immuno therapy is the treatment modality used to treat, cure the cancer, and kill the cancer tumor by increasing the self defense system to fight against cancer cell
What is immunology?
What is Tumor?
Types of tumor
Classification of Malignant tumors
Malignant transformation of cells
General features of Tumor immunity
Tumor antigens
Tumor specific antigen
Tumor associated antigens
Immune response to tumor
Evasion of immune response by tumor
Cancer Immunosurveillance versus Immunoediting
Immunotechniques
RIA
ELISA
What is immunology?
What is Tumor?
Types of tumor
Classification of Malignant tumors
Malignant transformation of cells
General features of Tumor immunity
Tumor antigens
Tumor specific antigen
Tumor associated antigens
Immune response to tumor
Evasion of immune response by tumor
Cancer Immunosurveillance versus Immunoediting
Immunotechniques
RIA
ELISA
In this webinar:
Dr. Michele Ardolino, Assistant Professor at the University of Ottawa, Department of Biochemistry, Microbiology, and Immunology and Scientist Ottawa Hospital Research Institute, discusses: The body has a phenomenal weapon to fight infections and cancer: the immune system. This seminar focuses on how the immune system recognizes and shapes cancer and on how research in tumor immunology led to the development of life-saving and revolutionizing immuno-therapies.
The webinar is followed by a question & answer session.
View the video:
https://youtu.be/-a7DfHT8dU8
To learn more about CCSN, visit us at survivornet.ca
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A detailed ppt about cancer immunotherapy.
includes:-
Immunosurveillance and Immunoediting
Dentritic cell vaccines
Antibody therapy
Combined therapy
immune blockades
Cytokine therapy
T cell therapy
Include latest research finding about therapy.
IMMUNE RESPONSE TO TUMORS-Humoral immunity
-Cellular Immunity- Failure of Host Defenses
- Evasion of Immune Responses by Tumors
- Cancer Immunosurveillance vs Immunoediting- Immunotherapy
This presentation deals with the concept of Tumor immunity. It cover different types of Tumor and tumor antigens. How immunology plays role in tumor detection and diagnosis is also explained in this presentation. Concept of Tumor imunoprophylaxis and tumor immunotherapy is also explained.
In this webinar:
Dr. Michele Ardolino, Assistant Professor at the University of Ottawa, Department of Biochemistry, Microbiology, and Immunology and Scientist Ottawa Hospital Research Institute, discusses: The body has a phenomenal weapon to fight infections and cancer: the immune system. This seminar focuses on how the immune system recognizes and shapes cancer and on how research in tumor immunology led to the development of life-saving and revolutionizing immuno-therapies.
The webinar is followed by a question & answer session.
View the video:
https://youtu.be/-a7DfHT8dU8
To learn more about CCSN, visit us at survivornet.ca
Follow CCSN on social media:
Twitter - https://twitter.com/survivornetca
Facebook - https://www.facebook.com/CanadianSurv...
Instagram: https://www.instagram.com/survivornet...
Pinterest - https://www.pinterest.com/survivornet...
A detailed ppt about cancer immunotherapy.
includes:-
Immunosurveillance and Immunoediting
Dentritic cell vaccines
Antibody therapy
Combined therapy
immune blockades
Cytokine therapy
T cell therapy
Include latest research finding about therapy.
IMMUNE RESPONSE TO TUMORS-Humoral immunity
-Cellular Immunity- Failure of Host Defenses
- Evasion of Immune Responses by Tumors
- Cancer Immunosurveillance vs Immunoediting- Immunotherapy
This presentation deals with the concept of Tumor immunity. It cover different types of Tumor and tumor antigens. How immunology plays role in tumor detection and diagnosis is also explained in this presentation. Concept of Tumor imunoprophylaxis and tumor immunotherapy is also explained.
Immunotherapeutics (Types of immunotherapeutics, humanisation antibody therap...NikitaBankoti2
Immunotherapy
➢ Treatment to stimulate or restore the ability of the immune (defence) system to fight
against infection or disease.
➢ It is also sometimes called Biologic therapy or Biotherapy.
➢ Biological therapy is thus any form of treatment that uses the body’s natural abilities
that constitute the immune system to fight infection and disease or to protect the body
from some of the side effects of treatment e.g. – cancer.
Types of Immunotherapeutics
1. Monoclonal antibody
2. Cancer vaccines therapy
3. Immune checkpoint inhibitors
4. Non-specific Immunotherapies
5. Chimeric antigen receptor (CAR) T-cell therapy
Humanized Antibody- They are antibodies from non-human species whose protein sequences have
been modified to increase their similarity to antibody variants produced naturally in humans.
➢The process of humanization is usually applied to monoclonal antibodies developed for administration
to humans. (e.g- antibodies developed as anti-cancer drugs)
We know that mesothelioma patients would rather stay local when receiving treatment,rnso we will review options for private medical centers, surgical consultants, clinical trials,rnand match you up with friendly, local physicians wherever we can.
Learn about the immune system and what Nature's Sunshine supplements you can take to help protect it. For more help on natural health and fitness be sure to visit BrilliantHealthandFitness.com or order supplements directly from Natures Sunshine. Be sure to use sponsor MCM Products, LLC (Sponsor Number: 2849323).
Cancer is one of the most challenging diseases and up until now. One of the most challenging things about cancer treatment is not the cure itself but the differentiation between the tumor cells and the normal cells. Most of the medical treatments of the cancer today cannot differentiate between the cancer cells and the normal one as well as it damages the hall tissue and it is still considered as a low-effect treatment to be applied in cancer. One of the most popular treatments of this kind is chemotherapy which is known for damaging the hall cells, cancer, and normal ones. Our research is focusing on generating a new therapy that can target the cancer cell itself so it will give us more efficiency ratio to stop cancer and will keep the other cells without any damage. We will use an antibody body for the protein antigen ErbB-2 which is located rabidly in the lung cancer cells' membrane surface. These antibodies will be produced by the immune system so it will target the tumor cells especially and stop the cell growth and damage it in some cases.
Chest physiotherapy (CPT) refers to a group of therapies used in combination to mobilize pulmonary secretions. CPT is helpful to mobilize or loosen the secretions in the lungs and respiratory tract especially for patients with large amount of secretions or ineffective cough.
this slide will help the students and other care provider to know about importance of chest physiotherapy and its practical use and able to write in exam if asked
and to improve nurses in their skills regarding chest physiotherapy as well as to teach to their colleague and students
thank you !!!!
otitis media is the inflammation of the ear drum or tympanic membrane this topic include its definition , etiology, pathophysiology, clinical manifestation, diagnosis and its treatment which can be used by nursing students for taking care of the patient suffering from otitis media and for learning for their examination and knowledge purpose
and care of the child with acute otitis media and chronic otitis media and make their family aware about the complication of the otitis media like hearing loss meningitis
Anatomy and physiology of male reproductive systemPallavi Lokhande
The organs of the male reproductive system include the testes, a system of ducts (including the epididymis, ductus deferens, ejaculatory ducts, and urethra), accessory sex glands (seminal vesicles, prostate, and bulbourethral glands), and several supporting Structures, including the scrotum and the penis.
and knowledge of this system can help in knowing abnormality in it as well as can be used as study material
The respiratory system (also respiratory apparatus, ventilatory system) is a biological system, consisting of specific organs and structures used for gas exchange in human.
and the knowledge of this system give details view regarding respiratory system and its abnormality
vitals sign is the basic parameter used for all the patients to know the vital and general parameter for the patients and any changes in this parameter can cause the life threatening condition for the patients or clients life the proper technique and its alternatives assessment knowledge can help the nurses to improve academic performance and can be apply this knowledge in their clinical practices
pelvic inflammatory disease is the infectious disease in the female upper genital organ and its causes discomfort to the patient and knowledge of this ppt can help the patients and nurses to know the disease process well and can apply this knowledge into their clinical practices
amenorrhea is a condition when female do not have regular mensural cycles by puberty or due to any causes this ppt can help the patient and nurses to gain knowledge about this disease process and apply their knowledge into their clinical practices
abortion or miscarriage is the condition which causes the end of pregnancy before the child can survive extrauterine area this ppt include abortion and its management and this ppt help nurses to know this condition well and apply this condition in their clinical practice
abnormal uterine bleeding or vaginal bleeding the the conditions refer to female genital organ disfunction and term with their meaning this ppt include different bleeding pattern in female its terminology and its management this ppt help the nurses to know the disease condition well and apply this knowledge in their clinical practice and in their academic performance
stomach cancer is the common melignancy in male and female can leads to death of patient this ppt help in knowing the condition and its management and help nurses for their knowledge, to improve academic performance and application in their clinical practice
cancer of rectum is the abnormal proliferation of the rectal cells this ppt will help the nursing students to know the disease process and its management and also this help the students to apply these in their clinical practice and to improve their academic performance
cancer of the larynx is also known as the cancer of voice box and basic knowledge about this is important to treat the patient and give better care for the patient this knowledge will help the nursing students to give better care, to improve their academic performance and to improve their skills in their clinical practice
lungs cancer is the 2nd most common cancer in males with high morbidity and mortality the treatment of this type cancer and its knowledge, awareness is very important in both health care workers and general public this ppt is help nurses to know about this type of cancer and application of this knowledge in there clinical practice and in their theoretical knowledge, examination
documentation and reporting is the basic of nursing care and can be used in all health care setting why, how and when to documented that is described in the ppt the nurses and all health care professional for study, examination and application of this knowledge into their clinical practice
bone marrow transplant is the surgical procedure for replacement of the cancerous or abnormal cells present in the blood or cells and to improve the blood quality and quantity to fight against the diseases and for learning purpose for all the nursing student and application of these knowledge in their clinical practice
directing process is a process of advising, supervision, motivation, and capacity of influence other in any organization, it helps in formulating leader, leadership skills and also can be used as a study material by nurses and nurse manager for their knowledge skill development and application in their clinical practice and examination
oral cancer is the common melignancy in male and can leads to death of patient and social isolation among patient this ppt help in knowing the condition and refers by nurses for their knowledge and application in their clinical practice
cervical cancer is the most common type of cancer in females and death by its meglancy, there are many female who are unaware of this cancer and its treatment, early detection and its treatment can help females in good prognosis and speedly recovery and can be refer by all nursing student for their knowledge, study, improving skills and application in their clinical practices
breast cancer is the malignent condition of breast and it is the 2nd most common cancer in females with needs to be special attention as it its a very private things for female for early detection and its treatment, and provide a brief knowledge regarding breast cancer to all the nursing students and for their application in their c
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ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
2. CANCER
• Cancer is the uncontrolled proliferation
abnormal cells in the body.
There are five main categories of cancer:
1. Carcinomas begin in the skin or tissues that line
the internal organs.
2. Sarcomas develop in the bone, cartilage, fat,
muscle or other connective tissues.
3. Leukemia begins in the blood and bone
marrow.
4. Lymphomas start in the immune system.
1. Central nervous system cancers develop in the
brain and spinal cord.
3. TREATMENT FOR CANCER
Treatment options depend on the type of cancer, its stage
(if the cancer has spread) and general health. The goal of
treatment is to kill as many cancerous cells while
minimizing damage to normal cells nearby.
The four main treatments are:
1. SURGERY : directly removing the tumor
2. CHEMOTHERAPHY : using chemicals to kill
cancer cells
3. RADIATION : using X-rays to kill cancer
cells
4. IMMUNOTHERAPHY : Boosting immune
system
4. CANCER
IMMUNOTHERAPY
BIOLOGIC THERAPY or BIOTHERAPY.
Immuno therapy for cancer was first
introduced by
ROSENBERG & et.al, National
Institute of Health, USA.
It is a type of cancer treatment designed to
boost the body's natural defenses to fight
the cancer.
5. Definition
Immunotherapy can be defined as
boosting the own immune system to
kill the abnormal cell / cencerous cell
and cure, control or protect the
patients from cancer
6. • Cancer immunotherapy harness & enhances the innate
powers of the immune system to fight cancer.
• It represents the most promising new cancer treatment
approach since the development of the first
chemotherapies in the late 1940’s.
• Cancer immunotherapy today is a highly active &
exciting field, with unprecedented potential to deliver on
the decades-long promise of discovering, developing,
delivering safe & effective treatments that make a
meaningful difference in the lives of patients fighting the
disease.
7. IMPORTANCE OF IMMUNE
THERAPY
• our immune system is a collection of organs,
special cells, and substances that help
protect us from infections and some other
diseases.
• Immune cells and the substances travel
through out our body to protect us from
germs that cause infections.
• Germs like viruses, bacteria, and parasites
are like hostile, foreign armies that are not
normally found in your body.
8. • They try to invade your body to use host
resources and result in harmful effects.
• our immune system is our body’s defense
force.
• Sometimes the immune system doesn’t see the
cancer cells as foreign because the cells are not
different enough from normal cells. Sometimes
the immune system recognizes the cancer cells,
but the response might not be strong enough to
destroy the cancer.
9. To overcome this, researchers have
found ways to help the immune
system recognize cancer cells and
strengthen its response, so that
immune system will destroy them.
10. • Immunotherapy use immune system
components such as proteins called antibodies
that are made in the lab.
• They boost the immune system once they are
in the body.
• The antibodies themselves target certain
proteins that help cancer cells grow.
• By binding to cancer-aiding proteins, the
antibodies stop cancer cells from growing or
make them die.
• These types of antibodies are also known as
TARGETED THERAPHY.
11. TYPES OF IMMUNOTHERAPY
• MONOCLONAL ANTIBODIES: These are
INVITRO versions of immune system proteins.
Antibodies can be very useful in treating cancer
because they can be designed to attack a very
specific part of a cancer cell.
12. • CANCER VACCINES: Vaccines are
substances put into the body to start an
immune response against certain
diseases. We usually think of them as
being given to healthy people to help
prevent infections. But some vaccines
can help prevent or treat cancer.
• NON-SPECIFIC IMMUNTHERAPIES:
These treatments boost the immune
system in a general way, but this can
still help the immune system attack
cancer cells.
13. 1. MONOCLONAL ANTIBODIES
• One way the immune system attacks foreign
substances in the body is by making large numbers of
antibodies.
• An antibody is a protein that sticks to a specific
protein called an antigen
• . Antibodies circulate in the body until they find and
attach to the antigen.
• Once attached, they can recruit other parts of the
immune system to destroy the cells containing the
antigen.
• the copies of that antibody synthesised in the lab.
These are known as monoclonal antibodies (mAbs or
moAbs).
14. • To make a monoclonal antibody, researchers first
have to identify the right antigen to attack. For cancer,
this is not always easy.
• Over the past couple of decades, the US Food and Drug
Administration (FDA) has approved more than a dozen
mAbs to treat certain cancers.
a. Naked monoclonal antibodies
Example : alemtuzumab (Campath®), which is used to
treat some patients with chronic lymphocytic leukemia
(CLL).
• Alemtuzumab binds to the CD52 antigen, which is
found on cells called lymphocytes (which include the
leukemia cells).
• Once attached, the antibody attracts immune cells to
destroy these cells.
15. b. Radiolabeled antibodies have small radioactive
particles attached to them.
Eg: Ibritumomab tiuxetan (Zevalin®) is an example of a
radiolabeled mAb. This is an antibody against the
CD20 antigen, which is found on lymphocytes called B
cells. The antibody delivers radioactivity directly to
cancerous B cells and can be used to treat some
types of non-hodgkinlymphoma.
c. Chemolabeled antibodies: These mAbs have
powerful chemotherapy (or other) drugs attached to
them. They are also known as antibody-drug
conjugates (ADCs). (The drug is often too powerful to
be used on its own – it would cause too many side
effects if not attached to an antibody.)
16. 2. CANCER VACCINES
vaccines use weakened or killed germs like viruses or
bacteria to start an immune response in the body.
Getting the immune system ready to defend against
these germs helps keep people from getting infections.
Some cancer treatment vaccines are made up of cancer
cells, parts of cells, or pure antigens.
Sometimes a patient’s own immune cells are removed
and exposed to these substances in the lab to create the
vaccine. Once the vaccine is ready, it’s injected into the
body to increase the immune response against cancer
cells.
17. • Cancer vaccines cause the immune system to attack
cells with one or more specific antigens. Because the
immune system has special cells for memory, it’s
hoped that the vaccine might continue to work long
after it’s given.
• Sipuleucel-T (Provenge®) is the only vaccine
approved so far by the US Food and Drug
Administration (FDA) to treat cancer. It is used to
treat advanced prostate cancer that is no longer
being helped by hormone therapy.
18. PROCEDURE FOR CANCER VACCINE
1. immune system cells are removed from the patient’s
blood and sent to a lab.
2. There they are exposed to chemicals that turn them
into special immune cells called dendritic cells.
3. They are also exposed to a protein calledprostatic
acid phosphatase (PAP), which should produce an
immune response against prostate cancer.
4. The dendritic cells are then given back to the patient
by infusion into a vein (IV).
5. This process is repeated twice more, 2 weeks apart,
so that the patient gets 3 doses of cells.
6. Back in the body, the dendritic cells help other
immune system cells attack the prostate cancer.
19. 3. NON-SPECIFIC CANCER
IMMUNOTHERAPIES AND ADJUVANTS
• Non-specific immunotherapies don’t target cancer
cells specifically.
1. Cytokines
• Cytokines are chemicals made by some immune
system cells. They are crucial in controlling the
growth and activity of other immune system cells
and blood cells in the body.
• Cytokines are injected, either under the skin, into a
muscle, or into a vein. The most common ones are
discussed here.
20. 2. Interleukins
• (IL-2) helps immune system cells grow and divide more
quickly. A man-made version of IL-2 is approved to
treat advanced kidney cancer and
metastatic melanoma.
3. Interferons
• Interferons, first discovered in the late 1950s, help the
body resist virus infections and cancers. The types of
interferon (IFN) are named after the first 3 letters of
the Greek alphabet: IFN-alfa, IFN-beta, and IFN-
gamma.
• Only IFN-alfa is used to treat cancer. It boosts the
ability of certain immune cells to attack cancer cells. It
may also slow the growth of cancer cells directly, as
well as the blood vessels that tumors need to grow.
21. The FDA has approved IFN-alfa for use against
these cancers:
• Hairy cell leukemia
• Chronic myelogenous leukemia (CML)
• Follicular non-Hodgkin lymphoma
• Cutaneous (skin) T-cell lymphoma
• Kidney cancer
• Melanoma
• Kaposi sarcoma
22. Nursing management
Assess the patients condition for immune
system
Provide psychological support
Wear PPE for patient and personal
safety
Properly sent sample to the laboratory
with date and time of sample drawn
Check for any adverse reaction during
treatment
Inform to doctors for presence of any
side effect
23. Reassessment of vitals organ for their
proper functioning
Provide the patient with high protein
and calcium rich diet