This document describes two case studies of health and status monitoring systems used to monitor large, complex datasets and detect anomalies. In the first case study, a system monitored thousands of servers in a data center and detected dead or slow nodes that reduced overall performance. The second case study monitored billions of payment card transactions and developed over 15,500 statistical models to detect data quality issues and interoperability problems, improving approval rates and saving millions. Both cases highlighted the importance of executive support, dashboards, governance programs, and developing numerous statistical models tailored to different data segments.