The document discusses different types of tablets and their characteristics. It begins with defining tablets and their general properties. It then describes various oral and non-oral tablet types including enteric coated, floating, sublingual, buccal, implants and effervescent tablets. It discusses targeted drug delivery using colonic and gastroretentive tablets. Characteristics and examples of chewable, dispersible, lozenges and molded tablets are also provided. The document provides a detailed overview of different tablet classification and characteristics.
Tablets are solid dosage forms usually obtained by single or multiple compression of powders or granules. In certain cases tablets may be obtained by molding or extrusion techniques. They are uncoated or coated. Tablets are normally right circular solid cylinders, the end surfaces of which are flat or convex and the edges of which may be bevelled. They may have lines or break-marks (scoring), symbols or other markings.Tablets contain one or more active ingredients. They may contain excipients such as diluents, binders, disintegrating agents, glidants, lubricants, substances capable of modifying the behaviour of the dosage forms and the active ingredient(s) in the gastrointestinal tract, colouring matter authorized by the appropriate national or regional authority and flavouring substances. When such excipients are used it is necessary to ensure that they do not adversely affect the stability, dissolution rate, bioavailability, safety or efficacy of the active ingredient(s); there must be no incompatibility between any of the components of the dosage form.
Tablets are single-dose preparations intended for oral administration. Some are intended to be swallowed whole, some after being chewed and some after being crushed, some are intended to be dissolved or dispersed in water before being taken and some are intended to be retained in the mouth where the active ingredient(s) is/are liberated.
Tablets are solid dosage forms usually obtained by single or multiple compression of powders or granules. In certain cases tablets may be obtained by molding or extrusion techniques. They are uncoated or coated. Tablets are normally right circular solid cylinders, the end surfaces of which are flat or convex and the edges of which may be bevelled. They may have lines or break-marks (scoring), symbols or other markings.Tablets contain one or more active ingredients. They may contain excipients such as diluents, binders, disintegrating agents, glidants, lubricants, substances capable of modifying the behaviour of the dosage forms and the active ingredient(s) in the gastrointestinal tract, colouring matter authorized by the appropriate national or regional authority and flavouring substances. When such excipients are used it is necessary to ensure that they do not adversely affect the stability, dissolution rate, bioavailability, safety or efficacy of the active ingredient(s); there must be no incompatibility between any of the components of the dosage form.
Tablets are single-dose preparations intended for oral administration. Some are intended to be swallowed whole, some after being chewed and some after being crushed, some are intended to be dissolved or dispersed in water before being taken and some are intended to be retained in the mouth where the active ingredient(s) is/are liberated.
Tablets: a.Introduction, ideal characteristics of tablets, Classification of tablets. Excipients, Formulation of tablets, granulation methods, compression and processing problems.
this presentation discusses about; Dosage forms
Tablet dosage forms
Desirable properties of tablets
Classification of tablets
Types of tablets
Tablet ingredients
Tablet manufacturing methods
Major equipments used for wet granulation
Evaluation of tablets
Tableting problems and their remedies
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5. Definition
Tablet is defined as a compressed solid dosage form
containing medicaments with or without excipients.
According to the Indian Pharmacopoeia Pharmaceutical
tablets are solid, flat or biconvex dishes, unit dosage
form, prepared by compressing a drugs or a mixture of
drugs, with or without diluents.
They vary in shape and differ greatly in size and
weight, depending on amount of medicinal substances
and the intended mode of administration.
It is the most popular dosage form and 70% of the
total medicines are dispensed in the form of Tablet.
5
6. General properties
Accurate dosage of medicament,
uniform in weight, appearance and
diameter.
Have the strength to withstand the mechanical shocks
encountered in its production, packaging, shipping and
dispensing.
Release the medicinal agents in the body in a
predictable and reproducible manner.
Elegant product, acceptable size and shape.
Chemical and physical stabilities.
6
7. Advantages
Production aspect
Large scale production at lowest cost
Easiest and cheapest to package and ship
Greatest chemical and microbial stability
over all oral dosage form.
User aspect (doctor, pharmacist, patient)
Easy to handling
Lightest and most compact
Greatest dose precision & least content
variability
Coating can mark unpleasant tastes &
improve patient acceptability
7
8. Disadvantages
Some drugs resist compression into
dense compacts.
Drugs with poor wetting, slow dissolution,
intermediate to large dosages may be difficult
or impossible to formulate and manufacture as
a tablet that provide adequate or full drug
bioavailability.
Bitter taste drugs, drugs with an
objectionable odor, or sensitive to oxygen or
moisture may require encapsulation or
entrapment prior to compression or the
tablets may require coating.
8
9. ORAL TABLETS FOR INGESTION
Standard compressed tablets e.g. Paracetamol
tablet
Multiple compressed tablets
I. Compression coated tablet
*sugar coated tablet
*Film coated tablet
*Gelatin coated tablet
*Enteric coated tablet
II. Layered tablet
III. Inlay tablet
Targeted tablet
I. Floating tablet
II. Colon targeting tablet
Chewable tablet e.g. Antacid tablet
Dispersible tablet
9
10. TABLETS USED IN THE ORAL CAVITY
Lozenges and troches
Sublingual tablet e.g. Vitamin-c tablet
Buccal tablet e.g. Vitamin-c tablet
Dental cones
Mouth dissolved tablet/ rapidly
dissolving tablets
TABLETS ADMINISTERED BY OTHER
ROUTES
vaginal tablet e.g. Clotrimazole tablet
Rectal tablet
Hypodermic tablet
Implants
10
11. TABLETS USED TO PREPARE SOLUTION
Effervescent tablet e.g. Dispirin
tablet (Aspirin)
Molded tablets
I. Hypodermic tablet
II. Dispensing /soluble tablet
e.g. Enzyme tablet (Digiplex)
Tablet triturates e.g. Enzyme
tablet (Digiplex)
11
12. Standard compressed tablet
• These are the standard uncoated
tablets made by either
direct compression
wet granulation
dry granulation
• They may be used for local action
in GIT/
systemic action.
• In addition to medicinal agents
they
usually contain a number of
pharmaceutical adjuvants. 12
13. Multiple compressed tablet
I. compression coated tablet
Function like sugar-coated or film-coated
tablets or gelatin-coated, enteric coated.
Coating of a tablet may
a.mask a bitter taste, odor, color of the
substance
b.conceal an unpleasant or mottled appearance
c.provide a barrier for a substance irritating to
the stomach
d.Provide physical and chemical protection for
one inactivated by gastric juice.
e.Control the release of drug from the tablet.
13
14. film coated pills sugar coated pills
Disadvantages:
Improper centration of core either
vertically/ horizontally produces weak
edges and coating will not hold together.
More expensive because of multiple
granulation.
Unequal coating off centre
Faults in compression coating
14
15. II. Layered tablet
• Multilayer tablets (2 or 3) are prepared
by
repeated compression of powders and
are
made primarily to separate incompatible
drugs from each other.
o It makes possible SR release preparation
with the ISTANT RELEASE in one-layer
and slow-release portion in the second, a
third layer with an intermediate release
might be added.
1. Analgesic-antipyretic decongestant containing aspirin and phenyl
propanolamine. A thin layer of placebo is placed between them to
negate the chemical incompatibility of active ingredient.
15
16. Advantages-
Coloring the separate layers provides
many possibilities for unique tablet
identity.
Pre compression lengthens dwell time and
aid in bonding.
Layer presses find employment in
manufacture of chewable antacid tablets.
(MgO heavy USP) first layer, (Al(OH)2
dried gel USP) as second layer.
16
17. Targeted tablets
Under this category we have two
types of tablets:
I. GASTRO- RETENTIVE TABLET
when API release is desired in stomach (antacids,
API’s used against H. pylori infection)
Floating tablet
To retain the drug for longer time period in
stomach following approaches can be used:
Low density tablet
Tablet that can expand in gastric environment
(swelling or unfolding).
Using muco - adhesive polymer
Supine position is to be avoided.
o Drugs like diazepam, levodopa, benserazide and
ciprofloxacin are successfully marketed.
17
18. II. COLONIC TABLETS
For the drugs having poor absorption in stomach or small
intestine, colonic drug delivery is an answer of choice.
The pH in this region varies from 6.4-7 and presence of
microbial flora plays an important role in drug release.
Various mechanisms adopted for drug release in this area
are:
Coating with pH sensitive polymer
Biodegradable polymer which are sensitive to
colonic bacteria.
Bio- adhesive polymer e.g., poly carbophils/poly
ethanes.
Redox sensitive polymers.
18
19. Chewable tablets
Chewable tablets are to be chewed and thus
mechanically disintegrated in the mouth, so that
NO DISINTEGRANT IS INCLUDED.
Flavoring, sweetening and coloring agents are
important.
Sorbitol and mannitol are common examples of
fillers in chewable tablets, (mannitol has
negative heat of solution which results in cooling
effect and also has sweetening action).
19
20. Advantages of chewable tablets
Provide quick and complete disintegration of the tablet and thus
obtain a rapid drug effect after swallowing and dissolution.
Easy administration, especially for infants and elderly people.
Patient convenience through elimination of need of water for
swallowing.
Examples
Chewable Aspirin tablets (for children in the treatment of
rheumatoid and to prevent clot formations in adults).
Antacid tablets
Chewable multi vitamin tablet
20
21. Dispersible tablets
Disintegrate either rapidly in water to form
stabilized suspension or disperse
instantaneously in the mouth to be swallowed
without the aid of water.
ADVANTAGES:
For pediatric patients who cannot swallow.
For API’s unstable if formulated in liquid
formulation.
Faster onset of action compared to standard
compressed tablet.
Patients having prolonged illness who are
prone to nauseatic sensation.
Examples: Analgesics (aspirin, ibuprofen etc.)
21
22. Lozenges and trouches
Lozenges are flavored medicated dosage forms
intended to be sucked and held in mouth or
pharynx.
Two lozenge forms include hard (or boiled)
candy lozenges and compressed tablet lozenges
(TROUCHES).
Lozenges may be used for;
Local medications in the mouth or throat,
e.g. local anesthetics, anti histamines, decongestants,
analgesics, demulcents, antiseptics & antibiotics
Systemic drug uptake.
22
23. A soft variety of lozenge, called a pastille, consists of
medicament in a gelatin or glycero-gelatin or in a base
of acacia, sucrose and water.
No disintegrant is included in compressed lozenges
composition
Other additives (binder and filler) must have pleasant
taste or feeling during dissolution.
Common binder used in compressed lozenges is gelatin,
common fillers are (Sorbitol,
mannitol and glucose).
23
24. sublingual tablets
Requirements of sublingual tablets are speed of
absorption and a correspondingly rapid physiological
response.
Intended to be placed beneath
the tongue and held there until
absorption has taken place.
Absorption through oral cavity
avoids first pass metabolism
.
1. Molded sublingual tablets-
Prepared from soluble ingredients so that
the tablets are completely and rapidly soluble.
Examples- codeine phosphate tablets, scopolamine HBr
tablets, nitroglycerine tablets.
Sublingual tablet is
placed under the
tongue (rich in
blood supply)
24
25. 2. Compressed sublingual tablets-
This type has less weight variation,
better content uniformity, also
harder and less fragile.
Examples- Glyceryl trinitrate
nitroglycerine tablet
25
26. Buccal tablets
• Intended to be dissolved in buccal pouch.
• Tablets are designed not to disintegrate.
• It is placed near the opening of parotid duct to
provide the medium to dissolve the tablet.
• Buccal tablets are most often used when
replacement hormonal therapy is the goal, e.g.,
Methyl testosterone, testosterone propionate.
26
27. Long- acting buccal tablets-
Use of viscous natural or synthetic gums
or mixtures of gums can be compressed to
form a hydrated surface layer from which
the medicament slowly diffuses and is
available for absorption through buccal
mucosa.
Examples- nitroglycerin buccal tablets
27
28. Dental cones
These tables are designed to be loosely
packed in the empty socket remaining
following a tooth extraction.
Main purpose behind the use of this
tablet is either to prevent multiplication of
bacteria in the socket by employing a slow
releasing antibacterial compound or to
reduce bleeding by an astringent or
coagulant containing tablet.
28
29. Vaginal tablets
Designed for vaginal administration in
treatment of local vaginal infections, for
systemic absorption and absorption into
vaginal tissue.
Can be inserted with aid of an
appliantor.
In the treatment of localized vaginal
infections such as, Candida albicans,
yeast and Haemophilus vaginalis.
29
30. Rectal tablets
Old and acceptable means of treatment.
The volume and nature of rectal fluid, its buffer
capacity, pH and surface tension play a large part in
this but are subject to wide variation, even within single
subject, resulting in variability of absorption by this
route.
Advantages:
Tablets have distinct advantages over suppositories is
Not requiring refrigeration
Better product stability even at room temperature
Suppositories containing such compounds as Aspirin and
Penicillin G sodium have limited product stability even
under refrigeration.
30
31. Disadvantages:
Possibility of premature expulsion
of the dosage form before
sufficient absorption takes place.
Unfortunately, little is known
about the rectal delivery from
tablet.
Additional studies would be
required to demonstrate the
extent of bioavailability.
31
32. implants
Designed for subcutaneous implantation by
surgical procedure where they are slowly
absorbed over a period of month or a year.
Special injector with a hollow needle and plunger
is used to administer the rod shaped tablet.
For other shapes surgery is used.
They are sterile formulations without excipients.
Mainly these tablets are prepared to deliver
growth hormones to food producing animals.
Ear is preferred site for administration of drug.
Safety problems
32
33. Effervescent tablets
• Effervescent tablets are dropped into a
glass of water before administration during
which CO2 is liberated. This facilitates
tablet disintegration and drug dissolution;
the tablet disintegration should complete
within few minutes.
• (Effervescence is a special mechanism for
disintegration) CO2 is created by the
reaction between carbonate or bicarbonate
and a weak acid such as citric acid or
tartaric acid.
33
34. Advantages of effervescent tablets
Rapid drug action e.g. analgesics and antacids.
Facilitate drug intake, for example vitamins.
Special conditions
moderate to cool temperature
(250c) in processing areas is essential.
Effervescent tablets should be protected
from moisture, may be packed in blister
packs.
Examples
wide range of effervescent tablets include antibiotics,
ergotamines, digoxin, methadone, L- dopa. Preparation for
veterinary use have also been developed.
34
35. 35
Molded tablets
I. Hypodermic tablets
• They are intended to be added in
WFI of sterile water to form a clear
solution which is to be injected
parenterally.
o Widely used by rural physician due to its
portability.
o Can be used for medicaments whose stability in
water is very poor.
o Their use in this manner should be discouraged,
since the resulting solutions are not sterile.
35
36. II. Dispensing/ soluble tablet
They are to be added to water or other
solvents to make a solution containing a fixed
concentration of API.
Should contain no insoluble materials (including
glidants, binders etc.), since they will be made
into clear solution.
Examples
Mercuric chloride dispensing tablet (antiseptic), tablet for ophthalmic drops
of neomycin sulfate.
Others include topical local anesthetics (cocaine), antibiotics (bacitracin).
36
37. Tablet triturates
• They are small, usually cylindrical,
molded or compressed tablets
containing small amounts of usually
potent drugs.
• Only a minimal pressure is applied
during their manufacturing, since
they must be readily and
completely soluble in water.
37
38. ENTERIC COATED TABLET
• Protect the drug from being destroyed by
gastric contents, either enzymes or highly
acidic gastric fluids. E.g., low pH destroys
some drugs (erythromycin)
• Prevent or reduce nausea and vomiting
associated with a drug’s irritation of gastric
mucosa. E.g., aspirin, strong electrolytes such
as NH4Cl, KCl
• Deliver the drug to its absorption site in the
intestine.
• Deliver the drugs intended for local action in
the intestine. E.g., intestinal antibacterial or
antiseptic agents.
38
39. Coating composition
Enteric polymers e.g., shellac, CAP, HPMC
phthalate,
Plasticizers e.g., glycerin, PEG, propylene glycol,
castor oil, phthalate esters.
Solvents
Enteric coating materials-
Action of enteric coating results from
difference in the composition of gastric and
intestinal environments with respect to both pH
and enzymes.
1.Materials that rely on erosion
2.Materials that rely on change in pH/ pH
sensitive materials
39
40. Modified release tablets
• Release the medicament slowly for long time duration
after administration of a single tablet.
• Used to target the site specific releases.
Comparison of blood concentration vs. time
• Any adjuvant that can alter water uptake rate, swelling,
and gelling characteristics can alter the release rate of
API. E.g., electrolytes in HPMC matrix tablet.
40
41. The drug release can be modified by providing suitable
micro environment pH in the tablet. E.g., acidic polymer,
succinic acid etc.
Inclusion of alkaline polymers results in desirable drug
release of acidic drugs.
Advantages-
patient compliance
Disadvantages-
Increases the cost of manufacturing.
Chances of burst of drug release.
In case of accidental poisoning, the doctor has to deal
with special treatment problems.
Due to large size, patient may feel difficulties in
swallowing as the matrixing agent to drug ratio is high.
41