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Pharmaceutical Suspension
- 32. Take solids | Triturate in pestle mortar | Add sufficient vehicle to form smooth cream | Add more solvent to make pourable | Examine carefully for foreign particles | Rinse the mortar and pestle | Add liquid ingredient if any | Make up volume Take solids + tragacanth powder | Triturate in pestle mortar | Add sufficient vehicle to form smooth cream | Add more solvent to make pourable | Examine carefully for foreign particles | Rinse the mortar and pestle | Add liquid ingredient if any | Make up volume Take solids | Triturate in pestle mortar + tragacanth mucilage | 1. Diffusible Solids 2. Indiffusible Solids
- 33. 3. PRECIPITATE FORMING LIQUIDS • Certain liquid preparation on addition to water forms precipitate • Ex: Banzoin tincture, Tolu tincture etc • Insoluble and indiffusible precipitate Take solids + tragacanth powder | Triturate in pestle mortar | Add sufficient vehicle to form smooth cream, add more vehicle to make pourable | Add precipitate forming liquid with slow stream in centre with rapid stirring | Carefully Examine for foreign particle | Rinse the mortar and pestle | Add liquid ingredient if any | Make up volume Take solids | Triturate in pestle mortar + tragacanth mucilage |
- 34. Suspension prepared by chemical reaction In this type of suspension highly diluted solutions are mixed together so as to form very finely divided precipitates that can be easily distributed throughout the liquid by shaking Example Rx Sulphorated potash 5.0gm Zinc sulphate 5.0g Concentrated camphor water 2.5ml Water add upto 100.0ml Make a mixture Method: Dissolve the potash Dissolve zinc sulphate in small quantity of water in small quantity of water | | Add potash solution to zinc sulphate solution with constant stirring | Add camphor water then volume is make up
- 35. Packaging and Storage of Suspensions: 1) Should be packaged in wide mouth containers having adequate air space above the liquid. 2) Should be stored in tight containers protected from: freezing, excessive heat & light. 3) Label: "Shake Before Use" to ensure uniform distribution of solid particles and thereby uniform and proper dosage. 4) Stored in room temperature if it is dry powder (25 0C). Note: It should be stored in the refrigerator after opening or reconstitute (freezing should be avoided to prevent aggregation) 5) Parental suspension must be packed in amber color ampoule or vial.
- 36. STABILITY OF SUSPENSION A stable suspension can be redisperse homogeneously with moderate shaking. Can be easily pourable through its shelf life If suspension is flocculated suspension can be redisperse easily at anytime with moderate shaking. If suspension is deflocculated so particles should not get settle and can be made stable by decreasing particle size, increasing density and viscosity.