The HMP shunt involves oxidative and non-oxidative phases, with the oxidative phase consisting of 4 steps to produce NADPH and pentose sugars, and the non-oxidative phase rearranging phosphates. The shunt provides reducing power in the form of NADPH for antioxidant functions like maintaining red blood cell integrity, and produces pentose sugars used for nucleotide synthesis. Clinical significance includes G6PD deficiency causing hemolytic anemia and favism when exposed to oxidative stress, as well as other conditions related to NADPH levels like methemoglobinemia and Wernicke-Korsakoff syndrome.

1. HMP Shunt

2. Oxidative phase

3. STEP 1

4. STEP 2

5. STEP 3

6. STEP 4

7. Non-oxidative phase

8. STEP 1

12. STEP 2

14. STEP 3

15. Summary of phase 2

17. Regulation
gggGLU6PO4 is
shunted between
glycolysis and HMP
Shunt

18. • Glycolysis , gluconeogenesis and HMP shunt
are inter -related

19. Physiological significance
• 1)NADPH
• 2)Pentose sugar ribose

20. Physiological significance

21. Free radical scavenging

22. Maintenance of RBC
membrane integrity NADPH CONCENTRATION
5mM

23. Sorbitol pathway

24. Respiratory burst

26. Clinical significance
• 1)G6PD deficiency and favism
• Normal concentration of G6PD IS
• 6 – 12 U/ gm Hb
• 2)MethHb
• 3)Wernickes korsakoff syndrome