Dr. David Steenblock discusses how to treat and help heal ALS (Lou Gherig's Disease). To learn more about how stem cells can help treat ALS, simply call Dr. Steenblock's office at 1-800-300-1063.

1. Healing ALS
By David Steenblock, BS,MS,DO
Mission Viejo, CA
There are three major problems to fix
 Chronic inflammation of the terminal ileum
 Acute and chronic inflammation of a spinal nerve
 Mutated and or damaged prions that are poisoning the spinal cord

2. GUT INFLAMMATION
Virtually no patient with ALS complains of intestinal tract problems
so doctors don’t believe the gut has anything to do with ALS.
Need specialized laboratory testing to determine all of the problems in the gut.
Tests needed:
1) Comprehensive Digestive Stool Test (CDSA) – to determine what “bad” bugs
are present in the gut and what to use to get rid of them.
2) Quantitative Urine Organic Acid Test (to verify and monitor the neurotoxins
present)
3) Toxic element Challenge test using DMSA to determine heavy metal poisons

3. SPINAL NERVE INJURY
ALS MOST OFTEN OCCURS SOON AFTER
AN ACUTE INJURY OF A SPINE THAT
ALREADY HAS PRE-EXISTING
DEGENERATIVE JOINT DISEASE (IN MY EXPERIENCE).

4. ALS
Gut inflammation is due to a microbial biofilm part of which is yeast. As yeast
hyphae penetrate into the gut, Tumor Necrosis Factor, Gamma Interferon and other
cytokines are produced in the gut wall.
The gut wall becomes more permeable.
Another part of the biofilm are gram negative bacteria which deposit fragments of
their outer cell wall (endotoxins=lipopolysaccharides) into the gut wall.
White blood cells called monocytes and small cell particles called platelets circulate
through the gut wall continuously to pick up serotonin and carry it to the nervous
system.
The gut inflammation and the cytokines produced cause a problem with the
conversion of tryptophan in food into serotonin. Thus little serotonin is absorbed
into the body and the nervous system becomes susceptible to injury because of the
lack of serotonin.

5. SECRET CAUSE OF ALS
The white blood cells called monocytes are the fraction of the white cells that carry
the bone marrow stem cells that heal your body.
Both the monocytes and stem cells acquire damage from the endotoxins, the
Tumor Necrosis Factor and the Gamma Interferon as well as neurotoxins from other
bacteria such as clostridia (about 80% of ALS patients have clostridia) all of which
are in the BIOFILM that is lining the wall of the terminal ilem and ileocecal valve
area i.e. the cecum.
These injured monocytes and stem cells then circulate and do not cause a problem
until there is an injury of a spinal nerve. Once that occurs these monocytes and
stem cells rush to that injury site to assist in the healing.
Because this is a spinal nerve injury the spinal nerve itself produces a huge amount
of Tumor Necrosis Factor and gamma interferon. The monocytes and stem cells
thus are subjected to repetitive injuries from these cytokines – first in the gut and
then in the spinal nerve. It is these injuries that damage the prions in these cells.

6. NON-INFECTIOUS
PRIONS
ARE THE CAUSE!
PRIONS are usually considered to be infectious proteins and as such are the
cause of terrible diseases such as Mad Cow Disease Creutzfieldt-Jakob disease, etc.
No one has ever been able to transmit ALS from one person to another so it is not
an infectious disease.
The normal body has normal non-infectious prions however but these can be
damaged by major physical stresses such as occurs in the gut and spinal nerve of
patients with ALS. These damaged prions enter the cord via the injured spinal nerve.
Research is now showing that damaged prion proteins can spread in the nervous
system in a migratory fashion and these damaged proteins can cause a great amount
of damage via a glutamate excitation.

7. Treatments that work
Cleanse the gut. Easier said than done. Antifungals, antibiotics etc. depending on the
test results.
5-HTP 100 mg three times a day is helpful in increasing the amount of serotonin in
the blood. This will help the nervous system. Best taken on an empty stomach. Can
be taken all at once at bedtime to help with sleep.
Melatonin in doses as high as tolerated (up to 300 mg per day have been used) since
this helps decrease the inflammation.
Naltrexone 3-4.5 mg at bedtime to help the immune system
Probiotics such as VSL #3 One to three caps 2 to 3 times per day i.e. as much as you
can tolerate. Side effects are gas, bloating and cramping. Decrease dose as needed.

8. Treatments that work for ALS
Histone Deacetylase Inhibitors- inhibit the histone deacetylase enzymes which means that
histone acetylases work better. Histone acetyl transferase acetylates (adds an acetyl
molecule) to the lysine residues in core histones which leads to a less compact and more
transcriptionally active chromatin. These HDAC inhibitors have anti-cancer effects with little
to no toxicity, have anti-inflammatory and anti-pain activities.
The ones that are useful and available are
Butyric acid
Phenylbutyrate
Nicotinamide
Ketones- See Ketogenic diet under www.stemcellmd.org
Sulforphane- 3 day old broccoli sprouts, cruciferous vegetables
Curcumin

9. Treatments that work for ALS
The spinal cord and cecum both suffer from a problem with chronic lack of
adequate oxygen. This may be due to the inflammatory processes but in the cord is
most likely due to the chronic damage from arthritis and other degenerative
conditions which have impinged the spinal arteries leading to marginal
oxygenation.
A test called “Nocturnal Oximetry” should be done and if there is intermittent lack
of oxygen at night while sleeping, oxygen should be prescribed and the patient
given oxygen to breath during their sleeping hours. This helps take away some of
the free radical stress that is occurring in the gut and spine.
Daily treatments with Hyperbaric Oxygen is helpful but only if used in combination
with a proper treatment of the gut and spine.

10. SPINAL NERVE TREATMENTS
The injuries to the spinal nerve that damage the prions and allows them into the
cord must be fixed and further injuries must be prevented.
If the patient does not complain of pain in the back then the physician should
carefully examine their back while looking at a CT exam of their spine. Generally
over the area of the spine that has DJD the doctor will be able to palpate the area
that the spinal nerve is injured. This painful area then is treated with an injection of
the buffy coat from an iliac crest bone marrow aspirate.
You may need only the buffy coat from one 50 ml conical centrifuge tube so up to
six more 50 ml tubes of bone marrow aspirate can be drawn and given
intravenously to the patient. If there are more sites of injury than one, you may
need to use more bone marrow to make more buffy coat for more extensive
injections.

11. STEM CELLS ARE GREAT
Bone Marrow aspiration is safe, simple and often of great help in these cases.
First of all the buffy coat from the bone marrow is easily prepared and this should be
injected into and around all inflamed spinal nerve areas that either can be seen on X-Ray or
palpated. This should be done soon after arrival in the clinic so the attending physician can
determine if another treatment of the same is needed before the patient leaves.
If all of the first day’s bone marrow is used to treat the spine then the next day’s bone
marrow should be given back to the patient intravenously in order to help heal the gut and
the injured spine via the blood rather than a direct injection as was done the day before.
IF the patient still has a good amount of abdominal fat then a liposuction could be
performed and the stromal vascular fraction given to the patient intravenously (not into
the CSF though). If a stem cell lab is available then either or both the bone marrow and/or
the fat can have the stem cells isolated and grown in tissue culture and then in 1 to 3
weeks the cells could be injected into the CSF.

12. More treatments that help
Many patients with ALS have chronic back pain. For this I recommend the use of
daily injections (subcutaneous or IM) of
1 ML OF ADENOSINE
1/2 ML OF HYDROXYCOBALAMINE
½ ML OF METHYLCOBALAMINE
IF FOR SOME REASON THESE ARE NOT HELPING, AFTER TWO WEEKS OF USING THIS
COMBO AND YOU ARE STILL HAVING PAIN, I WOULD ADD ONE ML OF KUTAPRESSIN
PLUS 1 ML OF LIDOCAINE TO EACH INJECTION. THE KUTAPRESSIN IS A GOOD ANTIINFLAMMATORY FOR THE NERVES.

13. MORE TREATMENTS THAT
WORK
Some patients will be dying literally when someone that cares for them reads this.
These patients often will be suffering from the “bulbar” form where the swallowing
centers are being affected and they are in danger of aspirating.
If these patients can not fly or travel out of the country or to California they really have
little chance unless they find a physician who has the knowledge to do at least one bone
marrow treatment and preferable two immediately. The spinal nerve injury needs to be
injected with stem cells immediately and then observed for two days. If no improvement it
should be repeated since the physician at times may have a hard time finding the right
location to inject the stem cells.
Once they are better then the proper testing mentioned earlier should be done and the
patient treated according to the results of the testing. The use of stem cells into the CSF
and or intranasally should be done ASAP as well.

14. CRITICISMS OF THIS
PROTOCOL
It is always amazing to me how terrible and verbally abusive my critics can be.
This protocol is offered to the world in hopes that others will take this information
and either prove it or disprove it. After 40 years of practice and examining and
treating many ALS patients I am convinced as to the validity of what I am putting out
here. However, since no one else has ever put the pieces together in this fashion I am
constantly being confronted with statements like “it can’t be true, since I have never
heard of such a theory” or “Dr Steenblock has run afoul of the law and is on
probation”, (multiple attacks by the establishment for being the first to use many
treatments such as hyperbaric oxygen for stroke patients).
However, I still have a legal full medical license to practice medicine in California.
Another question is how many patients have you treated in a double blind fashion
and what are the results?
My answer is that I have not treated many and many of my patients have died BUT
the fact is my record is as good or better than anyone else in the world in regard to
these patients. The bottom line is that this is a new protocol but one too valuable to
keep in the research lab while patients are dying. The big question is – Does it cause
harm? The answer is NO! Does it do good? The answer is a resounding YES!