Immunosuppressive drugs play an important role in organ transplantation by suppressing the immune system and preventing graft rejection. There are several classes of immunosuppressive drugs including calcineurin inhibitors like cyclosporine and tacrolimus, mTOR inhibitors like sirolimus, antiproliferative drugs like azathioprine and mycophenolate mofetil, glucocorticoids, and biological agents. These drugs have different mechanisms of action but generally suppress both humoral and cell-mediated immunity. Immunosuppressive combinations of drugs are used for induction therapy after transplantation, maintenance therapy to prevent long-term rejection, and treatment of acute rejection episodes. Prolonged use can
Immunosuppressants are drugs or medicines that lower the body's ability to reject a transplanted organ. Another term for these drugs is anti-rejection drugs. There are 2 types of immunosuppressants:
Induction drugs: Powerful antirejection medicine used at the time of transplant
Maintenance drugs: Antirejection medications used for the long term.
This is a presentation detailing the development, dosing and precautions for Thalidomide, Lenalidomide and Pomalidomide, citing the key clinical trials an evidence.
Immunosuppressants are drugs or medicines that lower the body's ability to reject a transplanted organ. Another term for these drugs is anti-rejection drugs. There are 2 types of immunosuppressants:
Induction drugs: Powerful antirejection medicine used at the time of transplant
Maintenance drugs: Antirejection medications used for the long term.
This is a presentation detailing the development, dosing and precautions for Thalidomide, Lenalidomide and Pomalidomide, citing the key clinical trials an evidence.
Immunosuppressants are drugs which inhibit cellular/humoral or both types of immune responses and have their major use in organ transplantation and autoimmune diseases.
Immunosuppressants are drugs which inhibit cellular/humoral or both types of immune responses and have their major use in organ transplantation and autoimmune diseases.
DMARDs and biologics have made a huge difference in the lives of people with RA and other rheumatologic disorders. Biologics era was showed+ in the year 1998 with the FDA approval of TNF antagonist and etanercept. Biologics bring the disease under control in 4–6 weeks compared to 3–6 months taken by traditional DMARDs.
Hello friends. In this PPT I am talking about anti-cancer drugs. If you like it, please do let me know in the comments section. A single word of appreciation from you will encourage me to make more of such videos. Thanks. Enjoy and welcome to the beautiful world of pharmacology where pharmacology comes to life. This video is intended for MBBS, BDS, paramedical and any person who wishes to have a basic understanding of the subject in the simplest way.
Immunosuppressants drugs and their mechanism of action in organ transplantati...Sreedhar Reddy
immunosuppressants are drugs used to supress immune system
1)introduction and classification 2)mechanism with flow chat 3) use of immunosuppressants and adverse effects and contraindications
immunosuppressant mainly used to treat autoimmune disorder and organ transplantation
Role of biological agents in immunosuppression in Autoimmune rheumatoid arthritis and organ transplantation
inhibition of humoral and cellular immune response
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
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Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
1. Immunosuppressive agents and their role in organ transplantation
PC-660
Subject teacher: Dr. B.V.S Lakshmi
Presented by: Aditya Ajit Singh
Department of Pharmacology and
Toxicology
Reg. no. : PC/2019/212
2. General Introduction
• These are drugs that suppress immune responses.
• These drugs are useful in case of autoimmune disorders.
• They have capability of suppressing both humoral as well as cell mediated immunity.
• Highly successful in Organ Transplantation process.
5. Calcineurin Inhibitors
Cyclosporine
• It is a cyclic polypeptide with 11 amino acids and obtained from the
fungus Tolypolcadium inflatum
• It profoundly and selectively inhibit T cell proliferation also
synthesis and sensitivity to Interleukins is inhibited.
• Plasma life is 27 hrs.
• Dose is 50mg
Uses:
• Severe Rheumatoid Arthritis
• Uveitis
• Graft rejection reaction (Renal, hepatic, bone marrow transplant)
Drug interactions/Pharmacokinetics:
• Absorption from GIT is only 20-30%
• Interacts with CYP3A4 inhibitors like antifungals
6. Calcineurin Inhibitors
Tacrolimus
• Tacrolimus is called FK 506
• It is a macrolide derived from soil bacterium
called Streptomyces tsukabaensis
• 50-100 times more potent than Cyclosporine
• Dose is 5mg
Uses:
• Fistulating Crohn’s disease
• Atopic Dermatitis
• Autoimmune and graft rejection reactions
(particularly liver as absorption dosen’t
depend on bile)
Drug interactions/Pharmacokinetics:
• Binds to α glycoprotein, absorption from GIT is variable
• Enzyme inhibitor of CYP450 enzyme
7. Side effects
• Hypertension
• Hirsutism
• Gum Hyperplasia
• Hyperuricaemia ( More seen in Cyclosporine)
• Diabetes ( More with Tacrolimus)
Hyperplasic gum Classic Hirsutism
8. m-TOR Inhibitors
• It is a macrolide antibiotic like Tacrolimus
• The MOA remains the same only difference being binding to a different kinase molecule
• Sirolimus arrests the immune response at a later stage than Cyclosporine
• Well absorbed orally, but Fatty meal reduces absorption
• The side effects remain similar
10. Antiproliferative drugs
Azathioprine
• It is a purine antimetabolite
• Selectively being up taken by immune cells, it gets converted to active
metabolites 6-MP
• Further this metabolite is transformed and blocks DNA synthesis and cell
proliferation of T cells
• Dose is 1-2mg/kg
Uses:
• Prevention of graft rejection (Particularly renal)
• Inflammatory bowel disease
Methotrexate
• It is a folate antagonist
• Prevents cytokine production and
suppresses cellular immunity
Uses:
• Rheumatoid Arthritis
• Psoriasis
• Pemphigus
Pemphigus
11. Antiproliferative drugs
Cyclophosphamide
• Marked effect on B cells and humoral
immunity
• Particularly used for marrow transplantation
• Reserve drug for Rheumatoid arthritis
• Dose is 10mg
Mycophenolate mofetil
• Prodrug, active form is mycophenolic acid
• Inhibits ionosine monophosphate dehydrogenase, thus guanosine nucleotides for
synthesis of B and T cells are not formed
• Half life is 16 hrs
• Dose is 1 g oral
Glucocorticoids
• Anti inflammatory in nature
• Particularly inhibit MHC expression in T cells
Drug interactions/Pharmacokinetics:
• Given orally and through i.v route
• Metabolite acrolein causes bladder cancer
Drug interactions/Pharmacokinetics:
• Well absorbed orally
• Interaction with antacids retards absorption
12. Biological agents
TNF-α INHIBITORS:
Etanercept
• Fusion protein of TNF receptor and Fc portion of IgG1 antibody
• Prevents activation of macrophages and T cells
• Used for ankylosing spondylitis
Infliximab and Adalimumab
These are monoclonal antibodies
Both inhibit TNF-α activation
Used in spondilytis
13. Biological agents
(Interleukin Inhibitors)
Anakinra
• It is a IL-1 receptor antagonist
• Selectively inhibits the binding of IL-1 to its receptor
• It is used in Rheumatoid Arthritis
Daclizumab and Infliximab
• These antibodies are directed to CD-25 molecules
• Acts as an IL-2 receptor antagonist
• Half life of Daclizumab is 3 weeks and that of Infliximab is 1 week
14. Anti CD3 antibody:
Muromonab CD3
• It is a murine antibody
• Binds to CD3 antigen and subsequently obstruct MHC complex binding to helper T cells
• Oldest discovered antibody
• Used for acute transplant reactions
• Causes cytokine release syndrome associated to chills and fever
• Dose 10mg/kg i.v
Polyclonal antibodies
• Includes two drugs : Antithymocyte globulin(ATG) and Anti D immunoglobulin
• ATG is obtained from purified rabbit plasma, binds to T lymphocytes and depletes them
• Anti D immunoglobulin is human IgG antibody against Rh(D) antigen
• Both drugs are hardly used for organ transplant
Biological agents
15. Immunosuppression and Organ transplantation
Induction regimen:
1. Given pre-operative just before surgery and post
transplant for 2-12 weeks.
2. Triple therapy of cyclosporine/tacrolimus/sirolimus +
prednisolone + MMF/Azathioprine
3. Combination of sirolimus + prednisolone + MMF avoids
renal toxicity
Maintenance regimen:
1. Given for prolonged periods
2. Therapy includes cyclosporine/tacrolimus, sirolimus,
prednisolone, azathioprine/ MMF
3. Nephrotoxicity generally seen in cyclosporine and
tacrolimus, thus after a year cyclosporine is dropped
Antirejection regimen:
1. Given to suppress an acute rejection reaction
2. In case of no response, Muromonab CD3 is given as
rescue therapy
3. If maintenance therapy is not given, its addition can treat
acute rejection reactions
Adverse effects:
1. Increased risk of bacterial, viral, fungal and other
opportunistic infections
2. Leads to development of melanoma and lymphoma after
a long latency
16. Summary
• Immunosuppressive drugs are used to treat variety of autoimmune disorders and other diseases
• Recently, role of these drugs have been defined and included for management of COVID-19 Infection,
owing to their potential to alleviate ‘cytokine storm’
• These drugs are well tolerated with minimums side effects, but problems related to opportunistic are deadly
• Maintenance therapy is very important for treating graft rejection reactions
• Prolonged use can lead to cancer of blood cells
17. References
1. K. D. Tripathi, Essentials of Medical Pharmacology, 8th Edition, Page no: 885-891, Jaypee Brothers
Medical Publishers (P) LTD, New Delhi, 2015.
2. Dale, M M, H P. Rang, and Maureen M. Dale. Rang & Dale's Pharmacology, Page no: 317-329 .
Edinburgh: Churchill Livingstone, 2007.
3. Goodman & Gilman's: The Pharmacological Basis of Therapeutics, Thirteenth Edition, Page no: 1005-
1031.
4. Satoskar, Kale, Bhandarkar's Pharmacology and pharmacotherapeutics. Chapter XV.