The document discusses various hematological manifestations that can occur in systemic diseases. It covers how diseases like chronic disorders, malignancies, autoimmune diseases, renal diseases, liver diseases, and infections can impact red blood cells, white blood cells, platelets, and coagulation. The hematological effects are often related to the stage and chronicity of the underlying disease, and can present as anemias, leukocytosis, thrombocytopenia, or coagulation disorders. Treatment may be aimed at the underlying disease or specific hematological abnormalities.