In the elderly osteoporotic fractures although the principles are the same but some special considerations in management of the soft tissues and the bony injuries are considered.
In the elderly osteoporotic fractures although the principles are the same but some special considerations in management of the soft tissues and the bony injuries are considered.
presentation about minimally invasive bridge plating technique usage in pediatric femoral shaft fracture , showing a prospective case series study done over thirty child
presentation about minimally invasive bridge plating technique usage in pediatric femoral shaft fracture , showing a prospective case series study done over thirty child
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
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Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
4. Case history
• Age, sex, occupation
• Presenting complain
• History of PC / Event
• Past medical history
• Past surgical history
• Drugs, Allergies
• Social history
9. Fracture and its type
• Left ulna shaft fracture with radial head
dislocation
• Monteggia fracture
• Bado type 3
10. Montegia fracture
Giovanni Battista Monteggia of Milan.
1814Monteggia GB. Instituzioni Chirrugiche. vol 5. Milan: Maspero; 1814
• proximal ulna fracture with ant. Dislocation of
radial head
• Described in pre-roentgen era, on basis of
clinical examination.
• Perticular fracture patteren is 60% of total
monteggia lession
11. Bado classification
• 1967, Bado described term Monteggia lesion
– classified the injury in 4 types
– Bado JL. The Monteggia lesion. Clin Orthop Relat Res. Jan-Feb
1967;50:71-86
• Type I - Fracture of the proximal third of the ulna with
anterior dislocation of the radial head.
• Type II - posterior dislocation of the radial head
• Type III - lateral dislocation of the radial head
• Type IV - proximal radius fracture with anterior dislocation of
the radial head
Dislocation of radial head in the direction of ulna fracture apex.
12. Monteggia lession
• The Monteggia lesion is most precisely
characterized as a forearm fracture in
association with dislocation of the proximal
radioulnar joint.
• 5% of total forearm fracture.
• Type-I 59%, Type-III 26%, Type-II 5%, Type IV
1%.
– Bruce H.E., Harvey J.P., Wilson J.C. Monteggia Fractures. J Bone Joint Surg
Am. 1974;56:1563.
– Reckling F.W. Unstable fracture-dislocation of the forearm (Monteggia and
Galeazzi lesions). J Bone Joint Surg Am. 1982;64:857
13. Mechanism of injury
• Falls on an outstretched hand with forced pronation,
• In case of flexed elbow, the chance of a type II or III
lesion is greater,
• direct blow to the forearm
• High energy Trauma, RTA
• Low energy Trauma, fall from standing height
• Evans-1949 & Penrose-1951 studied the etiology of
Monteggia fractures on cadavers
– Evans EM. Pronation injuries of the forearm with special reference to anterior Monteggia fractures. J
Bone Joint Surg. 1949;31B:578-588.
– Penrose JH. The Monteggia fracture with posterior dislocation of the radial head. J Bone Joint Surg.
1951;33B:65-73.
14. Associated nerve injuries
• posterior interosseous nerve (branch of the
radial nerve) 10% in acute injuries
– particularly in Bado type II injuries
• Ruchelsman DE, Pasqualetto M, Price AE, Grossman JA. Persistent posterior
interosseous nerve palsy associated with a chronic type I monteggia fracture-
dislocation in a child: a case report and review of the literature. Hand (N Y). Jun
2009;4(2):167-72
• Anterior interosseous nerve of median nerve and
lunar nerve injuries are aso reported
• Most nerve injuries are neurapraxias and typically
resolve over a period of 4-6 months
15. Treatment
• Factor effecting the treatment
• Age pediatric or adult
• Pediatric fracture pattern ( plastic deformity,
green stick, Transverse or short oblique,
comminuted or long oblique)
– Ring D, Jupiter JB, Waters PM. Monteggia fractures in children and adults. J Am Acad
Orthop Surg. 1998; 6(4):215–224.
– Ring D, Waters PM. Operative fixation of Monteggia fractures in children. J Bone Joint
Surg Br. 1996; 78(5):734–739
• Close reduction and casting preferred for
pediatric age group
• Adult group with ORIF
16. Treatment in pediatric group
• Why nonoperative treatment is successful for most
Monteggia injuries in children?
1. fractures are inherently stable
2. shorter time required for both the osseous and the
ligamentous injuries to heal.
3. Less elbow stiffness even after elbow imobilization for
4-6 wks.
4. remodeling of mild, residual angular deformities <
10°.
Ring D, Jupiter JB, Waters PM. Monteggia fractures in children and adults. J
Am Acad Orthop Surg. 1998; 6(4):215–224.
Leonidou A, Pagkalos J, Lepetsos P, Antonis K, Flieger I, Tsiridis E, et al.
Pediatric Monteggia fractures: a single-center study of the
management of 40 patients. J Pediatr Orthop. Jun 2012;32(4):352-6
17. Treatment in pediatric group
• Fracture in children which are not stable and
comminuted or long obliqe recommended to
be treated with surgical management
intramadullary nailing or platting.
18. Treatment in pediatric group
• In case of delayed diagnosis or missed
dislocation
• Multiple surgical interventions can b used e.g
ulnar osteotmy, open reduction of radial head
with anular ligament repair, transcapitalar
wire fixation.
Degreef I, De Smet L. Missed radial head dislocations in children associated with ulnar
deformation: treatment by open reduction and ulnar osteotomy. J Orthop Trauma.
2004; 18(6):375–378.
Hui JH, Sulaiman AR, Lee HC, Lam KS, Lee EH. Open reduction and annular ligament
reconstruction with fascia of the forearm in chronic monteggia lesions in children. J
Pediatr Orthop. 2005; 25(4):501–506.
David-West KS, Wilson NI, Sherlock DA, Bennet GC. Missed Monteggia injuries. Injury. 2005;
36(10):1206–1209
Ladermann A, Ceroni D, Lefevre Y, De Rosa V, De Coulon G, Kaelin A. Surgical treatment of
missed Monteggia lesions in children. J Child Orthop. 2007; 1(4):237–242
19. Treatment in pediatric group
• Nakamura et al evaluated the long-term clinical and
radiographic outcomes after open reduction for the
treatment of missed Monteggia fracture-dislocations in
22 children (14 boys, 8 girls; age range, 4 y to 15y 11
mo). The postoperative Mayo Elbow Performance
Index at follow-up ranged from 65 to 100, with 19
excellent results, 2 good results, 1 fair result, and zero
poor results. In 17 patients, the radial head remained
in a completely reduced position, and it was subluxated
in 5 patients. Osteoarthritic changes were seen at the
radiohumeral joint in 4 patients. Radiographically,
there were 15 good results, 7 fair results, and zero poor
results. A good radiographic result was seen in all
patients who underwent open reduction within 3 years
after injury or before reaching 12 years of age
Nakamura K, Hirachi K, Uchiyama S, Takahara M, Minami A, Imaeda T, et al. Long-term
clinical and radiographic outcomes after open reduction for missed Monteggia fracture-
dislocations in children. J Bone Joint Surg Am. Jun 2009;91(6):1394-404
20. Forearm outcome criteria
• In 1991, Anderson and Meyer used criteria to
evaluate forearm fractures and their prognosis, as
follows:
– Excellent: Union with less than 10° loss of elbow and
wrist flexion/extension and less than 25% loss of
forearm rotation
– Satisfactory: < 20° loss of elbow and wrist
flexion/extension & < 50% loss of forearm rotation
– Unsatisfactory: > 30° loss of elbow and wrist
flexion/extension & > 50% loss of forearm rotation
– Failure: Malunion, nonunion, or chronic
osteomyelitis
Anderson LE, Meyer FN. Fractures of the shafts of the radius and ulna. In:
Rockwood CA, Green DP, and Bucholz R, eds. Fractures in Adults. vol 1. 3rd ed.
Philadelphia, Pa: JB Lippincott; 1991
21. Adult treatment
• Close reduction and casting fails in adults due
to shortning and angulation in ulna post
reduction
• Recommended in adult ORIF with platting
– Ring D, Jupiter JB, Simpson NS. Monteggia fractures in adults. J Bone Joint Surg
Am. 1998; 80(12):1733–1744.
– Guitton TG, Ring D, Kloen P. Long-term evaluation of surgically treated anterior
monteggia fractures in skeletally mature patients. J Hand Surg Am. 2009;
34(9):1618–1624
22. Adult treatment
• Retrospective analysis of 47 adult Monteggia
fracture cases, Konrad et al identified several
negative prognostic indicators for patients
undergoing operative treatment. They found
that Bado type 2 fractures, coronoid process
fractures, radial head or neck fractures, and
complications necessitating additional surgery
correlated with poorer clinical outcomes.
– Konrad GG, Kundel K, Kreuz PC, Oberst M, Sudkamp NP. Monteggia
fractures in adults: long-term results and prognostic factors. J Bone Joint
Surg Br. 2007
23. Adult treatment
• Guitton et al performed a retrospective study on the functional and
radiologic long-term outcome of open reduction and internal
fixation in 11 skeletally mature patients with Bado type 1
Monteggia fractures. Two patients had subsequent surgery for
nonunion, and 3 elbows had radiographic signs of arthrosis. The
mean arc of elbow flexion increased from 110º (range, 35º-140º) at
early follow-up to 120º (range, 40º-150º) at late follow-up. The
mean arc of forearm rotation increased from 145º (range, 90º-180º)
to 149º (range, 90º-180º). The mean Broberg and Morrey score
increased from 89 points (range, 62-100 points) to 94 points (range,
76-100 points), and the median DASH score was 7 points (range, 0-
34 points) at long-term follow-up.
– Guitton TG, Ring D, Kloen P. Long-term evaluation of surgically treated anterior
monteggia fractures in skeletally mature patients. J Hand Surg Am. Nov
2009;34(9):1618-24