HxRefactored - Mad*Pow - Dustin Ditommaso
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The document discusses concepts from Michel Foucault and ED Deci & Richard Ryan regarding technologies of power, technologies of the self, and self-determination. It notes that technologies of the self can be technologies of domination, and that one can be as tyrannical toward oneself as others can be through control. The document also briefly outlines behaviorism and its non-motivational account of human behavior based on external environmental factors and reinforcements rather than internal intentionality or motivation.
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Last year at HxRefactored, we launched the "A Bill You Can Understand" Challenge. Now hear the latest on this challenge and what's to come!
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As the debate in Washington rages on the future of the Affordable Care Act, one set of reforms continues unabated - the movement to redesign the care delivery system around a patient’s needs. In this session, Aneesh will share his perspective on why we are entering the golden era of IT-fueled care delivery innovation, and issue a call to action for developers and designers to put the emerging open API standards to work in helping consumers taking a more active role in navigating the health care delivery system. He will offer a pragmatic path to build the necessary foundation for organizing, enriching and (securely) sharing patient health data, including taking full advantage of the emerging “health internet,” efforts worth advancing even amidst this period of policy uncertainty.
HXR 2017: Amy Cueva, Mad*Pow: Purpose Driven Design
The health care industry is in the midst of a great deal of disruption and change. We are trying to heal pain and improve care but we know that technology isn't always the answer. How can we channel our empathy to better understand the health ecosystem and re-orient it to deliver meaningful change? Hear from Amy as she speaks on how purpose-driven design can provide us with a solution
HXR 2016: Sustainable Design -Jen Briselli, James Christie, Mad*Pow
Discover the carbon impact of the internet (hint: it's bigger than that of entire countries and due to hit 9 billion tons of CO2 by 2020)
How to design, build, and host low-carbon websites
Learn behavior change techniques that can help consumers make greener choices online
Attitudes and beliefs: design for audiences with diverse world-views (including those who disagree about climate change)
HXR 2016: Designing for Addiction and Recovery -Mary Beth Schoening, Behavior...
This panel is comprised of parents who’ve lost their children to addiction, a parent whose son is in recovery, and individuals themselves in long-term recovery. We will hear directly from them about their struggles, the impact on individuals and families dealing with addiction, as well as their opinions on where the system could benefit from solutions. The addiction issue is complex and would benefit from solutions in many areas. We invite you to join us to hear first hand.
HXR 2016: Addressing the Opioid Crisis
David W Casavant and Stephen Carson present on the Online Pediatric Pain and Opioid Education Program. The presentation discusses treating non-cancer pain with minimal risk of addiction or abuse, focusing on physician compensation and patient satisfaction. Resources are provided from the Substance Abuse and Mental Health Services Administration on the 2013 National Survey on Drug Use and Health.
HXR 2016: New Models for Care Delivery -Andrew Schutzbank, Iora Health
Andrew’s passion for revolutionizing health care began as a medical student at Tulane in pre- and post-Katrina New Orleans, continuing during his Internal Medicine & Primary Care residency at the Beth Israel Deaconess Medical Center. Andrew has worked across Iora Health since its founding: building the collaborative care platform, advancing a dynamic model of primary care.
HXR 2016: New Models for Care Delivery -Ethan Berke, Dartmouth-Hitchcock
ImagineCare is a digital health platform developed by Dartmouth-Hitchcock Health System to help people better manage chronic diseases. The platform was designed using principles of behavior change and focuses on making services easy to use, continuously valuable, and aimed at behavior modification. It incorporates consumer health wearables, evidence-based care pathways, and secure cloud technologies. The goal of ImagineCare is to empower individuals to live healthier lives and better self-manage chronic conditions through a mobile app that enables 24/7 access to personalized care plans, remote patient monitoring, and proactive support.
HXR 2016: Human Focused Innovation in a Clinical Setting -Lesley Solomon, Bri...
The Brigham and Women's Hospital Innovation Hub (iHub) was created to foster innovation among clinicians and staff and help move ideas from concept to implementation. The iHub provides programs like innovation accelerators and advisory services to help innovators overcome common barriers to innovation such as lack of funding, time, and clarity on next steps. Notable innovations supported include reducing MRI analysis time from 3 days to 3 seconds. Innovators report that the iHub helped connect them to resources and partners to further develop their ideas.
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HXR 2017: Denise Gosnell, Pokitdok: Blockchain: The Now and The Future:
HXR 2017: Denise Gosnell, Pokitdok: Blockchain: The Now and The Future:
HXR 2017: Susan Hunt Stevens, WeSpire: Holistic Wellbeing
HXR 2017: Susan Hunt Stevens, WeSpire: Holistic Wellbeing
HXR 2017: John Weiss, Human Design: Building a Culture of Health
HXR 2017: John Weiss, Human Design: Building a Culture of Health
HXR 2017: Heather Patrick, Carrot Sense: Motivation and Health Behavior Change
HXR 2017: Heather Patrick, Carrot Sense: Motivation and Health Behavior Change
HXR 2017: Bakul Patel: How the FDA Is Promoting Innovation and Protecting the...
HXR 2017: Bakul Patel: How the FDA Is Promoting Innovation and Protecting the...
HXR 2017: Jay Gupta, RxRelax: RxRelax to Reverse Polypharmacy Trends
HXR 2017: Jay Gupta, RxRelax: RxRelax to Reverse Polypharmacy Trends
HXR 2017: Kathleen Howland, Berklee College of Music: Music Therapy in Health...
HXR 2017: Kathleen Howland, Berklee College of Music: Music Therapy in Health...
HXR 2017: Center for Health Experience Design Announcement
HXR 2017: Center for Health Experience Design Announcement
HXR 2017: Paul Kahn, Mad*Pow: Lessons Learned from a Bill you can understand
HXR 2017: Paul Kahn, Mad*Pow: Lessons Learned from a Bill you can understand
HXR 2017: Aneesh Chopra, NavHealth: Call to Action: All Hands on Deck to Brin...
HXR 2017: Aneesh Chopra, NavHealth: Call to Action: All Hands on Deck to Brin...
HXR 2017: Amy Cueva, Mad*Pow: Purpose Driven Design
HXR 2017: Amy Cueva, Mad*Pow: Purpose Driven Design
HXR 2016: Sustainable Design -Jen Briselli, James Christie, Mad*Pow
HXR 2016: Sustainable Design -Jen Briselli, James Christie, Mad*Pow
HXR 2016: Designing for Addiction and Recovery -Mary Beth Schoening, Behavior...
HXR 2016: Designing for Addiction and Recovery -Mary Beth Schoening, Behavior...
HXR 2016: New Models for Care Delivery -Andrew Schutzbank, Iora Health
HXR 2016: New Models for Care Delivery -Andrew Schutzbank, Iora Health
HXR 2016: New Models for Care Delivery -Ethan Berke, Dartmouth-Hitchcock
HXR 2016: New Models for Care Delivery -Ethan Berke, Dartmouth-Hitchcock
HXR 2016: Human Focused Innovation in a Clinical Setting -Lesley Solomon, Bri...
HXR 2016: Human Focused Innovation in a Clinical Setting -Lesley Solomon, Bri...
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PGx Analysis in VarSeq: A User’s Perspective
Since our release of the PGx capabilities in VarSeq, we’ve had a few months to gather some insights from various use cases. Some users approach PGx workflows by means of array genotyping or what seems to be a growing trend of adding the star allele calling to the existing NGS pipeline for whole genome data. Luckily, both approaches are supported with the VarSeq software platform. The genotyping method being used will also dictate what the scope of the tertiary analysis will be. For example, are your PGx reports a standalone pipeline or would your lab’s goal be to handle a dual-purpose workflow and report on PGx + Diagnostic findings.
The purpose of this webcast is to:
Discuss and demonstrate the approaches with array and NGS genotyping methods for star allele calling to prep for downstream analysis.
Following genotyping, explore alternative tertiary workflow concepts in VarSeq to handle PGx reporting.
Moreover, we will include insights users will need to consider when validating their PGx workflow for all possible star alleles and options you have for automating your PGx analysis for large number of samples. Please join us for a session dedicated to the application of star allele genotyping and subsequent PGx workflows in our VarSeq software.
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Home
Organization
Academy of Oriental Medicine at Austin
Academy of Oriental Medicine at Austin
Academy of Oriental Medicine at Austin
About AOMA: The Academy of Oriental Medicine at Austin offers a masters-level graduate program in acupuncture and Oriental medicine, preparing its students for careers as skilled, professional practitioners. AOMA is known for its internationally recognized faculty, award-winning student clinical internship program, and herbal medicine program. Since its founding in 1993, AOMA has grown rapidly in size and reputation, drawing students from around the nation and faculty from around the world. AOMA also conducts more than 20,000 patient visits annually in its student and professional clinics. AOMA collaborates with Western healthcare institutions including the Seton Family of Hospitals, and gives back to the community through partnerships with nonprofit organizations and by providing free and reduced price treatments to people who cannot afford them. The Academy of Oriental Medicine at Austin is located at 2700 West Anderson Lane. AOMA also serves patients and retail customers at its south Austin location, 4701 West Gate Blvd. For more information see www.aoma.edu or call 512-492-303434.
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Breast cancer: Post menopausal endocrine therapy
Breast cancer in postmenopausal women with hormone receptor-positive (HR+) status is a common and complex condition that necessitates a multifaceted approach to management. HR+ breast cancer means that the cancer cells grow in response to hormones such as estrogen and progesterone. This subtype is prevalent among postmenopausal women and typically exhibits a more indolent course compared to other forms of breast cancer, which allows for a variety of treatment options.
Diagnosis and Staging
The diagnosis of HR+ breast cancer begins with clinical evaluation, imaging, and biopsy. Imaging modalities such as mammography, ultrasound, and MRI help in assessing the extent of the disease. Histopathological examination and immunohistochemical staining of the biopsy sample confirm the diagnosis and hormone receptor status by identifying the presence of estrogen receptors (ER) and progesterone receptors (PR) on the tumor cells.
Staging involves determining the size of the tumor (T), the involvement of regional lymph nodes (N), and the presence of distant metastasis (M). The American Joint Committee on Cancer (AJCC) staging system is commonly used. Accurate staging is critical as it guides treatment decisions.
Treatment Options
Endocrine Therapy
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Selective Estrogen Receptor Modulators (SERMs): Tamoxifen is a SERM that binds to estrogen receptors, blocking estrogen from stimulating breast cancer cells. It is effective but may have side effects such as increased risk of endometrial cancer and thromboembolic events.
Aromatase Inhibitors (AIs): These drugs, including anastrozole, letrozole, and exemestane, lower estrogen levels by inhibiting the aromatase enzyme, which converts androgens to estrogen in peripheral tissues. AIs are generally preferred in postmenopausal women due to their efficacy and safety profile compared to tamoxifen.
Selective Estrogen Receptor Downregulators (SERDs): Fulvestrant is a SERD that degrades estrogen receptors and is used in cases where resistance to other endocrine therapies develops.
Combination Therapies
Combining endocrine therapy with other treatments enhances efficacy. Examples include:
Endocrine Therapy with CDK4/6 Inhibitors: Palbociclib, ribociclib, and abemaciclib are CDK4/6 inhibitors that, when combined with endocrine therapy, significantly improve progression-free survival in advanced HR+ breast cancer.
Endocrine Therapy with mTOR Inhibitors: Everolimus, an mTOR inhibitor, can be added to endocrine therapy for patients who have developed resistance to aromatase inhibitors.
Chemotherapy
Chemotherapy is generally reserved for patients with high-risk features, such as large tumor size, high-grade histology, or extensive lymph node involvement. Regimens often include anthracyclines and taxanes.
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HxRefactored - Mad*Pow - Dustin Ditommaso
- 7. TECHNOLOGIES OF POWER ~ MICHEL FOUCAULT | 1988 determine the conduct of individuals and submit them to certain ends or domination, objectivizing the subject.” “
- 8. TECHNOLOGIES OF THE SELF ~ MICHEL FOUCAULT | 1988 permit individuals to effect by their own means… so as to transform I themselves in order to attain a certain state of happiness, purity, wisdom, perfection, or immortality.” “
- 10. TECHNOLOGIES OF THE SELF ~ MICHEL FOUCAULT | 1988 Technologies of the self are also technologies of domination.” “
- 11. ON SELF-DETERMINATION ~ ED DECI & RICHARD RYAN | 1985 One can be as tyrannical toward oneself as others can be. The issue is not so much whether the source of control is oneself or another, but whether or not one is being controlled.” “
- 12. Origin or Pawn?
- 17. ON BEHAVIORISM « Non-Motivational Account of the Causality of Human Behavior. « Rejects internal intentionality as explanation for behavior. « Focus on external environment and reinforcements to induce action. « Reinforcements DO NOT technically motivate behavior, but they function to CONTROL its occurrence.
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