wise
structure
wise
Action
wise
• Tablet for oral ingestion
• In oral cavity
• By other routes
• To prepare solution
• Divisible tablet
• Aperture tablet
• Concave-convex tablet
• Core tablet
• Layered tablet
• Modified release tablet
• Delayed action tablet
e.g :- enteric coated
Bisacodyl tablet
8. Oral tablet for ingestion
Standard compressed tablet e.g.; Paracetamol tablet
Multiple compressed tablet
I. Compression tablet
* Sugar coated tablet
* Film coated tablet
* Gelatin coated tablet
* Enteric coated tablet
II. Layered tablet
III. Inlay tablet
Targeted tablet
* Floating tablet
* Colon targeting tablet
Chewable tablet
Dispersible tablet
9. Tablets used in the oral
cavity
Lozenges and troches
Sublingual tablet e.g. vitamin-c tablet
Buccal tablet e.g. vitamin-c tablet
Dental cones
Mouth dissolved tablet/ rapidly dissolving tablet
Tablets administered by other
routes
Vaginal tablet e.g. clotrimazole tablet
Rectal tablet
Hypodermic tablet
Implants
11. Standard compression tablet
These are the standard uncoated tablets made by
either
• direct compression
• wet granulation
• dry granulation
They may be used for local action in GIT/ systemic
action
In addition to medicinal agents they usually contain a
number of pharmaceutical adjuvants
12. Multiple compression tablet
I. Compression coated tablet
Function like sugar-coated or film-coated tablets
or gelatin-coated, enteric coated.
Coating of a tablet may
• mask a bitter taste, odor, color of the substance
• conceal an unpleasant or mottled appearance
• provide physical and chemical protection from
gastric juice
• control the release of drug from the tablet
* film coated tablet * sugar coated tablet
13. Layered tablet
Multilayer tablets (2-3) are prepared by repeated
compression of powders and are made primarily to
separate incompatible drugs from each other.
It makes possible to produce repeat-action or
prolonged-action products.
for e.g. Admixture containing Phenylephedrine HCL
and ascorbic acid with Paracetamol.
Paracetamol + phenylephedrine HCL——› one layer
Paracetamol + ascorbic acid ——› another layer
14. Targeted tablets
Under this category we have two types of
tablets:
I. Gastro-retentive tablet
Opted when API release is desired in
stomach (antacids, API’s used against
H.pylori infection.
• Floating tablet
to retain the drug for longer time period in
stomach following approaches can be
used:
low density tablet
tablet that can expand in gastric
environment(swelling or unfolding).
Using muco-adhesive polymer.
15. II. Colonic tablets
For the drugs having poor absorption in stomach or
small intestine, colonic drugs delivery is an answer of
choice.
The pH of this region varies from 6.4 to 7 and
presence of microbial flora plays an important role in
drug release.
Various mechanism adopted for drug release in this
area are:
Coating with Ph sensitive polymer e.g. Eudragit S100
and L 100
Biodegradable polymer which are sensitive to colonic
bacteria.
Bio-adhesive polymer e.g. poly
16. Chewable tablets
Chewable tablets are to be chewed and
thus mechanically disintegrated in the
mouth, so that NO DISINTEGRANT IS
ADDED.
Flavoring, sweetening and coloring agents
are important.
Sorbitol and mannitol are common
examples of fillers in chewable tablets.
Provide quick and complete disintegration
of the tablet and thus obtain a rapid drug
effect after swallowing and dissolution.
Easy administration, especially for infants
and elderly people.
Examples: Chewable asprin tablet
Antacid tablet
17. Dispersible Tablets
Disintegrate either rapidly in water to form
stabilized suspension or disperse
instantaneously in the mouth to be
swallowed without the aid of water.
The properties such as porosity, hardness,
DT, increase in viscosity after dispersion
are necessary to investigate during
manufacturing.
ADVANTAGES
For pediatric patients who cannot swallow.
For API’s unstable if formulated in liquid
formulation.
Faster onset of action compared to
standard compressed tablet.
Example:- Analgesics( Asprin, Ibuprofen,
18. Lonzenges and trouches
Lonzenges are flavored medicated dosage
forms intended to be sucked and held in mouth
or pharynx.
Two lonzenges forms include hard (or boiled)
candy lonzenges and compressed tablet
lonzenges (Trouches)
Lonzenges may be used for:
Local medications in the mouth and throat,
e.g. local anesthetics, anti-histamines,
decongestion, analgesics, demulcents,
antiseptics & antibiotics.
Systemic drug uptake
No disintegrant is included in compressed
lonzenges composition.
Common binder used:- gelatin, common fillers
are (sorbitol, mannitol, and glucose)
19. Sublingual tablets
Reguirements of sublingual tablets are
speed of absorption and a
correspondingly rapid physiological
response.
Intended to be placed beneath the
tongue and held there until absorption
has taken place.
Absorption through oral cavity, avoids
First pass metabolism .
Example:- codeine phosphate tablets,
scopolamine HBr tablets, nitroglycerine
tablets etc…
20. Buccal tablets
Intended to be dissolved in buccal
pouch.
Tablets are designed not to
disintegrate.
It is placed near the opening of
parotid duct to provide the medium
to dissolve the tablet.
Buccal tablets are most often used
when replacement hormonal
therapy is the goal, e.g., methyl
testosterone, testosterone
propionate.
21. Dental cones
These tablets are designed to be
loosely packed in the empty socket
remaining following a tooth extraction.
Main purpose behind the use of this
tablet is either to prevent multiplication
of bacteria in the socket by employing a
slow releasing antibacterial compound
or to reduce bleeding by an astringent
or coagulant containing tablet.
It’s formulated to disslove or erode
slowly in presence of a small volume of
serum or fluid over 20-40 minutes
period.
22. Vaginal tablets
Designed for vaginal administration in treatment of
local vaginal infections, for systemic absorption and
absorption into vaginal tissue.
Can be inserted with aid of appliantor
In the treatment of localized vaginal infections such
as, Candida albicans, yeast and Haemophilus
vaginalis.
Examples;-
Cyclodextran formulations of hydrophilic drugs such
as amino-glycosides, beta-lactum antibiotics and
peptides.
23. Implants
Designed for subcutaneous implantation
by surgical procedure where they are
slowly absorbed over a period of month or
a year.
Special injector with a hollow needle and
plunger is used to administer the rod
shaped tablet.
For other shapes surgery is used.
They are sterile formulation without
excipients.
Mainly these tablets are prepared to
deliver growth hormones to food producing
24. Effervescent tablets
Effervescent tablets are dropped into a
glass of water before administration during
which carbon-dioxide is liberated. This
facilitates tablet disintegration and drug
dissolution; the tablet disintegration should
complete within few minutes.
(Effervescence is a special mech. For
disintegration) carbon-dioxide is created
by the reaction between carbonate or
bicarbonate and a weak acid such as citric
acid or tartaric acid.
ADVANTAGES
Rapid drug action e.g. analgesics and
antacids.
Facilitate drug intake, e.g. vitamins.
25. Hypodermic tablets
They are intended to be added in WFI of
sterile water to form a clear solution which
is to be injected parenetrally.
Widely used by rural physician due to its
portability.
Can be used for medicaments whose
stability in water is very poor
They use in this manner should be
discouraged. Since resulting solutions are
not sterile.
26. Tablet Triturates
They are small, usually cylindrical, molded or
compressed tablets containing small amounts of
usually potent drugs.
Only a minimal pressure is applied during their
manufacturing, since they must be readily and
completely soluble in water.
27. Tablet design and formulation
TABLET DESIGN
The objective of design & manufacture of the
compressed tablet is to deliver orally the correct
amount of drug in the proper form, at or over the
proper time & in the desired location.
Aside from the physical or chemical properties of the
medicinal agents, the actual physical design,
manufacturing process, and complete chemical
makeup of the tablet can have a profound effect on
the efficacy of the drug being administerd.
28. Formulation components
In addition to the active ingredients, tablet contains a
number of inert materials known as additives or
excipients.
Different types of excipients are :-
Diluents.
Binders & Adhesives.
Disintegrents.
Lubricants & Glidants.
Coloring agents.
Flavoring agents.
Sweetening agents.
30. Diluents
They are used to make required bulk of the tablet
when the drug dosage itself is inadequate to produce
bulk.
It provide better tablet properties such as improve
cohesion, to promote flow.
DESIRED PROPERTIES:-
Non-toxic.
Cost must be low.
Commercially available in acceptable grade.
Must be chemically & physically stable.
Do not alter the bioavailability of the drug.
Must be color compatible.
32. Binders & Adhesives
These materials are added either dry or wet-form to
granules or to form cohesive compacts for directly
compressed tablet.
Example:-
Acacia, Tragacanth – solution for 10-25% conc.
Cellulose derivatives- Methyl cellulose, Hydroxy
propyl cellulose.
Gelatin-10-20% solution.
Polyvinyl pyrrolidine (PVP)- 2% solution.
Starch paste- 10-20% solution.
Sodium Alginate.
Sorbitol.
33. Disintegrants
Added to a tablet formulation to facilitate its
breaking or disintegration when it contacts in water
in the GIT.
Example:-
Starch- 5-20% of tablet weight.
Starch derivative- Primogel & Explotab (1-8%).
Clays- Veegum HV, Bentonite 10% level in colored
tablet.
Cellulose.
Alginate.
34. Lubricants & Glidants
Lubricants are intended to prevent adhesion of the
tablet materials to the surface of dies and punches,
reduce inter particle friction & may improve the rate
of flow of the tablet granulation.
Glidants are intended to promote flow of granules or
powder material by reducing the friction between the
particles.
Examples:-
Lubricants:- stearic acid, mag. Stearate, talc, PEG,
Surfactants.
Glidants:- corn starch, talc, silica derivatives:-
colloidal silicas, syloid, etc.
35. Coloring Agents
The use of colors & dyes in a tablet has three
purposes:-
i) Masking of off color drugs
ii) Product identification.
iii)Production of more elegant product.
All coloring agents must be approved & certified by
FDA.
Two forms of colors are used in tablet preparation- FD
& C And D&C dyes.
These dyes are applied as a solution in
the granulating agents or lake form of these dyes.
Examples:- FD&C yellow 6-sunset yellow, FD&C
Green 3- Fast Green, etc
36. Flavoring agents
For chewable tablet- flavor oil are used
Sweetning agents
For chewable tablets: e,g;-mannitol, sugar, etc.
Saccharine(artificial): 500 times sweeter then
sucrose.
Aspartame
37. Evaluation test
i) General Appearance.
ii) Organoleptic properties.
iii) Weight Variation.
iv) Content uniformity.
v) Hardness.
vi) Friability.
vii) Dissolution test.
viii) Disintegration test
38. General Appearance
Size & shape :-
Thickness : ±5% of standard value.
Thickness of tablet is measured with a micrometer.
Organoleptic Properties
Color: color of product must be uniform (no
mottling).
Instruments used:-
Reflectance spectrophotometer.
Tristimulus colorimetry.
Micro-reflectance photometer.
odor: (e.g. film coated tablets).
Taste: (e.g. chewable tablet).
39. Weight Variation
20 tablets weighed ——› Average individual weight.
No more than 2 tablets are outside of limit.
IP % USP
Less than 85mg ±10% Weighing 130 mg
or less
85mg-250mg ± 7.5% Weighing 130-
324mg
Greater than
250mg
±5% Weighing 324 mg
or more
40. Content Uniformity
30 Tablets are selected and 10 are assayed
individually.
9 of the 10 tablets must contain not less than 85% or
more than 115% of the labeled drug content.
Hardness test
It is the force required to break a tablet in a diametric
compression also called tablet crushing strength.
The force required to break the tablet is measured in
kg & usually 4kg is considered to be minimum for
satisfactory tablets.
41. Instruments used
The Monsanto hardness tester
The strong- cobb apparatus
Pfizer tester
42. Friability
Resistance shown by the tablet during
packaging and transhipment.
20 tablets are weighed & placed in
apparatus-Roche Friabilator ——›
Revolution at 25 rpm for 4 min(100
revolution) ——› Dropping from 6 inches.
The tablets are weighed & the weight
compared with the initial weight.
% Friability =initial weight – final weight x
100
initial weight
limit :- 0.5-1%
43. Dissolution test
It is defined as the amount of
drug substance that goes into
solution per unit time under
standardized conditions of
liquid/solid interface,
temperature and solvent
composition.
It is carried out in:-
i) USP dissolution apparatus
type I (basket type)
ii) USP dissolution apparatus
type II (Paddle type)
44. Disintegration test
6 test tubes & 3 inch long ——› 10 mesh
screen —› 1L beaker of water(0.1N HCL)
simulated gastric fluid or simulated
intestinal fluid ——› temp 37±2ºC ——› up
& down from 5-6 cm ——› Frequency- 28-
32 cycle/minute.
tablet should remain 2.5 cm below the
surface of liquid on their upward
movement & same for downward
movement.
uncoated tablets:- as low as 5 min
Majority of tablets has disintegration time
of 30 min.
Enteric coated:- simulated gastric fluid:-
no evidence of disintegration after one
hour.
simulated intestinal fluid:-
45. Quality control of coated tablet
After coating, the tablets should be inspected &
tested for appearance such as color, size & any
physical defects.
In-vitro performance of the coated product is
evaluated by disintegration & dissolution testing.
Crushing strength of coated tablets can be
determined with the tablet hardness tester.
Adhesion tests with tensile-strength testers have
been used to measure the force required to peel
the film from the tablet surface.
Additional testing of coated tablets may also
includes tests for resistance to chipping & cracking
during handling.
METHODS & DEVICES FOR THESE
TESTS ARE SIMILAR TO THOSE USED FOR
UNCOATED TABLETS.
46. Lieberman’s Lachman;”The theory and practice
of Indusdtrial Pharmacy”,CBS publishers &
distributors pvt ltd, fourth edition, pp:- 449-522