This document summarizes a breakout session at a health literacy conference on using tweets for engagement and health messaging. It introduces the three presenters and their areas of expertise in health communication and social media. It then outlines the objectives of the session, which are to effectively use Twitter and tweet chats for health literacy messaging, establish and structure tweet chats, and analyze participant feedback. The rest of the document provides details on how to create effective health messages as tweets, examples of good and bad tweets, how to create and structure a tweet chat, and Twitter tools and etiquette.