High pressure processing is an advanced non-thermal food preservation technique that uses high pressure, between 400-600 MPa, to deactivate pathogens and microorganisms at temperatures below 45°C. It was first studied in 1899 to pasteurize milk. High pressure inactivates microbes by inducing changes in cell volume according to Le Chatelier's principle and isostatic rule. Advantages include better retention of quality attributes like flavor, color and nutrients compared to heat. However, it has limitations such as high equipment costs and inability to process large volumes. It is commercially used to preserve products like jams, fruit juices, soups and meats.