The document discusses various immunosuppressive drugs used to prevent organ transplant rejection and treat autoimmune diseases. It describes the cellular and molecular mechanisms of transplant rejection and how drugs like cyclosporine, sirolimus, prednisone, cyclophosphamide, and methotrexate act at different steps to inhibit rejection. It also discusses antibodies used as immunosuppressants and their mechanisms of action in blocking T cell activation and cytokine signaling to suppress the immune response.
Immunosupressants and Immunostimulants their pharmacology, uses etc. Basics of immunology, innate immune response, acquired immune response, role of complement in innate immune response. Major histocompatibility complex, antibody structure. classification of immunosupressants, their mechanism of action, uses and adverse effects.
Immunosupressants and Immunostimulants their pharmacology, uses etc. Basics of immunology, innate immune response, acquired immune response, role of complement in innate immune response. Major histocompatibility complex, antibody structure. classification of immunosupressants, their mechanism of action, uses and adverse effects.
Introduction to the endocrine system
Growth hormone: Mechanism of Action, secretion, regulation.
Prolactin
Sex hormones
Oral contraceptives
Corticosteroids
Protozoal infections and antiprotozoal drugs(therapy).Gagandeep Jaiswal
presentation comprising knowledge about various protozoal infections and therapy options available for the treatment of those infections. various different drugs used in the therapy with their proposed mechanism of action. Hope it will be useful for understanding the pharmacology of antiprotozoals.
immunostimulants
Immunomodulators are natural or synthetic materials that regulate the immune system and induce innate and adaptive defense mechanisms. These substances are classified into two types, immunostimulants and immunosuppressants.
Immunostimulants can enhance body's resistance against various infections through increasing the basal levels of immune response.
Immunosuppressants are drugs which inhibit cellular/humoral or both types of immune responses and have their major use in organ transplantation and autoimmune diseases.
Introduction to the endocrine system
Growth hormone: Mechanism of Action, secretion, regulation.
Prolactin
Sex hormones
Oral contraceptives
Corticosteroids
Protozoal infections and antiprotozoal drugs(therapy).Gagandeep Jaiswal
presentation comprising knowledge about various protozoal infections and therapy options available for the treatment of those infections. various different drugs used in the therapy with their proposed mechanism of action. Hope it will be useful for understanding the pharmacology of antiprotozoals.
immunostimulants
Immunomodulators are natural or synthetic materials that regulate the immune system and induce innate and adaptive defense mechanisms. These substances are classified into two types, immunostimulants and immunosuppressants.
Immunostimulants can enhance body's resistance against various infections through increasing the basal levels of immune response.
Immunosuppressants are drugs which inhibit cellular/humoral or both types of immune responses and have their major use in organ transplantation and autoimmune diseases.
Immunosuppressants drugs and their mechanism of action in organ transplantati...Sreedhar Reddy
immunosuppressants are drugs used to supress immune system
1)introduction and classification 2)mechanism with flow chat 3) use of immunosuppressants and adverse effects and contraindications
immunosuppressant mainly used to treat autoimmune disorder and organ transplantation
Role of biological agents in immunosuppression in Autoimmune rheumatoid arthritis and organ transplantation
inhibition of humoral and cellular immune response
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Acute scrotum is a general term referring to an emergency condition affecting the contents or the wall of the scrotum.
There are a number of conditions that present acutely, predominantly with pain and/or swelling
A careful and detailed history and examination, and in some cases, investigations allow differentiation between these diagnoses. A prompt diagnosis is essential as the patient may require urgent surgical intervention
Testicular torsion refers to twisting of the spermatic cord, causing ischaemia of the testicle.
Testicular torsion results from inadequate fixation of the testis to the tunica vaginalis producing ischemia from reduced arterial inflow and venous outflow obstruction.
The prevalence of testicular torsion in adult patients hospitalized with acute scrotal pain is approximately 25 to 50 percent
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Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
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ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
2. Immunopharmacology Drugs
Objectives:
• Know the mechanisms, clinical uses, and adverse effects
associated with:
Cyclosporine
Sirolimus
Prednisone
Cyclophosphamide
Methotrexate
Mycophenolate Mofetil
• Know the mechanism and clinical uses of antibodies as
immunosuppressants
3. Outline:
I. Purpose of Immunosuppressive Drugs
II. Organ transplant rejection
Cellular basis for rejection
Molecular basis for rejection
Mechanism of action of immunosuppressive
drugs
III. Antibodies as immunosuppressants
4. I. Purpose of Immunosuppressive Drugs
•Prevention of organ transplant rejection
•Treatment of autoimmune diseases
Multiple Sclerosis
Lupus
Rheumatoid Arthritis
Crohn’s Disease
Type I Diabetes
5. The dream of transplants
The 3rd Century,
Saints Cosmas and Damian
6.
7. Relationships between Donor and
Recipient
Syngeneic - between genetically identical individuals, usually the
same individual, identical twins or isogenic strains
Allogeneic - from one individual to another of the same species
Xenogeneic - between individuals of different species.
8. Immunological Rejection
Major Histocompatibility Complex (MHC) is the major concern.
Rejections:
Antibody mediated
T cells mediated
Hyperacute rejection
e.g., Blood type mismatch
Acute Graft Rejection
Direct recognition of allogenic MHC; rejection about 10 days
Chronic rejection
Take many months to years. Due to failure of immunosuppressants
9. II. Organ transplant rejection
Cellular basis for rejection:
(Figures modified from Lechler et al., (2005) Nature Medicine, 11, 605-613)
IL2 = T cell growth factor
1.Antigen presenting cell
(APC) activates T Cells
2.T cells produce Interleukin
2 (IL2)
3.IL2 stimulates the
proliferation of T cells and
the production of additional
cytokines that stimulate the
proliferation of multiple
types of immune cells: T
cells, B cells, macrophages,
…
4.Activated immune cells
attack transplanted organ
(allograft)
1.
2.
3.
4.
10. Molecular basis for rejection
(Steps 1 and 2 - T cell activation and IL2 production):
Calcineurin
NFAT = Nuclear Factor of Activated T cells
IL-2 mRNA
IL-2 Protein:
NFAT PO3
NFAT
Nucleus
IL-1
[Ca2+]
11. Molecular basis for rejection
(Step 3 - IL2 stimulation of T cell proliferation):
IL2
Receptor
mTOR
T Cell
T Cell
Cell Proliferation
T Cell
T Cell
Cytokine Production
Activation of multiple types of immune cells
12. Molecular basis for rejection
(Steps 1 and 2 - T cell activation and IL2 production):
Calcineurin
NFAT PO3
NFAT
NFAT = Nuclear Factor of Activated T cells
IL-2 mRNA
IL-2 Protein:
Nucleus
IL-1
Tacrolimus(FK506)/FKBP
Cyclosporine/Cyclophilin
TPrednisone
[Ca2+]
13. Molecular basis for rejection
(Step 3 - IL2 stimulation of T cell proliferation):
IL2
Receptor
mTOR
T Cell
T Cell
Cell Proliferation
T Cell
T Cell
Cytokine Production
Activation of multiple types of immune cells
T
Anti-IL-2 T
Anti-IL-2
receptor
Sirolimus(rapamycin)/
FKBP
Cyclophosphamide
Methotrexate
Mycophenolate Mofetil
16. Anti-inflammatory and Immunosuppressive Drugs
Nonsteroid anti-inflammatory drugs: Aspirin, Vioxxx (no longer
used), and Celebrex. Work through COX1/2
(cylooxygeneases, which are involved in the
synthesis of prostaglandins)
Antihistamines: Blockers of histamine receptors: Allegra,
Claritin, Clarinex, Benadryl
*Steroid hormones: Glucocorticoid derivatives: prednisone,
dexamethasone, and hydrocortisone
*Lymphocyte specific immunosuppressants: Cyclosoprine, FK506,
rapamycin, FTY720, specific antibodies
and receptors (bioactive).
Cytotoxic agents: cyclophosphamide
17. Simplified Schematic of an Immune Response
Class I
MHC class II/peptides
APCs
Protein antigens
CD8+ T cells
CD4+ T cells
B cells Plasma cells
CD8+ cytolytic T cells
CD4+ immune cells
(delayed hypersensitivity)
antibody
production
proliferation &
differentiation
Cytokines
Costim. Mol.
IL-4,-5,-6
proliferation &
differentiation
APC
Class II
proliferation &
differentiation
22. Mechanism of Action of
Helper T-cell blockers
X
X
From Hardman and Limbird, The Pharmacological Basis of Therapeutics
23. Cyclophilin is a peptidyl-prolyl cis-trans-isomerase which catalyzes the cis-trans
isomerization of proline imidic peptide bonds. Helps protein folding.
FKBPs are also known to participate in many cellular processes such as cell
signaling, protein transport (such as Notch) and transcription.
Immunophilins
25. Newton, Thorax 2000;55:603-613
Mechanisms of Glucocorticoid Action
1. Inhibit the production of
proinflammatory cytokines
2. Promote the production of
inflammatory cytokines
3. Induce apoptosis in
inflammatory cells
4. Interfere with cytokine signals
26. Glucocorticoid-sensitive sites of
the immune response
MHC Class I/peptides
APCs
MHC Class II/peptides
APCs
Protein antigen
CD8 T-cell
CD4 T-cell
(helper T-cells)
B-cell Plasma cell
CD8 cytolytic T-cells
CD4 immune cell
(delayed hypersensitivity)
antibody
production
proliferation &
differentiation
proliferation
IL-1
IL-1, -4,-5,-6
proliferation &
differentiation
GC
X
X
GC
X
X
27. Use of Glucocorticoid as Immunosuppressants
• Most widely used effective anti-inflammatory drugs
• Used with other immunophilin inhibitors to prevent transplant
rejection and GVHD
– natural glucocorticoids not used due to mineralocorticoid activity
• Prednisone and prednisolone are used orally at moderate to high
doses; Very high doses of methylprednisolone used i.v. during acute
organ rejection
• Used before and after anti-thymocyte Abs to inhibit allergic reactions
28. General Principles of Immunosuppression
• Primary immune responses are more easily
suppressed than secondary (memory)
• Different immunosuppressants have
different effects on different immune
reactions
• Suppression is more likely achieved if
therapy begins before exposure to the
immunogen
29. Uses of Calcineurin inhibitors
(TCR activation blockers)
• Cyclosporine commonly used with prednisone
and other immunosuppressants to prevent
allograft rejections in renal, hepatic and cardiac
transplants, and in RA and psoriasis
– use is delayed posttransplantation due to
neurotoxicity concerns
• FK506 (Tacrolimus) is approved for
prevention of solid-organ allograft rejection,
and eczema (topical)
– Treatment begins prior to surgery, and is
maintained well afterwards
30. Glucocorticoid effects related to immunosuppression
• Reduced immune cell content of lymph nodes, spleen and
blood
– lymphopenia, monocytopenia, eosinopenia, but
neutrophilia
• Interference with APC, T-cell and macrophage functions
31. Sirolimus (Rapamycin, Rapamune):
a new T-cell blocker
• different mechanism of action
– blocks mTOR kinase
• similar poor bioavailability as cyclosporine and tacrolimus, much
longer half-life; 62 h v. 18 and 12 h
• same metabolism (CYP3A) and potential drug interactions
• used for prophylaxis of organ transplant rejection in combination
with a calcineurin inhibitor and glucocorticoids
• toxicities include:
– hyperlipidemia, lymphocoele, anemia, leukopenia,
thrombocytopenia, fever, GI effects, hyper- or
hypokalemia
32. Toxicity of Glucocorticoids
• Major side effects are common due to high
doses necessary for suppression
– Cushings syndrome
– glucose intolerance
– infections
– bone dissolution
– muscle wasting
33. Cytotoxic Agents as immunosuppressants
• Antineoplastic drugs will also prevent clonal expansion of T- and
B-cells
– azathioprine (prodrug of nucleotide anti-
metabolite)
– mycophenolate mofetil
• becomes MPA; inhibits IMP dehydrogenase
– cyclophosphamide (DNA alkylating agent)
– methotrexate (inhibits dihydrofolate reductase)
34. Uses of cytotoxic agents
• Azathioprine; with cyclosporine and/or prednisone for organ
transplant rejection and severe RA
• Mycophenolate mofetil; with cyclosporine and prednisone for
renal transplants
• Cyclophosphamide; for BMT
• Methotrexate; GVHD prophylaxis
35. Bioactive Immunosuppressants
• Anti-thymocyte antibodies
– 3 types available
• all derived from non-human sources
• Rh(D) immune globulin
• OKT3, OKT4, Anti-CD20, anti-TNF, anti-ICAMs, and
CTLA4-Ig
• Repeated blood transfusion; transfusion of apoptotic cells
36. III. Antibodies as immunosupressants
Antibody Molecule
Constant Fragment-Fc
Antigen Binding Sites
•Proteins produced by B
cells (plasma cells)
•Function by binding to
antigens and neutralizing
them through several
mechanisms
37. Clinically Useful Antibodies:
• Muromonab-CD3 (OKT-3)
– Binds CD3 on the surface of T cells and
inhibits T cell function; Used to treat acute
transplant rejection
• Anti-IL-2 receptor antibodies (Daclizumab)
– Blocks IL-2 receptor activation, thus blocking T
cell activation; Used to treat acute transplant
rejection
38. •Rh(D) immune globulin
Background: Rh(D) negativemother will generate antibodies
to Rh(D) antigen on the erythrocytes of an Rh(D) positive
newborn. The mother will be exposed to the newborn
erythrocytes shortly after giving birth.
If the mother is given Rh(D) immune globulin shortly after
giving birth (within 72 h), it will lyse the erythrocytes from
the baby before the mother generates an immune response.
A subsequent Rh(D) positive baby will be protected from
hemolytic disease.
[Will not work once the mother has developed
Rh(D)antibodies.]
39.
40. Ideal Immunosuppressant
• Strongly Immunosuppressive
• Specific, No Overall Immunosuppression
• Anti-infection ability
• Low Toxicity for Vital Organs
• Low cost
• Long in vivo bioactivity
• Easy to use