Granulation is a process that binds together primary powder particles to form larger multi-particle structures called granules. There are three main types of granulation: wet granulation, dry granulation, and direct compression. Dry granulation is used for heat or moisture sensitive drugs, drugs with a high dose, or drugs that do not compress well after wet granulation. It involves weighing, sieving, pre-mixing, slug formation, screening, and final mixing without the use of a binding solution. Common excipients used include diluents, glidants, lubricants, and disintegrants. Equipment for dry granulation includes a chilsonator and hammer mill. The key advantages are that it requires less equipment

1. GRANULATION
SACHIN SURYAWANSHI
M. PHARM

2. GRANULATION -
• Granulation is the size enlargement process in which
primary powder particles are made to adhere to form
larger, multi particle entities called granules.
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3. TYPES OF GRANULATION -
1. Wet Granulation
2. Dry Granulation
3. Direct Compresssion
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5. DRY GRANULATION -
We Need Some Properties of Dry Method –
 Heat sensitive drugs.
 Moisture sensitive drugs.
 Drug dose is too high.
 Do not compress well after wet granulation.
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6. STEPS IN DRY GRANULATION -
1. Weighing
2. Seiving
3. Pre Mixing
4. Formation Of Sluggs
5. Screening of Sluggs
6. Final Mixing
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7. WHICH EXCIPIENT ARE USED IN
DRY GRANULATION ?
• Dilluents
• Glidants
• Lubricants
• Disintegrents
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8. EQUIPMENTS –
1 CHILSONATOR 2 HAMMER MILL
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9. ADVANTAGES -
 less Equipment
Eliminate Need Of Binder Solution
No Need of moisture and heat.
Coast effective.
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10. REFERANCE –
I. Arvind K. Bansal, ... Sneha Sheokand, in Handbook
of Pharmaceutical Wet Granulation, 2019
II. http://www.sciencedirect.com
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11. THANK YOU
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