This case report documents a 28 month old girl presenting with progressive ataxia and lower extremity weakness. Imaging reveals a heterogeneous posterior fossa mass with calcifications, hydrocephalus, and mass effect. Histopathology of the tumor shows a "small blue cell" neoplasm positive for synaptophysin and GFAP. The proliferation index varies within the tumor. The findings are consistent with medulloblastoma, the most common pediatric brain tumor of the posterior fossa.
This document summarizes the case of a 67-year-old woman presenting with chronic headache and right-sided weakness. Imaging revealed a heterogeneous mass centered in the splenium of the corpus callosum, with significant edema. The differential diagnosis includes glioblastoma, lymphoma, metastasis, demyelination, and toxoplasmosis. Histopathology found features consistent with glioblastoma such as cellular atypia, necrosis, endothelial proliferation, and GFAP positivity.
Presentation1.pptx, imaging modalities of intra cerebral lymphoma.Abdellah Nazeer
Primary central nervous system lymphoma (PCNSL) refers to lymphoma isolated to the brain and spinal cord. Imaging plays an important role in diagnosis. On CT, PCNSL typically appears as a hyperdense, solitary mass without necrosis or hemorrhage. On MRI, it has intermediate-low T1 signal, iso-hypointense T2 signal, and homogeneous enhancement. Location is commonly the supratentorial white matter. In immunocompromised patients, PCNSL can appear atypical with multiple lesions, necrosis, and heterogeneous enhancement. Advanced techniques like perfusion MRI and PET can aid in differentiating PCNSL from other tumors like glioblastoma and metastasis.
This patient presented with chronic headache and right-sided weakness. Imaging revealed a heterogeneous mass centered in the splenium of the corpus callosum, with significant edema. Histopathology of a biopsy showed features of a high-grade glioma such as cellular atypia, endothelial proliferation, and a high Ki-67 proliferation index. Immunohistochemistry was positive for GFAP. Features were consistent with glioblastoma multiforme.
This document discusses embryonal brain tumors in children. Some key points:
- Embryonal tumors account for a large fraction of pediatric brain tumors and have a tendency to disseminate through cerebrospinal fluid.
- Major embryonal tumor types include medulloblastoma, CNS primitive neuroectodermal tumor, and atypical teratoid/rhabdoid tumor.
- Medulloblastoma is the most common malignant primary brain tumor in children. It can be classified based on histology and molecular markers into subgroups like WNT, SHH, Group 3 and Group 4 that have different clinical behaviors and prognoses.
- Treatment involves surgery, chemotherapy and radiation therapy
This document discusses various congenital intracranial tumors that can occur in fetuses and infants. It provides details on the most common types such as teratomas, astrocytomas, choroid plexus papillomas, medulloblastomas, atypical teratoid/rhabdoid tumors, and craniopharyngiomas. It also discusses the imaging appearance and characteristics of these tumors using modalities such as ultrasound, MRI, and CT. Management involves surgical excision when possible, with the goal of preventing complications like cerebral spinal fluid leaks.
Pineal gland is essentially an extra axial midline structure lying at the roof of dienchephalon rostral to the quadrigeminal cistern surrounded by important neurovascular structure, occurring in the geometric center of brain with same depth of trajectory had made the surgery in this region a formidable challenge to neurosurgeons, however radical resection must be the goal in selected pathologies, if not pure germ cell tumor.
This document discusses various types of embryonal brain tumors that occur in children. It begins by providing background on the incidence of childhood cancers and CNS tumors specifically. It then lists and describes the main embryonal brain tumor types seen in children, including medulloblastoma, atypical teratoid/rhabdoid tumor, embryonal tumor with multilayered rosettes, pineoblastoma, and pituitary blastoma. For each tumor type, it discusses characteristics such as age of onset, location, histopathological features, molecular markers, treatment approaches, and prognosis. It emphasizes the importance of molecular classification in determining treatment strategies and clinical outcomes for these tumors.
This document discusses embryonal brain tumours according to the 2016 WHO classification. It first introduces some epidemiology of childhood cancers and CNS tumours. It then details the various subtypes of medulloblastoma, which is the most common embryonal brain tumour in children. These include genetically defined subtypes based on molecular alterations as well as histologically defined subtypes. Other embryonal tumour types discussed include AT/RT, embryonal tumours with multi-layered rosettes, and CNS neuroblastoma. Key diagnostic features, molecular markers, and prognosis are provided for each tumour subtype.
This document summarizes the case of a 67-year-old woman presenting with chronic headache and right-sided weakness. Imaging revealed a heterogeneous mass centered in the splenium of the corpus callosum, with significant edema. The differential diagnosis includes glioblastoma, lymphoma, metastasis, demyelination, and toxoplasmosis. Histopathology found features consistent with glioblastoma such as cellular atypia, necrosis, endothelial proliferation, and GFAP positivity.
Presentation1.pptx, imaging modalities of intra cerebral lymphoma.Abdellah Nazeer
Primary central nervous system lymphoma (PCNSL) refers to lymphoma isolated to the brain and spinal cord. Imaging plays an important role in diagnosis. On CT, PCNSL typically appears as a hyperdense, solitary mass without necrosis or hemorrhage. On MRI, it has intermediate-low T1 signal, iso-hypointense T2 signal, and homogeneous enhancement. Location is commonly the supratentorial white matter. In immunocompromised patients, PCNSL can appear atypical with multiple lesions, necrosis, and heterogeneous enhancement. Advanced techniques like perfusion MRI and PET can aid in differentiating PCNSL from other tumors like glioblastoma and metastasis.
This patient presented with chronic headache and right-sided weakness. Imaging revealed a heterogeneous mass centered in the splenium of the corpus callosum, with significant edema. Histopathology of a biopsy showed features of a high-grade glioma such as cellular atypia, endothelial proliferation, and a high Ki-67 proliferation index. Immunohistochemistry was positive for GFAP. Features were consistent with glioblastoma multiforme.
This document discusses embryonal brain tumors in children. Some key points:
- Embryonal tumors account for a large fraction of pediatric brain tumors and have a tendency to disseminate through cerebrospinal fluid.
- Major embryonal tumor types include medulloblastoma, CNS primitive neuroectodermal tumor, and atypical teratoid/rhabdoid tumor.
- Medulloblastoma is the most common malignant primary brain tumor in children. It can be classified based on histology and molecular markers into subgroups like WNT, SHH, Group 3 and Group 4 that have different clinical behaviors and prognoses.
- Treatment involves surgery, chemotherapy and radiation therapy
This document discusses various congenital intracranial tumors that can occur in fetuses and infants. It provides details on the most common types such as teratomas, astrocytomas, choroid plexus papillomas, medulloblastomas, atypical teratoid/rhabdoid tumors, and craniopharyngiomas. It also discusses the imaging appearance and characteristics of these tumors using modalities such as ultrasound, MRI, and CT. Management involves surgical excision when possible, with the goal of preventing complications like cerebral spinal fluid leaks.
Pineal gland is essentially an extra axial midline structure lying at the roof of dienchephalon rostral to the quadrigeminal cistern surrounded by important neurovascular structure, occurring in the geometric center of brain with same depth of trajectory had made the surgery in this region a formidable challenge to neurosurgeons, however radical resection must be the goal in selected pathologies, if not pure germ cell tumor.
This document discusses various types of embryonal brain tumors that occur in children. It begins by providing background on the incidence of childhood cancers and CNS tumors specifically. It then lists and describes the main embryonal brain tumor types seen in children, including medulloblastoma, atypical teratoid/rhabdoid tumor, embryonal tumor with multilayered rosettes, pineoblastoma, and pituitary blastoma. For each tumor type, it discusses characteristics such as age of onset, location, histopathological features, molecular markers, treatment approaches, and prognosis. It emphasizes the importance of molecular classification in determining treatment strategies and clinical outcomes for these tumors.
This document discusses embryonal brain tumours according to the 2016 WHO classification. It first introduces some epidemiology of childhood cancers and CNS tumours. It then details the various subtypes of medulloblastoma, which is the most common embryonal brain tumour in children. These include genetically defined subtypes based on molecular alterations as well as histologically defined subtypes. Other embryonal tumour types discussed include AT/RT, embryonal tumours with multi-layered rosettes, and CNS neuroblastoma. Key diagnostic features, molecular markers, and prognosis are provided for each tumour subtype.
The document discusses meninges and related tumors. It begins by describing the three layers of meninges - the outer dura mater, middle arachnoid mater, and inner pia mater - that cover and protect the brain. It then discusses different types of primary meningeal tumors, focusing on meningiomas. Meningiomas are the most common type of meningeal tumor in adults. The document outlines various subtypes of meningiomas, genetic factors involved in their development and malignant progression, typical locations, clinical features, microscopic appearance and distinguishing characteristics of different histological subtypes.
This document describes a case of tuberous sclerosis in a 15-year-old female patient. Radiological findings from CT and MRI scans show a calcified cortical tuber in the left frontal region as well as lissencephaly and pachygyria of the cerebral cortex. Additional findings include characteristic radial white matter lesions extending from the ventricles to the cortex and subependymal nodules forming protrusions into the ventricular cavity. The diagnosis of tuberous sclerosis is discussed based on the pathological features of cortical tubers, subependymal nodules, and white matter lesions visible on imaging and microscopy. Genetic causes and characteristics are also summarized.
Primitive neuroectodermal tumor (PNET) of the kidney is a rare and highly aggressive small round cell malignancy of neural crest origin. It commonly presents in young adults with nonspecific symptoms like flank pain and abdominal mass. Diagnosis involves histological examination showing small round cells and immunohistochemistry positive for markers like CD99. Treatment requires complete surgical resection combined with intensive chemotherapy and possibly radiotherapy. However, prognosis remains poor with an overall 5-year survival rate of around 50% despite aggressive multimodal treatment.
Choroid plexus papilloma is a rare, benign tumor that arises from the choroid plexus epithelium in the ventricles of the brain. It most commonly occurs in the lateral and third ventricles in children. On imaging, it appears as a lobulated, enhancing mass. Histopathology shows papillary fronds lined by columnar epithelium. The main treatment is surgical resection, with favorable long-term prognosis though rare recurrences or metastases are possible.
The document discusses various masses that can occur in the third and lateral ventricles. It describes 10 types of anterior third ventricular masses including astrocytomas, ependymomas, germinomas, metastatic tumors, epidermoid tumors, craniopharyngiomas, colloid cysts, pituitary tumors, and others. It also describes 7 types of posterior third ventricular masses and 8 types of lateral ventricle masses. For each mass, it provides information on symptoms, imaging appearance, diagnosis, and treatment options.
A 5-year-old male presented with a 1 month history of headache and vomiting. Imaging showed a hyperintense solid mass in the fourth ventricle with surrounding edema and hydrocephalus. MRI revealed a heterogeneous mass in the posterior fossa filling the fourth ventricle and invading the vermis, with areas of necrosis and decreased diffusion. The mass strongly enhanced with contrast. Based on these findings, the diagnosis was medulloblastoma, a highly malignant pediatric brain tumor originating in the cerebellum.
Medulloblastoma- A primitive neuroectodermal tumors (PNETs) is the most common malignant brain tumor of childhood (WHO IV)
arising from the vermis in the inferior medullary velum.
It comprises up to 18% of all pediatric brain tumors.
WNT and Shh pathway plays major role in its pathogenesis.
c-erbB-2 (HER2/neu) oncogene expression has prognostic value. Norcantharidin, Vismodegib, Sonidegib are the future in medulloblastoma.
1) Wilhelm Roentgen discovered X-rays in 1895 and Arthur Schiiller studied skull X-rays systematically, establishing neuroradiology. 2) Advances like ventriculography and cerebral angiography in the early 20th century allowed visualization of the brain. 3) Magnetic resonance imaging was developed in the 1940s-1980s and became the preferred method for evaluating brain tumors due to its superior soft tissue contrast compared to CT.
Brain tumors are responsible for approximately 2% of cancer deaths. They are the most common solid tumors in young patients, accounting for 20% of pediatric cancers. The overall incidence of brain tumors is 8-10 per 100,000 people per year, increasing with age to a maximum of 16 per 100,000 in the 7th decade of life. Brain tumors are classified based on the cell of origin, with gliomas arising from glial cells being the most common type. Astrocytomas range from low-grade to highly malignant and present with symptoms of increased intracranial pressure, focal neurological signs, or epilepsy.
The document discusses the anatomy and functions of different lobes of the brain including the frontal, temporal, parietal, occipital and limbic lobes. It also describes key areas involved in language, hearing, speech, motor control and sensation. Various brain tumors are discussed such as gliomas, meningiomas and metastases. Treatment options including surgery, radiation and chemotherapy are summarized.
This document discusses tumors of the nervous system. It notes that nervous system tumors are rare but can cause significant morbidity and mortality. The most common primary tumor is glioblastoma, which arises from glial cells. Symptoms vary depending on the location of the tumor but may include headaches, seizures, vomiting, impaired sensorium, focal neurological deficits, and signs of increased intracranial pressure such as papilledema. Diagnosis is made through MRI with contrast and CSF examination. Treatment involves steroids, surgery, radiation, chemotherapy, and ventricular drainage depending on the type and location of the tumor.
This document provides an overview of the pineal gland and pineal region tumors. It begins with the anatomy and histology of the pineal gland, then discusses common tumor types including germinomas, teratomas, pineocytomas, pineoblastomas, and others. For each tumor type, the characteristics, imaging appearance, histology, and clinical features are described. The document also reviews the surgical anatomy of the pineal region and historical aspects of pineal tumor surgery. Overall, it serves as a comprehensive reference for the pineal gland and tumors that originate within this region.
This document outlines the World Health Organization's 2016 classification of central nervous system tumors. It lists 17 categories of CNS tumors and provides brief descriptions of some of the tumor types within categories 1, 2, and 10, including diffuse astrocytic and oligodendroglial tumors, other astrocytic tumors characterized by more circumscribed growth and specific genetic alterations, and the various subtypes of meningiomas ranging from low to high grade.
The document summarizes various tumors of the central nervous system (CNS) and peripheral nervous system. It describes different types of gliomas, neuronal and mixed neuronal tumors, embryonal tumors, meningiomas, and other primary and secondary CNS tumors. It also discusses peripheral nerve sheath tumors, diseases of the peripheral nerves including various hereditary, infectious, inflammatory, and acquired neuropathies.
The document discusses tumors of the pineal gland. It begins by describing the location and structure of the pineal gland. Pineal region tumors constitute a small percentage of intracranial tumors but are clinically important due to their location. Symptoms include increased intracranial pressure, headaches, nausea, and visual problems. The document then discusses the different types of pineal tumors and how they appear on various imaging modalities like MRI, CT, and radiography. Common tumors mentioned are germinomas, pineoblastomas, pineocytomas, and pineal cysts. MRI is the preferred imaging method for delineating pineal masses and distinguishing true pineal tumors from parapineal masses.
Medulloblastomas are the most common malignant brain tumors in children. They arise in the cerebellum and can spread through the CSF pathways. Complete surgical resection followed by craniospinal irradiation is the main treatment approach. CSI provides improved local and systemic tumor control compared to other radiation techniques based on early studies. Medulloblastomas are highly radiosensitive tumors, making radiation an important part of management, though younger patients and those with residual disease or metastasis have poorer outcomes.
This presentation discusses craniopharyngiomas, which are benign but malignant behaving brain tumors. They have a bimodal age distribution with peaks between ages 5-14 and over 65. Common presenting symptoms include headache, endocrine dysfunction, and visual disturbances. Imaging typically shows an enhancing suprasellar mass that is calcified and cystic. Treatment options include attempting gross total resection or limited surgery followed by radiotherapy.
This document discusses the classification, clinical features, pathology, genetics, and treatment of brain tumors. It covers the major types of gliomas including diffuse astrocytomas, anaplastic astrocytomas, glioblastoma, oligodendrogliomas, and oligoastrocytomas. It describes their histopathological features, genetic alterations, imaging appearance, prognosis, and treatment approaches. Ependymomas are also summarized, noting their occurrence along the ventricular system in children and young adults.
Meningeal Based Intracranial Masses Beyond MeningiomaDr Varun Bansal
Dural based masses other than meningioma ( which is the most common dural based intracranial mass) their appearance on imaging modalities such as CT and MRI.
This document discusses various types of brain tumors and how they appear on different types of MRI sequences. It provides information on distinguishing between intra-axial and extra-axial tumors and describes signs that suggest a tumor's location and origin. Key tumor types are discussed like gliomas, metastases and meningiomas. The document also outlines characteristics of tumors visible on T1-weighted, T2-weighted, diffusion weighted and post-contrast scans that can help determine a tumor's properties and aid in diagnosis.
The document provides suggestions for self-care activities during menstruation including relaxation, yoga, aromatherapy, natural face treatments, and creating a spa-like atmosphere at home. It also outlines content marketing strategies like creating blog posts, videos, and social media updates around these self-care topics to engage customers and tie partnerships with related non-profits or local businesses.
The document discusses meninges and related tumors. It begins by describing the three layers of meninges - the outer dura mater, middle arachnoid mater, and inner pia mater - that cover and protect the brain. It then discusses different types of primary meningeal tumors, focusing on meningiomas. Meningiomas are the most common type of meningeal tumor in adults. The document outlines various subtypes of meningiomas, genetic factors involved in their development and malignant progression, typical locations, clinical features, microscopic appearance and distinguishing characteristics of different histological subtypes.
This document describes a case of tuberous sclerosis in a 15-year-old female patient. Radiological findings from CT and MRI scans show a calcified cortical tuber in the left frontal region as well as lissencephaly and pachygyria of the cerebral cortex. Additional findings include characteristic radial white matter lesions extending from the ventricles to the cortex and subependymal nodules forming protrusions into the ventricular cavity. The diagnosis of tuberous sclerosis is discussed based on the pathological features of cortical tubers, subependymal nodules, and white matter lesions visible on imaging and microscopy. Genetic causes and characteristics are also summarized.
Primitive neuroectodermal tumor (PNET) of the kidney is a rare and highly aggressive small round cell malignancy of neural crest origin. It commonly presents in young adults with nonspecific symptoms like flank pain and abdominal mass. Diagnosis involves histological examination showing small round cells and immunohistochemistry positive for markers like CD99. Treatment requires complete surgical resection combined with intensive chemotherapy and possibly radiotherapy. However, prognosis remains poor with an overall 5-year survival rate of around 50% despite aggressive multimodal treatment.
Choroid plexus papilloma is a rare, benign tumor that arises from the choroid plexus epithelium in the ventricles of the brain. It most commonly occurs in the lateral and third ventricles in children. On imaging, it appears as a lobulated, enhancing mass. Histopathology shows papillary fronds lined by columnar epithelium. The main treatment is surgical resection, with favorable long-term prognosis though rare recurrences or metastases are possible.
The document discusses various masses that can occur in the third and lateral ventricles. It describes 10 types of anterior third ventricular masses including astrocytomas, ependymomas, germinomas, metastatic tumors, epidermoid tumors, craniopharyngiomas, colloid cysts, pituitary tumors, and others. It also describes 7 types of posterior third ventricular masses and 8 types of lateral ventricle masses. For each mass, it provides information on symptoms, imaging appearance, diagnosis, and treatment options.
A 5-year-old male presented with a 1 month history of headache and vomiting. Imaging showed a hyperintense solid mass in the fourth ventricle with surrounding edema and hydrocephalus. MRI revealed a heterogeneous mass in the posterior fossa filling the fourth ventricle and invading the vermis, with areas of necrosis and decreased diffusion. The mass strongly enhanced with contrast. Based on these findings, the diagnosis was medulloblastoma, a highly malignant pediatric brain tumor originating in the cerebellum.
Medulloblastoma- A primitive neuroectodermal tumors (PNETs) is the most common malignant brain tumor of childhood (WHO IV)
arising from the vermis in the inferior medullary velum.
It comprises up to 18% of all pediatric brain tumors.
WNT and Shh pathway plays major role in its pathogenesis.
c-erbB-2 (HER2/neu) oncogene expression has prognostic value. Norcantharidin, Vismodegib, Sonidegib are the future in medulloblastoma.
1) Wilhelm Roentgen discovered X-rays in 1895 and Arthur Schiiller studied skull X-rays systematically, establishing neuroradiology. 2) Advances like ventriculography and cerebral angiography in the early 20th century allowed visualization of the brain. 3) Magnetic resonance imaging was developed in the 1940s-1980s and became the preferred method for evaluating brain tumors due to its superior soft tissue contrast compared to CT.
Brain tumors are responsible for approximately 2% of cancer deaths. They are the most common solid tumors in young patients, accounting for 20% of pediatric cancers. The overall incidence of brain tumors is 8-10 per 100,000 people per year, increasing with age to a maximum of 16 per 100,000 in the 7th decade of life. Brain tumors are classified based on the cell of origin, with gliomas arising from glial cells being the most common type. Astrocytomas range from low-grade to highly malignant and present with symptoms of increased intracranial pressure, focal neurological signs, or epilepsy.
The document discusses the anatomy and functions of different lobes of the brain including the frontal, temporal, parietal, occipital and limbic lobes. It also describes key areas involved in language, hearing, speech, motor control and sensation. Various brain tumors are discussed such as gliomas, meningiomas and metastases. Treatment options including surgery, radiation and chemotherapy are summarized.
This document discusses tumors of the nervous system. It notes that nervous system tumors are rare but can cause significant morbidity and mortality. The most common primary tumor is glioblastoma, which arises from glial cells. Symptoms vary depending on the location of the tumor but may include headaches, seizures, vomiting, impaired sensorium, focal neurological deficits, and signs of increased intracranial pressure such as papilledema. Diagnosis is made through MRI with contrast and CSF examination. Treatment involves steroids, surgery, radiation, chemotherapy, and ventricular drainage depending on the type and location of the tumor.
This document provides an overview of the pineal gland and pineal region tumors. It begins with the anatomy and histology of the pineal gland, then discusses common tumor types including germinomas, teratomas, pineocytomas, pineoblastomas, and others. For each tumor type, the characteristics, imaging appearance, histology, and clinical features are described. The document also reviews the surgical anatomy of the pineal region and historical aspects of pineal tumor surgery. Overall, it serves as a comprehensive reference for the pineal gland and tumors that originate within this region.
This document outlines the World Health Organization's 2016 classification of central nervous system tumors. It lists 17 categories of CNS tumors and provides brief descriptions of some of the tumor types within categories 1, 2, and 10, including diffuse astrocytic and oligodendroglial tumors, other astrocytic tumors characterized by more circumscribed growth and specific genetic alterations, and the various subtypes of meningiomas ranging from low to high grade.
The document summarizes various tumors of the central nervous system (CNS) and peripheral nervous system. It describes different types of gliomas, neuronal and mixed neuronal tumors, embryonal tumors, meningiomas, and other primary and secondary CNS tumors. It also discusses peripheral nerve sheath tumors, diseases of the peripheral nerves including various hereditary, infectious, inflammatory, and acquired neuropathies.
The document discusses tumors of the pineal gland. It begins by describing the location and structure of the pineal gland. Pineal region tumors constitute a small percentage of intracranial tumors but are clinically important due to their location. Symptoms include increased intracranial pressure, headaches, nausea, and visual problems. The document then discusses the different types of pineal tumors and how they appear on various imaging modalities like MRI, CT, and radiography. Common tumors mentioned are germinomas, pineoblastomas, pineocytomas, and pineal cysts. MRI is the preferred imaging method for delineating pineal masses and distinguishing true pineal tumors from parapineal masses.
Medulloblastomas are the most common malignant brain tumors in children. They arise in the cerebellum and can spread through the CSF pathways. Complete surgical resection followed by craniospinal irradiation is the main treatment approach. CSI provides improved local and systemic tumor control compared to other radiation techniques based on early studies. Medulloblastomas are highly radiosensitive tumors, making radiation an important part of management, though younger patients and those with residual disease or metastasis have poorer outcomes.
This presentation discusses craniopharyngiomas, which are benign but malignant behaving brain tumors. They have a bimodal age distribution with peaks between ages 5-14 and over 65. Common presenting symptoms include headache, endocrine dysfunction, and visual disturbances. Imaging typically shows an enhancing suprasellar mass that is calcified and cystic. Treatment options include attempting gross total resection or limited surgery followed by radiotherapy.
This document discusses the classification, clinical features, pathology, genetics, and treatment of brain tumors. It covers the major types of gliomas including diffuse astrocytomas, anaplastic astrocytomas, glioblastoma, oligodendrogliomas, and oligoastrocytomas. It describes their histopathological features, genetic alterations, imaging appearance, prognosis, and treatment approaches. Ependymomas are also summarized, noting their occurrence along the ventricular system in children and young adults.
Meningeal Based Intracranial Masses Beyond MeningiomaDr Varun Bansal
Dural based masses other than meningioma ( which is the most common dural based intracranial mass) their appearance on imaging modalities such as CT and MRI.
This document discusses various types of brain tumors and how they appear on different types of MRI sequences. It provides information on distinguishing between intra-axial and extra-axial tumors and describes signs that suggest a tumor's location and origin. Key tumor types are discussed like gliomas, metastases and meningiomas. The document also outlines characteristics of tumors visible on T1-weighted, T2-weighted, diffusion weighted and post-contrast scans that can help determine a tumor's properties and aid in diagnosis.
The document provides suggestions for self-care activities during menstruation including relaxation, yoga, aromatherapy, natural face treatments, and creating a spa-like atmosphere at home. It also outlines content marketing strategies like creating blog posts, videos, and social media updates around these self-care topics to engage customers and tie partnerships with related non-profits or local businesses.
BMW expanded its product line and production capacity at its Spartanburg, South Carolina plant to capture more of the premium vehicle market. The plant's production capacity increased from 160,000 to 240,000 vehicles per year through a $750 million investment. Since starting production in 1994, the Spartanburg plant has manufactured over 1.6 million BMW vehicles. To support its organizational changes amid an evolving market, BMW implemented systems like its Value-Added Production System to streamline processes and increase productivity while maintaining quality and culture.
The staff meeting focused on planning an alternate site evacuation drill. Staff were asked to review evacuation procedures before the meeting to discuss how to improve safety plans. On April 1st, staff would participate in a lockdown drill and evacuation to the designated alternate site, the Chisago Community Center. On May 23rd, a drill with students would take place. Staff were given questions to consider regarding the logistics and roles for an off-site evacuation. The role of law enforcement would also be discussed. Staff were asked to review lockdown and evacuation procedures in preparation for the meeting.
HCL Infosystems launches MyEduWorld, a new educational ecosystem for India encompassing digital curriculum, applications, videos, animations, and quizzes. It is available on Android tablets as MyEduWorld Tab and Windows PCs/laptops as MyEduWorld Drive. The platform allows self-paced learning anywhere and tracks student progress through assessment tests and reports to parents. It aims to make learning more engaging for students.
El documento describe el proceso convencional de compras, que incluye la generación de una orden de compra por parte del departamento de compras, la recepción y almacenamiento del producto en el almacén, y el pago al vendedor una vez recibida la factura.
AngularJS: A framework to make your life easierWilson Mendes
AngularJS is a javascript framework built and maintained by Google engineers Group, it uses HTML as a "template engine", all this in order to provide a complete solution for the client-side of your application. Also has full compatibility with the most used javascript libraries such as jQuery. It's a new concept for developing web apps client-site.
This document discusses business strategy and its key elements. It begins with an introduction to an upcoming assessment on emerging technologies. It then defines business strategy as establishing principles to achieve organizational goals. The basic principles of strategy according to Porter are outlined, including starting with long-term returns, delivering value, having a distinctive value chain, involving trade-offs, integrating strategic elements, and maintaining continuity of direction. Finally, the key elements of business strategy - mission, vision, objectives, and market strategy - are defined and examples are provided. Students are assigned homework to further research these elements.
Rainbow Grocery is a cooperative grocery store founded in San Francisco in 1975 as a "hippy collective" that has grown to become the largest cooperative-owned grocery store in the country. It is committed to only selling 100% organic and local produce while protecting the environment and promoting social responsibility. The document discusses Rainbow Grocery's use of various online platforms like Tumblr, WordPress, YouTube, and a Facebook game to engage customers, educate about food issues, and tell their story through different types of multimedia content.
El documento presenta información sobre la Federación Latinoamericana de Sociedades de Neurocirugía (FLANC), incluyendo su directorio, comités, capítulos y presidentes honorarios y de sociedades asociadas. Resume la estructura y liderazgo de esta organización dedicada a promover la neurocirugía en América Latina.
Este documento presenta varias ilusiones ópticas para explorar, incluyendo mirar fijamente un punto negro y mover la cabeza para ver cuántos puntos aparecen, y mirar un árbol para ver si se puede encontrar un bebé escondido. El propósito es entretener y desafiar la percepción visual a través de efectos ópticos engañosos.
This document discusses central nervous system (CNS) tumors. It begins by dividing CNS tumors into primary tumors, which originate in the brain, and secondary tumors, which have metastasized from other parts of the body. It then covers various types and grading systems of CNS tumors, including gliomas, the most common primary malignant brain tumors. Specific low-grade gliomas such as astrocytomas, oligodendrogliomas, and oligoastrocytomas are discussed in detail. Treatment options mentioned include observation, supportive care, surgery such as biopsy or resection, and chemotherapy or radiation.
The document discusses medulloblastoma (MB), the most common malignant brain tumor in children. MB originates in the cerebellum and projects into the fourth ventricle. It is thought to arise from primitive neuroepithelial cells. On imaging, MB typically appears as a large lobulated mass in the posterior fossa that compresses the fourth ventricle and causes hydrocephalus. Molecular analysis has classified MB into four subgroups: SHH, WNT, Group III, and Group IV, which have different characteristics and prognoses. Prognostic factors include age at diagnosis, extent of disease, extent of resection, histology, and biological markers.
A 32-year-old male presented with a single grand mal seizure. CT scans showed extradural masses in the left parietal and frontal regions, compressing the brain and ventricles. Surgery revealed nodular dural thickening without brain infiltration. Biopsy diagnosed non-Hodgkin B-cell lymphoma. Further staging found extensive extraneural disease, though the CNS manifestations were the initial presentation. The patient was referred for oncology management for epidural secondary CNS lymphoma.
This document provides an overview of glioblastoma multiforme (GBM), the most common and aggressive type of primary brain tumor. It describes the etiology, epidemiology, pathophysiology, presentation, diagnosis through imaging, histologic findings, treatment options including surgery, radiation and chemotherapy, and prognosis. GBM is difficult to treat due to tumor heterogeneity, rapid growth and recurrence. The standard of care involves maximal surgical resection followed by radiation and chemotherapy, but the median survival time remains less than 2 years.
CHOROID PLEXUS PAPILLOMAS Presentation..Anas Ahmed
Choroid plexus tumors arise from the choroid plexus in the ventricles of the brain. They range from benign choroid plexus papillomas (CPP, WHO grade I) to atypical choroid plexus papillomas (WHO grade II) and malignant choroid plexus carcinomas (CPC, WHO grade III). CPPs typically present with symptoms of increased intracranial pressure due to hydrocephalus in children. On imaging, CPPs enhance strongly with contrast. Surgical resection is the primary treatment, with the goal of total removal while preserving neurological function.
Dr Vandana, cranio spinal irradiation, radiotherapy, medulloblastoma, cancer, radiation, treatment, diagnosis, management, natural history of medulloblastoma, signs & symptoms of medulloblastoma,
current approach, future advancements
1) Brain metastases are a common consequence of systemic cancer that spreads via hematogenous spread, most often originating from the lung, breast, skin (melanoma), kidney, or colon.
2) Treatment options include surgical resection to reduce symptoms from mass effect, whole brain radiation therapy to control multiple metastases, and stereotactic radiosurgery for limited metastases.
3) Patient prognosis depends on factors like age, functional status, extent of primary cancer, and number/size of brain metastases, with standardized grading systems used to assess survival outcomes.
This document discusses the case of a 4 year old male child presenting with abdominal swelling, fever, and cachexia. Imaging findings showed a large heterogeneous enhancing mass in the left suprarenal region. Differential diagnoses for abdominal masses in young children were provided, including neuroblastoma, Wilms tumor, and lymphoma. The document then focuses on neuroblastoma, describing its characteristics, typical imaging appearance on ultrasound, CT, and MRI, as well as patterns of metastasis. Round cell tumors with similar histology and manifestations as neuroblastoma are also listed.
The document discusses various types of brain tumors, including:
- Oligodendrogliomas, which are slow-growing tumors that often appear calcified. They typically occur in frontal and temporal lobes.
- Ependymomas, which most commonly arise in the fourth ventricle in children. They can cause symptoms like nausea, vomiting, and headache.
- Mixed gliomas like oligo-astrocytomas, which contain both oligodendroglial and astrocytic cells.
- Choroid plexus papillomas, which are typically benign tumors arising from the choroid plexus epithelium in the ventricles. They can cause hydrocephalus.
A 67-year-old male presented with headache, facial weakness, and limb weakness. Imaging showed lesions in the left thalamus, midbrain, pons, and cerebellum enhancing on MRI. Biopsy of the thalamic lesion found diffuse large B-cell lymphoma. Further testing found lymphoma in peri-renal soft tissue as well. This represents either secondary CNS lymphoma with systemic involvement or synchronous primary lesions, unusual for primary CNS lymphoma.
This document discusses several types of primary brain tumors that can occur in the posterior fossa of adult patients. It first provides an overview of the posterior fossa anatomy. It then describes several specific tumor types:
1) Hemangioblastoma, the most common primary posterior fossa tumor in adults. They are highly vascular grade I meningeal tumors that often present as a cyst with an enhancing mural nodule.
2) Medulloblastoma, an embryonal tumor that is more common in children but can occur in adults. They often appear hyperattenuating on CT and hypointense on T2-weighted MRI with circumscribed margins.
3) Pilocytic astrocyt
The document discusses various types of brain tumors categorized by location, age of patient, and other distinguishing features. It provides details on meningiomas, epidermoid tumors, glioblastomas, oligodendrogliomas, hemangioblastomas, and medulloblastomas including typical locations, appearances on imaging, and other characteristics. Example cases are presented and differential diagnoses are discussed.
PINEAL REGION TUMORS DIAGNOSIS & SURGICAL APPROACHES.pptxMedhatMoustafa3
Anatomy and related vascular structures of pineal region.pathological classification and incidence. Clinical Presentations and different diagnostics modalities. Different surgical approaches for pineal region
This document discusses neuroblastoma and nephroblastoma (Wilms tumor). Neuroblastoma is the most common extracranial solid tumor in children, arising from the sympathetic nervous system. It presents heterogeneously from spontaneous regression to aggressive forms. The causes are largely unknown. Nephroblastoma (Wilms tumor) is the most common malignant renal tumor of childhood. Both tumors are diagnosed through imaging and urine/blood tests. Prognosis and treatment varies depending on tumor histology and staging. Aggressive forms of neuroblastoma and anaplastic Wilms tumor remain difficult to treat.
The document provides information on pilocytic astrocytomas including:
- Pilocytic astrocytomas most commonly occur in the cerebellum in children between 5-15 years old. They present as well-circumscribed yet non-encapsulated masses that are often cystic with a projecting nodule.
- Microscopically, they have a biphasic pattern of dense, elongated astrocytes alternating with loose, microcystic regions. They frequently contain Rosenthal fibers and abnormal, thick-walled blood vessels.
- Pilocytic astrocytomas are considered low-grade tumors that grow slowly by expansion rather than infiltration. They have a benign
Presentation1.pptx, radiological imaging of extra nodal lymphoma.Abdellah Nazeer
This document discusses extranodal lymphoma, which refers to lymphomatous infiltration of sites other than lymph nodes. It provides examples of extranodal lymphoma in many organs and tissues throughout the body, as seen on various imaging modalities like CT, MRI, PET, and ultrasound. Extranodal lymphoma can mimic other diseases, so it should be considered in the differential diagnosis of mass lesions and focal abnormalities. Biopsy is often needed for definitive diagnosis.
Similar to Harbor UCLA Neuro-Radiology Case 8 (20)
El documento presenta una revisión sobre el consenso de la Sociedad de Neuro-oncología de 2023 sobre el manejo de la epilepsia relacionada con tumores cerebrales. Se discuten las características clínicas y los mecanismos fisiopatológicos subyacentes, así como las opciones de tratamiento farmacológico y quirúrgico. Se enfatiza la importancia del control de las crisis convulsivas para mejorar la calidad de vida de los pacientes oncológicos. También se presentan perspectivas sobre el tratamiento endov
Este documento presenta un resumen de varios artículos científicos relacionados con temas de neurociencia. En el primer artículo, se explora el plexo braquial, sus lesiones y formas de evaluación. El segundo artículo evalúa la invasión de la pared medial del seno cavernoso por adenomas hipofisarios. El tercer artículo compara los resultados de la microcirugía frente a la microcirugía con embolización preoperatoria para el tratamiento de malformaciones arteriovenosas cerebrales. Finalmente, el cuart
Este documento presenta un resumen de un artículo científico reciente que describe una nueva capa de membrana en el espacio subaracnoideo del cerebro, denominada SLYM, que podría representar un sistema linfático local y jugar un papel importante en la respuesta inmune cerebral. El documento también incluye otros artículos sobre neurocirugía craneal y un caso clínico de radionecrosis cerebral tratada con éxito mediante esteroides y bevacizumab.
Este documento presenta una discusión sobre la propuesta de cambiar el término "Diabetes Insípida" por "Deficiencia de Arginina-Vasopresina" para evitar confusiones con la Diabetes Mellitus. También resume los desafíos de diagnosticar la espondilodiscitis, una infección de los cuerpos vertebrales que suele presentar síntomas inespecíficos. Finalmente, analiza las opciones de tratamiento médico y quirúrgico para esta afección, incluyendo la antibioticoterapia y la cirugía mínimamente
El documento describe el rol del equipo neurocrítico en el manejo de pacientes en condiciones de emergencias masivas. Originalmente conformado por neurocirujanos y neurointensivistas, el equipo se ha expandido para incluir oftalmólogos y otorrinolaringólogos. En situaciones de emergencia, su sistema operativo dinámico y capacidad de resolución in situ ha mejorado los resultados. Procedimientos comunes incluyen craniectomías, esquirlectomías y reconstrucciones craneales. El equipo neurocrítico ha de
Este documento discute la investigación sobre la ablación ultrasónica en neurocirugía. Explica que existen técnicas térmicas y no térmicas, y que las técnicas no invasivas guiadas por resonancia magnética tienen mayor evidencia de eficacia. Sin embargo, las técnicas mecánicas permiten crear lesiones más cercanas al cráneo. El documento también describe los avances tecnológicos recientes como transductores hemisféricos y la integración con resonancia magnética, y concluye resumi
El documento presenta 3 estudios sobre el uso de realidad aumentada mediante lentes Hololens para la planeación quirúrgica en neurocirugía. El primer estudio encontró que la localización del tumor fue más precisa con la práctica, mientras que los otros 2 estudios encontraron una precisión similar entre la realidad aumentada y la neuronavegación convencional, aunque con una curva de aprendizaje para la nueva tecnología. En general, los estudios sugieren que la realidad aumentada podría usarse como una alternativa a la neuronavegación, aunque se
Este documento presenta una revisión de la meningitis crónica. Se define como la inflamación de las meninges que dura al menos 4 semanas. Puede ser causada por infecciones o en pacientes inmunodeprimidos. Los síntomas comunes incluyen cefalea, letargo y alteraciones cognitivas. El diagnóstico se realiza mediante análisis del líquido cefalorraquídeo y resonancia magnética. Se recomienda evaluar cuidadosamente los riesgos y beneficios del tratamiento antimicrobiano antes de inic
El documento describe los posibles mecanismos neurológicos por los que las personas infectadas con COVID-19 pueden sufrir síntomas neurológicos. Estos incluyen daño celular como la infección de astrocitos, disfunción vascular que causa hipoperfusión cerebral, y anomalías en el sistema inmunológico donde los autoanticuerpos podrían dañar neuronas. Aunque se han propuesto varios mecanismos, aún se investiga para comprender plenamente cómo el virus causa daño cerebral y qué tratamientos podrían prevenir complicaciones
Este documento conmemora el 15 aniversario de la revista Neurocirugía Hoy. Contiene cartas de felicitación de varios neurocirujanos y editores que destacan la importante labor educativa de la revista al difundir información científica de calidad sobre neurociencias y neurocirugía en América del Norte, Central y del Sur durante los últimos 15 años. El editor en jefe Rodrigo Ramos agradece a todos los colaboradores por su apoyo constante para consolidar una publicación de divulgación científica con altos estándares de calidad
El documento presenta información sobre un volumen de la publicación Neurocirugía Hoy que incluye artículos sobre evidencia científica y toma de decisiones en neurocirugía, estudios cuantitativos basados en PET para el diagnóstico de epilepsia farmacorresistente, telemedicina en neurocirugía, evidencia actual de trombólisis en infarto cerebral isquémico, y regeneración endógena de la médula espinal mediante la inducción de oligodendrocitos a partir de células ependimarias. El documento también incl
Este documento presenta un resumen de tres oraciones de las recomendaciones clave de la Comisión Lancet sobre la pandemia de Covid-19 y de la ONU. 1) Se enfatizan las estrategias no farmacológicas como medidas universales de protección personal, distanciamiento e higiene. 2) Se recomienda el acceso universal y equitativo a las pruebas diagnósticas, tratamientos y vacunas. 3) Se destaca la necesidad de proteger a los grupos vulnerables y de apoyar la recuperación económica de man
El documento presenta un resumen de un estudio multicéntrico que evaluó 154 embolizaciones de la arteria meníngea media para el tratamiento de hematomas subdurales crónicos. El objetivo terapéutico fue reducir el volumen del hematoma en más de un 50% a los 90 días. El 97% de las embolizaciones tuvieron éxito, el 70% de los pacientes mostraron una reducción mayor al 50% del volumen del hematoma y el 31% mejoría clínica. La tasa de complicaciones fue de 6.5% y la mortalidad de 4
Este documento resume el impacto de la pandemia de COVID-19 en la neurocirugía desde varias perspectivas. Describe cambios en los sistemas de salud de Italia y Estados Unidos como la reducción de camas y personal para neurocirugía y la suspensión de cirugías electivas. También discute los retos en la atención pediátrica y la educación médica, incluyendo el cambio a la enseñanza en línea. Finalmente, analiza los efectos psicológicos en los neurocirujanos y la incertidumbre sobre
Este documento es un volumen de la publicación trimestral Neurocirugía Hoy que contiene varios artículos de investigación sobre temas de neurocirugía. Incluye artículos sobre la filogenia y ontogenia del lóbulo frontal, el bienestar en residentes de neurocirugía, la ética en alertas de salud, las limitaciones de la neuroimagen funcional para la elección de pacientes y planificación quirúrgica en cirugía de gliomas, evidencia de una red psicoemocional en el cerebro mediante resonancia magnética funcional, lesion
Este documento discute la significancia estadística en la investigación científica. Expertos matemáticos han propuesto una reevaluación del uso del valor p<0.05 y enfatizar más el análisis causal. Un estudio encontró que solo el 49% de artículos científicos interpretaron correctamente los resultados estadísticos, sugiriendo que factores como el diseño del estudio y la comprensión de los mecanismos son más importantes que el valor p. Los investigadores deben prestar más atención a explicar todos los valores dentro del intervalo
Este documento presenta un resumen de un estudio alemán sobre la eficacia de nuevos fármacos lanzados al mercado entre 2011-2017. El estudio encontró que solo el 25% de los 216 nuevos fármacos tuvieron un efecto considerable de beneficio comparado con tratamientos previos. Para la evaluación del beneficio, el 16% no pudieron ser cuantificados y el 58% no demostraron un beneficio adicional. Para neurología y psiquiatría, solo uno de 18 fármacos demostró mayor beneficio. Esto sugiere que
Este documento resume el estado actual y las perspectivas futuras de las inteligencias artificiales en medicina y neurocirugía. Recientemente, los sistemas de IA han demostrado ser útiles a nivel clínico al mejorar la interpretación de imágenes y datos, a nivel de los sistemas de salud al mejorar los flujos de trabajo, y a nivel de los pacientes al permitirles procesar sus propios datos de salud. En neurocirugía, las IA se usan cada vez más para predecir resultados, diagnosticar tumores y planificar tratamientos. Aunque
Este documento presenta información sobre varios temas de neurocirugía y neurociencias. Incluye resúmenes de artículos científicos sobre atención neuroquirúrgica pediátrica a nivel mundial, el uso de la neuroendoscopía para la extracción de craneofaringiomas, y predictores de persistencia y oclusión de aneurismas cerebrales después de la redirección de flujo. También presenta información sobre el uso de endoscopios telefónicos en neurocirugía de mínima invasión, una rara presentación
Promoting Wellbeing - Applied Social Psychology - Psychology SuperNotesPsychoTech Services
A proprietary approach developed by bringing together the best of learning theories from Psychology, design principles from the world of visualization, and pedagogical methods from over a decade of training experience, that enables you to: Learn better, faster!
- Video recording of this lecture in English language: https://youtu.be/kqbnxVAZs-0
- Video recording of this lecture in Arabic language: https://youtu.be/SINlygW1Mpc
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Basavarajeeyam is an important text for ayurvedic physician belonging to andhra pradehs. It is a popular compendium in various parts of our country as well as in andhra pradesh. The content of the text was presented in sanskrit and telugu language (Bilingual). One of the most famous book in ayurvedic pharmaceutics and therapeutics. This book contains 25 chapters called as prakaranas. Many rasaoushadis were explained, pioneer of dhatu druti, nadi pareeksha, mutra pareeksha etc. Belongs to the period of 15-16 century. New diseases like upadamsha, phiranga rogas are explained.
Adhd Medication Shortage Uk - trinexpharmacy.comreignlana06
The UK is currently facing a Adhd Medication Shortage Uk, which has left many patients and their families grappling with uncertainty and frustration. ADHD, or Attention Deficit Hyperactivity Disorder, is a chronic condition that requires consistent medication to manage effectively. This shortage has highlighted the critical role these medications play in the daily lives of those affected by ADHD. Contact : +1 (747) 209 – 3649 E-mail : sales@trinexpharmacy.com
These lecture slides, by Dr Sidra Arshad, offer a quick overview of the physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar lead (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
6. Describe the flow of current around the heart during the cardiac cycle
7. Discuss the placement and polarity of the leads of electrocardiograph
8. Describe the normal electrocardiograms recorded from the limb leads and explain the physiological basis of the different records that are obtained
9. Define mean electrical vector (axis) of the heart and give the normal range
10. Define the mean QRS vector
11. Describe the axes of leads (hexagonal reference system)
12. Comprehend the vectorial analysis of the normal ECG
13. Determine the mean electrical axis of the ventricular QRS and appreciate the mean axis deviation
14. Explain the concepts of current of injury, J point, and their significance
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. Chapter 3, Cardiology Explained, https://www.ncbi.nlm.nih.gov/books/NBK2214/
7. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Histololgy of Female Reproductive System.pptxAyeshaZaid1
Dive into an in-depth exploration of the histological structure of female reproductive system with this comprehensive lecture. Presented by Dr. Ayesha Irfan, Assistant Professor of Anatomy, this presentation covers the Gross anatomy and functional histology of the female reproductive organs. Ideal for students, educators, and anyone interested in medical science, this lecture provides clear explanations, detailed diagrams, and valuable insights into female reproductive system. Enhance your knowledge and understanding of this essential aspect of human biology.
TEST BANK For Community Health Nursing A Canadian Perspective, 5th Edition by...Donc Test
TEST BANK For Community Health Nursing A Canadian Perspective, 5th Edition by Stamler, Verified Chapters 1 - 33, Complete Newest Version Community Health Nursing A Canadian Perspective, 5th Edition by Stamler, Verified Chapters 1 - 33, Complete Newest Version Community Health Nursing A Canadian Perspective, 5th Edition by Stamler Community Health Nursing A Canadian Perspective, 5th Edition TEST BANK by Stamler Test Bank For Community Health Nursing A Canadian Perspective, 5th Edition Pdf Chapters Download Test Bank For Community Health Nursing A Canadian Perspective, 5th Edition Pdf Download Stuvia Test Bank For Community Health Nursing A Canadian Perspective, 5th Edition Study Guide Test Bank For Community Health Nursing A Canadian Perspective, 5th Edition Ebook Download Stuvia Test Bank For Community Health Nursing A Canadian Perspective, 5th Edition Questions and Answers Quizlet Test Bank For Community Health Nursing A Canadian Perspective, 5th Edition Studocu Test Bank For Community Health Nursing A Canadian Perspective, 5th Edition Quizlet Test Bank For Community Health Nursing A Canadian Perspective, 5th Edition Stuvia Community Health Nursing A Canadian Perspective, 5th Edition Pdf Chapters Download Community Health Nursing A Canadian Perspective, 5th Edition Pdf Download Course Hero Community Health Nursing A Canadian Perspective, 5th Edition Answers Quizlet Community Health Nursing A Canadian Perspective, 5th Edition Ebook Download Course hero Community Health Nursing A Canadian Perspective, 5th Edition Questions and Answers Community Health Nursing A Canadian Perspective, 5th Edition Studocu Community Health Nursing A Canadian Perspective, 5th Edition Quizlet Community Health Nursing A Canadian Perspective, 5th Edition Stuvia Community Health Nursing A Canadian Perspective, 5th Edition Test Bank Pdf Chapters Download Community Health Nursing A Canadian Perspective, 5th Edition Test Bank Pdf Download Stuvia Community Health Nursing A Canadian Perspective, 5th Edition Test Bank Study Guide Questions and Answers Community Health Nursing A Canadian Perspective, 5th Edition Test Bank Ebook Download Stuvia Community Health Nursing A Canadian Perspective, 5th Edition Test Bank Questions Quizlet Community Health Nursing A Canadian Perspective, 5th Edition Test Bank Studocu Community Health Nursing A Canadian Perspective, 5th Edition Test Bank Quizlet Community Health Nursing A Canadian Perspective, 5th Edition Test Bank Stuvia
Osteoporosis - Definition , Evaluation and Management .pdfJim Jacob Roy
Osteoporosis is an increasing cause of morbidity among the elderly.
In this document , a brief outline of osteoporosis is given , including the risk factors of osteoporosis fractures , the indications for testing bone mineral density and the management of osteoporosis
Does Over-Masturbation Contribute to Chronic Prostatitis.pptxwalterHu5
In some case, your chronic prostatitis may be related to over-masturbation. Generally, natural medicine Diuretic and Anti-inflammatory Pill can help mee get a cure.
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
NVBDCP.pptx Nation vector borne disease control program
Harbor UCLA Neuro-Radiology Case 8
1. HARBOR UCLA NEURO CASE # 8
Anton Mlikotic, MD, Department of Radiology
Marcia Cornford, MD, PhD, Department of Pathology
Los Angeles County
Department of Health Sciences
2. Clinical presentation
The patient is a 28 month-old baby girl presenting with
progressive ataxia and lower extremity weakness, who
failed to achieve developmental milestones.
3. The screening non-enhanced CT study of the brain revealed a midline posterior fossa mass of
heterogeneous density containing calcifications. There is complete effacement of the fourth
ventricle and prepontine cistern with dilatation of the temporal horns of the lateral ventricle (left).
The mass secondarily results in significant obstructive hydrocephalus with areas of periventricular
trans-ependymal edema. (right)
4. 3
C
This sagittal T1-weighted image shows a mass of heterogeneous though predominantly isointense signal
with respect to the brain, centered in the posterior fossa (arrows), with compression of the fourth ventricle
and cerebellum (C) and dilatation of the third ventricle (3). There is significant mass effect upon the brain
stem as well, with flattening of the pons and medulla oblongata.
5. FLAIR images reveal a high water content of the neoplasm with foci of dark signal corresponding
to calcifications and vascular flow voids. Note the periventricular areas of high signal related to
trans-ependymal flow of cerebrospinal fluid secondary to long standing ventricular obstruction.
6. The coronal T2-weighted image also indicates that the tumor has a high water content, demonstrated by
increased signal intensity. Also, the mass extends into the supratentorial compartment through the
tentorial incisura, marked by the arrows.
7. Prior to gadolinium contrast administration (left), the mass is predominately low in signal intensity
on T1-weighted imaging, with scattered foci of bright and dark signal. Note the superior cerebellar
peduncle (arrow), which is surrounded by the mass. Following intravenous delivery of gadolinium
contrast (right) , there is minimal appreciable enhancement.
8. Diffusion weighted images demonstrate evidence for restriction, a finding associated with
masses that have compact cells with a high nuclear to cytoplasmic ratio.
11. T
N
At low power, the specimen in paraffin stained with haematoxolin and eosin shows sheets of tumor
cells (T), with invasion of normal cerebellar white matter (N).
13. At higher power, there are uniform sheets of tumor with cells containing pleomorphic nuclei and more
abundant cytoplasm than usual for this entity. No rosette formation or cellular palisading is appreciated
14. For comparison, in another patient, the above pattern of Homer-Wright rosette formation with
central fibrillary material in another patient is a typical, though inconsistent feature.
15. IMHC staining for synaptophysin shows uptake by the tumor both peripherally within the cell
membrane (top, right) and internally within the cytoplasm (bottom, right).
16. This section of tumor best demonstrates synaptophysin positivity, where the immunohistochemical
marker concentrates at synaptic connections.
17. The tumor shows positivity for glial fibrillary acidic protein (GFAP).
18. There are scant areas of uptake of the IMHC CD99 marker, although it is largely negative.
19. Staining with IMHC CD-34 shows uptake by both stromal and capillary endothelial components.
20. A
B
The IMHC Ki-67 marker uptake demonstrates a highly variable proliferation index, with areas
of both high (A) and low (B) mitotic activity.
21. There is marked uptake of Ki-67 by this portion of tumor, with a proliferation index of >25%,
indicating a high grade neoplasm.
22. Summary of Histopathologic Findings
The specimen demonstrates a “small blue cell” neoplasm, lacking rosette
formation and palisading features. The nuclei are, on average, larger and
more variegated in size, and the cytoplasmic component is more abundant
than usual .
IMHC marker localization helps to confirm diagnosis. There is synaptophysin
localization, at the cell surface, within the cytoplasm, and especially at the
synaptic connections. The tumor also shows areas of positivity for glial
fibrillary acidic protein (GFAP) and CD-34 uptake of both the stromal and
endothelial components. Of note, there is lack of true IMHC CD99 localization,
and additional staining with INI-1 , a nuclear antigen marker, was negative.
23.
24.
25. Medulloblastoma
Medulloblastoma is a highly malignant primary brain tumor that usually
forms in the vicinity of the fourth ventricle, between the brainstem and
cerebellum. It is the most common pediatric central nervous system
malignancy of the posterior fossa in children (38% of all pediatric posterior
fossa tumors), occurring more frequently in males and most commonly before
the age of 10. It accounts for 6% to 8% of all central nervous system tumors
and 12% to 25% of tumor subtypes in the pediatric population.
In constitutes only 0.4% to 1% of all central nervous system tumors in adults,
however, presenting usually in the second or third decades of life.
26. Medulloblastoma: Clinical Presentation
Symptoms result from secondary increased intracranial pressure due to blockage
of the fourth ventricle and present less than months before diagnosis. Headache and
persistent vomiting are common, and truncal ataxia accompanied by spasticity, result
from destruction of the cerebellar vermis. Other clinical findings include papilledema,
nystagmus, limb ataxia, and dysdiadokokinesis.
On examination, one third of patients have a positive Babinski and Hoffman signs.
Abducens nerve palsy results from compression of the nucleus of the sixth cranial nerve
along the anterior margin of the fourth ventricle. Other findings may reflect distal
metastatic seeding to the brain or spinal cord.
27. Medulloblastoma: Imaging
The tumor is characteristically high in density on unenhanced CT studies,
reflecting the compactness of the tumor cell, which has a high nuclear to
cytoplasmic ratio. It is typically heterogeneous, related to the presence of
cystic degeneration or necrosis, hemorrhage, and calcification. The mass is
characteristically midline in children, often arising from the cerebellar vermis.
In adults, a more lateral location is typical in the posterior fossa. The mass
usually incites vasogenic edema in the surrounding brain tissue, and the
degree of contrast enhancement is variable, though most commonly
homogeneous. Secondary obstructive hydrocephalus results from compression
of the fourth ventricle.
On MR, the mass is isointense to hypointense relative to white matter on T1
weighted imaging and has variable signal intensity on T2 weighted imaging.
Similar to CT, the contrast enhancement of these lesions is highly variable,
which may reflect the subtype of the lesion or degree of malignancy. Diffusion-
weighted imaging is helpful for both diagnosis and post-operative surveillance,
as the neoplasm shows high signal, reflecting restriction of the random motion
of water molecules in cells with low cytoplasmic content.
28. Medulloblastoma: Imaging
At the time of diagnosis, over 30% of cases show evidence of
leptomeningeal spread, both in the brain and the spine.
The differential diagnosis in children includes ependymoma, pilocytic
astrocytoma, and atypical teratoid / rhabdoid tumor. Other
considerations are metastasis, hemangioblastoma, astrocytoma,
lymphoma, and dysplastic cerebellar gangliocytoma.
29. Medulloblastoma: Histogenesis
Although currently classified as a subset of primitive neuroectodermal tumor
(PNET), originating from immature or embryonal cells at their earliest stage
of development, the exact cell of origin or “medulloblast” is unknown, and may
arise from cerebellar stem cells that are prevented from differentiating into
normal cell types. Molecular genetics have isolated a gene deletion on the long
arm of chromosome 17, distal to the p53 gene, and genetic profiling has
demonstrated a molecular profile that is distinct from other PNET neoplasms.
30. Medulloblastoma: Histology
On gross inspection, medulloblastomas have a variable appearance. They
may present as discrete, firm masses or may be soft and less well defined.
Histologically, medulloblastomas are small, blue-cell tumors that may
resemble other entities, such as pineoblastomas. The presence of Homer
Wright rosettes, with central neurofibrillary processes, is a hallmark finding,
but is not always present. Mitotic activity is conspicuous, and necrosis may
occur both on the cellular level (apoptosis) and in confluent fields.
Large cell or anaplastic medulloblastoma has a closely packed cell
arrangement, similar to the usual type of medulloblastoma, however the nuclei
have increased diameters and the nucleoli are prominent. This variant also
shows striking immunohistochemical staining for synaptophysin.
In contradistinction, atypical teratoid / rhabdoid tumors have a less overall
organized appearance and show only scant, focal areas of synaptophysin and
GFAP uptake. This tumor also shows uniform positivity for CD-99 and
negativity for INI-1(integrase interactor 1), a tumor suppressor gene normally
expressed but lost in malignant rhabdoid tumors and epithelioid sarcomas.
32. Immunohistochemical Profile for Medulloblastoma
Marker Endothelial Stromal
component component
VEGF + +
CD 31 + -
CD 34 + +
FACTOR 8 + -
GFAP - Occasionally
EMA - -
CYTOKERATIN - -
VIMENTIN - +
ERYTHROPOEITIN - Occasionally
NSE - +
VEGF = Vascular endothelial growth factor
GFAP = Glial fibrillary acidic protein
EMA = Endothelial membrane antigen
NSE = Neuron specific enolase
Information derived from Pathologyoutlines.com and Manual of Basic Neuropathology, 4th Edition
33. Medulloblastoma: Subtype classification
The World Health Organization recognizes four major subtypes of this grade 4 lesion:
1- The classic subtype is defined by dense, sheet like growth of cells with hyperchromatic,
round to oval nuclei, accompanied by increased mitotic activity and apoptosis.
Commonly visualized are neuroblastic or Homer-Wright rosettes, consisting of
neoplastic cell nuclei in a radial arrangement around fibrillary processes.
2- The desmoplastic subtype shows nodular, reticulin-free “pale islands” surrounded by
reticulin-staining collagen fibers
3- The subtype termed “medulloblastoma with extensive nodularity and advanced neuronal
differentiation” occurs primarily in children less than 3 years, associated with
“grapelike” nodularity that can be appreciated on cross-sectional imaging. Intranodular
cellular uniformity, accompanied by a fine fibrillary matrix and occasional mature
ganglion cells, is typical. This variant is termed cerebellar neuroblastoma.
34. Medulloblastoma: Subtype classification
4- Large cell medulloblastoma is the least common form (4% of cases), and is characterized
by large round nuclei with prominent nucleoli, nuclear molding, and abundant cytoplasm.
This subtype carries the poorest prognosis, and a variant of this form has been termed “large
cell anaplastic variant.”
Other less common subtypes include medullomyoblastoma and melanotic medulloblastoma.
35. Medulloblastoma: Treatment / Prognosis
Treatment begins with maximal resection of the tumor, and the addition of radiation to
the entire neuroaxis and chemotherapy may permit a 5 year survival in over 80% of
cases. Prognosis worsens however with a very young presentation (less than 3 years of
age), an inadequate degree of resection, or with distal spread.
36. Post-operative imaging
Following surgical debulking of the non-enhancing tumor, the residual tumor burden is
best appreciated on the diffusion weighted images. Approximately 80 to 90% was successfull
removed, and the portion that was closely adherent to the brainstem was preserved. A small
amount of intraventricular hemorrhage is also noted.
37.
38. Answer: Contrast-enhanced imaging of the neuroaxis
Leptomeningeal metastasis occurs in 33% of cases at diagnosis. Primitive
neuroectodermal tumors, such as medulloblastoma, may spread via
subarachnoid seeding. Therefore, complete contrast-enhanced imaging
of the neuroaxis should be performed to assess for distal spread.
Whether post-operative surveillance with MRI should be performed remains
controversial in terms of prognosis. It may be useful though in assessing the
efficacy of adjuvant therapies to treat this disease.
39.
40. MR Spectroscopy
In another patient, single voxel proton spectroscopy sampling a midline posterior fossa neoplasm,
proven to be a medulloblastoma, shows an elevated choline peak, a signature for neoplasm, at 3.2 ppm.
Elevated choline peaks reflect the increased turnover of cell membrane phosphatidylcholine in more
rapidly dividing tumor cells. In addition, there is a taurine peak of 3.4 ppm, considered fairly specific
for medulloblastoma and related PNET tumors.
AJNR March, 2006; 27: 560-572
41. References
• Medulloblastoma: A Comprehensive Review with Radiologic-Pathologic
Correlation. Radiographics 2003; 23: 1613-1637.
• Escourolle and Poirier Manual of Basic Neuropathology: Fourth Edition. F Gray,
U De Girolami, J Poirier. Pages 23-24.
Editor's Notes
Lamia Britt and Taylor Mackey
Low power showing sheets of tumor cells M normal brain and tumor sheet molecular layer on folium
Tumor with calcification of vascular wall (unusual for medulloblastoma)
Classkc pnet nice round nuclei, no nucleoli small clear lightly eosinophili cytoplasm no rosettes or paslisading so not ependymoma uniform sheets of tumor
Classkc pnet nice round nuclei, no nucleoli small clear lightly eosinophili cytoplasm no rosettes or paslisading so not ependymoma uniform sheets of tumor