Hadorn Biostec 2010
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This document discusses the challenges of developing multicompartment drug delivery systems. It outlines three main challenges: 1) defining the architecture so aggregates have distinct containers and self-terminate, 2) enabling defined communication between compartments, and 3) achieving defined encapsulation of drugs. DNA-mediated self-assembly may help address the first challenge of creating well-defined, self-assembled and self-terminated aggregates. Future work is still needed to solve challenges around compartment communication and encapsulation to realize the benefits of multicompartment drug delivery systems.
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![Prodrugs =overcoming barriers in clinical drug application « Many therapeutic drugs have undesirable properties that may become […] barriers in clinical drug application. […] Prodrugs [are] pharmacologically inert chemical derivatives that can be converted [e.g. enzymatically] in vivo to the active drug molecules to exert a therapeutic effect. Ideally, the prodrug should be converted to the original drug as soon as the goal is achieved […]. Han HK, 2000. AAPS Pharmsci2(1):article 6. »](data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7)
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TISSUE ENGINEERING
DEFINITION , EXAMPLES, SCAFFOLDS & ITS TYPES ,APPLICATIONS OF TISSUE ENGINEERING , PROS AND CONS OF TISSUE ENGINEERING
Crimson Publishers - Tissue Engineering Applications in Medicine
Tissue Engineering Applications in Medicine by Lara Tutunji* in Research in Medical & Engineering Sciences
poster-template-horizontal-3-purrington
Stem cells are undifferentiated cells that can replace damaged cells through cell division. Sources of stem cells include adult, embryonic, induced pluripotent, and cancerous stem cells. Regenerative medicine uses stem cells to create living tissues to repair damage from aging, disease, injury, or defects by replacing lost tissues. This field holds promise for increasing healthy lifespans and offers advantages over organ transplants like avoiding immunosuppression and shorter recovery times. However, challenges remain such as ensuring stem cells integrate properly after transplantation and developing sufficient biomaterials for tissue engineering applications.
Cell Therapy: The New Approach to Dermatology and Dermatologic Surgery
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Extracellular vesicles as drug delivery systems.pptx
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Tissue engineering
Tissue engineering is the use of a combination of cells, engineering and materials methods, and suitable biochemical and physicochemical factors to improve or replace biological functions.
The term has also been applied to efforts to perform specific biochemical functions using cells within an artificially-created support system (e.g. an artificial pancreas, or a bio artificial liver).
A commonly applied definition of tissue engineering, as stated by Langer and Vacanti is “An interdisciplinary field that applies the principles of engineering and life sciences toward the development of biological substitutes that restore, maintain, or improve [Biological tissue] function or a whole organ”
UROPProposalA_Marks
Andrea Marks proposes research to design an enzymatically degradable hydrogel for cartilage tissue engineering. Specifically, the hydrogel will incorporate an MMP-7 degradable peptide linker that degrades at a rate proportional to cartilage matrix deposition by human mesenchymal stem cells (hMSCs) encapsulated in the hydrogel. The research aims to determine an appropriate degradable peptide linker, incorporate it into a hydrogel, characterize the hydrogel's degradation kinetics, and investigate how the degradable linker affects hMSC chondrogenesis. Previous work showed biodegradable scaffolds can improve tissue formation by allowing more extracellular matrix deposition compared to nondegradable scaffolds. The proposed research seeks to create a hydrogel
Regenerative Medicine: A Multidisciplinary Approach to a Complex Problem_Crim...
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Despite the successful progresses in organ transplant, the organs shortage and the long waiting lists make it of the most challenging issues of our times. In fact, just a small percentage of patients receive transplants [1,2]. while every day around 18 people die waiting for them [3]. The possibility to create de novo tissues and organs and/or to promote their regeneration is of prominent interest in the research community. In the last years, many innovative approaches have been introduced and new technological advancements are undergoing. Currently, the most diffused methodologies rely on regenerative medicine, that combines the use of stem cells, stimulated with specific factors, and scaffolds, where cells can grow to substitute damaged tissues, inducing their repair and improving their functions [4]. Scaffolds possess a defined structure, with precise pore size and distribution [5,6], and determined mechanical properties which can tackle stress ensuring biological interconnections [7]. Regenerative medicine combines different disciplines, such as chemistry, physics, biology and tissue engineering to obtain functional materials. In this minireview, we will focus on the materials and fabrication methods that are used to prepare the scaffolds, the type of cells that are commonly used for regeneration, and finally the current advances in clinical approval.Biohacker Summit 2022 presentation – 10 Hallmarks of Aging & Reversal
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This document discusses the challenges of novel antibacterial discovery and potential strategies to address it. It notes that no new classes of antibiotics have been registered since 1984, despite efforts focused on single enzyme targets which often lead to resistance. Successful strategies may include pursuing multi-target agents less prone to resistance, understanding physicochemical properties required for entry into gram-negative bacteria, and taking a more empirical screening-based approach informed by these insights. Combination therapies may also help prevent resistance from single mutations. Overall, antibacterial discovery is a multi-faceted problem requiring consideration of targets, resistance potential, and mechanisms of bacterial entry and efflux.
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Hadorn Biostec 2010
- 1. TOWARDS PERSONALIZED DRUG DELIVERY – Preparation of an Encapsulated Multicompartment System
- 2. Prodrugs =overcoming barriers in clinical drug application « Many therapeutic drugs have undesirable properties that may become […] barriers in clinical drug application. […] Prodrugs [are] pharmacologically inert chemical derivatives that can be converted [e.g. enzymatically] in vivo to the active drug molecules to exert a therapeutic effect. Ideally, the prodrug should be converted to the original drug as soon as the goal is achieved […]. Han HK, 2000. AAPS Pharmsci2(1):article 6. »
- 3. Prodrugs =demanding in application
- 4. Single Liposomes =30 years ofevolution of drug carriers immuno- liposome long-circulating liposome long-circulating immunoliposome new generation liposome liposome Torchilin VP, 2005. Nature Reviews Drug Discovery 4(2):145-160.
- 5. Scenario = personalized drug delivery modified: Davis ME, Chen Z, et al., 2008. Nature Reviews Drug Discovery7(9):771-782.
- 8. Defined Encapsulationprodrug carrying liposome enzymosome
- 11. Defined Encapsulationlong-circulating immunoliposome prodrug carrying liposome enzymosome
- 13. no multitude of containersChiruvolu S, Walker S, Israelachvili J, Schmitt FJ, Leckband D, and Zasadzinski JA, 1994. Science 264(5166):1753-1756.
- 15. Challenge 1.2: self-termination Adhesion Plaques = creating the ‘HALT’
- 16. Challenge 1.2: self-termination Adhesion Plaques = creating the ‘HALT’
- 17. Challenge 1.2: self-termination Adhesion Plaques = creating the ‘HALT’
- 18. Challenge 1.2: self-termination Adhesion Plaques = creating the ‘HALT’
- 19. Challenge 1.2: self-termination Adhesion Plaques = creating the ‘HALT’ Hadorn M, Burla B, and Eggenberger Hotz P, 2009. 4th Australian Conf. on Artificial Life.
- 20. 1st Challenge: defined architecture DNA-mediated self-assembled and self-terminated aggregates Hadorn M, Eggenberger Hotz P (2010). DNA-Mediated Self-Assembly of Artificial Vesicles. Plos One 5(3):e9886.
- 23. Defined Encapsulationlong-circulating immunoliposome prodrug carrying liposome enzymosome
- 24. 2nd Challenge = defined communication www.orwarlab.org Stengel G, Zahn R, and Hook F, 2007. Journal of the American Chemical Society129(31):9584-9585. Bolinger PY, Stamou D, et al., 2008. Angewandte Chemie-International Edition47(30):5544-5549.
- 27. Defined Encapsulationlong-circulating immunoliposome prodrug carrying liposome enzymosome
- 28. 3rd Challenge = defined encapsulation Bolinger PY, Stamou D, et al., 2008. Angewandte Chemie-International Edition47(30):5544-5549. Walker SA, Kennedy MT, and Zasadzinski JA,1997. Nature387(6628):61-64.
- 29. 3rd Challenge = defined encapsulation Hadorn M and Eggenberger Hotz P, 2010. BIOSTEC, Valencia, Spain, Jan 20-23, 2010.
- 30. Peter EggenbergerHotz Associated Professor Mærsk Mc-Kinney Møller Institute University of Southern Denmark Enrico Martinoia Professor Institute of Plant Biology University of Zurich Rolf Pfeifer Professor Artificial Intelligence Laboratory University of Zurich Acknowledgments Bo Burla PhD Student Institute of Plant Biology University of Zurich Eva Bönzli PhD Student Faculty of Veterinary Medicine University of Zurich EU_ProjectPACE EU-IST-FP6-FET-002035 SNSF-Project EES 200020-118127