1) Existing cities and future urban development present major opportunities for reducing greenhouse gas emissions but will require systemic and integrated mitigation strategies rather than limited actions. 2) Most new urbanization and urban emissions growth will occur in developing country cities which face challenges of governance capacity and fragmentation limiting climate actions. 3) Guiding new urban development over the next few decades through low-carbon infrastructure and spatial planning represents a significant window to mitigate emissions but this opportunity is rapidly closing.