Ultrasonic nebulizers can increase temperature during treatment and are not suitable for suspensions. Breath-actuated nebulizers only generate aerosol during inspiration. New soft mist inhalers and vibrating mesh devices produce low-velocity aerosols between 2.2-5.5 μm for effective drug delivery while being portable.

1. Inhaled Drugs
BY
DR. Magdy Shafik
Senior Pediatric Consultant
Diploma, M.S ,Ph.D of Pediatric

2. .

21. Ultrasonic Nebulizers •
• The temperature can rise 10-15°C over a
10- minute treatment period, which may
adversely affect heat-sensitive
components of formulations
• Ultrasonic nebulizers also are not suitable
for nebulizing suspensions

22. • Breath-Actuated Nebulizers
• generate aerosol only during inspiration
New-generation nebulizers Soft Mist
Inhalers
• uses mechanical energy to create an
aerosol with a low-velocity spray
• aerosol ranges 2.2-5.5 μm MMD Middleton
8th edition

23. • Vibrating Mesh Devices:
• Passive • generate aerosol only during
inspiration Vibrating Mesh Devices
• Active • vibrates at a high frequency
• high FPFs and very low dead volumes •
battery-operated

26. Thank You