The document discusses "Grand Challenges," which are ambitious yet achievable goals in areas of national and global priority that aim to have a significant positive impact. Grand Challenges can catalyze innovation across sectors and disciplines by clearly defining motivating goals. Successful Grand Challenge programs articulate why the goal is important, seek broad input to define the target and approach, adapt frameworks and roles to the specific goal, use a portfolio of funding methods, execute long-term engagement plans, and track progress indicators over multiple years. The document advocates for expanding participation in Grand Challenges to more organizations, communities of practice, stakeholders, students, and addressing social policy challenges.