Are you thinking about what you need to fund your company? Where do you start? Funding is not “one size fits all”. Every company has to approach their pathway to funding with a unique approach. Join our fundraising experts for an in-depth discussion of what options you have for funding and how to decide which paths are right for you and your company. We’ll have a specific focus on life science focused companies and technologies and the funding choices available for them.
Are you ready to make that leap from bootstrapping to investment capital? If you're ready to accelerate the growth of your startup, check out this presentation from Kristine Di Bacco, Associate with Fenwick and West, LLP (www.fenwick.com) and Sirk Roh, COO for Early Growth Financial Services (www.earlygrowthfinancialservices.com), which covers how to take your startup to the next level of financing -- including an in-depth look at convertible promissory notes and term sheets.
"How to maximize your potential to attract US capital" by John Bautista TheFamily
By John Bautista, Partner at Orrick.
Join us IRL next time! http://meetup.com/thefamilyspecialevents
The contents of this video are intended for general information purposes only and should not be considered or construed as legal advice. The distribution of this presentation or its content is not intended to create, and receipt of it does not constitute, an attorney-client relationship. (The views set forth herein are the personal views of the presenters and do not necessarily reflect those of Orrick, Herrington & Sutcliffe.)
Raising Capital: Negotiating with Potential Investors (Series: The Start-Up/S...Financial Poise
Every business needs capital (cash) to fund its activities. But not all capital is created equal. At the most macro level, a business can raise cash by selling equity or by borrowing (and these alternatives are not by any means mutually exclusive).
This webinar explains the different types of capital available to fund a startup; how to identify potential funding sources; how to evaluate competing funding proposals; and how (and when) to negotiate financing terms. In addition, this webinar will address the kinds of investors for entrepreneurs to consider for their start-ups.
To view the accompanying webinar, go to: https://www.financialpoise.com/financial-poise-webinars/raising-capital-negotiating-with-potential-investors-2021/
Scott droney - financing start-up and growthScott Droney
Scott Droney is provide financial services spectrum as well as data processing and managing segments. Since most of its financial services were retail focused, the need to build scale and skill in the transaction processing domain became imperative.
Analysis on an decade of data relating to start-up which would guide the budding start-ups towards the way of success and also provide them the right place for maximum funding.
Are you ready to make that leap from bootstrapping to investment capital? If you're ready to accelerate the growth of your startup, check out this presentation from Kristine Di Bacco, Associate with Fenwick and West, LLP (www.fenwick.com) and Sirk Roh, COO for Early Growth Financial Services (www.earlygrowthfinancialservices.com), which covers how to take your startup to the next level of financing -- including an in-depth look at convertible promissory notes and term sheets.
"How to maximize your potential to attract US capital" by John Bautista TheFamily
By John Bautista, Partner at Orrick.
Join us IRL next time! http://meetup.com/thefamilyspecialevents
The contents of this video are intended for general information purposes only and should not be considered or construed as legal advice. The distribution of this presentation or its content is not intended to create, and receipt of it does not constitute, an attorney-client relationship. (The views set forth herein are the personal views of the presenters and do not necessarily reflect those of Orrick, Herrington & Sutcliffe.)
Raising Capital: Negotiating with Potential Investors (Series: The Start-Up/S...Financial Poise
Every business needs capital (cash) to fund its activities. But not all capital is created equal. At the most macro level, a business can raise cash by selling equity or by borrowing (and these alternatives are not by any means mutually exclusive).
This webinar explains the different types of capital available to fund a startup; how to identify potential funding sources; how to evaluate competing funding proposals; and how (and when) to negotiate financing terms. In addition, this webinar will address the kinds of investors for entrepreneurs to consider for their start-ups.
To view the accompanying webinar, go to: https://www.financialpoise.com/financial-poise-webinars/raising-capital-negotiating-with-potential-investors-2021/
Scott droney - financing start-up and growthScott Droney
Scott Droney is provide financial services spectrum as well as data processing and managing segments. Since most of its financial services were retail focused, the need to build scale and skill in the transaction processing domain became imperative.
Analysis on an decade of data relating to start-up which would guide the budding start-ups towards the way of success and also provide them the right place for maximum funding.
Venture Financings 101 (SAFEs, Convertible Notes, Seed and Series A) | Bardia...UCICove
An introductory crash course on the typical legal and business terms involved with, and negotiated in, venture capital fundraising including SAFE, Convertible Note, Series Seed and Series A financings.
Have a great idea, but not sure how to get funding to turn it into a business? This presentation highlights the many ways to find funding and focuses on the pros & cons of using venture capital to launch.
Entrepreneurs need to put a value on their start-ups in order to raise money, and investors need to put a value on their investments to ensure an adequate return on investment. No negotiating item between entrepreneur and investor creates a wider gulf than this one. The two parties may agree on every other point but will have diametrically opposing views on what the start-up is worth and how much equity the investor should receive in exchange for his capital.
Valuation is challenging for a start-up. Since young businesses take time to become profitable, the trick of valuing start-ups is to focus on the future. If you want your start-up to be a masterpiece, you’ll need to use the right side of your brain as much as your left to determine value.
Is business valuation art or science? Is it possible to place a credible valuation on a Start-up? What is Pre-money valuation? What is Post-money valuation? How much your company worth? Are you really worth anything until you’re profitable? How to value your start-up for a VC? What are the Start-up valuation methods?
Get funded Expert Advice from the People Who KnowIntelligent_ly
When it comes to startups, SVB has been around the block. Many times. They've helped countless founders and CEOs negotiate the ups and downs of startup financing.
Confused about the how to choose the right funding strategy? Don't be.
On November 12th, SVB’s Dan Allred and Smith Anderson will break it down for you. They'll introduce five of the most important and popular avenues for startup funding:
Bootstrapping
Crowdfunding
Angel Investors
Venture Capital
Debt
Managing startup equity (Equity For Startups)Kesava Reddy
Among the more important decisions that an entrepreneur makes is that of raising capital. Many choices have to be made in this context: Debt versus Equity. Own funds versus Funding from outside investors and so on. These choices have long term implications for the entrepreneur as well as the start-up. Equity funding is essential for the growth of a startup. Apart from providing critical funding equity investors also often bring added value by way of connections and strategic advice.
At the same time raising equity capital means sharing control and sharing wealth with the investors in the firm. Allowing investors to engage with the management of the startup calls for a certain degree of compatibility between the investor and the management of the enterprise. Absence of such compatibility can lead to unhappy relationships between the investor and the management team.
All things considered, managing the equity of a start-up is among the most critical decisions that an entrepreneur needs to make. It involves many trade-offs on the entrepreneurial journey. Which makes Managing the Equity of A Start Up a challenge. What does dilution of equity mean? How does the arithmetic of dilution work? How does an entrepreneur decide on when to raise equity? And how much of equity to raise?
Angel investing is a great way to participate in the growing trend of entrepreneurship. Responsible investing is very important for the health of your portfolio and for your relationships with founders. Don't invest without understanding a few simple things. Equity investments are long term relationships. Investors must do their part to be good investment partners.
Cashing in - how to make money investing in startupsOurCrowd
Join Zack Miller, Head of the Investor Community at OurCrowd, and David Stark, Investment Associate at OurCrowd, as they discuss the investment strategies necessary to build and maintain a successful startup portfolio. By nature, startup investments are a high risk/high reward asset class. Knowledge, therefore, is key in maximizing your profit potential when investing in startups.
Join us to learn:
The startup math that investors use to get rich
Understand how companies' valuations change over time and what that means for your investments</li>
Learn how OurCrowd and other startup investors see an eventual return on their investment and how those returns are calculated
This webinar is appropriate for both investors and entrepreneurs alike.
A short introduction to Venture Capital Term Sheets, and in particular the concept of liquidation preferences. Leo Dirac's talk from Ignite Seattle 4. For more detail, see http://embracingchaos.com/business
Are you a physician, innovator, or entrepreneur with a commercial idea and ready to make it a fundable company? Join us for this full-day program to understand today’s unique challenges for life science, med device, and healthcare entrepreneurs starting companies and raising capital. Learn from and meet some of the leading life science investors, entrepreneurs, and early-stage experts in New England.
Building on the success of The Capital Network’s annual Fast Track Boot Camp for Entrepreneurs, this Life Science Fast Track is an intensive, interactive full-day seminar designed to provide entrepreneurs and innovators an in-depth understanding of what it takes to raise early stage capital for a life science startup.
Venture Financings 101 (SAFEs, Convertible Notes, Seed and Series A) | Bardia...UCICove
An introductory crash course on the typical legal and business terms involved with, and negotiated in, venture capital fundraising including SAFE, Convertible Note, Series Seed and Series A financings.
Have a great idea, but not sure how to get funding to turn it into a business? This presentation highlights the many ways to find funding and focuses on the pros & cons of using venture capital to launch.
Entrepreneurs need to put a value on their start-ups in order to raise money, and investors need to put a value on their investments to ensure an adequate return on investment. No negotiating item between entrepreneur and investor creates a wider gulf than this one. The two parties may agree on every other point but will have diametrically opposing views on what the start-up is worth and how much equity the investor should receive in exchange for his capital.
Valuation is challenging for a start-up. Since young businesses take time to become profitable, the trick of valuing start-ups is to focus on the future. If you want your start-up to be a masterpiece, you’ll need to use the right side of your brain as much as your left to determine value.
Is business valuation art or science? Is it possible to place a credible valuation on a Start-up? What is Pre-money valuation? What is Post-money valuation? How much your company worth? Are you really worth anything until you’re profitable? How to value your start-up for a VC? What are the Start-up valuation methods?
Get funded Expert Advice from the People Who KnowIntelligent_ly
When it comes to startups, SVB has been around the block. Many times. They've helped countless founders and CEOs negotiate the ups and downs of startup financing.
Confused about the how to choose the right funding strategy? Don't be.
On November 12th, SVB’s Dan Allred and Smith Anderson will break it down for you. They'll introduce five of the most important and popular avenues for startup funding:
Bootstrapping
Crowdfunding
Angel Investors
Venture Capital
Debt
Managing startup equity (Equity For Startups)Kesava Reddy
Among the more important decisions that an entrepreneur makes is that of raising capital. Many choices have to be made in this context: Debt versus Equity. Own funds versus Funding from outside investors and so on. These choices have long term implications for the entrepreneur as well as the start-up. Equity funding is essential for the growth of a startup. Apart from providing critical funding equity investors also often bring added value by way of connections and strategic advice.
At the same time raising equity capital means sharing control and sharing wealth with the investors in the firm. Allowing investors to engage with the management of the startup calls for a certain degree of compatibility between the investor and the management of the enterprise. Absence of such compatibility can lead to unhappy relationships between the investor and the management team.
All things considered, managing the equity of a start-up is among the most critical decisions that an entrepreneur needs to make. It involves many trade-offs on the entrepreneurial journey. Which makes Managing the Equity of A Start Up a challenge. What does dilution of equity mean? How does the arithmetic of dilution work? How does an entrepreneur decide on when to raise equity? And how much of equity to raise?
Angel investing is a great way to participate in the growing trend of entrepreneurship. Responsible investing is very important for the health of your portfolio and for your relationships with founders. Don't invest without understanding a few simple things. Equity investments are long term relationships. Investors must do their part to be good investment partners.
Cashing in - how to make money investing in startupsOurCrowd
Join Zack Miller, Head of the Investor Community at OurCrowd, and David Stark, Investment Associate at OurCrowd, as they discuss the investment strategies necessary to build and maintain a successful startup portfolio. By nature, startup investments are a high risk/high reward asset class. Knowledge, therefore, is key in maximizing your profit potential when investing in startups.
Join us to learn:
The startup math that investors use to get rich
Understand how companies' valuations change over time and what that means for your investments</li>
Learn how OurCrowd and other startup investors see an eventual return on their investment and how those returns are calculated
This webinar is appropriate for both investors and entrepreneurs alike.
A short introduction to Venture Capital Term Sheets, and in particular the concept of liquidation preferences. Leo Dirac's talk from Ignite Seattle 4. For more detail, see http://embracingchaos.com/business
Are you a physician, innovator, or entrepreneur with a commercial idea and ready to make it a fundable company? Join us for this full-day program to understand today’s unique challenges for life science, med device, and healthcare entrepreneurs starting companies and raising capital. Learn from and meet some of the leading life science investors, entrepreneurs, and early-stage experts in New England.
Building on the success of The Capital Network’s annual Fast Track Boot Camp for Entrepreneurs, this Life Science Fast Track is an intensive, interactive full-day seminar designed to provide entrepreneurs and innovators an in-depth understanding of what it takes to raise early stage capital for a life science startup.
Terra Prima Partners - Investing in Sustainable Solutions that WILL change th...Anric Blatt
Terra Prima is a venture capital and private equity firm that helps entrepreneurs turn breakthroughs within emerging Renewable and Sustainable Life and Physical Science Technologies into world-changing businesses.
Led by leading experts in the field of startup financing, the limited-seat Fast Track is an intensive, interactive full-day seminar designed to provide entrepreneurs and investors an in-depth understanding of what it takes to raise early-stage capital for a startup.
http://www.thecapitalnetwork.org/programs/venture-fast-track/
Founder Equity Issues: Structuring Founder Relationships, Stockholder Agreeme...The Capital Network
Paul Sweeney - Founder Equity 2013
As you set up your company and add co-founders, investors and staff it’s important that your stockholder agreements are structured correctly. This lunch will cover invaluable information on structuring founder equity to avoid the pitfalls that can harm a company’s ability to attract investment capital.
Working lunch programs are hosted by The Capital Network’s professional service sponsors in New England to provide tactical level information designed to accelerate entrepreneurial development and fundraising processes for Boston-area startups.
www.thecapitalnetwork.org
Funding options early stage companies april30 v2-lsn.pptx
Are you thinking about what you need to fund your company? Where do you start?
Funding is not one size fits all. Every company has to approach their pathway to funding with a unique approach. Join our fundraising experts for an in depth discussion of what options you have for funding and how to decide which paths are right for you and your company.
Topics covered will include investment criteria, time to closing, investment range, success rates, control features, compliance requirements and the overall costs of capital from each such source.
www.thecapitalnetwork.org
Are you thinking about what you need to fund your company? Where do you start? Funding is not “one size fits all”. Every company has to approach their pathway to funding with a unique approach. Join our fundraising experts for an in-depth discussion of what options you have for funding and how to decide which paths are right for you and your company. Topics covered will include investment criteria, time to closing, investment range, success rates, control features, compliance requirements and the overall costs of capital from each such source.
Jean Hammond – LearnLaunchX, LearnLaunch.org, Hub Angels, Launchpad Venture Group, Golden Seeds
Robert Bishop - Goodwin Procter
In partnership with:
Founders Workbench
Funding Options at Harvard iLab
Are you thinking about what you need to fund your company? Where do you start? Funding is not one size fits all. Every company has to approach their pathway to funding with a unique approach. Join our fundraising experts for an in depth discussion of what options you have for funding and how to decide which paths are right for you and your company. Topics covered will include investment criteria, time to closing, investment range, success rates, control features, compliance requirements and the overall costs of capital from each such source.
www.thecapitalnetwork.org
Presentation on the investment basics for Startups. Essentials of startup investments, focusing on funding cycles, risk management and investor structures.
Babson How2Tuesdays: How to Raise a Seed Round - Feb 2020David Chang
Overview of tech/startup fundraising basics, a 5-step how-to on the tactics of raising a seed round from angels/VCs, and some key pitch tips/lessons learned
From the Women Helping Women in Entrepreneurship on July 24, 2013 at MassChallenge
The Boston entrepreneurial community is home to some of the strongest and most successful women in entrepreneurship. Join the women of Golden Seeds and several local serial entrepreneurs for a discussion on sources of capital for your business. The discussion will be followed by small breakout sessions that focus on the challenges your company may be facing.
www.thecapitalnetwork.org
Part of the all day Venture Fast Track: http://www.thecapitalnetwork.org/programs/venture-fast-track/
Plan for funding: What Stage Is Your Business and What Are Your Options
Is your business an idea, in the midst of formation, or ready to raise capital? The first step to identifying what comes next is understanding the stage of your business.
Join our fundraising experts for an in-depth discussion of what options you have for funding and how to decide which ones are right for you and for your company.
Topics covered will include investment criteria, time to closing, investment range, success rates, control features, compliance requirements, and the overall costs of capital from each such source.
Experts:
- Ben Littauer – Boston Harbor Angels & Walnut Venture Associates
- Panos Panay – Sonicbids
How to Split the Pie, Raise Money, and Reward Contributors (Idea To IPO)Roger Royse
What’s my startup worth? How much equity should founders have? How much equity should I give to employees and consultants? How much should I give to the venture capitalists?
Silicon Valley startup attorney Roger Royse of the Royse Law Firm discusses the basic valuation and ownership issues involved in a startup’s life, from formation to financing to exit, including how to value your company and the contributions of stakeholders and investors at each step with a particular emphasis on different models, best practices and traps to avoid.
How do you figure out how much money you need, and when? We’ll look at a case study and talk P&L to help you determine the right market for your product and which funding source is most appropriate to maximize the exit for your company.
We originally created the 'OWN YOUR RAISE' Fellowship for Female Founders to solve some of the unique issues women founders face when it comes to raising money: lack of access to knowledge and investor networks and a need for greater confidence and executive leadership growth in scenarios where they are often the only woman in the room. But this program is now so much more: it's a safe space where Fellows can be inspired by and champion each other, connect and build on their leadership & fundraising strategy, and execute & celebrate their many milestones together.
The pressures of running a business while looking for funding causes many founders to underestimate the importance of creating a clear fundraising strategy. You don’t want to waste your time seeking capital without a clear timeline and plan. In this workshop, the experienced investors and entrepreneurs will guide you on how to best prepare, plan and execute a strategy that’s best suited to your business.
This workshop will also address the specifics of what it means to raise capital as a female founder and provide practical tips, checklists, templates and interactive exercises so you can start applying these to your company and Own Your Raise.
Key topics addressed include:
What’s the landscape of raising money for female founders?
What does raising capital mean for me and for my business?
Is my company ready to raise?
How much should I raise?
What’s the process and timeline of raising from angels/VCs?
How can I best prepare to raise my first outside capital?
How do I figure out and understand who the right investors are for my company?
How can I best align running my company and running a fundraising round?
What are the resources out there that can help me fundraise?
By attending this workshop, you will:
Understand what raising outside capital means for you and your business
Have a clear understanding of how to create a fundraising strategy that makes sense for you and for your company
Learn about resources to help you fundraise
Get checklists and templates for planning and executing your raise
Get access to the slides & recording
Please note that this is a woman-only event. Use of “women” & “female” is inclusive of and welcomes trans women, nonbinary folks, and anyone who identifies with womxnhood in any way that is significant to them.
Tcn investment & inclusion series - emerging fund managers opportunities and ...The Capital Network
Emerging Fund Managers, or those managers who generally have less than $100M under management, are managing fewer than three institutional funds, and focused on early or seed-stage ventures, have become one of the fastest-growing segments in the venture capital industry. Many of these managers come from diverse backgrounds and/or are interested in investing in diverse founders. Our conversation will highlight the opportunities and challenges faced by emerging fund managers as they aim to diversify the venture capital funding landscape.
Back in 2016, we created our 'OWN YOUR RAISE' program to solve some of the unique issues women founders face when it comes to raising money: lack of access to knowledge and investor networks and a need for greater confidence and executive leadership growth in scenarios where they are often the only woman in the room. We have created a safe space where fellows can be inspired by and champion each other, where they can connect and build on their leadership and fundraising strategy, and where they can ultimately OWN. THEIR. RAISE.
Crowdfunding has become an increasingly popular funding strategy for early stage entrepreneurs — but it’s not a guaranteed success. We’re partnering with IFundWomen, a crowdfunding platform for women-led businesses to bring you this workshop. Whether you are creating a campaign for funding or for market validation, we’ll help you create an enticing campaign that will resonate with your audience and provide your business with the capital it needs to keep growing. Our crowdfunding experts will walk you through practical ways to hone your pitch, map your network, strategically estimate your fundraising goal, market to your target audience, and design rewards that sell. We’ll also provide useful resources, playbooks, toolkits, etc that you will need to rock your crowdfunding campaign.
Cash flow is the lifeblood of a startup. Effective cash flow management is fundamental to a business’s success.
As a founder, understanding your cash position is super important and you must have a firm grasp of cash flow mechanics to keep your business operating smoothly. To help you stay on top of it, in this webinar, we’ll break down the basics of cash flow management and provide tips so you can guarantee a healthy cash flow for your business.
With a clear understanding of your company’s cash flow, you can get through downturns and be in a strong position to grow in a new post-COVID environment.
In 2016 we created the Fellowship For Female Founders, a 6 month+ program to support women from the New England area looking for their 1st outside capital to get the support they deserve.
This fellowship helps them Own Their Story, Own Their Numbers and Own Their Network so they can confidently OWN THEIR RAISE.
Tcn investment & inclusion panel - dei & vc firms- structural barriers to eq...The Capital Network
Recent conversations around DEI in VC firms have centered on diversifying portfolios and hiring. But what happens if the very organizational processes and governance of these firms are actively creating barriers to achieving DEI initiatives? In this conversation, we discuss Pledges, Riders, Board Placements and more to understand what works and doesn’t, and what VC firms can do differently to create structural change.
In 2016 we created the Fellowship For Female Founders, a 6 month+ program to support women from the New England area looking for their 1st outside capital to get the support they deserve.
This fellowship helps them Own Their Story, Own Their Numbers and Own Their Network so they can confidently OWN THEIR RAISE.
The Fellowship For Female Founders - Applications & What You Receive As A Fel...The Capital Network
In 2016 we created the Fellowship For Female Founders, a 6 month+ program to support women from the New England area looking for their 1st outside capital to get the support they deserve.
This fellowship helps them Own Their Story, Own Their Numbers and Own Their Network so they can confidently OWN THEIR RAISE.
The $2 trillion federal coronavirus relief package signed recently, officially known as the CARES Act, includes the nearly $350 Paycheck Protection Program to help small businesses affected by the Coronavirus Pandemic. The new loan program is designed to help small businesses with their payroll and other business operating expenses. The Small Business Administration (SBA) will forgive the portion of the loan proceeds that are used to cover the first eight weeks of payroll costs, rent, utilities, and mortgage interest.
The SBA and the Department of Treasury have released the information that will guide the programs. To help entrepreneurs better understand how can they benefit from the program, we created the webinar in partnership with the SBA, Cambridge Trust and the law firm Nutter to answer questions including:
Who are eligible for a Paycheck Protection Program loan?
How do businesses apply? What information is needed?
How much money can a business receive through the loan program?
When will the loans be available?
What’s the interest rate?
What does the payment schedule look like?
How does the Affiliation Rules affect VC-backed startup’s eligibility?
Can the loan eventually be forgiven? What’s the eligibility for loan forgiveness?
What if the PPP Loan does not cover a business’s needs? What are the other options under the CARES Act?
Unfamiliar with the SBIR program and don’t know where to start? Here are some tips from The Isis Group on how to prepare your company for your first SBIR/STTR submission.
You might be interested in getting your startup into an accelerator – and rest assured Boston has no shortage of options – but it’s hard to know exactly what the best options for your stage and industry are.
From business support, mentorship and desk space, to equity vs non-equity, marketing, and even prize money – accelerators offer a whole lot and can really help you develop your product, brand, and network.
Calculate Financial Projections for Investment PresentationsThe Capital Network
Financial Projections are key in all aspects of the fundraising process: Pitching, Valuation, Due Diligence, and in the long term planning of your company. Join our experts in an overview discussion of financial projections and learn the key metrics that will get investors to notice you, as well as those that will get you rejected. With the expert advice of serial Startup CFOs and VC Analysts we’ll walk you though the process of what you need to know. If you have no or little idea where to begin with your financial projections, this program is for you.
Understanding Angel & Venture Term Sheets: A Play In 3 Acts. An re-enactment of negotiations between entrepreneurs, engineers and investors. For early stage entrepreneurs and startups.
We understand the unique challenges pickleball players face and are committed to helping you stay healthy and active. In this presentation, we’ll explore the three most common pickleball injuries and provide strategies for prevention and treatment.
Struggling with intense fears that disrupt your life? At Renew Life Hypnosis, we offer specialized hypnosis to overcome fear. Phobias are exaggerated fears, often stemming from past traumas or learned behaviors. Hypnotherapy addresses these deep-seated fears by accessing the subconscious mind, helping you change your reactions to phobic triggers. Our expert therapists guide you into a state of deep relaxation, allowing you to transform your responses and reduce anxiety. Experience increased confidence and freedom from phobias with our personalized approach. Ready to live a fear-free life? Visit us at Renew Life Hypnosis..
One of the most developed cities of India, the city of Chennai is the capital of Tamilnadu and many people from different parts of India come here to earn their bread and butter. Being a metropolitan, the city is filled with towering building and beaches but the sad part as with almost every Indian city
Welcome to Secret Tantric, London’s finest VIP Massage agency. Since we first opened our doors, we have provided the ultimate erotic massage experience to innumerable clients, each one searching for the very best sensual massage in London. We come by this reputation honestly with a dynamic team of the city’s most beautiful masseuses.
CRISPR-Cas9, a revolutionary gene-editing tool, holds immense potential to reshape medicine, agriculture, and our understanding of life. But like any powerful tool, it comes with ethical considerations.
Unveiling CRISPR: This naturally occurring bacterial defense system (crRNA & Cas9 protein) fights viruses. Scientists repurposed it for precise gene editing (correction, deletion, insertion) by targeting specific DNA sequences.
The Promise: CRISPR offers exciting possibilities:
Gene Therapy: Correcting genetic diseases like cystic fibrosis.
Agriculture: Engineering crops resistant to pests and harsh environments.
Research: Studying gene function to unlock new knowledge.
The Peril: Ethical concerns demand attention:
Off-target Effects: Unintended DNA edits can have unforeseen consequences.
Eugenics: Misusing CRISPR for designer babies raises social and ethical questions.
Equity: High costs could limit access to this potentially life-saving technology.
The Path Forward: Responsible development is crucial:
International Collaboration: Clear guidelines are needed for research and human trials.
Public Education: Open discussions ensure informed decisions about CRISPR.
Prioritize Safety and Ethics: Safety and ethical principles must be paramount.
CRISPR offers a powerful tool for a better future, but responsible development and addressing ethical concerns are essential. By prioritizing safety, fostering open dialogue, and ensuring equitable access, we can harness CRISPR's power for the benefit of all. (2998 characters)
Antibiotic Stewardship by Anushri Srivastava.pptxAnushriSrivastav
Stewardship is the act of taking good care of something.
Antimicrobial stewardship is a coordinated program that promotes the appropriate use of antimicrobials (including antibiotics), improves patient outcomes, reduces microbial resistance, and decreases the spread of infections caused by multidrug-resistant organisms.
WHO launched the Global Antimicrobial Resistance and Use Surveillance System (GLASS) in 2015 to fill knowledge gaps and inform strategies at all levels.
ACCORDING TO apic.org,
Antimicrobial stewardship is a coordinated program that promotes the appropriate use of antimicrobials (including antibiotics), improves patient outcomes, reduces microbial resistance, and decreases the spread of infections caused by multidrug-resistant organisms.
ACCORDING TO pewtrusts.org,
Antibiotic stewardship refers to efforts in doctors’ offices, hospitals, long term care facilities, and other health care settings to ensure that antibiotics are used only when necessary and appropriate
According to WHO,
Antimicrobial stewardship is a systematic approach to educate and support health care professionals to follow evidence-based guidelines for prescribing and administering antimicrobials
In 1996, John McGowan and Dale Gerding first applied the term antimicrobial stewardship, where they suggested a causal association between antimicrobial agent use and resistance. They also focused on the urgency of large-scale controlled trials of antimicrobial-use regulation employing sophisticated epidemiologic methods, molecular typing, and precise resistance mechanism analysis.
Antimicrobial Stewardship(AMS) refers to the optimal selection, dosing, and duration of antimicrobial treatment resulting in the best clinical outcome with minimal side effects to the patients and minimal impact on subsequent resistance.
According to the 2019 report, in the US, more than 2.8 million antibiotic-resistant infections occur each year, and more than 35000 people die. In addition to this, it also mentioned that 223,900 cases of Clostridoides difficile occurred in 2017, of which 12800 people died. The report did not include viruses or parasites
VISION
Being proactive
Supporting optimal animal and human health
Exploring ways to reduce overall use of antimicrobials
Using the drugs that prevent and treat disease by killing microscopic organisms in a responsible way
GOAL
to prevent the generation and spread of antimicrobial resistance (AMR). Doing so will preserve the effectiveness of these drugs in animals and humans for years to come.
being to preserve human and animal health and the effectiveness of antimicrobial medications.
to implement a multidisciplinary approach in assembling a stewardship team to include an infectious disease physician, a clinical pharmacist with infectious diseases training, infection preventionist, and a close collaboration with the staff in the clinical microbiology laboratory
to prevent antimicrobial overuse, misuse and abuse.
to minimize the developme
Leading the Way in Nephrology: Dr. David Greene's Work with Stem Cells for Ki...Dr. David Greene Arizona
As we watch Dr. Greene's continued efforts and research in Arizona, it's clear that stem cell therapy holds a promising key to unlocking new doors in the treatment of kidney disease. With each study and trial, we step closer to a world where kidney disease is no longer a life sentence but a treatable condition, thanks to pioneers like Dr. David Greene.
Global launch of the Healthy Ageing and Prevention Index 2nd wave – alongside...ILC- UK
The Healthy Ageing and Prevention Index is an online tool created by ILC that ranks countries on six metrics including, life span, health span, work span, income, environmental performance, and happiness. The Index helps us understand how well countries have adapted to longevity and inform decision makers on what must be done to maximise the economic benefits that comes with living well for longer.
Alongside the 77th World Health Assembly in Geneva on 28 May 2024, we launched the second version of our Index, allowing us to track progress and give new insights into what needs to be done to keep populations healthier for longer.
The speakers included:
Professor Orazio Schillaci, Minister of Health, Italy
Dr Hans Groth, Chairman of the Board, World Demographic & Ageing Forum
Professor Ilona Kickbusch, Founder and Chair, Global Health Centre, Geneva Graduate Institute and co-chair, World Health Summit Council
Dr Natasha Azzopardi Muscat, Director, Country Health Policies and Systems Division, World Health Organisation EURO
Dr Marta Lomazzi, Executive Manager, World Federation of Public Health Associations
Dr Shyam Bishen, Head, Centre for Health and Healthcare and Member of the Executive Committee, World Economic Forum
Dr Karin Tegmark Wisell, Director General, Public Health Agency of Sweden
2. The
Panel
Jeremy
Halpern
Partner,
Nu@er
McClennen
&
Fish
jhalpern@nu@er.com
@startupboston
Yumin
Choi
Partner,
HLM
Venture
Partners
ychoi@hlmvp.com
@yuminvc
Paul
Hartung
President
and
CEO,
Cognotpix,
Inc
PHartung@cognop*x.com
3. Funding
the
Company
Assuming
you
plan
to
be
a
“high
growth”
company…
What
are
your
funding
op*ons?
4. Entrepreneurship
comes
in
many
types
4
NORMAL
GROWTH
COMPANY
HIGH
GROWTH
COMPANY
EXTREME
HIGH
GROWTH
COMPANY
SOCIAL
VENTURE
COMPANY
• Includes all
service
businesses
• Exploiting a local
market need
• Team has ‘great
jobs’
• Growth by adding
resources one by
one
• Exit will be based
on value of cash
flow (mature biz.)
• Growth profile
ultra-scalable
• Team focus is exit
• Revenue $40M+
with lots of room
for growth (5 yr.)
• Based on $20M+
investment
• Exit targeted to
IPO or by ‘large’
M&A event
• Goal is to fulfill
a social need
• Has mission
orientation
• Team needs to
support
mission
• Growth profile
often one
resource at a
time
• Exit …much
harder to find
fit
• Company can
grow fast (on-line)
or has a scalable
system
• Team often
motivated by exit
• $10m revenue in
5 yrs & market
size allows
significant
additional growth
• Capital efficient
total investment
$2-4M
• Exit by M&A
5. Close
Up:
Extreme
High
Growth
vs
High
Growth
5
Capital Needs
Time
High
Risk
Low
Risk
Formal
Venture
Capital
M&A or
IPO
Crystallize
Ideas
Demonstrate
Product
Early Scaling
Growth
Sustained
Growth
Angel Group
(or Micro-cap)
Syndication
Angels or
Accelerators
or Micro-cap
funds Angels or
Accelerators
or Micro-cap
fundsBusines
s Angels
Market Entry
M&A
Later VC
Rounds
Extreme
High Growth
High Growth
Friends,
Family &
Founders
Friends,
Family &
Founders
6. High
Growth
Company
Characteris*cs
• Disrup*ve
Innova*on
with
Strong
value
proposi*on
– Correla*on
between
Large
Unmet
Need
:
Solu*on
• High
Margin
Product
(Ra*o
of
Revenue
:
COGS)
– Some*mes
Massive
Volume
Products
where
innova*on
is
incremental
• High
Rate
of
Revenue
Growth
over
sustained
period
• Scalable
(Fixed
cost
is
a
low
percent
of
Revenue)
• No
major
barriers
to
con*nued
growth
(ex.
blocking
IP;
geography;
regulatory)
• Repeatable
sales
and
distribu*on
model
with
many
credit
worthy
customers
• Large
Total
Addressable
Market
(TAM)
• Defensible
innova*on
able
to
withstand
compe**on
and
changing
condi*ons
• [Capital
efficient]
6
7. Return
on
Equity
Return
on
Debt
Income
High
Return
NON
PROFIT
ORGANIZATION
Capital
Source
View
7
Debt-
Pay it back
Fixed Amounts
Equity –
Ownership stake
% of Future Value
Charity
$$
Impact
/
Tax
Write
off
NORMAL
GROWTH
COMPANY
HIGH
GROWTH
(COMPANY)
EXTREME
HIGH
GROWTH
(COMPANY)
Risk / Return
SOCIAL
VENTURE
COMPANY
8. Match
Funding
Sources
8
NORMAL
GROWTH
COMPANY
HIGH
GROWTH
COMPANY
EXTREME
HIGH
GROWTH
COMPANY
SOCIAL
VENTURE
COMPANY
• Friends family,
founders
• Debt Bank and
other
• (Future) Crowd
funding (portal
style)
Early on
• Accelerators
• Individual Angels
• Micro Cap VCs
• Seed from VC
Later stages
• Venture Funds
• Strategic VCs
• Angel
Syndication
• Friends
family,
founders
• Charity$$
• Crowds (Kick-
starter)
• Impact Angels
• (Future)
Crowd funding
(portal style)
• Angels
• Angel Groups
• Angel Group
Syndication
• Angel List
• Micro-cap Funds
• (Future) Crowd
funding (portal
style)
• Increasingly
Strategic
Corporate VCs
9. Non-‐Equity
Sources
• Accelerators
(some)
• Kickstarter
type
dona5ons
• Pre-‐orders
from
end-‐customers
• Credit
from
vendors
• Strategic
VCs
• Strategic
NREs
• Distribu5on
Contracts
Common
Theme:
Providing
early
cash
in
exchange
for
a
beHer
commercial
opportunity
9
10. Equity
Sources
• Accelerators
(some)
• Friends
&
Family
Common
Theme:
Suppor5ng
success
of
the
entrepreneur;
business
terms
vary
• Portal
Funding
• Early
Angels
• Super
Angels
• Angel
Groups
• Micro
VC
• Tradi5onal
VC
(1st
Round)
Common
Theme:
All
are
looking
for
– sale
(or
IPO)
of
the
Company
at
4-‐10
x
original
investment
– Capital
gains
treatment
on
all
sale
proceeds
– Preferen5al
treatment
on
subop5mal
exit
versus
the
founders
10
11. Sources
of
Equity
Capital
Must
have
exits
for
equity
model
to
work!!
– 2011
US
IPOs
-‐
$36B
– 2011
US
M&A
-‐
$57B
– 2011
US
Private
Equity
-‐$35B
• Exit
sources
extremely
variable
…
health
of
economy
• All
exits:
indica*ve
of
future
cash
flow
or
market
control
Idea
Stage
• Friends
family,
founders
• Grants
• Crowds
(Kick-‐
starter)
Demonstrate
Product
&
Market
Interest
• Accelerators
• Individual
Angels
• Angel
Groups
• Accelerators
• Micro
Cap
VCs
Market
Entry
&
Early
Growth
•
Crowdfunding
(portal
style)
•
Angel
Groups
•
Angel
Group
SyndicaSon
•
Angel
List
•
Micro-‐cap
Funds
Early
Scaling
Growth
• Most
Venture
Funds
• Angel
SyndicaSon
Repeatable
Growth
• Most
Venture
Funds
• Strategic
VCs
• Angel
SyndicaSon
• Private
Equity
12. High
Growth
Capital
by
Stage
&Amount
12
Venture Stage
Investment
Size
Friends & Family
Vendors
Angels
Traditional VC
Angel Groups
Corporate Venturing
Grants
Customers
Crowdfunding
Portal Funding
AngelList
Micro VC
Equipment Financing
Founder
13. Capital
Sources:
Size
&
Cost
Investment Size
Investment
“Cost”
Traditional VC
Micro VC
Equipment Financing
Angel GroupsAngels
AngelList
Corporate / Strategic
Venture
Customers
Portal Funding
Vendors
Founder
Friends & Family
Crowdfunding
Grants
Venture
DebtBank
Loans
Personal
Loans
Private Equity
14. So
What
is
Equity
Anyway?
• Stock
=
right
to
residual
economic
interests
upon
sale/liquida*on
+
stockholder
vo*ng
rights
(usually
limited
to
Board
of
Directors
and
Sale
of
the
Company)
• Preferred
Stock
=
right
to
be
paid
before
Common
Stock
Par*cipa*ng
=
original
investment
PLUS
a
pro
rata
share
of
remainder
Non-‐Par*cipa*ng
=
original
investment
OR
a
pro
rata
share
• Common
Stock
=
whatever
is
let
ater
all
other
creditors
and
preferred
stockholders
are
paid
• Dividend
=
a
right
to
an
addi*onal
amount
upon
liquida*on
measured
as
a
func*on
of
*me
x
percentage
of
original
investment
.
Ex.
6.0%
per
annum
• OpSons
/
Warrants
=
Contracts
allowing
holder
to
purchase
an
amount
of
stock
in
the
future
at
a
pre-‐determined
price
• Control
Rights
=
Statutory
and
Contractual
14
15. Equity
Type
Comparisons
15
Solo
Angel
Super
Angel
Angel
Group
MicroVC
VC
Valua*ons
High
rela*ve
to
stage
High
rela*ve
to
stage
Low
rela*ve
to
stage
Low
rela*ve
to
stage
Medium
Type
-‐
Likely
(less
likely)
Common
(Warrants)
Conv
Note
(Preferred)
Preferred
(Conv
Note)
Preferred
(Conv
Note)
Preferred
Board
Seat
Maybe
1
or
none
1-‐2
of
5
+/-‐
Observer
1
of
5
+/-‐
Observer
1-‐2
of
5
+/-‐
Observer
Audited
Financials
No
No
No
(reviewed)
Yes
Yes
Nega*ve
Covenants
No
Some*mes
Yes
Yes
Yes
Preemp*ve
Rights
No
Some*mes
Yes
Yes
Yes
Ver*cal
Exper*se
Some*mes
Rarely
Some
Usually
Always
16. Equity
Type
Comparisons
16
Solo
Angel
Super
Angel
Angel
Group
MicroVC
VC
Exit
Horizon
(from
$
in)
7
years
5
years
4
years
5
-‐7
years
4-‐5
years
Exit
Range
$20m+
$40m+
$50m+
$100m+
$250m+
17. Structure
of
an
Equity
Deal
• Company
and
Investors
agree
on
a
“pre-‐money
valua*on”
(PM)
which
leads
to
a
price
per
share
• Investors
put
in
$X
• Investors
then
own:
X
/
(X
+
PM)
of
the
company
Example:
PM
=
$1M
X
=
$0.5M
Investors
own
0.5/1.5
=
33%
Remember:
New
issuance
NOT
transfer
17
18. Understand
the
Funding
Path
• We’re
talking
about
1st
funding
here
• What
is
the
probable
complete
funding
picture?
– This
is
only
funding
– Another
small
round
then
probable
small
exit
– Big
money
needed
before
exit
• Each
funding
event
should
occur
at
an
“inflec5on
point”
– Hopefully
at
a
point
where
risk
is
removed
– Increased
PM
=
so-‐called
“up
round”
18
19. Understand
the
Funding
Path,
cont.
• What
if
things
aren’t
going
so
well?
– Flat
or
decreased
PM
=
so-‐called
“down
round”
• More
money
coming
in
without
increased
PM
means
everyone
gets
diluted,
but…
• Depending
on
anS-‐diluSon
provision
entrepreneur
may
carry
more
burden
than
the
investors
19
20. What
about
Conver*ble
Debt?
• Many
seed-‐stage
companies
use
an
instrument
called
Conver5ble
Debt.
Huh?
• Conver5ble
debt
is
not
tradi5onal
bank
debt
• Converts
exist
for
two
major
reasons
– Investors
and
Entrepreneurs
find
it
hard
to
agree
on
a
PM
valua5on
– Some5mes
quicker
and
cheaper
to
document
than
equity
deals
(but
not
really)
20
21. Conver*ble
Debt
provides
Op*onality
• ConverSble
Debt
=
unsecured
debt
obliga*on
of
the
Company
that
may
be
converted
into
equity
of
the
Company.
• Conversion
Trigger
=
Qualified
Financing
usually
at
some
minimum
amount
of
funds
(ex.
$500,000)
• If
Notes
stays
as
Debt
=
Get
back
principal
and
interest
ahead
of
other
equity
(behind
other
creditors
typically)
• If
Notes
Convert
=
Convert
amount
of
debt
and
interest
into
equity
at
the
valua*on
in
the
next
round
•
ater
applica*on
of
a
Discount
(oten
5
–
20%)
•
subject
to
a
maximum
valua*on
amount
(the
“Cap”)
21
22. Basic
Structure
of
Conver*ble
Debt
• Investor
loans
$
to
Company
an5cipa5ng
another
round
of
funding
• Investment
accrues
small
interest
• When
the
funding
occurs,
investment
+
interest
convert
to
equity,
usually
at
a
discount
(5-‐20%
typically)
Example:
• Investors
loan
$200K
to
Company
• 20%
discount
• As
of
conversion,
interest
of
$10k
has
accrued
• Next
Round
PM
=
$2m
• Conversion
Amount
=
1/(1
-‐
0.2)*
$210k
=
$262,500
At
Conversion,
Noteholders
receive
262.5K
/
(PM
+
262.5K
+
New
Money)
22
23. Conver*ble
Debt
–
Complica*ons!
• When
does
the
debt
convert?
• What
happens
if
PM
of
next
round
is
huge?
• Does
the
investor
have
any
say
in
things?
• What
if
there
is
an
equity
investment
that
doesn’t
trigger
conversion?
• What
happens
if
it
never
converts?
• What
happens
if
Company
gets
bought?
23
24. Conver*ble
Debt
–
Solu*ons?
• Caps
and
Floors
– May
defeat
purpose
with
signaling
• Default
conversion
price
and
security
at
maturity
• Quick
sale
preferences
(ex.
2x)
• Governance
provisions
• Careful
agenSon
to
conversion
condiSons
24
25. Conver*ble
Debt
–
Worse
than
Equity?
• MulSple
liquidaSon
preference
(circa
2008)
– Ex.
$500k
of
Notes
with
cap
at
$2m
PM
– Next
Round
at
$6m
PM
– Issue
Noteholders
3x
number
of
shares
– 3x
shares
equals
3x
liquidaSon
preference!!
• Without
a
floor,
effecSvely
Full
Ratchet
AnS-‐diluSon
• Preference
Overhang
– In
prior
example
Noteholders
bought
$262,500
of
preference
for
$200,000.
– All
other
Series
A
Holders
bought
1:1
preference
• Not
Just
a
Price
Adjustment
25